Academic Journal
View in EDS

Food-Derived Omega-3 Fatty Acids and Cognitive Aging: Integrating Nutritional Neuroscience and Geroscience.

Bibliographic Details
Title: Food-Derived Omega-3 Fatty Acids and Cognitive Aging: Integrating Nutritional Neuroscience and Geroscience.
Authors: Mózes N; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Lipécz Á; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Csípő T; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Fazekas-Pongor V; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Major D; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Hung WY; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Zábó V; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Csík B; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Fehér Á; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Bérczi B; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary., Klesch L; Infectious Disease Control Department, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Fekete M; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.
Source: Nutrients [Nutrients] 2026 Aug 07; Vol. 18 (16). Date of Electronic Publication: 2026 Aug 07.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI Publishing
MeSH Terms: Fatty Acids, Omega-3*/administration & dosage , Fatty Acids, Omega-3*/pharmacology , Cognitive Aging*/physiology , Geroscience*, Brain/drug effects ; Cognition/drug effects ; Docosahexaenoic Acids/administration & dosage ; Cognitive Dysfunction/prevention & control ; Eicosapentaenoic Acid/administration & dosage ; Humans ; Aging ; Neurosciences ; Cognitive Enhancement
Abstract: Within the emerging field of nutritional neuroscience, omega-3 fatty acids are among the most extensively investigated dietary bioactive compounds with potential relevance to cognitive aging. As populations continue to age worldwide, identifying modifiable nutritional factors that support cognitive health has become an important public health priority. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), obtained primarily from marine sources, are integral components of neuronal membranes and serve as precursors of specialized pro-resolving lipid mediators. This narrative review integrates concepts from nutritional neuroscience and geroscience to examine how dietary omega-3 fatty acids may influence biological pathways involved in age-related cognitive decline. Current evidence suggests that DHA and EPA affect multiple processes linked to brain aging, including neuroinflammation, synaptic plasticity, mitochondrial function, oxidative stress, cerebrovascular integrity, cellular senescence, and gut-brain axis signaling. These mechanisms overlap with several hallmarks of aging and may contribute to the maintenance of cognitive function during later life. Observational studies generally associate higher dietary intake or circulating omega-3 status with better cognitive performance and a lower risk of cognitive decline and dementia. Findings from randomized controlled trials are less consistent, although benefits appear more likely in individuals with low baseline omega-3 status, mild cognitive impairment, or increased biological vulnerability. Beyond their established anti-inflammatory effects, omega-3 fatty acids may influence multiple aging-related pathways, particularly inflammaging, vascular aging, and mitochondrial dysfunction. Although heterogeneity in study design, dosage, intervention timing, and participant characteristics precludes firm conclusions, viewing omega-3 fatty acids through a geroscience lens offers a useful framework for interpreting existing evidence and informing future research. Overall, omega-3 fatty acids represent a promising nutritional strategy for supporting cognitive health across the lifespan, warranting further investigation in well-characterized populations and precision nutrition approaches.
References: Annu Rev Food Sci Technol. 2018 Mar 25;9:345-381. (PMID: 29350557)
Nature. 2014 Jun 5;510(7503):92-101. (PMID: 24899309)
J Exp Bot. 2012 Apr;63(7):2397-410. (PMID: 22291131)
Essays Biochem. 2020 Sep 23;64(3):443-462. (PMID: 32885825)
J Nutr Health Aging. 2013 Sep;17(9):726-34. (PMID: 24154642)
Inflamm Regen. 2022 Apr 2;42(1):11. (PMID: 35365245)
Clin Nutr. 2022 Feb;41(2):405-414. (PMID: 34999335)
Semin Immunol. 2015 May;27(3):200-15. (PMID: 25857211)
Eur J Med Res. 2025 Jan 16;30(1):32. (PMID: 39815306)
J Physiol. 2016 Apr 15;594(8):2001-24. (PMID: 25639909)
Genome Biol. 2017 May 5;18(1):83. (PMID: 28476144)
Ageing Res Rev. 2013 Mar;12(2):579-94. (PMID: 23395782)
Stroke. 2011 Sep;42(9):2672-713. (PMID: 21778438)
Clin Nutr. 2022 Mar;41(3):589-598. (PMID: 35124466)
Geroscience. 2026 Apr;48(2):2743-2756. (PMID: 40728817)
Prostaglandins Leukot Essent Fatty Acids. 2013 Jul;89(1):1-8. (PMID: 23676322)
Nat Aging. 2025 Aug;5(8):1378-1379. (PMID: 40660004)
Appetite. 2013 Apr;63:119-28. (PMID: 23291218)
J Nutr Health Aging. 2016 Feb;20(2):161-9. (PMID: 26812512)
Geroscience. 2025 Jun;47(3):3111-3130. (PMID: 39797935)
Front Aging Neurosci. 2024 Jan 12;15:1303912. (PMID: 38283067)
Front Aging Neurosci. 2015 Apr 21;7:52. (PMID: 25954194)
Nat Rev Immunol. 2016 Jan;16(1):51-67. (PMID: 26688348)
Annu Rev Pathol. 2010;5:99-118. (PMID: 20078217)
Crit Rev Food Sci Nutr. 2022;62(18):4982-4997. (PMID: 33576691)
Nutr Rev. 2018 Jan 1;76(1):1-20. (PMID: 29240924)
Geroscience. 2026 Apr;48(2):2887-2901. (PMID: 40770530)
Hypertension. 2014 Aug;64(2):210-4. (PMID: 24799614)
Biochem Soc Trans. 2017 Oct 15;45(5):1105-1115. (PMID: 28900017)
Curr Opin Genet Dev. 2011 Feb;21(1):107-12. (PMID: 21093253)
Lancet Neurol. 2018 Nov;17(11):1006-1015. (PMID: 30244829)
Nat Rev Neurosci. 2014 Dec;15(12):771-85. (PMID: 25387473)
Cell. 2022 Apr 28;185(9):1455-1470. (PMID: 35487190)
Geroscience. 2026 Jun;48(3):4923-4956. (PMID: 41832380)
Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838)
Nature. 2014 May 22;509(7501):503-6. (PMID: 24828044)
Am J Clin Nutr. 2018 May 1;107(5):754-762. (PMID: 29722833)
Geroscience. 2020 Dec;42(6):1751-1764. (PMID: 33025410)
Am J Clin Nutr. 2007 Apr;85(4):1142-7. (PMID: 17413117)
Curr Dev Nutr. 2025 Jun 18;9(7):107485. (PMID: 40697195)
Nat Rev Neurosci. 2006 Jan;7(1):30-40. (PMID: 16371948)
Front Nutr. 2025 May 30;12:1598588. (PMID: 40521363)
Genes Nutr. 2023 Feb 25;18(1):2. (PMID: 36841786)
Aging (Albany NY). 2018 Apr 18;10(4):573-591. (PMID: 29676998)
Cell. 2025 Apr 17;188(8):2043-2062. (PMID: 40250404)
Geroscience. 2024 Aug;46(4):3801-3818. (PMID: 38012365)
Am J Clin Nutr. 2009 Jul;90(1):170-6. (PMID: 19474131)
Brain Sci. 2024 Dec 03;14(12):. (PMID: 39766423)
Alzheimers Res Ther. 2023 Nov 6;15(1):192. (PMID: 37926851)
Ageing Res Rev. 2015 Mar;20:1-10. (PMID: 25555677)
Gut. 2018 Nov;67(11):1974-1983. (PMID: 28951525)
Cell. 2018 May 17;173(5):1073-1081. (PMID: 29775591)
Mol Aspects Med. 2018 Dec;64:18-33. (PMID: 30244005)
J Neurotrauma. 2004 Oct;21(10):1457-67. (PMID: 15672635)
Trends Neurosci. 2021 Sep;44(9):714-727. (PMID: 34366147)
J Clin Invest. 2005 Oct;115(10):2774-83. (PMID: 16151530)
Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):85-91. (PMID: 19269799)
Nat Rev Cardiol. 2018 Sep;15(9):505-522. (PMID: 30065258)
J Nutrigenet Nutrigenomics. 2011;4(2):69-89. (PMID: 21625170)
Brain Sci. 2024 Jun 27;14(7):. (PMID: 39061395)
Food Chem. 2014 Oct 1;160:393-400. (PMID: 24799253)
J Am Med Dir Assoc. 2020 Oct;21(10):1439-1450.e21. (PMID: 32305302)
Geroscience. 2023 Oct;45(5):2819-2834. (PMID: 37213047)
J Neurosci. 2009 Oct 14;29(41):12795-801. (PMID: 19828791)
Cell. 2014 Nov 6;159(4):709-13. (PMID: 25417146)
Mol Aspects Med. 2018 Dec;64:1-17. (PMID: 28802833)
Nat Rev Drug Discov. 2016 Aug;15(8):551-67. (PMID: 27020098)
Nutrients. 2018 Nov 04;10(11):. (PMID: 30400360)
Mol Neurodegener. 2020 May 29;15(1):30. (PMID: 32471464)
Phytother Res. 2022 Jan;36(1):164-188. (PMID: 34553434)
Nutrients. 2025 Jun 28;17(13):. (PMID: 40647258)
Geroscience. 2026 Jun 16;:. (PMID: 42301612)
Orv Hetil. 2021 Jan 03;162(1):23-30. (PMID: 33388735)
Mol Neurodegener. 2022 Jun 17;17(1):43. (PMID: 35715821)
Alzheimers Dement. 2010 Nov;6(6):456-64. (PMID: 20434961)
Ageing Res Rev. 2020 May;59:101037. (PMID: 32109604)
Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):461-478. (PMID: 31123355)
Geroscience. 2025 Jun;47(3):2895-2923. (PMID: 39821819)
Age (Dordr). 2013 Aug;35(4):1495-505. (PMID: 22791395)
J Neuroinflammation. 2016 Sep 29;13(1):257. (PMID: 27688126)
Int J Mol Sci. 2018 Sep 27;19(10):. (PMID: 30261683)
Biomed Res Int. 2015;2015:172801. (PMID: 26301243)
Nutrients. 2024 Oct 21;16(20):. (PMID: 39458561)
Geroscience. 2024 Feb;46(1):683-696. (PMID: 37999901)
Geriatrics. 2005 Jun;Suppl:9-14. (PMID: 16025770)
Lancet. 2024 Aug 10;404(10452):572-628. (PMID: 39096926)
Kidney Med. 2021 Oct 04;3(6):1041-1049. (PMID: 34939013)
Geroscience. 2026 Feb;48(1):937-950. (PMID: 40366519)
Nutrients. 2016 Jun 02;8(6):. (PMID: 27271660)
Curr Opin Clin Nutr Metab Care. 2024 Mar 1;27(2):116-124. (PMID: 38170690)
Front Cell Neurosci. 2019 Aug 07;13:363. (PMID: 31440144)
Int J Geriatr Psychiatry. 2003 Dec;18(12):1121-34. (PMID: 14677145)
Nutrients. 2018 Mar 14;10(3):. (PMID: 29538286)
Free Radic Biol Med. 2022 Nov 20;193(Pt 2):736-750. (PMID: 36402440)
Nutrients. 2020 Dec 24;13(1):. (PMID: 33374235)
Arch Neurol. 2006 Nov;63(11):1545-50. (PMID: 17101822)
J Clin Med. 2023 Feb 22;12(5):. (PMID: 36902545)
Front Nutr. 2023 Jun 29;10:1213223. (PMID: 37457976)
Nat Rev Neurol. 2018 Mar;14(3):133-150. (PMID: 29377008)
Front Hum Neurosci. 2023 Sep 13;17:1240630. (PMID: 37780962)
Circ Res. 2018 Sep 14;123(7):825-848. (PMID: 30355078)
J Alzheimers Dis. 2024;101(s1):S455-S466. (PMID: 39422948)
Chem Phys Lipids. 2003 Nov;126(1):1-27. (PMID: 14580707)
Longev Healthspan. 2014 Mar 03;3(1):3. (PMID: 24588808)
Alzheimers Dement. 2015 Sep;11(9):1007-14. (PMID: 25681666)
J Neurosci. 2007 Apr 18;27(16):4385-95. (PMID: 17442823)
Public Health Nutr. 2018 Jul;21(10):1921-1932. (PMID: 29551101)
Int J Mol Sci. 2020 Feb 18;21(4):. (PMID: 32085487)
Sci Rep. 2025 Aug 20;15(1):30610. (PMID: 40836005)
Cell. 2021 Jan 7;184(1):33-63. (PMID: 33340459)
Front Cardiovasc Med. 2018 Feb 22;5:12. (PMID: 29564335)
Eur J Nutr. 2024 Jun;63(4):1003-1022. (PMID: 38300291)
Geroscience. 2025 Jun;47(3):5365-5376. (PMID: 39825168)
Nat Rev Drug Discov. 2020 Sep;19(9):609-633. (PMID: 32709961)
Int J Mol Sci. 2017 Dec 07;18(12):. (PMID: 29215589)
Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):213-21. (PMID: 19523795)
Neurology. 2007 Nov 13;69(20):1921-30. (PMID: 17998483)
Trends Neurosci. 2017 Mar;40(3):151-166. (PMID: 28190529)
Nat Aging. 2021 Jul;1:598-615. (PMID: 34888528)
Nat Rev Microbiol. 2021 Apr;19(4):241-255. (PMID: 33093662)
Cell Host Microbe. 2017 Apr 12;21(4):455-466.e4. (PMID: 28407483)
Neurology. 2012 Feb 28;78(9):658-64. (PMID: 22371413)
Nutrients. 2024 Mar 15;16(6):. (PMID: 38542764)
Cochrane Database Syst Rev. 2018 Nov 01;11:CD011905. (PMID: 30383288)
Psychosom Med. 2024 Jun 1;86(5):360-365. (PMID: 38718171)
J Exp Med. 2009 Jan 16;206(1):15-23. (PMID: 19103881)
Nat Rev Neurosci. 2020 Aug;21(8):433-444. (PMID: 32601397)
J Neurol Sci. 2022 Mar 15;434:120166. (PMID: 35144237)
Geroscience. 2025 Jun;47(3):3565-3581. (PMID: 39777701)
J Intern Med. 2014 Mar;275(3):214-28. (PMID: 24605806)
Aging (Albany NY). 2017 Apr;9(4):1096-1129. (PMID: 28379838)
Am J Clin Nutr. 2013 May;97(5):1134-43. (PMID: 23515006)
J Lipid Res. 2009 Apr;50 Suppl:S400-5. (PMID: 19018037)
Front Immunol. 2018 Jan 10;8:1960. (PMID: 29375577)
Ageing Res Rev. 2018 Jul;44:1-7. (PMID: 29544875)
J Cell Biol. 2018 Feb 5;217(2):459-472. (PMID: 29196460)
Nat Med. 2019 Dec;25(12):1822-1832. (PMID: 31806905)
Adv Nutr. 2019 Nov 1;10(6):1040-1065. (PMID: 31209456)
Geroscience. 2023 Aug;45(4):2601-2627. (PMID: 37059838)
BMJ. 2018 Oct 17;363:k4067. (PMID: 30333104)
Nutrients. 2026 Aug 04;18(15):. (PMID: 42588171)
Lancet Public Health. 2022 Feb;7(2):e105-e125. (PMID: 34998485)
JAMA Netw Open. 2024 Aug 1;7(8):e2426872. (PMID: 39088212)
Neuron. 2017 Sep 27;96(1):17-42. (PMID: 28957666)
J Nutr Health Aging. 2021;25(10):1167-1178. (PMID: 34866144)
Geroscience. 2022 Oct;44(5):2541-2554. (PMID: 35794436)
J Am Coll Cardiol. 2011 Nov 8;58(20):2047-67. (PMID: 22051327)
Front Aging. 2024 Dec 16;5:1395649. (PMID: 39743988)
Nutrients. 2025 Jul 27;17(15):. (PMID: 40806031)
Nutr Rev. 2020 Jul 1;78(7):563-578. (PMID: 31841161)
Ann Palliat Med. 2022 Sep;11(9):2819-2829. (PMID: 35948470)
Geroscience. 2025 Feb;47(1):1105-1121. (PMID: 39090501)
Neurobiol Dis. 2019 Oct;130:104481. (PMID: 31136814)
Adv Nutr. 2020 Nov 16;11(6):1405-1413. (PMID: 32770212)
Curr Neuropharmacol. 2017;15(4):534-542. (PMID: 27306037)
J Physiol. 2014 Mar 15;592(6):1341-52. (PMID: 24396061)
Korean J Intern Med. 2023 May;38(3):282-289. (PMID: 36514212)
Arch Neurol. 2003 Jul;60(7):940-6. (PMID: 12873849)
Front Pharmacol. 2019 Aug 23;10:902. (PMID: 31507410)
J Alzheimers Dis. 2018;62(3):1403-1416. (PMID: 29036828)
Curr Opin Lipidol. 2023 Feb 1;34(1):12-21. (PMID: 36637075)
JAMA. 2019 Aug 06;322(5):430-437. (PMID: 31302669)
Int J Mol Sci. 2022 Feb 28;23(5):. (PMID: 35269827)
Ann Neurol. 2006 Jun;59(6):912-21. (PMID: 16622828)
Lancet. 2020 Aug 8;396(10248):413-446. (PMID: 32738937)
Food Nutr Res. 2024 Mar 05;68:. (PMID: 38571914)
Age Ageing. 2022 Aug 2;51(8):. (PMID: 35977150)
Am J Lifestyle Med. 2022 Sep 20;17(4):560-588. (PMID: 37426732)
BMB Rep. 2026 Jan;59(1):51-59. (PMID: 41407319)
Cureus. 2024 Nov 10;16(11):e73390. (PMID: 39659348)
Nat Metab. 2024 Aug;6(8):1454-1478. (PMID: 39174768)
Front Neurosci. 2024 Oct 23;18:1481390. (PMID: 39513042)
Biomolecules. 2021 Dec 28;12(1):. (PMID: 35053186)
Ann Neurol. 1997 Nov;42(5):776-82. (PMID: 9392577)
Am J Epidemiol. 2018 May 1;187(5):933-940. (PMID: 29053784)
Nutrients. 2014 Feb 21;6(2):799-814. (PMID: 24566438)
Nutrients. 2026 Apr 30;18(9):. (PMID: 42124031)
Geroscience. 2024 Oct;46(5):4037-4057. (PMID: 38922379)
Microb Cell Fact. 2012 Jul 25;11:96. (PMID: 22830315)
BMC Med. 2024 Mar 12;22(1):109. (PMID: 38468309)
Psychopharmacology (Berl). 2013 Feb;225(3):605-12. (PMID: 22932777)
Nutrients. 2014 Sep 16;6(9):3727-33. (PMID: 25255830)
J Affect Disord. 2025 Jun 01;378:263-270. (PMID: 40044083)
Geroscience. 2026 May 19;:. (PMID: 42154116)
Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S. (PMID: 16841856)
Nutr Rev. 2025 Jul 1;83(7):e2113-e2126. (PMID: 39499795)
Front Aging Neurosci. 2012 Sep 12;4:15. (PMID: 22988437)
Geroscience. 2023 Jun;45(3):1997-2009. (PMID: 37046127)
Pharmacol Rev. 2018 Jan;70(1):12-38. (PMID: 29217656)
Prostaglandins Other Lipid Mediat. 2018 Jan;134:131-140. (PMID: 28802571)
Int J Mol Sci. 2023 Mar 30;24(7):. (PMID: 37047492)
Neurology. 2017 Jan 31;88(5):449-455. (PMID: 28053008)
Nature. 2018 Oct;562(7728):578-582. (PMID: 30232451)
J Clin Invest. 2022 May 16;132(10):. (PMID: 35575089)
J Clin Invest. 2018 Apr 2;128(4):1208-1216. (PMID: 29457783)
FAO Food Nutr Pap. 2010;91:1-166. (PMID: 21812367)
Nature. 2021 Jul;595(7866):315-319. (PMID: 34135507)
Int J Mol Sci. 2015 Oct 16;16(10):24600-13. (PMID: 26501267)
Cochrane Database Syst Rev. 2016 Apr 11;4:CD009002. (PMID: 27063583)
Lancet Neurol. 2017 May;16(5):377-389. (PMID: 28359749)
Physiol Rev. 2025 Jul 1;105(3):1609-1694. (PMID: 40111763)
Int J Geriatr Psychiatry. 2022 May;37(5):. (PMID: 35373862)
Aging Clin Exp Res. 2024 Mar 22;36(1):77. (PMID: 38519775)
Int J Geriatr Psychiatry. 2015 Mar;30(3):234-46. (PMID: 25504093)
Maturitas. 2024 Jun;184:107952. (PMID: 38457981)
Physiol Rev. 2019 Oct 1;99(4):1877-2013. (PMID: 31460832)
J Clin Invest. 2018 Jul 2;128(7):2657-2669. (PMID: 29757195)
Nat Rev Neurol. 2021 Mar;17(3):157-172. (PMID: 33318676)
Reprod Nutr Dev. 2005 Sep-Oct;45(5):581-97. (PMID: 16188209)
EBioMedicine. 2020 Sep;59:102883. (PMID: 32690472)
JAMA Neurol. 2023 Dec 1;80(12):1284-1294. (PMID: 37930705)
Brain Behav Immun. 2017 Jan;59:21-37. (PMID: 27423492)
Nutrients. 2016 Jan 04;8(1):. (PMID: 26742060)
Am J Clin Nutr. 2023 Jun;117(6):1096-1109. (PMID: 37028557)
Nutrients. 2026 May 05;18(9):. (PMID: 42124071)
Brain Behav Immun. 2022 Jan;99:289-298. (PMID: 34755655)
PLoS One. 2015 Mar 18;10(3):e0120391. (PMID: 25786262)
Geroscience. 2024 Dec;46(6):6625-6639. (PMID: 38967696)
Nutrients. 2026 Jul 31;18(15):. (PMID: 42588100)
JAMA. 2020 Dec 8;324(22):2268-2280. (PMID: 33190147)
Front Aging Neurosci. 2023 Oct 27;15:1227112. (PMID: 37965493)
Adv Nutr. 2016 Sep 15;7(5):905-16. (PMID: 27633106)
J Alzheimers Dis Rep. 2025 Feb 25;9:25424823251324397. (PMID: 40034504)
BMJ. 2004 Jan 3;328(7430):30-5. (PMID: 14703544)
Nat Med. 2020 Jan;26(1):83-90. (PMID: 31932806)
Geroscience. 2024 Feb;46(1):981-998. (PMID: 37308768)
Alzheimers Dement. 2024 May;20(5):3567-3586. (PMID: 38477378)
Nat Rev Neurol. 2025 Jan;21(1):5-16. (PMID: 39572782)
Lipids Health Dis. 2013 Dec 05;12:178. (PMID: 24304605)
Annu Rev Nutr. 2018 Aug 21;38:329-356. (PMID: 29852087)
Cochrane Database Syst Rev. 2012 Jun 13;(6):CD005379. (PMID: 22696350)
Alzheimers Res Ther. 2020 Dec 18;12(1):167. (PMID: 33339532)
Nat Aging. 2025 Aug;5(8):1441-1454. (PMID: 40813813)
Neuron. 2013 Nov 20;80(4):844-66. (PMID: 24267647)
J Alzheimers Dis. 2013;35(4):697-713. (PMID: 23481688)
Biomol Ther (Seoul). 2021 Sep 1;29(5):455-464. (PMID: 34162770)
Nat Rev Endocrinol. 2018 Oct;14(10):576-590. (PMID: 30046148)
Circulation. 2018 Oct 30;138(18):1951-1962. (PMID: 30018169)
Nutrients. 2021 Jul 15;13(7):. (PMID: 34371930)
Prostaglandins Leukot Essent Fatty Acids. 2022 Mar;178:102415. (PMID: 35338847)
Clin Nutr. 2019 Feb;38(1):10-47. (PMID: 30005900)
Neural Regen Res. 2025 Apr 1;20(4):990-1008. (PMID: 38989933)
Alzheimers Dement. 2020 Oct 8;:. (PMID: 33090665)
Nutr Rev. 2018 Aug 1;76(8):603-617. (PMID: 29718511)
Nutrients. 2023 Nov 23;15(23):. (PMID: 38068754)
Geroscience. 2018 Aug;40(4):361-364. (PMID: 30084059)
Cell. 2023 Aug 31;186(18):3758-3775. (PMID: 37657418)
Gut Microbes. 2020;11(2):135-157. (PMID: 31368397)
Int J Mol Sci. 2022 Mar 23;23(7):. (PMID: 35408832)
Nat Rev Neurosci. 2008 Jul;9(7):568-78. (PMID: 18568016)
Int J Mol Sci. 2019 Oct 11;20(20):. (PMID: 31614433)
Ageing Res Rev. 2023 Jul;88:101939. (PMID: 37116664)
Neurology. 2012 Aug 14;79(7):642-50. (PMID: 22855869)
Am J Clin Nutr. 2023 Aug;118(2):369-381. (PMID: 37315924)
Geroscience. 2025 Feb;47(1):515-542. (PMID: 39352664)
Food Res Int. 2025 May;208:116171. (PMID: 40263835)
Nutrients. 2023 Dec 15;15(24):. (PMID: 38140375)
Elife. 2020 Jun 09;9:. (PMID: 32515735)
Acta Neuropathol. 2016 May;131(5):687-707. (PMID: 27038189)
Biogerontology. 2016 Feb;17(1):7-19. (PMID: 25921609)
Neurology. 2008 Aug 5;71(6):430-8. (PMID: 18678826)
Trends Endocrinol Metab. 2017 Mar;28(3):199-212. (PMID: 27789101)
Genes Immun. 2021 Oct;22(5-6):289-303. (PMID: 33875817)
Circulation. 2019 Sep 17;140(12):e673-e691. (PMID: 31422671)
Crit Rev Food Sci Nutr. 2014;54(1):98-114. (PMID: 24188235)
Ageing Res Rev. 2021 Nov;71:101422. (PMID: 34391943)
Grant Information: TKP2021-NKTA-47 National Research, Development and Innovation Office; RRF-2.3.1-21-2022-00003 Ministry of Innovation and Technology under the National Cardiovascular Laboratory Program; 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1 European University for Well-Being (EUniWell) program
Contributed Indexing: Keywords: DHA; EPA; brain aging; cognitive aging; geroscience; healthy aging; inflammaging; neuroinflammation; nutritional neuroscience; omega-3 fatty acids
Substance Nomenclature: 0 (Fatty Acids, Omega-3)
25167-62-8 (Docosahexaenoic Acids)
AAN7QOV9EA (Eicosapentaenoic Acid)
Entry Date(s): Date Created: 20260827 Date Completed: 20260827 Latest Revision: 20260829
Update Code: 20260829
PubMed Central ID: PMC13516186
DOI: 10.3390/nu18162594
PMID: 42654174
Database: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=20726643&ISBN=&volume=18&issue=16&date=20260807&spage=&pages=&title=Nutrients&atitle=Food-Derived%20Omega-3%20Fatty%20Acids%20and%20Cognitive%20Aging%3A%20Integrating%20Nutritional%20Neuroscience%20and%20Geroscience.&aulast=M%C3%B3zes%20N&id=DOI:10.3390/nu18162594
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 42654174
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Food-Derived Omega-3 Fatty Acids and Cognitive Aging: Integrating Nutritional Neuroscience and Geroscience.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Mózes+N%22">Mózes N</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Lipécz+Á%22">Lipécz Á</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Csípő+T%22">Csípő T</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Fazekas-Pongor+V%22">Fazekas-Pongor V</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Major+D%22">Major D</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Hung+WY%22">Hung WY</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Zábó+V%22">Zábó V</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Csík+B%22">Csík B</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Fehér+Á%22">Fehér Á</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Bérczi+B%22">Bérczi B</searchLink>; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.<br /><searchLink fieldCode="AU" term="%22Klesch+L%22">Klesch L</searchLink>; Infectious Disease Control Department, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Fekete+M%22">Fekete M</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101521595%22">Nutrients</searchLink> [Nutrients] 2026 Aug 07; Vol. 18 (16). <i>Date of Electronic Publication: </i>2026 Aug 07.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Review
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+Publishing%22">MDPI Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101521595 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2072-6643 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220726643%22">20726643 </searchLink><i>NLM ISO Abbreviation: </i>Nutrients <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Basel, Switzerland : MDPI Publishing
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Fatty+Acids%2C+Omega-3%22">Fatty Acids, Omega-3*</searchLink>/<searchLink fieldCode="MM" term="%22Fatty+Acids%2C+Omega-3+administration+%26+dosage%22">administration & dosage</searchLink> <br /><searchLink fieldCode="MM" term="%22Fatty+Acids%2C+Omega-3%22">Fatty Acids, Omega-3*</searchLink>/<searchLink fieldCode="MM" term="%22Fatty+Acids%2C+Omega-3+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cognitive+Aging%22">Cognitive Aging*</searchLink>/<searchLink fieldCode="MM" term="%22Cognitive+Aging+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Geroscience%22">Geroscience*</searchLink><br /><searchLink fieldCode="MH" term="%22Brain%22">Brain</searchLink>/<searchLink fieldCode="MH" term="%22Brain+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Cognition%22">Cognition</searchLink>/<searchLink fieldCode="MH" term="%22Cognition+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Docosahexaenoic+Acids%22">Docosahexaenoic Acids</searchLink>/<searchLink fieldCode="MH" term="%22Docosahexaenoic+Acids+administration+%26+dosage%22">administration & dosage</searchLink> ; <searchLink fieldCode="MH" term="%22Cognitive+Dysfunction%22">Cognitive Dysfunction</searchLink>/<searchLink fieldCode="MH" term="%22Cognitive+Dysfunction+prevention+%26+control%22">prevention & control</searchLink> ; <searchLink fieldCode="MH" term="%22Eicosapentaenoic+Acid%22">Eicosapentaenoic Acid</searchLink>/<searchLink fieldCode="MH" term="%22Eicosapentaenoic+Acid+administration+%26+dosage%22">administration & dosage</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Aging%22">Aging</searchLink> ; <searchLink fieldCode="MH" term="%22Neurosciences%22">Neurosciences</searchLink> ; <searchLink fieldCode="MH" term="%22Cognitive+Enhancement%22">Cognitive Enhancement</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Within the emerging field of nutritional neuroscience, omega-3 fatty acids are among the most extensively investigated dietary bioactive compounds with potential relevance to cognitive aging. As populations continue to age worldwide, identifying modifiable nutritional factors that support cognitive health has become an important public health priority. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), obtained primarily from marine sources, are integral components of neuronal membranes and serve as precursors of specialized pro-resolving lipid mediators. This narrative review integrates concepts from nutritional neuroscience and geroscience to examine how dietary omega-3 fatty acids may influence biological pathways involved in age-related cognitive decline. Current evidence suggests that DHA and EPA affect multiple processes linked to brain aging, including neuroinflammation, synaptic plasticity, mitochondrial function, oxidative stress, cerebrovascular integrity, cellular senescence, and gut-brain axis signaling. These mechanisms overlap with several hallmarks of aging and may contribute to the maintenance of cognitive function during later life. Observational studies generally associate higher dietary intake or circulating omega-3 status with better cognitive performance and a lower risk of cognitive decline and dementia. Findings from randomized controlled trials are less consistent, although benefits appear more likely in individuals with low baseline omega-3 status, mild cognitive impairment, or increased biological vulnerability. Beyond their established anti-inflammatory effects, omega-3 fatty acids may influence multiple aging-related pathways, particularly inflammaging, vascular aging, and mitochondrial dysfunction. Although heterogeneity in study design, dosage, intervention timing, and participant characteristics precludes firm conclusions, viewing omega-3 fatty acids through a geroscience lens offers a useful framework for interpreting existing evidence and informing future research. Overall, omega-3 fatty acids represent a promising nutritional strategy for supporting cognitive health across the lifespan, warranting further investigation in well-characterized populations and precision nutrition approaches.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Annu Rev Food Sci Technol. 2018 Mar 25;9:345-381. (PMID: <searchLink fieldCode="PM" term="%2229350557%22">29350557)</searchLink><br />Nature. 2014 Jun 5;510(7503):92-101. (PMID: <searchLink fieldCode="PM" term="%2224899309%22">24899309)</searchLink><br />J Exp Bot. 2012 Apr;63(7):2397-410. (PMID: <searchLink fieldCode="PM" term="%2222291131%22">22291131)</searchLink><br />Essays Biochem. 2020 Sep 23;64(3):443-462. (PMID: <searchLink fieldCode="PM" term="%2232885825%22">32885825)</searchLink><br />J Nutr Health Aging. 2013 Sep;17(9):726-34. (PMID: <searchLink fieldCode="PM" term="%2224154642%22">24154642)</searchLink><br />Inflamm Regen. 2022 Apr 2;42(1):11. (PMID: <searchLink fieldCode="PM" term="%2235365245%22">35365245)</searchLink><br />Clin Nutr. 2022 Feb;41(2):405-414. (PMID: <searchLink fieldCode="PM" term="%2234999335%22">34999335)</searchLink><br />Semin Immunol. 2015 May;27(3):200-15. (PMID: <searchLink fieldCode="PM" term="%2225857211%22">25857211)</searchLink><br />Eur J Med Res. 2025 Jan 16;30(1):32. (PMID: <searchLink fieldCode="PM" term="%2239815306%22">39815306)</searchLink><br />J Physiol. 2016 Apr 15;594(8):2001-24. (PMID: <searchLink fieldCode="PM" term="%2225639909%22">25639909)</searchLink><br />Genome Biol. 2017 May 5;18(1):83. (PMID: <searchLink fieldCode="PM" term="%2228476144%22">28476144)</searchLink><br />Ageing Res Rev. 2013 Mar;12(2):579-94. (PMID: <searchLink fieldCode="PM" term="%2223395782%22">23395782)</searchLink><br />Stroke. 2011 Sep;42(9):2672-713. (PMID: <searchLink fieldCode="PM" term="%2221778438%22">21778438)</searchLink><br />Clin Nutr. 2022 Mar;41(3):589-598. (PMID: <searchLink fieldCode="PM" term="%2235124466%22">35124466)</searchLink><br />Geroscience. 2026 Apr;48(2):2743-2756. (PMID: <searchLink fieldCode="PM" term="%2240728817%22">40728817)</searchLink><br />Prostaglandins Leukot Essent Fatty Acids. 2013 Jul;89(1):1-8. (PMID: <searchLink fieldCode="PM" term="%2223676322%22">23676322)</searchLink><br />Nat Aging. 2025 Aug;5(8):1378-1379. (PMID: <searchLink fieldCode="PM" term="%2240660004%22">40660004)</searchLink><br />Appetite. 2013 Apr;63:119-28. (PMID: <searchLink fieldCode="PM" term="%2223291218%22">23291218)</searchLink><br />J Nutr Health Aging. 2016 Feb;20(2):161-9. (PMID: <searchLink fieldCode="PM" term="%2226812512%22">26812512)</searchLink><br />Geroscience. 2025 Jun;47(3):3111-3130. (PMID: <searchLink fieldCode="PM" term="%2239797935%22">39797935)</searchLink><br />Front Aging Neurosci. 2024 Jan 12;15:1303912. (PMID: <searchLink fieldCode="PM" term="%2238283067%22">38283067)</searchLink><br />Front Aging Neurosci. 2015 Apr 21;7:52. (PMID: <searchLink fieldCode="PM" term="%2225954194%22">25954194)</searchLink><br />Nat Rev Immunol. 2016 Jan;16(1):51-67. (PMID: <searchLink fieldCode="PM" term="%2226688348%22">26688348)</searchLink><br />Annu Rev Pathol. 2010;5:99-118. (PMID: <searchLink fieldCode="PM" term="%2220078217%22">20078217)</searchLink><br />Crit Rev Food Sci Nutr. 2022;62(18):4982-4997. (PMID: <searchLink fieldCode="PM" term="%2233576691%22">33576691)</searchLink><br />Nutr Rev. 2018 Jan 1;76(1):1-20. (PMID: <searchLink fieldCode="PM" term="%2229240924%22">29240924)</searchLink><br />Geroscience. 2026 Apr;48(2):2887-2901. (PMID: <searchLink fieldCode="PM" term="%2240770530%22">40770530)</searchLink><br />Hypertension. 2014 Aug;64(2):210-4. (PMID: <searchLink fieldCode="PM" term="%2224799614%22">24799614)</searchLink><br />Biochem Soc Trans. 2017 Oct 15;45(5):1105-1115. (PMID: <searchLink fieldCode="PM" term="%2228900017%22">28900017)</searchLink><br />Curr Opin Genet Dev. 2011 Feb;21(1):107-12. (PMID: <searchLink fieldCode="PM" term="%2221093253%22">21093253)</searchLink><br />Lancet Neurol. 2018 Nov;17(11):1006-1015. (PMID: <searchLink fieldCode="PM" term="%2230244829%22">30244829)</searchLink><br />Nat Rev Neurosci. 2014 Dec;15(12):771-85. (PMID: <searchLink fieldCode="PM" term="%2225387473%22">25387473)</searchLink><br />Cell. 2022 Apr 28;185(9):1455-1470. (PMID: <searchLink fieldCode="PM" term="%2235487190%22">35487190)</searchLink><br />Geroscience. 2026 Jun;48(3):4923-4956. (PMID: <searchLink fieldCode="PM" term="%2241832380%22">41832380)</searchLink><br />Cell. 2013 Jun 6;153(6):1194-217. (PMID: <searchLink fieldCode="PM" term="%2223746838%22">23746838)</searchLink><br />Nature. 2014 May 22;509(7501):503-6. (PMID: <searchLink fieldCode="PM" term="%2224828044%22">24828044)</searchLink><br />Am J Clin Nutr. 2018 May 1;107(5):754-762. (PMID: <searchLink fieldCode="PM" term="%2229722833%22">29722833)</searchLink><br />Geroscience. 2020 Dec;42(6):1751-1764. (PMID: <searchLink fieldCode="PM" term="%2233025410%22">33025410)</searchLink><br />Am J Clin Nutr. 2007 Apr;85(4):1142-7. (PMID: <searchLink fieldCode="PM" term="%2217413117%22">17413117)</searchLink><br />Curr Dev Nutr. 2025 Jun 18;9(7):107485. (PMID: <searchLink fieldCode="PM" term="%2240697195%22">40697195)</searchLink><br />Nat Rev Neurosci. 2006 Jan;7(1):30-40. (PMID: <searchLink fieldCode="PM" term="%2216371948%22">16371948)</searchLink><br />Front Nutr. 2025 May 30;12:1598588. (PMID: <searchLink fieldCode="PM" term="%2240521363%22">40521363)</searchLink><br />Genes Nutr. 2023 Feb 25;18(1):2. (PMID: <searchLink fieldCode="PM" term="%2236841786%22">36841786)</searchLink><br />Aging (Albany NY). 2018 Apr 18;10(4):573-591. (PMID: <searchLink fieldCode="PM" term="%2229676998%22">29676998)</searchLink><br />Cell. 2025 Apr 17;188(8):2043-2062. (PMID: <searchLink fieldCode="PM" term="%2240250404%22">40250404)</searchLink><br />Geroscience. 2024 Aug;46(4):3801-3818. (PMID: <searchLink fieldCode="PM" term="%2238012365%22">38012365)</searchLink><br />Am J Clin Nutr. 2009 Jul;90(1):170-6. (PMID: <searchLink fieldCode="PM" term="%2219474131%22">19474131)</searchLink><br />Brain Sci. 2024 Dec 03;14(12):. (PMID: <searchLink fieldCode="PM" term="%2239766423%22">39766423)</searchLink><br />Alzheimers Res Ther. 2023 Nov 6;15(1):192. (PMID: <searchLink fieldCode="PM" term="%2237926851%22">37926851)</searchLink><br />Ageing Res Rev. 2015 Mar;20:1-10. (PMID: <searchLink fieldCode="PM" term="%2225555677%22">25555677)</searchLink><br />Gut. 2018 Nov;67(11):1974-1983. (PMID: <searchLink fieldCode="PM" term="%2228951525%22">28951525)</searchLink><br />Cell. 2018 May 17;173(5):1073-1081. (PMID: <searchLink fieldCode="PM" term="%2229775591%22">29775591)</searchLink><br />Mol Aspects Med. 2018 Dec;64:18-33. (PMID: <searchLink fieldCode="PM" term="%2230244005%22">30244005)</searchLink><br />J Neurotrauma. 2004 Oct;21(10):1457-67. (PMID: <searchLink fieldCode="PM" term="%2215672635%22">15672635)</searchLink><br />Trends Neurosci. 2021 Sep;44(9):714-727. (PMID: <searchLink fieldCode="PM" term="%2234366147%22">34366147)</searchLink><br />J Clin Invest. 2005 Oct;115(10):2774-83. (PMID: <searchLink fieldCode="PM" term="%2216151530%22">16151530)</searchLink><br />Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):85-91. (PMID: <searchLink fieldCode="PM" term="%2219269799%22">19269799)</searchLink><br />Nat Rev Cardiol. 2018 Sep;15(9):505-522. (PMID: <searchLink fieldCode="PM" term="%2230065258%22">30065258)</searchLink><br />J Nutrigenet Nutrigenomics. 2011;4(2):69-89. (PMID: <searchLink fieldCode="PM" term="%2221625170%22">21625170)</searchLink><br />Brain Sci. 2024 Jun 27;14(7):. (PMID: <searchLink fieldCode="PM" term="%2239061395%22">39061395)</searchLink><br />Food Chem. 2014 Oct 1;160:393-400. (PMID: <searchLink fieldCode="PM" term="%2224799253%22">24799253)</searchLink><br />J Am Med Dir Assoc. 2020 Oct;21(10):1439-1450.e21. (PMID: <searchLink fieldCode="PM" term="%2232305302%22">32305302)</searchLink><br />Geroscience. 2023 Oct;45(5):2819-2834. (PMID: <searchLink fieldCode="PM" term="%2237213047%22">37213047)</searchLink><br />J Neurosci. 2009 Oct 14;29(41):12795-801. (PMID: <searchLink fieldCode="PM" term="%2219828791%22">19828791)</searchLink><br />Cell. 2014 Nov 6;159(4):709-13. (PMID: <searchLink fieldCode="PM" term="%2225417146%22">25417146)</searchLink><br />Mol Aspects Med. 2018 Dec;64:1-17. (PMID: <searchLink fieldCode="PM" term="%2228802833%22">28802833)</searchLink><br />Nat Rev Drug Discov. 2016 Aug;15(8):551-67. (PMID: <searchLink fieldCode="PM" term="%2227020098%22">27020098)</searchLink><br />Nutrients. 2018 Nov 04;10(11):. (PMID: <searchLink fieldCode="PM" term="%2230400360%22">30400360)</searchLink><br />Mol Neurodegener. 2020 May 29;15(1):30. (PMID: <searchLink fieldCode="PM" term="%2232471464%22">32471464)</searchLink><br />Phytother Res. 2022 Jan;36(1):164-188. (PMID: <searchLink fieldCode="PM" term="%2234553434%22">34553434)</searchLink><br />Nutrients. 2025 Jun 28;17(13):. (PMID: <searchLink fieldCode="PM" term="%2240647258%22">40647258)</searchLink><br />Geroscience. 2026 Jun 16;:. (PMID: <searchLink fieldCode="PM" term="%2242301612%22">42301612)</searchLink><br />Orv Hetil. 2021 Jan 03;162(1):23-30. (PMID: <searchLink fieldCode="PM" term="%2233388735%22">33388735)</searchLink><br />Mol Neurodegener. 2022 Jun 17;17(1):43. (PMID: <searchLink fieldCode="PM" term="%2235715821%22">35715821)</searchLink><br />Alzheimers Dement. 2010 Nov;6(6):456-64. (PMID: <searchLink fieldCode="PM" term="%2220434961%22">20434961)</searchLink><br />Ageing Res Rev. 2020 May;59:101037. (PMID: <searchLink fieldCode="PM" term="%2232109604%22">32109604)</searchLink><br />Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):461-478. (PMID: <searchLink fieldCode="PM" term="%2231123355%22">31123355)</searchLink><br />Geroscience. 2025 Jun;47(3):2895-2923. (PMID: <searchLink fieldCode="PM" term="%2239821819%22">39821819)</searchLink><br />Age (Dordr). 2013 Aug;35(4):1495-505. (PMID: <searchLink fieldCode="PM" term="%2222791395%22">22791395)</searchLink><br />J Neuroinflammation. 2016 Sep 29;13(1):257. (PMID: <searchLink fieldCode="PM" term="%2227688126%22">27688126)</searchLink><br />Int J Mol Sci. 2018 Sep 27;19(10):. (PMID: <searchLink fieldCode="PM" term="%2230261683%22">30261683)</searchLink><br />Biomed Res Int. 2015;2015:172801. (PMID: <searchLink fieldCode="PM" term="%2226301243%22">26301243)</searchLink><br />Nutrients. 2024 Oct 21;16(20):. (PMID: <searchLink fieldCode="PM" term="%2239458561%22">39458561)</searchLink><br />Geroscience. 2024 Feb;46(1):683-696. (PMID: <searchLink fieldCode="PM" term="%2237999901%22">37999901)</searchLink><br />Geriatrics. 2005 Jun;Suppl:9-14. (PMID: <searchLink fieldCode="PM" term="%2216025770%22">16025770)</searchLink><br />Lancet. 2024 Aug 10;404(10452):572-628. (PMID: <searchLink fieldCode="PM" term="%2239096926%22">39096926)</searchLink><br />Kidney Med. 2021 Oct 04;3(6):1041-1049. (PMID: <searchLink fieldCode="PM" term="%2234939013%22">34939013)</searchLink><br />Geroscience. 2026 Feb;48(1):937-950. (PMID: <searchLink fieldCode="PM" term="%2240366519%22">40366519)</searchLink><br />Nutrients. 2016 Jun 02;8(6):. (PMID: <searchLink fieldCode="PM" term="%2227271660%22">27271660)</searchLink><br />Curr Opin Clin Nutr Metab Care. 2024 Mar 1;27(2):116-124. (PMID: <searchLink fieldCode="PM" term="%2238170690%22">38170690)</searchLink><br />Front Cell Neurosci. 2019 Aug 07;13:363. (PMID: <searchLink fieldCode="PM" term="%2231440144%22">31440144)</searchLink><br />Int J Geriatr Psychiatry. 2003 Dec;18(12):1121-34. (PMID: <searchLink fieldCode="PM" term="%2214677145%22">14677145)</searchLink><br />Nutrients. 2018 Mar 14;10(3):. (PMID: <searchLink fieldCode="PM" term="%2229538286%22">29538286)</searchLink><br />Free Radic Biol Med. 2022 Nov 20;193(Pt 2):736-750. (PMID: <searchLink fieldCode="PM" term="%2236402440%22">36402440)</searchLink><br />Nutrients. 2020 Dec 24;13(1):. (PMID: <searchLink fieldCode="PM" term="%2233374235%22">33374235)</searchLink><br />Arch Neurol. 2006 Nov;63(11):1545-50. (PMID: <searchLink fieldCode="PM" term="%2217101822%22">17101822)</searchLink><br />J Clin Med. 2023 Feb 22;12(5):. (PMID: <searchLink fieldCode="PM" term="%2236902545%22">36902545)</searchLink><br />Front Nutr. 2023 Jun 29;10:1213223. (PMID: <searchLink fieldCode="PM" term="%2237457976%22">37457976)</searchLink><br />Nat Rev Neurol. 2018 Mar;14(3):133-150. (PMID: <searchLink fieldCode="PM" term="%2229377008%22">29377008)</searchLink><br />Front Hum Neurosci. 2023 Sep 13;17:1240630. (PMID: <searchLink fieldCode="PM" term="%2237780962%22">37780962)</searchLink><br />Circ Res. 2018 Sep 14;123(7):825-848. (PMID: <searchLink fieldCode="PM" term="%2230355078%22">30355078)</searchLink><br />J Alzheimers Dis. 2024;101(s1):S455-S466. (PMID: <searchLink fieldCode="PM" term="%2239422948%22">39422948)</searchLink><br />Chem Phys Lipids. 2003 Nov;126(1):1-27. (PMID: <searchLink fieldCode="PM" term="%2214580707%22">14580707)</searchLink><br />Longev Healthspan. 2014 Mar 03;3(1):3. (PMID: <searchLink fieldCode="PM" term="%2224588808%22">24588808)</searchLink><br />Alzheimers Dement. 2015 Sep;11(9):1007-14. (PMID: <searchLink fieldCode="PM" term="%2225681666%22">25681666)</searchLink><br />J Neurosci. 2007 Apr 18;27(16):4385-95. (PMID: <searchLink fieldCode="PM" term="%2217442823%22">17442823)</searchLink><br />Public Health Nutr. 2018 Jul;21(10):1921-1932. (PMID: <searchLink fieldCode="PM" term="%2229551101%22">29551101)</searchLink><br />Int J Mol Sci. 2020 Feb 18;21(4):. (PMID: <searchLink fieldCode="PM" term="%2232085487%22">32085487)</searchLink><br />Sci Rep. 2025 Aug 20;15(1):30610. (PMID: <searchLink fieldCode="PM" term="%2240836005%22">40836005)</searchLink><br />Cell. 2021 Jan 7;184(1):33-63. (PMID: <searchLink fieldCode="PM" term="%2233340459%22">33340459)</searchLink><br />Front Cardiovasc Med. 2018 Feb 22;5:12. (PMID: <searchLink fieldCode="PM" term="%2229564335%22">29564335)</searchLink><br />Eur J Nutr. 2024 Jun;63(4):1003-1022. (PMID: <searchLink fieldCode="PM" term="%2238300291%22">38300291)</searchLink><br />Geroscience. 2025 Jun;47(3):5365-5376. (PMID: <searchLink fieldCode="PM" term="%2239825168%22">39825168)</searchLink><br />Nat Rev Drug Discov. 2020 Sep;19(9):609-633. (PMID: <searchLink fieldCode="PM" term="%2232709961%22">32709961)</searchLink><br />Int J Mol Sci. 2017 Dec 07;18(12):. (PMID: <searchLink fieldCode="PM" term="%2229215589%22">29215589)</searchLink><br />Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):213-21. (PMID: <searchLink fieldCode="PM" term="%2219523795%22">19523795)</searchLink><br />Neurology. 2007 Nov 13;69(20):1921-30. (PMID: <searchLink fieldCode="PM" term="%2217998483%22">17998483)</searchLink><br />Trends Neurosci. 2017 Mar;40(3):151-166. (PMID: <searchLink fieldCode="PM" term="%2228190529%22">28190529)</searchLink><br />Nat Aging. 2021 Jul;1:598-615. (PMID: <searchLink fieldCode="PM" term="%2234888528%22">34888528)</searchLink><br />Nat Rev Microbiol. 2021 Apr;19(4):241-255. (PMID: <searchLink fieldCode="PM" term="%2233093662%22">33093662)</searchLink><br />Cell Host Microbe. 2017 Apr 12;21(4):455-466.e4. (PMID: <searchLink fieldCode="PM" term="%2228407483%22">28407483)</searchLink><br />Neurology. 2012 Feb 28;78(9):658-64. (PMID: <searchLink fieldCode="PM" term="%2222371413%22">22371413)</searchLink><br />Nutrients. 2024 Mar 15;16(6):. (PMID: <searchLink fieldCode="PM" term="%2238542764%22">38542764)</searchLink><br />Cochrane Database Syst Rev. 2018 Nov 01;11:CD011905. (PMID: <searchLink fieldCode="PM" term="%2230383288%22">30383288)</searchLink><br />Psychosom Med. 2024 Jun 1;86(5):360-365. (PMID: <searchLink fieldCode="PM" term="%2238718171%22">38718171)</searchLink><br />J Exp Med. 2009 Jan 16;206(1):15-23. (PMID: <searchLink fieldCode="PM" term="%2219103881%22">19103881)</searchLink><br />Nat Rev Neurosci. 2020 Aug;21(8):433-444. (PMID: <searchLink fieldCode="PM" term="%2232601397%22">32601397)</searchLink><br />J Neurol Sci. 2022 Mar 15;434:120166. (PMID: <searchLink fieldCode="PM" term="%2235144237%22">35144237)</searchLink><br />Geroscience. 2025 Jun;47(3):3565-3581. (PMID: <searchLink fieldCode="PM" term="%2239777701%22">39777701)</searchLink><br />J Intern Med. 2014 Mar;275(3):214-28. (PMID: <searchLink fieldCode="PM" term="%2224605806%22">24605806)</searchLink><br />Aging (Albany NY). 2017 Apr;9(4):1096-1129. (PMID: <searchLink fieldCode="PM" term="%2228379838%22">28379838)</searchLink><br />Am J Clin Nutr. 2013 May;97(5):1134-43. (PMID: <searchLink fieldCode="PM" term="%2223515006%22">23515006)</searchLink><br />J Lipid Res. 2009 Apr;50 Suppl:S400-5. (PMID: <searchLink fieldCode="PM" term="%2219018037%22">19018037)</searchLink><br />Front Immunol. 2018 Jan 10;8:1960. (PMID: <searchLink fieldCode="PM" term="%2229375577%22">29375577)</searchLink><br />Ageing Res Rev. 2018 Jul;44:1-7. (PMID: <searchLink fieldCode="PM" term="%2229544875%22">29544875)</searchLink><br />J Cell Biol. 2018 Feb 5;217(2):459-472. (PMID: <searchLink fieldCode="PM" term="%2229196460%22">29196460)</searchLink><br />Nat Med. 2019 Dec;25(12):1822-1832. (PMID: <searchLink fieldCode="PM" term="%2231806905%22">31806905)</searchLink><br />Adv Nutr. 2019 Nov 1;10(6):1040-1065. (PMID: <searchLink fieldCode="PM" term="%2231209456%22">31209456)</searchLink><br />Geroscience. 2023 Aug;45(4):2601-2627. (PMID: <searchLink fieldCode="PM" term="%2237059838%22">37059838)</searchLink><br />BMJ. 2018 Oct 17;363:k4067. (PMID: <searchLink fieldCode="PM" term="%2230333104%22">30333104)</searchLink><br />Nutrients. 2026 Aug 04;18(15):. (PMID: <searchLink fieldCode="PM" term="%2242588171%22">42588171)</searchLink><br />Lancet Public Health. 2022 Feb;7(2):e105-e125. (PMID: <searchLink fieldCode="PM" term="%2234998485%22">34998485)</searchLink><br />JAMA Netw Open. 2024 Aug 1;7(8):e2426872. (PMID: <searchLink fieldCode="PM" term="%2239088212%22">39088212)</searchLink><br />Neuron. 2017 Sep 27;96(1):17-42. (PMID: <searchLink fieldCode="PM" term="%2228957666%22">28957666)</searchLink><br />J Nutr Health Aging. 2021;25(10):1167-1178. (PMID: <searchLink fieldCode="PM" term="%2234866144%22">34866144)</searchLink><br />Geroscience. 2022 Oct;44(5):2541-2554. (PMID: <searchLink fieldCode="PM" term="%2235794436%22">35794436)</searchLink><br />J Am Coll Cardiol. 2011 Nov 8;58(20):2047-67. (PMID: <searchLink fieldCode="PM" term="%2222051327%22">22051327)</searchLink><br />Front Aging. 2024 Dec 16;5:1395649. (PMID: <searchLink fieldCode="PM" term="%2239743988%22">39743988)</searchLink><br />Nutrients. 2025 Jul 27;17(15):. (PMID: <searchLink fieldCode="PM" term="%2240806031%22">40806031)</searchLink><br />Nutr Rev. 2020 Jul 1;78(7):563-578. (PMID: <searchLink fieldCode="PM" term="%2231841161%22">31841161)</searchLink><br />Ann Palliat Med. 2022 Sep;11(9):2819-2829. (PMID: <searchLink fieldCode="PM" term="%2235948470%22">35948470)</searchLink><br />Geroscience. 2025 Feb;47(1):1105-1121. (PMID: <searchLink fieldCode="PM" term="%2239090501%22">39090501)</searchLink><br />Neurobiol Dis. 2019 Oct;130:104481. (PMID: <searchLink fieldCode="PM" term="%2231136814%22">31136814)</searchLink><br />Adv Nutr. 2020 Nov 16;11(6):1405-1413. (PMID: <searchLink fieldCode="PM" term="%2232770212%22">32770212)</searchLink><br />Curr Neuropharmacol. 2017;15(4):534-542. (PMID: <searchLink fieldCode="PM" term="%2227306037%22">27306037)</searchLink><br />J Physiol. 2014 Mar 15;592(6):1341-52. (PMID: <searchLink fieldCode="PM" term="%2224396061%22">24396061)</searchLink><br />Korean J Intern Med. 2023 May;38(3):282-289. (PMID: <searchLink fieldCode="PM" term="%2236514212%22">36514212)</searchLink><br />Arch Neurol. 2003 Jul;60(7):940-6. (PMID: <searchLink fieldCode="PM" term="%2212873849%22">12873849)</searchLink><br />Front Pharmacol. 2019 Aug 23;10:902. (PMID: <searchLink fieldCode="PM" term="%2231507410%22">31507410)</searchLink><br />J Alzheimers Dis. 2018;62(3):1403-1416. (PMID: <searchLink fieldCode="PM" term="%2229036828%22">29036828)</searchLink><br />Curr Opin Lipidol. 2023 Feb 1;34(1):12-21. (PMID: <searchLink fieldCode="PM" term="%2236637075%22">36637075)</searchLink><br />JAMA. 2019 Aug 06;322(5):430-437. (PMID: <searchLink fieldCode="PM" term="%2231302669%22">31302669)</searchLink><br />Int J Mol Sci. 2022 Feb 28;23(5):. (PMID: <searchLink fieldCode="PM" term="%2235269827%22">35269827)</searchLink><br />Ann Neurol. 2006 Jun;59(6):912-21. (PMID: <searchLink fieldCode="PM" term="%2216622828%22">16622828)</searchLink><br />Lancet. 2020 Aug 8;396(10248):413-446. (PMID: <searchLink fieldCode="PM" term="%2232738937%22">32738937)</searchLink><br />Food Nutr Res. 2024 Mar 05;68:. (PMID: <searchLink fieldCode="PM" term="%2238571914%22">38571914)</searchLink><br />Age Ageing. 2022 Aug 2;51(8):. (PMID: <searchLink fieldCode="PM" term="%2235977150%22">35977150)</searchLink><br />Am J Lifestyle Med. 2022 Sep 20;17(4):560-588. (PMID: <searchLink fieldCode="PM" term="%2237426732%22">37426732)</searchLink><br />BMB Rep. 2026 Jan;59(1):51-59. (PMID: <searchLink fieldCode="PM" term="%2241407319%22">41407319)</searchLink><br />Cureus. 2024 Nov 10;16(11):e73390. (PMID: <searchLink fieldCode="PM" term="%2239659348%22">39659348)</searchLink><br />Nat Metab. 2024 Aug;6(8):1454-1478. (PMID: <searchLink fieldCode="PM" term="%2239174768%22">39174768)</searchLink><br />Front Neurosci. 2024 Oct 23;18:1481390. (PMID: <searchLink fieldCode="PM" term="%2239513042%22">39513042)</searchLink><br />Biomolecules. 2021 Dec 28;12(1):. (PMID: <searchLink fieldCode="PM" term="%2235053186%22">35053186)</searchLink><br />Ann Neurol. 1997 Nov;42(5):776-82. (PMID: <searchLink fieldCode="PM" term="%229392577%22">9392577)</searchLink><br />Am J Epidemiol. 2018 May 1;187(5):933-940. (PMID: <searchLink fieldCode="PM" term="%2229053784%22">29053784)</searchLink><br />Nutrients. 2014 Feb 21;6(2):799-814. (PMID: <searchLink fieldCode="PM" term="%2224566438%22">24566438)</searchLink><br />Nutrients. 2026 Apr 30;18(9):. (PMID: <searchLink fieldCode="PM" term="%2242124031%22">42124031)</searchLink><br />Geroscience. 2024 Oct;46(5):4037-4057. (PMID: <searchLink fieldCode="PM" term="%2238922379%22">38922379)</searchLink><br />Microb Cell Fact. 2012 Jul 25;11:96. (PMID: <searchLink fieldCode="PM" term="%2222830315%22">22830315)</searchLink><br />BMC Med. 2024 Mar 12;22(1):109. (PMID: <searchLink fieldCode="PM" term="%2238468309%22">38468309)</searchLink><br />Psychopharmacology (Berl). 2013 Feb;225(3):605-12. (PMID: <searchLink fieldCode="PM" term="%2222932777%22">22932777)</searchLink><br />Nutrients. 2014 Sep 16;6(9):3727-33. (PMID: <searchLink fieldCode="PM" term="%2225255830%22">25255830)</searchLink><br />J Affect Disord. 2025 Jun 01;378:263-270. (PMID: <searchLink fieldCode="PM" term="%2240044083%22">40044083)</searchLink><br />Geroscience. 2026 May 19;:. (PMID: <searchLink fieldCode="PM" term="%2242154116%22">42154116)</searchLink><br />Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S. (PMID: <searchLink fieldCode="PM" term="%2216841856%22">16841856)</searchLink><br />Nutr Rev. 2025 Jul 1;83(7):e2113-e2126. (PMID: <searchLink fieldCode="PM" term="%2239499795%22">39499795)</searchLink><br />Front Aging Neurosci. 2012 Sep 12;4:15. (PMID: <searchLink fieldCode="PM" term="%2222988437%22">22988437)</searchLink><br />Geroscience. 2023 Jun;45(3):1997-2009. (PMID: <searchLink fieldCode="PM" term="%2237046127%22">37046127)</searchLink><br />Pharmacol Rev. 2018 Jan;70(1):12-38. (PMID: <searchLink fieldCode="PM" term="%2229217656%22">29217656)</searchLink><br />Prostaglandins Other Lipid Mediat. 2018 Jan;134:131-140. (PMID: <searchLink fieldCode="PM" term="%2228802571%22">28802571)</searchLink><br />Int J Mol Sci. 2023 Mar 30;24(7):. (PMID: <searchLink fieldCode="PM" term="%2237047492%22">37047492)</searchLink><br />Neurology. 2017 Jan 31;88(5):449-455. (PMID: <searchLink fieldCode="PM" term="%2228053008%22">28053008)</searchLink><br />Nature. 2018 Oct;562(7728):578-582. (PMID: <searchLink fieldCode="PM" term="%2230232451%22">30232451)</searchLink><br />J Clin Invest. 2022 May 16;132(10):. (PMID: <searchLink fieldCode="PM" term="%2235575089%22">35575089)</searchLink><br />J Clin Invest. 2018 Apr 2;128(4):1208-1216. (PMID: <searchLink fieldCode="PM" term="%2229457783%22">29457783)</searchLink><br />FAO Food Nutr Pap. 2010;91:1-166. (PMID: <searchLink fieldCode="PM" term="%2221812367%22">21812367)</searchLink><br />Nature. 2021 Jul;595(7866):315-319. (PMID: <searchLink fieldCode="PM" term="%2234135507%22">34135507)</searchLink><br />Int J Mol Sci. 2015 Oct 16;16(10):24600-13. (PMID: <searchLink fieldCode="PM" term="%2226501267%22">26501267)</searchLink><br />Cochrane Database Syst Rev. 2016 Apr 11;4:CD009002. (PMID: <searchLink fieldCode="PM" term="%2227063583%22">27063583)</searchLink><br />Lancet Neurol. 2017 May;16(5):377-389. (PMID: <searchLink fieldCode="PM" term="%2228359749%22">28359749)</searchLink><br />Physiol Rev. 2025 Jul 1;105(3):1609-1694. (PMID: <searchLink fieldCode="PM" term="%2240111763%22">40111763)</searchLink><br />Int J Geriatr Psychiatry. 2022 May;37(5):. (PMID: <searchLink fieldCode="PM" term="%2235373862%22">35373862)</searchLink><br />Aging Clin Exp Res. 2024 Mar 22;36(1):77. (PMID: <searchLink fieldCode="PM" term="%2238519775%22">38519775)</searchLink><br />Int J Geriatr Psychiatry. 2015 Mar;30(3):234-46. (PMID: <searchLink fieldCode="PM" term="%2225504093%22">25504093)</searchLink><br />Maturitas. 2024 Jun;184:107952. (PMID: <searchLink fieldCode="PM" term="%2238457981%22">38457981)</searchLink><br />Physiol Rev. 2019 Oct 1;99(4):1877-2013. (PMID: <searchLink fieldCode="PM" term="%2231460832%22">31460832)</searchLink><br />J Clin Invest. 2018 Jul 2;128(7):2657-2669. (PMID: <searchLink fieldCode="PM" term="%2229757195%22">29757195)</searchLink><br />Nat Rev Neurol. 2021 Mar;17(3):157-172. (PMID: <searchLink fieldCode="PM" term="%2233318676%22">33318676)</searchLink><br />Reprod Nutr Dev. 2005 Sep-Oct;45(5):581-97. (PMID: <searchLink fieldCode="PM" term="%2216188209%22">16188209)</searchLink><br />EBioMedicine. 2020 Sep;59:102883. (PMID: <searchLink fieldCode="PM" term="%2232690472%22">32690472)</searchLink><br />JAMA Neurol. 2023 Dec 1;80(12):1284-1294. (PMID: <searchLink fieldCode="PM" term="%2237930705%22">37930705)</searchLink><br />Brain Behav Immun. 2017 Jan;59:21-37. (PMID: <searchLink fieldCode="PM" term="%2227423492%22">27423492)</searchLink><br />Nutrients. 2016 Jan 04;8(1):. (PMID: <searchLink fieldCode="PM" term="%2226742060%22">26742060)</searchLink><br />Am J Clin Nutr. 2023 Jun;117(6):1096-1109. (PMID: <searchLink fieldCode="PM" term="%2237028557%22">37028557)</searchLink><br />Nutrients. 2026 May 05;18(9):. (PMID: <searchLink fieldCode="PM" term="%2242124071%22">42124071)</searchLink><br />Brain Behav Immun. 2022 Jan;99:289-298. (PMID: <searchLink fieldCode="PM" term="%2234755655%22">34755655)</searchLink><br />PLoS One. 2015 Mar 18;10(3):e0120391. (PMID: <searchLink fieldCode="PM" term="%2225786262%22">25786262)</searchLink><br />Geroscience. 2024 Dec;46(6):6625-6639. (PMID: <searchLink fieldCode="PM" term="%2238967696%22">38967696)</searchLink><br />Nutrients. 2026 Jul 31;18(15):. (PMID: <searchLink fieldCode="PM" term="%2242588100%22">42588100)</searchLink><br />JAMA. 2020 Dec 8;324(22):2268-2280. (PMID: <searchLink fieldCode="PM" term="%2233190147%22">33190147)</searchLink><br />Front Aging Neurosci. 2023 Oct 27;15:1227112. (PMID: <searchLink fieldCode="PM" term="%2237965493%22">37965493)</searchLink><br />Adv Nutr. 2016 Sep 15;7(5):905-16. (PMID: <searchLink fieldCode="PM" term="%2227633106%22">27633106)</searchLink><br />J Alzheimers Dis Rep. 2025 Feb 25;9:25424823251324397. (PMID: <searchLink fieldCode="PM" term="%2240034504%22">40034504)</searchLink><br />BMJ. 2004 Jan 3;328(7430):30-5. (PMID: <searchLink fieldCode="PM" term="%2214703544%22">14703544)</searchLink><br />Nat Med. 2020 Jan;26(1):83-90. (PMID: <searchLink fieldCode="PM" term="%2231932806%22">31932806)</searchLink><br />Geroscience. 2024 Feb;46(1):981-998. (PMID: <searchLink fieldCode="PM" term="%2237308768%22">37308768)</searchLink><br />Alzheimers Dement. 2024 May;20(5):3567-3586. (PMID: <searchLink fieldCode="PM" term="%2238477378%22">38477378)</searchLink><br />Nat Rev Neurol. 2025 Jan;21(1):5-16. (PMID: <searchLink fieldCode="PM" term="%2239572782%22">39572782)</searchLink><br />Lipids Health Dis. 2013 Dec 05;12:178. (PMID: <searchLink fieldCode="PM" term="%2224304605%22">24304605)</searchLink><br />Annu Rev Nutr. 2018 Aug 21;38:329-356. (PMID: <searchLink fieldCode="PM" term="%2229852087%22">29852087)</searchLink><br />Cochrane Database Syst Rev. 2012 Jun 13;(6):CD005379. (PMID: <searchLink fieldCode="PM" term="%2222696350%22">22696350)</searchLink><br />Alzheimers Res Ther. 2020 Dec 18;12(1):167. (PMID: <searchLink fieldCode="PM" term="%2233339532%22">33339532)</searchLink><br />Nat Aging. 2025 Aug;5(8):1441-1454. (PMID: <searchLink fieldCode="PM" term="%2240813813%22">40813813)</searchLink><br />Neuron. 2013 Nov 20;80(4):844-66. (PMID: <searchLink fieldCode="PM" term="%2224267647%22">24267647)</searchLink><br />J Alzheimers Dis. 2013;35(4):697-713. (PMID: <searchLink fieldCode="PM" term="%2223481688%22">23481688)</searchLink><br />Biomol Ther (Seoul). 2021 Sep 1;29(5):455-464. (PMID: <searchLink fieldCode="PM" term="%2234162770%22">34162770)</searchLink><br />Nat Rev Endocrinol. 2018 Oct;14(10):576-590. (PMID: <searchLink fieldCode="PM" term="%2230046148%22">30046148)</searchLink><br />Circulation. 2018 Oct 30;138(18):1951-1962. (PMID: <searchLink fieldCode="PM" term="%2230018169%22">30018169)</searchLink><br />Nutrients. 2021 Jul 15;13(7):. (PMID: <searchLink fieldCode="PM" term="%2234371930%22">34371930)</searchLink><br />Prostaglandins Leukot Essent Fatty Acids. 2022 Mar;178:102415. (PMID: <searchLink fieldCode="PM" term="%2235338847%22">35338847)</searchLink><br />Clin Nutr. 2019 Feb;38(1):10-47. (PMID: <searchLink fieldCode="PM" term="%2230005900%22">30005900)</searchLink><br />Neural Regen Res. 2025 Apr 1;20(4):990-1008. (PMID: <searchLink fieldCode="PM" term="%2238989933%22">38989933)</searchLink><br />Alzheimers Dement. 2020 Oct 8;:. (PMID: <searchLink fieldCode="PM" term="%2233090665%22">33090665)</searchLink><br />Nutr Rev. 2018 Aug 1;76(8):603-617. (PMID: <searchLink fieldCode="PM" term="%2229718511%22">29718511)</searchLink><br />Nutrients. 2023 Nov 23;15(23):. (PMID: <searchLink fieldCode="PM" term="%2238068754%22">38068754)</searchLink><br />Geroscience. 2018 Aug;40(4):361-364. (PMID: <searchLink fieldCode="PM" term="%2230084059%22">30084059)</searchLink><br />Cell. 2023 Aug 31;186(18):3758-3775. (PMID: <searchLink fieldCode="PM" term="%2237657418%22">37657418)</searchLink><br />Gut Microbes. 2020;11(2):135-157. (PMID: <searchLink fieldCode="PM" term="%2231368397%22">31368397)</searchLink><br />Int J Mol Sci. 2022 Mar 23;23(7):. (PMID: <searchLink fieldCode="PM" term="%2235408832%22">35408832)</searchLink><br />Nat Rev Neurosci. 2008 Jul;9(7):568-78. (PMID: <searchLink fieldCode="PM" term="%2218568016%22">18568016)</searchLink><br />Int J Mol Sci. 2019 Oct 11;20(20):. (PMID: <searchLink fieldCode="PM" term="%2231614433%22">31614433)</searchLink><br />Ageing Res Rev. 2023 Jul;88:101939. (PMID: <searchLink fieldCode="PM" term="%2237116664%22">37116664)</searchLink><br />Neurology. 2012 Aug 14;79(7):642-50. (PMID: <searchLink fieldCode="PM" term="%2222855869%22">22855869)</searchLink><br />Am J Clin Nutr. 2023 Aug;118(2):369-381. (PMID: <searchLink fieldCode="PM" term="%2237315924%22">37315924)</searchLink><br />Geroscience. 2025 Feb;47(1):515-542. (PMID: <searchLink fieldCode="PM" term="%2239352664%22">39352664)</searchLink><br />Food Res Int. 2025 May;208:116171. (PMID: <searchLink fieldCode="PM" term="%2240263835%22">40263835)</searchLink><br />Nutrients. 2023 Dec 15;15(24):. (PMID: <searchLink fieldCode="PM" term="%2238140375%22">38140375)</searchLink><br />Elife. 2020 Jun 09;9:. (PMID: <searchLink fieldCode="PM" term="%2232515735%22">32515735)</searchLink><br />Acta Neuropathol. 2016 May;131(5):687-707. (PMID: <searchLink fieldCode="PM" term="%2227038189%22">27038189)</searchLink><br />Biogerontology. 2016 Feb;17(1):7-19. (PMID: <searchLink fieldCode="PM" term="%2225921609%22">25921609)</searchLink><br />Neurology. 2008 Aug 5;71(6):430-8. (PMID: <searchLink fieldCode="PM" term="%2218678826%22">18678826)</searchLink><br />Trends Endocrinol Metab. 2017 Mar;28(3):199-212. (PMID: <searchLink fieldCode="PM" term="%2227789101%22">27789101)</searchLink><br />Genes Immun. 2021 Oct;22(5-6):289-303. (PMID: <searchLink fieldCode="PM" term="%2233875817%22">33875817)</searchLink><br />Circulation. 2019 Sep 17;140(12):e673-e691. (PMID: <searchLink fieldCode="PM" term="%2231422671%22">31422671)</searchLink><br />Crit Rev Food Sci Nutr. 2014;54(1):98-114. (PMID: <searchLink fieldCode="PM" term="%2224188235%22">24188235)</searchLink><br />Ageing Res Rev. 2021 Nov;71:101422. (PMID: <searchLink fieldCode="PM" term="%2234391943%22">34391943)</searchLink>
– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: TKP2021-NKTA-47 National Research, Development and Innovation Office; RRF-2.3.1-21-2022-00003 Ministry of Innovation and Technology under the National Cardiovascular Laboratory Program; 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1 European University for Well-Being (EUniWell) program
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>DHA; EPA; brain aging; cognitive aging; geroscience; healthy aging; inflammaging; neuroinflammation; nutritional neuroscience; omega-3 fatty acids
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Fatty Acids, Omega-3)<br />25167-62-8 (Docosahexaenoic Acids)<br />AAN7QOV9EA (Eicosapentaenoic Acid)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260827 <i>Date Completed: </i>20260827 <i>Latest Revision: </i>20260829
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260829
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC13516186
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3390/nu18162594
– Name: AN
  Label: PMID
  Group: ID
  Data: 42654174
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42654174
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/nu18162594
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Brain drug effects
        Type: general
      – SubjectFull: Cognition drug effects
        Type: general
      – SubjectFull: Docosahexaenoic Acids administration & dosage
        Type: general
      – SubjectFull: Cognitive Dysfunction prevention & control
        Type: general
      – SubjectFull: Eicosapentaenoic Acid administration & dosage
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Aging
        Type: general
      – SubjectFull: Neurosciences
        Type: general
      – SubjectFull: Cognitive Enhancement
        Type: general
      – SubjectFull: Fatty Acids, Omega-3 administration & dosage
        Type: general
      – SubjectFull: Fatty Acids, Omega-3 pharmacology
        Type: general
      – SubjectFull: Cognitive Aging physiology
        Type: general
      – SubjectFull: Geroscience
        Type: general
    Titles:
      – TitleFull: Food-Derived Omega-3 Fatty Acids and Cognitive Aging: Integrating Nutritional Neuroscience and Geroscience.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Mózes N
      – PersonEntity:
          Name:
            NameFull: Lipécz Á
      – PersonEntity:
          Name:
            NameFull: Csípő T
      – PersonEntity:
          Name:
            NameFull: Fazekas-Pongor V
      – PersonEntity:
          Name:
            NameFull: Major D
      – PersonEntity:
          Name:
            NameFull: Hung WY
      – PersonEntity:
          Name:
            NameFull: Zábó V
      – PersonEntity:
          Name:
            NameFull: Csík B
      – PersonEntity:
          Name:
            NameFull: Fehér Á
      – PersonEntity:
          Name:
            NameFull: Bérczi B
      – PersonEntity:
          Name:
            NameFull: Klesch L
      – PersonEntity:
          Name:
            NameFull: Fekete M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 07
              M: 08
              Text: 2026 Aug 07
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2072-6643
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 16
          Titles:
            – TitleFull: Nutrients
              Type: main
ResultId 1