Academic Journal
Restoring comparative expertise to improve translation of animal models.
| Τίτλος: | Restoring comparative expertise to improve translation of animal models. |
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| Συγγραφείς: | Lloyd KCK; Department of Surgery, School of Medicine, Mouse Biology Program, and NAMs Testing Center, University of California Davis, Davis, CA 95618, USA. |
| Πηγή: | Disease models & mechanisms [Dis Model Mech] 2026 Aug 01; Vol. 19 (8). Date of Electronic Publication: 2026 Aug 26. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge : Company of Biologists Ltd., c2008- |
| Ιατρικοί όροι (MeSH): | Translational Research, Biomedical* , Models, Animal* , Disease Models, Animal*, Animals ; Humans |
| Περίληψη: | Animal models remain indispensable in biomedical research, particularly for discovering disease mechanisms within intact living organisms. Yet confidence in their human translational relevance has been weakened by apparent failures of preclinical findings to predict clinical outcomes. Although often attributed to species differences, such failures also reflect correctable problems in model selection, experimental design, endpoint choice and phenotype interpretation. A key, but overlooked, contributor is the erosion of comparative expertise in pathobiology and clinical medicine needed to relate animal phenotypes to human disease across species, strain, and developmental, physiological and pathological contexts. This expertise gap can lead investigators to mismatch models to biological questions, misinterpret background abnormalities as engineered phenotypes or extend mechanism-focused models beyond the questions they are suited to answer. New approach methodologies (NAMs), such as in vitro and in silico models, provide important complementary tools, but do not eliminate the need for whole-organism models or resolve this interpretive problem. Ensuring the reliability of biomedical research will require preserving well-justified animal models where whole-organism systems biology remains necessary, integrating validated NAMs only where they are fit for purpose, and rebuilding the comparative expertise needed to interpret both model types rigorously. (© 2026. Published by The Company of Biologists.) |
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| Contributed Indexing: | Keywords: Animal models; Comparative pathology; New approach methodologies; Translational research |
| Entry Date(s): | Date Created: 20260826 Date Completed: 20260826 Latest Revision: 20260918 |
| Update Code: | 20260918 |
| PubMed Central ID: | PMC13580584 |
| DOI: | 10.1242/dmm.053172 |
| PMID: | 42643125 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1754-8411 |
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| DOI: | 10.1242/dmm.053172 |