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Defend or divert: Reactive oxygen species signaling drives opposite EPS strategies in marine bacteria under nanoplastic stress.

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Τίτλος: Defend or divert: Reactive oxygen species signaling drives opposite EPS strategies in marine bacteria under nanoplastic stress.
Συγγραφείς: Wang Y; Department of Environmental Science, College of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, PR China., Xiong C; Department of Environmental Science, College of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, PR China., Wang J; Department of Environmental Science, College of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, PR China., Hong C; Department of Civil and Environmental Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States., Qiu H; School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China., Qiu Y; Department of Environmental Science, College of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, PR China. Electronic address: ypqiu@tongji.edu.cn.
Πηγή: Journal of hazardous materials [J Hazard Mater] 2026 Sep 15; Vol. 516, pp. 143365. Date of Electronic Publication: 2026 Aug 22.
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE
Imprint Name(s): Original Publication: Amsterdam : Elsevier
Ιατρικοί όροι (MeSH): Reactive Oxygen Species*/metabolism , Extracellular Polymeric Substance Matrix*/metabolism , Bacillus subtilis*/metabolism , Bacillus subtilis*/drug effects , Pseudomonas aeruginosa*/metabolism , Pseudomonas aeruginosa*/drug effects, Signal Transduction ; Stress, Physiological
Περίληψη: Nanoplastic pollution represents a pervasive threat to marine ecosystems, yet the molecular mechanisms governing microbial adaptation remain elusive. This study reveals how reactive oxygen species (ROS) signaling drives opposite extracellular polymeric substance (EPS) strategies in marine bacteria under NP stress. Pseudomonas aeruginosa enacts a proactive defend strategy, increasing EPS secretion by 6.66%-53.17%. Driven by a ROS surge, it allocates resources to EPS precursors and maintains transcriptional homeostasis through global fine-tuning to secure protein homeostasis and energy stability. Conversely, Bacillus subtilis undergoes a rapid metabolic divert response, causing a persistent EPS inhibition of 18.49%-27.31%. By systematically redirecting carbon and nitrogen fluxes away from EPS production through the downregulation of precursor-supplying pathways, this strain diverts energy and metabolic precursors toward emergency survival pathways such as membrane homeostasis maintenance, cellular stress protection, and sporulation. Our defend or divert framework provides a mechanistic paradigm for assessing how emerging contaminants dictate cellular resource allocation and reshape the ecological trajectory of marine microbial communities.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Bacillus subtilis; Extracellular polymeric substances; Nanoplastics; Pseudomonas aeruginosa; Reactive oxygen species
Substance Nomenclature: 0 (Reactive Oxygen Species)
Entry Date(s): Date Created: 20260825 Date Completed: 20260909 Latest Revision: 20261001
Update Code: 20261001
DOI: 10.1016/j.jhazmat.2026.143365
PMID: 42641514
Βάση Δεδομένων: MEDLINE
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  Data: Defend or divert: Reactive oxygen species signaling drives opposite EPS strategies in marine bacteria under nanoplastic stress.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Environmental Science, College of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, PR China.<br /><searchLink fieldCode="AU" term="%22Xiong+C%22">Xiong C</searchLink>; Department of Environmental Science, College of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Environmental Science, College of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, PR China.<br /><searchLink fieldCode="AU" term="%22Hong+C%22">Hong C</searchLink>; Department of Civil and Environmental Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States.<br /><searchLink fieldCode="AU" term="%22Qiu+H%22">Qiu H</searchLink>; School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Qiu+Y%22">Qiu Y</searchLink>; Department of Environmental Science, College of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, PR China. Electronic address: ypqiu@tongji.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229422688%22">Journal of hazardous materials</searchLink> [J Hazard Mater] 2026 Sep 15; Vol. 516, pp. 143365. <i>Date of Electronic Publication: </i>2026 Aug 22.
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  Data: <i>Original Publication</i>: Amsterdam : Elsevier
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  Data: <searchLink fieldCode="MM" term="%22Reactive+Oxygen+Species%22">Reactive Oxygen Species*</searchLink>/<searchLink fieldCode="MM" term="%22Reactive+Oxygen+Species+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Extracellular+Polymeric+Substance+Matrix%22">Extracellular Polymeric Substance Matrix*</searchLink>/<searchLink fieldCode="MM" term="%22Extracellular+Polymeric+Substance+Matrix+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Bacillus+subtilis%22">Bacillus subtilis*</searchLink>/<searchLink fieldCode="MM" term="%22Bacillus+subtilis+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Bacillus+subtilis%22">Bacillus subtilis*</searchLink>/<searchLink fieldCode="MM" term="%22Bacillus+subtilis+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Pseudomonas+aeruginosa%22">Pseudomonas aeruginosa*</searchLink>/<searchLink fieldCode="MM" term="%22Pseudomonas+aeruginosa+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Pseudomonas+aeruginosa%22">Pseudomonas aeruginosa*</searchLink>/<searchLink fieldCode="MM" term="%22Pseudomonas+aeruginosa+drug+effects%22">drug effects</searchLink><br /><searchLink fieldCode="MH" term="%22Signal+Transduction%22">Signal Transduction</searchLink> ; <searchLink fieldCode="MH" term="%22Stress%2C+Physiological%22">Stress, Physiological</searchLink>
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  Data: Nanoplastic pollution represents a pervasive threat to marine ecosystems, yet the molecular mechanisms governing microbial adaptation remain elusive. This study reveals how reactive oxygen species (ROS) signaling drives opposite extracellular polymeric substance (EPS) strategies in marine bacteria under NP stress. Pseudomonas aeruginosa enacts a proactive defend strategy, increasing EPS secretion by 6.66%-53.17%. Driven by a ROS surge, it allocates resources to EPS precursors and maintains transcriptional homeostasis through global fine-tuning to secure protein homeostasis and energy stability. Conversely, Bacillus subtilis undergoes a rapid metabolic divert response, causing a persistent EPS inhibition of 18.49%-27.31%. By systematically redirecting carbon and nitrogen fluxes away from EPS production through the downregulation of precursor-supplying pathways, this strain diverts energy and metabolic precursors toward emergency survival pathways such as membrane homeostasis maintenance, cellular stress protection, and sporulation. Our defend or divert framework provides a mechanistic paradigm for assessing how emerging contaminants dictate cellular resource allocation and reshape the ecological trajectory of marine microbial communities.<br /> (Copyright © 2026 Elsevier B.V. All rights reserved.)
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  Data: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Label: Contributed Indexing
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  Data: <i>Keywords: </i>Bacillus subtilis; Extracellular polymeric substances; Nanoplastics; Pseudomonas aeruginosa; Reactive oxygen species
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  Data: 0 (Reactive Oxygen Species)
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