Academic Journal
Efficacy of theracal as pulp capping material in permanent dentition: a systematic review and meta-analysis.
| Τίτλος: | Efficacy of theracal as pulp capping material in permanent dentition: a systematic review and meta-analysis. |
|---|---|
| Συγγραφείς: | Mohamed MA; Faculty of Dental Medicine, Al-Azhar University, Cairo, Egypt.; Medical Research Group of Egypt, Negida Academy, Arlington, Massachusetts, USA., Waly R; Medical Research Group of Egypt, Negida Academy, Arlington, Massachusetts, USA.; Faculty of Dentistry, Suez Canal University, Ismailia, Egypt., Mahmoud S; Faculty of Dental Medicine, Fayoum University, Fayoum, Egypt., Fayyad AA; Al-Anbar Health Directorate, Al-Fallujah Specialized Dental Center, Ministry of Health, Al-Anbar, Iraq., Azab A; Prosthodontics Department, Faculty of Oral and Dental Medicine, Alsalam University, Tanta, 31511, Egypt., Alamoush RA; Department of Fixed and Removable Prosthodontics, School of Dentistry, The University of Jordan, Queen Rania Street, Amman, 11942, Jordan.; Department of Dentistry, Jordan University Hospital, Amman, 11942, Jordan., Abozaid D; Dental Biomaterials Department, Faculty of Dentistry, Tanta University, Tanta, Egypt. dina_ezzat@dent.tanta.edu.eg. |
| Πηγή: | BMC oral health [BMC Oral Health] 2026 Jul 31; Vol. 26 (1). Date of Electronic Publication: 2026 Jul 31. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| Ιατρικοί όροι (MeSH): | Pulp Capping and Pulpectomy Agents*/therapeutic use , Dental Pulp Capping*/methods , Calcium Compounds*/therapeutic use , Silicates*/therapeutic use , Dentition, Permanent*, Humans ; Treatment Outcome ; Calcium Hydroxide ; Aluminum Compounds ; Drug Combinations ; Oxides |
| Περίληψη: | Background: Vital pulp therapy (VPT) aims to preserve pulp vitality through minimally invasive approaches, including indirect pulp capping (IPC), direct pulp capping (DPC), and pulpotomy. TheraCal LC, a light-cured resin-modified calcium silicate material, is widely used as a pulp-capping agent due to its favorable handling characteristics and bioactive properties. However, its clinical and radiographic efficacy remains insufficiently documented. Objective: This systematic review and meta-analysis evaluated the effectiveness of TheraCal LC in IPC and DPC procedures and compared its performance with other pulp-capping materials, including mineral trioxide aggregate (MTA), calcium hydroxide, and Biodentine. Methods: A comprehensive search of PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials was conducted up to August 2025. Randomized controlled trials assessing TheraCal LC in IPC or DPC of permanent teeth were included. Study selection, data extraction, and risk of bias assessment (ROB-2) were performed independently by multiple reviewers. Meta-analyses were conducted using random-effects models, with subgroup analyses based on follow-up duration. Results: From 606 records identified across four databases, 11 clinical studies published between 2015 and 2025 met the inclusion criteria. These studies compared TheraCal LC with calcium hydroxide, Biodentine, and MTA in IPC and DPC. TheraCal LC demonstrated comparable clinical success rates to other materials, with consistently low pain scores and satisfactory dentin bridge formation during follow-up periods of 6-36 months. Risk of bias assessment indicated that most studies presented some concerns, primarily related to randomization and selective reporting, although overall methodological quality was acceptable. Conclusions: TheraCal LC represents a viable alternative to MTA, calcium hydroxide, and Biodentine for direct and indirect pulp capping in permanent teeth. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Calcium silicate; Meta-analysis; Pulp capping; Systematic review; TheraCal; Vital pulp therapy |
| Substance Nomenclature: | 0 (Pulp Capping and Pulpectomy Agents) 0 (Calcium Compounds) 0 (TheraCal) 0 (Silicates) 0 (mineral trioxide aggregate) PF5DZW74VN (Calcium Hydroxide) 0 (Aluminum Compounds) 0 (Drug Combinations) 0 (Oxides) |
| Entry Date(s): | Date Created: 20260826 Date Completed: 20260827 Latest Revision: 20260909 |
| Update Code: | 20260910 |
| PubMed Central ID: | PMC13520471 |
| DOI: | 10.1186/s12903-026-09008-9 |
| PMID: | 42649488 |
| Βάση Δεδομένων: | MEDLINE |
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