Academic Journal
Chinese expert consensus on tetanus prophylaxis in major trauma (2026 Edition).
| Τίτλος: | Chinese expert consensus on tetanus prophylaxis in major trauma (2026 Edition). |
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| Συγγραφείς: | Li Y; Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China. Electronic address: Indiasuresh.vec04@gmail.com., Liu S; Peking University First Hospital, Beijing, 100034, China., Jin P; Yangming Hospital Affiliated to Ningbo University/Yuyao People's Hospital, Ningbo, 315400, Zhejiang, China., Mao X; Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Song Q; Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Li L; Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China., Li Z; Yangming Hospital Affiliated to Ningbo University/Yuyao People's Hospital, Ningbo, 315400, Zhejiang, China. Electronic address: lizilong55@vip.sina.com., Yu B; Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: yubinol@163.com., Wang C; Peking University People's Hospital, Beijing, 100044, China. Electronic address: wangchuanlinvip@163.com., Zhang L; Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400042, China. Electronic address: hpzhangly@163.com. |
| Συλλογικό Έργο: | Chinese Society of Traumatology of the Chinese Medical Association, Animal Injury Treatment Branch of the China Association for Disaster and Emergency Rescue Medicine, Youth Group of the Disaster Medicine Society of the Chinese Medical Association, Specialist Alliance for War Trauma Care of Army Hospital (Emergency Medicine), Western China Trauma Alliance, China County-level Hospital Emergency Alliance, Chongqing Emergency Care Consortium |
| Πηγή: | Chinese journal of traumatology = Zhonghua chuang shang za zhi [Chin J Traumatol] 2026 Sep; Vol. 29 (5), pp. 313-326. Date of Electronic Publication: 2026 Aug 24. |
| Τύπος έκδοσης: | Consensus Statement; Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Editorial Dept. of Chinese Journal of Traumatology Country of Publication: China NLM ID: 100886162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1008-1275 (Print) Linking ISSN: 10081275 NLM ISO Abbreviation: Chin J Traumatol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Chongqing : Editorial Dept. of Chinese Journal of Traumatology, c1998- |
| Ιατρικοί όροι (MeSH): | Tetanus*/prevention & control , Tetanus*/immunology , Wounds and Injuries*/immunology , Wounds and Injuries*/complications , Wounds and Injuries*/surgery , Consensus*, Humans ; China |
| Περίληψη: | Tetanus is an acute infectious disease caused by Clostridium tetani, which enters the body through contaminated wounds, proliferates under anaerobic conditions, and produces neurotoxin. Patients with major trauma are at a markedly increased risk of tetanus owing to extensive tissue injury, heavy wound contamination, and trauma-associated impairment of immune function. Existing guidelines and consensus statements on tetanus prophylaxis largely address general open wounds and provide little specific guidance for patients with major trauma, particularly those undergoing emergency life-saving surgery through expedited care pathways or admitted to the intensive care unit. To standardize tetanus prophylaxis in the management of major trauma, the writing committee convened Chinese experts in emergency medicine, trauma surgery, critical care medicine, and immunology to develop this expert consensus based on the best available evidence and current clinical practice in China. The consensus covers the fundamental principles of tetanus prophylaxis in major trauma, damage-control debridement, assessment of immune status, active and passive immunization strategies, management of special injury types, prophylaxis in immunocompromised patients, response to mass-casualty incidents, and preventive strategies under resource-limited conditions, and it aims to provide practical guidance for tetanus prophylaxis during the clinical management of major trauma. (Copyright © 2026. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of competing interests All experts who participated in the development of this consensus declare that they have no conflicts of interest. The expert voting and consensus development process was independent of any pharmaceutical enterprise or company. |
| Contributed Indexing: | Keywords: Active immunization; Expert consensus; Immunoprophylaxis; Major trauma; Passive immunization; Tetanus |
| Entry Date(s): | Date Created: 20260824 Date Completed: 20260929 Latest Revision: 20260930 |
| Update Code: | 20260930 |
| DOI: | 10.1016/j.cjtee.2026.06.002 |
| PMID: | 42637638 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1008-1275 |
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| DOI: | 10.1016/j.cjtee.2026.06.002 |