Academic Journal
Delivery of polyphenol-rich plant extracts using lactose-free whey permeate: cytotoxic and mitochondrial effects in Caco-2 cells.
| Τίτλος: | Delivery of polyphenol-rich plant extracts using lactose-free whey permeate: cytotoxic and mitochondrial effects in Caco-2 cells. |
|---|---|
| Συγγραφείς: | Peralta MI; Instituto de Investigaciones en Ciencias de la Salud (INICSA), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Escuela de Nutrición, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: mariana.isabel.peralta@unc.edu.ar., Albrecht C; Escuela de Nutrición, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina., Codemo CA; Instituto de Investigaciones en Ciencias de la Salud (INICSA), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina., Grondona E; Instituto de Investigaciones en Ciencias de la Salud (INICSA), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina., Velez AR; Instituto de Ciencia y Tecnología de los Alimentos (ICTA), Universidad Nacional de Cordoba (UNC), Av. Velez Sarsfield 1611, Córdoba, Argentina; Instituto de Investigacion y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA)-CONICET-UNC, Av. Velez Sarsfield 1611, Córdoba, Argentina., Soria EA; Instituto de Investigaciones en Ciencias de la Salud (INICSA), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina., Sabini MC; Instituto de Investigaciones en Ciencias de la Salud (INICSA), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Departamento de Microbiología e Inmunología, Universidad Nacional de Río Cuarto, Córdoba, Argentina. Electronic address: csabini@exa.unrc.edu.ar. |
| Πηγή: | Food research international (Ottawa, Ont.) [Food Res Int] 2026 Oct 31; Vol. 242 (Pt 5), pp. 120279. Date of Electronic Publication: 2026 Aug 03. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Ottawa, Ontario, Canada : Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science, c1992- |
| Ιατρικοί όροι (MeSH): | Polyphenols*/pharmacology , Polyphenols*/administration & dosage , Polyphenols*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/administration & dosage , Mitochondria*/drug effects , Mitochondria*/metabolism , Whey*/chemistry, Arachis/chemistry ; Lactose/chemistry ; Cell Survival/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Humans ; Caco-2 Cells ; Animals ; Chlorocebus aethiops |
| Περίληψη: | The development of functional food matrices for the delivery of bioactive compounds, together with the valorization of agro-industrial by-products, is a growing research area. Whey permeate (WP), an abundant dairy by-product suitable for human consumption, has attracted interest as a potential food-compatible matrix, although its use for incorporating bioactive compounds remains limited. This study investigated the biological activity of polyphenol-rich plant extracts incorporated into a lactose-free WP matrix on human colorectal adenocarcinoma Caco-2 cells. Extracts from peanut skin (Arachis hypogaea L.), Marcela del campo (Achyrocline satureioides (Lam.) D.C.), and yerba mate (Ilex paraguariensis A. St. Hil) were evaluated. Cytotoxicity (CC (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antioxidants; Apoptosis; Bioactivity; Colorectal adenocarcinoma; Functional food; Polyphenols |
| Substance Nomenclature: | 0 (Polyphenols) 0 (Plant Extracts) J2B2A4N98G (Lactose) |
| Entry Date(s): | Date Created: 20260824 Date Completed: 20260824 Latest Revision: 20260824 |
| Update Code: | 20260825 |
| DOI: | 10.1016/j.foodres.2026.120279 |
| PMID: | 42637393 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!