Academic Journal
Antibacterial and antibiofilm effects of immobilized hydrogen on pathogenic oral bacteria.
| Τίτλος: | Antibacterial and antibiofilm effects of immobilized hydrogen on pathogenic oral bacteria. |
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| Συγγραφείς: | Sato K; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Akizuki M; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Enggardipta RA; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan.; Department of Conservative Dentistry, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia., Kido R; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Inagaki Y; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Sumitomo T; Department of Oral Microbiology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Nambu K; Acche Corporation, Tokyo, 105-0001, Japan., Yumoto H; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan. |
| Πηγή: | Journal of applied microbiology [J Appl Microbiol] 2026 Sep 02; Vol. 137 (9). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9706280 Publication Model: Print Cited Medium: Internet ISSN: 1365-2672 (Electronic) Linking ISSN: 13645072 NLM ISO Abbreviation: J Appl Microbiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2022- : Oxford : Oxford University Press Original Publication: Oxford : Published for the Society for Applied Bacteriology by Blackwell Science, c1997- |
| Ιατρικοί όροι (MeSH): | Biofilms*/drug effects , Hydrogen*/pharmacology , Hydrogen*/chemistry , Enterococcus faecalis*/drug effects , Enterococcus faecalis*/genetics , Enterococcus faecalis*/physiology , Streptococcus mutans*/drug effects , Streptococcus mutans*/genetics , Streptococcus mutans*/physiology , Anti-Bacterial Agents*/pharmacology , Porphyromonas gingivalis*/drug effects , Porphyromonas gingivalis*/genetics , Porphyromonas gingivalis*/physiology , Mouth*/microbiology, Calcium Carbonate/pharmacology ; Calcium Carbonate/chemistry ; Humans ; Animals |
| Περίληψη: | Aims: Hydrogen, a colorless and odorless gas, possesses various physiological activities, including anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-apoptotic effects. Clinical applications of hydrogen have been investigated in the medical field. However, few studies have focused on hydrogen use in dentistry and its clinical applications have not yet progressed. This study aimed to evaluate the antibacterial and antibiofilm efficacies of hydrogen-loaded coral calcium carbonate powder (immobilized hydrogen) against pathogenic oral bacteria. Methods and Results: Three immobilized hydrogen suspensions (TU-A, -B, and -C) and three pathogenic oral bacteria (Porphyromonas gingivalis, Streptococcus mutans, and Enterococcus faecalis) were used. The direct and indirect antibacterial effects of immobilized hydrogen were evaluated by counting the colony-forming units. The biofilm-related gene expression levels in E. faecalis were analyzed using real-time RT-PCR. The antibacterial activity of the bacteria in the biofilm was observed under a fluorescence microscope after live/dead staining. All immobilized hydrogen suspensions significantly reduced the survival rates of the three oral bacteria, significantly increased the proportion of dead bacteria in the biofilm, and significantly decreased the biofilm-related gene expression levels in E. faecalis. Conclusions: This study highlights the potential of immobilized hydrogen as a novel antibacterial material, owing to its antibacterial and antibiofilm activities against pathogenic oral bacteria. (© The Author(s) 2026. Published by Oxford University Press on behalf of Applied Microbiology International.) |
| Grant Information: | Acche Corporation |
| Contributed Indexing: | Keywords: Enterococcus faecalis, calcium carbonate; Porphyromonas gingivalis; Streptococcus mutans; antibacterial; antibiofilm; hydrogen |
| Substance Nomenclature: | 7YNJ3PO35Z (Hydrogen) 0 (Anti-Bacterial Agents) H0G9379FGK (Calcium Carbonate) |
| Entry Date(s): | Date Created: 20260827 Date Completed: 20260908 Latest Revision: 20260909 |
| Update Code: | 20260909 |
| DOI: | 10.1093/jambio/lxag209 |
| PMID: | 42658185 |
| Βάση Δεδομένων: | MEDLINE |
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