Academic Journal
Demographic Characteristics, Clinical Features, and Treatment Patterns of Classic and AIDS-Related Kaposi Sarcoma: A Multicenter Real-World Study from Turkey.
| Τίτλος: | Demographic Characteristics, Clinical Features, and Treatment Patterns of Classic and AIDS-Related Kaposi Sarcoma: A Multicenter Real-World Study from Turkey. |
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| Συγγραφείς: | Dişli AK; Department of Medical Oncology, Kırşehir Education and Research Hospital, 40100 Kırşehir, Turkey., Durukan BM; Department of Medical Oncology, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey., Aşık E; Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey., Nuransoy Cengiz A; Department of Medical Oncology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey., Emin G; Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey., Yıldırım HÇ; Department of Medical Oncology, Faculty of Medicine, Ege University, 35100 İzmir, Turkey., Yıldırım Dişli Ş; Department of Medical Oncology, Acıbadem Kayseri Hospital, 38140 Kayseri, Turkey., Güven DC; Department of Medical Oncology, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey., Akın S; Department of Medical Oncology, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey., Bozkurt O; Department of Medical Oncology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey., Özdemir F; Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey., İnanç M; Department of Medical Oncology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey., Özkan M; Department of Medical Oncology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey. |
| Πηγή: | Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2026 Aug 01; Vol. 62 (8). Date of Electronic Publication: 2026 Aug 01. |
| Τύπος έκδοσης: | Journal Article; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2018- : Basel, Switzerland : MDPI Original Publication: Kaunas : Lietuvos gydytojų sąjunga |
| Ιατρικοί όροι (MeSH): | Sarcoma, Kaposi*/drug therapy , Sarcoma, Kaposi*/epidemiology , Sarcoma, Kaposi*/mortality , AIDS-Related Opportunistic Infections*/epidemiology , AIDS-Related Opportunistic Infections*/drug therapy, Turkey/epidemiology ; Doxorubicin/therapeutic use ; Doxorubicin/analogs & derivatives ; Polyethylene Glycols/therapeutic use ; Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Aged |
| Περίληψη: | Background and Objectives: Kaposi sarcoma (KS) is a rare angioproliferative malignancy driven by human herpesvirus-8 infection. Comparative real-world data on classic and AIDS-related KS from Mediterranean-endemic countries remain limited. Materials and Methods: We retrospectively analyzed 102 patients with histopathologically confirmed KS treated across five tertiary oncology centers in Turkey between January 2010 and December 2023. Demographic characteristics, clinical features, treatment patterns, and survival outcomes were compared between classic and AIDS-related KS subtypes. Results: Ninety-two patients (90.2%) had classic KS and ten (9.8%) had AIDS-related KS. The median age at diagnosis was significantly higher in the classic KS group (69 vs. 38.5 years; p < 0.001). Male sex predominated in both groups (classic KS: 76.1%; AIDS-related KS: 100%; p = 0.113). AIDS-related KS presented with more advanced disease at diagnosis, with 70% classified as poor-risk by ACTG-TIS criteria versus 9.8% Stage IV by Brambilla criteria in classic KS, and more frequent extracutaneous involvement (70% vs. 8.7%; p < 0.001). Paclitaxel was the most commonly used first-line agent in classic KS (42.9%), while pegylated liposomal doxorubicin predominated in AIDS-related KS (87.5%). Overall response rates were high and comparable between groups (90.7% vs. 88.9%). Median overall survival was significantly longer in classic KS (66.9 vs. 22.67 months; p = 0.012). Disease stage and lesion morphology were not significantly associated with survival in either group. Conclusions: Classic and AIDS-related KS differ substantially in clinical presentation and survival outcomes, yet demonstrate comparable chemosensitivity. Our findings in the AIDS-related Kaposi sarcoma group are preliminary and hypothesis-generating due to the small sample size, requiring confirmation in larger prospective cohorts. |
| References: | BMC Cancer. 2025 Apr 14;25(1):690. (PMID: 40229708) Int J Dermatol. 2019 May;58(5):538-542. (PMID: 29888407) Medicine (Baltimore). 2025 Feb 07;104(6):e41404. (PMID: 39928795) J Clin Invest. 2011 Feb;121(2):752-68. (PMID: 21245574) Nat Rev Dis Primers. 2019 Jan 31;5(1):9. (PMID: 30705286) Cancers (Basel). 2024 Sep 19;16(18):. (PMID: 39335165) Medicina (Kaunas). 2025 Apr 14;61(4):. (PMID: 40283016) Br J Cancer. 1996 Dec;74(11):1812-4. (PMID: 8956798) Medicine (Baltimore). 2023 Feb 3;102(5):e32866. (PMID: 36749246) Dermatopathology (Basel). 2024 Nov 25;11(4):333-341. (PMID: 39727617) Onco Targets Ther. 2024 Nov 07;17:961-976. (PMID: 39530040) Clin Dermatol. 2013 Jul-Aug;31(4):413-422. (PMID: 23806158) Eur J Cancer. 2019 Jun;114:117-127. (PMID: 31096150) J Acquir Immune Defic Syndr. 2025 Feb 1;98(2):e4-e6. (PMID: 39497247) Semin Oncol. 2015 Apr;42(2):223-46. (PMID: 25843728) Cancer. 2002 Nov 1;95(9):1982-7. (PMID: 12404293) Medicine (Baltimore). 2025 Aug 1;104(31):e43576. (PMID: 40760592) Cancer. 2010 Aug 15;116(16):3969-77. (PMID: 20564162) Bosn J Basic Med Sci. 2021 Dec 01;21(6):746-751. (PMID: 33596402) Cancers (Basel). 2024 Feb 06;16(4):. (PMID: 38398082) |
| Contributed Indexing: | Keywords: AIDS-related Kaposi sarcoma; Kaposi sarcoma; Turkey; classic Kaposi sarcoma; multicenter cohort; real-world evidence |
| Substance Nomenclature: | 80168379AG (Doxorubicin) 0 (liposomal doxorubicin) 3WJQ0SDW1A (Polyethylene Glycols) |
| SCR Disease Name: | AIDS-related Kaposi sarcoma |
| Entry Date(s): | Date Created: 20260827 Date Completed: 20260827 Latest Revision: 20260903 |
| Update Code: | 20260903 |
| PubMed Central ID: | PMC13515175 |
| DOI: | 10.3390/medicina62081483 |
| PMID: | 42654381 |
| Βάση Δεδομένων: | MEDLINE |
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