Academic Journal
Altered brain functional network segregation and integration in patients with insomnia disorder.
| Τίτλος: | Altered brain functional network segregation and integration in patients with insomnia disorder. |
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| Συγγραφείς: | Wang H; Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China; School of Future Technology, Xi'an Jiaotong University, Xi'an, 710049, China., Ye G; Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China., Chen H; Xi'an Jiaotong University, Xi'an, 710061, China., Li H; Positron Emission Tomography/Computed Tomography Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China., Sun Y; Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China., Liu Y; Xi'an Jiaotong University, Xi'an, 710061, China., Fatemeh NN; Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China., Sheng W; MR Research Collaboration, Siemens Healthineers Ltd, Chengdu, China., Chen W; Department of Medical Imaging Center, Ankang Hospital of Traditional Chinese Medicine, Ankang, 725000, China., Zhou Y; Department of Medical Imaging Center, Ankang Hospital of Traditional Chinese Medicine, Ankang, 725000, China., Wang R; School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an, China. Electronic address: tobous@mail.xjtu.edu.cn., Zhang M; Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China; School of Future Technology, Xi'an Jiaotong University, Xi'an, 710049, China. Electronic address: zhangming01@xjtu.edu.cn. |
| Πηγή: | Brain research bulletin [Brain Res Bull] 2026 Oct 15; Vol. 245, pp. 112097. Date of Electronic Publication: 2026 Aug 25. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : Elsevier Science Original Publication: Phoenix, N. Y. ANKHO International Inc. |
| Ιατρικοί όροι (MeSH): | Sleep Initiation and Maintenance Disorders*/physiopathology , Sleep Initiation and Maintenance Disorders*/diagnostic imaging , Brain*/physiopathology , Brain*/diagnostic imaging , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging, Magnetic Resonance Imaging/methods ; Depression/physiopathology ; Depression/diagnostic imaging ; Brain Mapping/methods ; Neural Pathways/physiopathology ; Humans ; Female ; Male ; Adult ; Middle Aged |
| Περίληψη: | Insomnia disorder (ID) is frequently accompanied by depressive symptoms, complicating clinical management. However, alterations in interregional brain interactions associated with depressive symptoms in patients with ID remain unclear. We enrolled 40 healthy controls (HCs), 43 patients with insomnia disorder without clinically significant depressive symptoms (ID-ND), and 20 patients with insomnia disorder with clinically significant depressive symptoms (ID-D), and collected clinical assessments and MRI data. The nested-spectral partition (NSP) method was applied to comprehensively characterize differences in functional brain networks among the three groups. Linear regression models and correlation analyses were further conducted to examine associations between clinical measures and neuroimaging metrics. The ID-D group showed more severe insomnia, depressive, and anxiety symptoms than the ID-ND group. ID-ND exhibited significantly greater whole-brain and network-level functional integration than HCs, and these findings were stable in stratified bootstrap analyses. At the regional level, ID-ND showed greater integration than HCs, mainly involving the prefrontal cortex, sensorimotor regions, insula, and parietal lobe. The functional integration within the prefrontal cortex, temporal gyrus, and fusiform gyrus was also higher in the ID-ND group than in the ID-D group, and these regional differences spatially corresponded with molecular maps of relatively high 5-HT1A, 5-HT2A and GABAA receptor distribution. In the ID-D group, depression severity was positively correlated with integration in the subcortical network, visual network, dorsal attention network, and somatosensory-motor network, but none of these survived FDR correction. Notably, the linear regression model revealed opposing association patterns of insomnia and depressive symptom severity with whole-brain functional segregation and integration in patients with ID. Our study investigated the neural network differences among ID subtypes, providing a foundation for understanding underlying mechanisms and informing intervention strategies. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare no competing interests. |
| Contributed Indexing: | Keywords: Depressive symptoms; Insomnia disorder; Nested-spectral partition; Resting-state functional magnetic resonance imaging |
| Entry Date(s): | Date Created: 20260825 Date Completed: 20261006 Latest Revision: 20261006 |
| Update Code: | 20261007 |
| DOI: | 10.1016/j.brainresbull.2026.112097 |
| PMID: | 42641769 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-2747 |
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| DOI: | 10.1016/j.brainresbull.2026.112097 |