Academic Journal
Impact of prehospital triggers, time of onset, and symptom-to-door time on the prognosis of patients with coronary heart disease.
| Τίτλος: | Impact of prehospital triggers, time of onset, and symptom-to-door time on the prognosis of patients with coronary heart disease. |
|---|---|
| Συγγραφείς: | Tan X; Infectious Diseases Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China., Wang X; Infectious Diseases Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China., Wang M; Department of Cardiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China., Wang J; Infectious Diseases Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China., Liu Y; Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China., Gao M; Infectious Diseases Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China., Pan Y; Infectious Diseases Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China., Chen M; Infectious Diseases Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China., Zhang C; Infectious Diseases Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China. |
| Πηγή: | Frontiers in public health [Front Public Health] 2026 Aug 10; Vol. 14, pp. 1834053. Date of Electronic Publication: 2026 Aug 10 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Editorial Office |
| Ιατρικοί όροι (MeSH): | Coronary Disease*/therapy , Coronary Disease*/diagnosis , Coronary Disease*/mortality , Emergency Medical Services*/statistics & numerical data , Time-to-Treatment*/statistics & numerical data, Beijing/epidemiology ; Humans ; Female ; Prognosis ; Male ; Middle Aged ; Time Factors ; Aged ; Risk Factors ; Treatment Delay ; Registries |
| Περίληψη: | Objective: This study aims to conduct a prehospital registry study on coronary heart disease (CHD) to investigate the effects of prehospital triggers, time of onset, and symptom-to-door time (S2D) on the prognosis of patients with CHD, thereby providing evidence to support early intervention and improve patient outcomes. Methods: This study enrolled 600 patients with CHD who were transported by the Emergency Medical Service Center of Chaoyang District, Beijing, between October 2022 and October 2023. The study endpoint was the occurrence of major adverse cardiovascular events (MACE) during a one-year follow-up period. Kaplan-Meier survival curve analysis and multivariable Cox regression were performed. S2D was analyzed as a continuous variable using restricted cubic splines with 4 knots (placed at the 5th, 35th, 65th, and 95th percentiles) to model potential non-linearity. Results: Among the 600 enrolled CHD patients, 78 (13.0%) reached the primary endpoint. The RCS curve demonstrates a significant non-linear association between S2D and MACE risk (P for non-linearity < 0.001; P for overall < 0.001). Risk increased gradually before 120 min and accelerated thereafter, with an inflection point at approximately 120 min. Multivariable Cox regression identified smoking (HR 1.351, 95% CI 1.062-1.719), hypertension (HR 1.774, 95% CI 1.141-2.757), hypercholesterolemia (HR 1.441, 95% CI 1.118-1.855), diabetes mellitus (HR 1.532, 95% CI 1.314-1.778), emotional stress (HR 1.524, 95% CI 1.284-1.804), symptom onset time between 00:00 a.m. and 05:59 a.m. (HR 1.663, 95% CI 1.122-2.467), and S2D (HR 1.253, 95% CI 1.152-1.363) as independent risk factors for poor prognosis (all p < 0.05). Conclusion: Smoking, hypertension, hypercholesterolemia, diabetes mellitus, emotional stress, symptom onset time between 00:00 a.m. and 05:59 a.m., and S2D are independent risk factors for poor prognosis in patients with CHD. These findings suggest that prehospital assessment of these factors-particularly S2D-could enable early risk stratification and guide timely interventions to improve clinical outcomes. (Copyright © 2026 Tan, Wang, Wang, Wang, Liu, Gao, Pan, Chen and Zhang.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: coronary heart disease; prehospital triggers; prognosis; symptom-to-door time; time of onset |
| Entry Date(s): | Date Created: 20260825 Date Completed: 20260825 Latest Revision: 20260826 |
| Update Code: | 20260826 |
| PubMed Central ID: | PMC13500482 |
| DOI: | 10.3389/fpubh.2026.1834053 |
| PMID: | 42638695 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2296-2565 |
|---|---|
| DOI: | 10.3389/fpubh.2026.1834053 |