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Luck favors the prepared in hepatic conversion.

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Τίτλος: Luck favors the prepared in hepatic conversion.
Συγγραφείς: Galloway KE; Department of Chemical Engineering, MIT, 25 Ames St., Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, 500 Main St., Cambridge, MA 02139, USA. Electronic address: katiegal@mit.edu.
Πηγή: Stem cell reports [Stem Cell Reports] 2026 Sep 08; Vol. 21 (9), pp. 103057. Date of Electronic Publication: 2026 Aug 27.
Τύπος έκδοσης: Journal Article; Comment
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
Imprint Name(s): Original Publication: [Cambridge, MA] : Cell Press, c 2013-
Ιατρικοί όροι (MeSH): Hepatocytes*/cytology , Hepatocytes*/metabolism , Liver*/cytology , Cellular Reprogramming*, Fibroblasts/cytology ; Fibroblasts/metabolism ; Animals ; Cell Lineage ; Humans ; Cell Differentiation
Περίληψη: Goto et al. in this issue use continuous lineage imaging to examine why only some fibroblasts become induced hepatocyte-like cells. The study suggests that hepatic reprogramming follows a hybrid elite-stochastic model: early asymmetric division produces elite-like lineages, and subsequent mitotic activity and chance determine which descendants ultimately complete conversion.
(Copyright © 2026 The Author. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of interests The authors declare no competing interests.
References: Stem Cell Reports. 2026 Sep 8;21(9):103056. (PMID: 42660117)
Science. 2019 Apr 26;364(6438):. (PMID: 30898844)
Cell Syst. 2025 Apr 16;16(4):101205. (PMID: 40086434)
Nature. 2009 Dec 3;462(7273):595-601. (PMID: 19898493)
Cell. 2014 Feb 13;156(4):649-62. (PMID: 24486105)
Cell Syst. 2024 Feb 21;15(2):109-133.e10. (PMID: 38335955)
Nature. 2011 Jun 29;475(7356):390-3. (PMID: 21716291)
Cell Stem Cell. 2019 Oct 3;25(4):486-500.e9. (PMID: 31523028)
Cell Stem Cell. 2008 Sep 11;3(3):346-353. (PMID: 18786421)
Cell Rep. 2025 Sep 23;44(9):116226. (PMID: 40913769)
Nature. 2009 Jul 2;460(7251):49-52. (PMID: 19571877)
Entry Date(s): Date Created: 20260827 Date Completed: 20260908 Latest Revision: 20260914
Update Code: 20260914
PubMed Central ID: PMC13555469
DOI: 10.1016/j.stemcr.2026.103057
PMID: 42660119
Βάση Δεδομένων: MEDLINE
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  Data: Luck favors the prepared in hepatic conversion.
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  Data: <searchLink fieldCode="AU" term="%22Galloway+KE%22">Galloway KE</searchLink>; Department of Chemical Engineering, MIT, 25 Ames St., Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, 500 Main St., Cambridge, MA 02139, USA. Electronic address: katiegal@mit.edu.
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  Data: <searchLink fieldCode="MM" term="%22Hepatocytes%22">Hepatocytes*</searchLink>/<searchLink fieldCode="MM" term="%22Hepatocytes+cytology%22">cytology</searchLink> <br /><searchLink fieldCode="MM" term="%22Hepatocytes%22">Hepatocytes*</searchLink>/<searchLink fieldCode="MM" term="%22Hepatocytes+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Liver%22">Liver*</searchLink>/<searchLink fieldCode="MM" term="%22Liver+cytology%22">cytology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cellular+Reprogramming%22">Cellular Reprogramming*</searchLink><br /><searchLink fieldCode="MH" term="%22Fibroblasts%22">Fibroblasts</searchLink>/<searchLink fieldCode="MH" term="%22Fibroblasts+cytology%22">cytology</searchLink> ; <searchLink fieldCode="MH" term="%22Fibroblasts%22">Fibroblasts</searchLink>/<searchLink fieldCode="MH" term="%22Fibroblasts+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Cell+Lineage%22">Cell Lineage</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Cell+Differentiation%22">Cell Differentiation</searchLink>
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  Data: Goto et al. in this issue use continuous lineage imaging to examine why only some fibroblasts become induced hepatocyte-like cells. The study suggests that hepatic reprogramming follows a hybrid elite-stochastic model: early asymmetric division produces elite-like lineages, and subsequent mitotic activity and chance determine which descendants ultimately complete conversion.<br /> (Copyright © 2026 The Author. Published by Elsevier Inc. All rights reserved.)
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  Data: Declaration of interests The authors declare no competing interests.
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  Data: Stem Cell Reports. 2026 Sep 8;21(9):103056. (PMID: <searchLink fieldCode="PM" term="%2242660117%22">42660117)</searchLink><br />Science. 2019 Apr 26;364(6438):. (PMID: <searchLink fieldCode="PM" term="%2230898844%22">30898844)</searchLink><br />Cell Syst. 2025 Apr 16;16(4):101205. (PMID: <searchLink fieldCode="PM" term="%2240086434%22">40086434)</searchLink><br />Nature. 2009 Dec 3;462(7273):595-601. (PMID: <searchLink fieldCode="PM" term="%2219898493%22">19898493)</searchLink><br />Cell. 2014 Feb 13;156(4):649-62. (PMID: <searchLink fieldCode="PM" term="%2224486105%22">24486105)</searchLink><br />Cell Syst. 2024 Feb 21;15(2):109-133.e10. (PMID: <searchLink fieldCode="PM" term="%2238335955%22">38335955)</searchLink><br />Nature. 2011 Jun 29;475(7356):390-3. (PMID: <searchLink fieldCode="PM" term="%2221716291%22">21716291)</searchLink><br />Cell Stem Cell. 2019 Oct 3;25(4):486-500.e9. (PMID: <searchLink fieldCode="PM" term="%2231523028%22">31523028)</searchLink><br />Cell Stem Cell. 2008 Sep 11;3(3):346-353. (PMID: <searchLink fieldCode="PM" term="%2218786421%22">18786421)</searchLink><br />Cell Rep. 2025 Sep 23;44(9):116226. (PMID: <searchLink fieldCode="PM" term="%2240913769%22">40913769)</searchLink><br />Nature. 2009 Jul 2;460(7251):49-52. (PMID: <searchLink fieldCode="PM" term="%2219571877%22">19571877)</searchLink>
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