Academic Journal
Luck favors the prepared in hepatic conversion.
| Title: | Luck favors the prepared in hepatic conversion. |
|---|---|
| Authors: | Galloway KE; Department of Chemical Engineering, MIT, 25 Ames St., Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, 500 Main St., Cambridge, MA 02139, USA. Electronic address: katiegal@mit.edu. |
| Source: | Stem cell reports [Stem Cell Reports] 2026 Sep 08; Vol. 21 (9), pp. 103057. Date of Electronic Publication: 2026 Aug 27. |
| Publication Type: | Journal Article; Comment |
| Language: | English |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, c 2013- |
| MeSH Terms: | Hepatocytes*/cytology , Hepatocytes*/metabolism , Liver*/cytology , Cellular Reprogramming*, Fibroblasts/cytology ; Fibroblasts/metabolism ; Animals ; Cell Lineage ; Humans ; Cell Differentiation |
| Abstract: | Goto et al. in this issue use continuous lineage imaging to examine why only some fibroblasts become induced hepatocyte-like cells. The study suggests that hepatic reprogramming follows a hybrid elite-stochastic model: early asymmetric division produces elite-like lineages, and subsequent mitotic activity and chance determine which descendants ultimately complete conversion. (Copyright © 2026 The Author. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no competing interests. |
| References: | Stem Cell Reports. 2026 Sep 8;21(9):103056. (PMID: 42660117) Science. 2019 Apr 26;364(6438):. (PMID: 30898844) Cell Syst. 2025 Apr 16;16(4):101205. (PMID: 40086434) Nature. 2009 Dec 3;462(7273):595-601. (PMID: 19898493) Cell. 2014 Feb 13;156(4):649-62. (PMID: 24486105) Cell Syst. 2024 Feb 21;15(2):109-133.e10. (PMID: 38335955) Nature. 2011 Jun 29;475(7356):390-3. (PMID: 21716291) Cell Stem Cell. 2019 Oct 3;25(4):486-500.e9. (PMID: 31523028) Cell Stem Cell. 2008 Sep 11;3(3):346-353. (PMID: 18786421) Cell Rep. 2025 Sep 23;44(9):116226. (PMID: 40913769) Nature. 2009 Jul 2;460(7251):49-52. (PMID: 19571877) |
| Entry Date(s): | Date Created: 20260827 Date Completed: 20260908 Latest Revision: 20260914 |
| Update Code: | 20260914 |
| PubMed Central ID: | PMC13555469 |
| DOI: | 10.1016/j.stemcr.2026.103057 |
| PMID: | 42660119 |
| Database: | MEDLINE |
| ISSN: | 2213-6711 |
|---|---|
| DOI: | 10.1016/j.stemcr.2026.103057 |