Academic Journal
Dietary anthocyanins and the MAPK signaling pathway: from food sources to molecular mechanisms.
| Τίτλος: | Dietary anthocyanins and the MAPK signaling pathway: from food sources to molecular mechanisms. |
|---|---|
| Συγγραφείς: | Luo J; School of Food & Pharmaceutical Science and Technology, Guangzhou College of Technology and Business, Guangzhou 510850, China., Luo J; Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai, Guangdong 519087, China; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China., Han B; Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai, Guangdong 519087, China; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China., Xu B; Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai, Guangdong 519087, China. Electronic address: baojunxu@bnbu.edu.cn. |
| Πηγή: | Food research international (Ottawa, Ont.) [Food Res Int] 2026 Oct 31; Vol. 242 (Pt 2), pp. 119932. Date of Electronic Publication: 2026 Jul 06. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Ottawa, Ontario, Canada : Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science, c1992- |
| Ιατρικοί όροι (MeSH): | Anthocyanins*/pharmacology , Anthocyanins*/administration & dosage , MAP Kinase Signaling System*/drug effects , Diet*, Humans ; Animals ; Inflammation |
| Περίληψη: | Anthocyanins (ACNs) are a sub-group of dietary polyphenols with well-studied safety, potency and efficacy against chronic inflammation and age-related diseases. However, the unified molecular mechanism remains not fully defined. This review integrates recent evidence on dietary ACNs, with emphasis on food sources, processing stability, and bioavailability, to elucidate how ACNs orchestrate health benefits via the MAPK signaling pathway. This review highlights an important, dualistic regulation: while suppressing stress-responsive p-p38 and p-JNK to prevent NF-κB-driven cytokine production and senescence-associated secretory phenotypes, ACNs facilitate the promotion of p-ERK1/2 to enhance the CREB-BDNF axis and promote synaptic plasticity. Translational validations involving various models and clinical trials demonstrate that ACNs can efficiently alleviate systemic inflammation (CRP, IL-6) and significantly prevent p-JNK. These effects are highly dependent on dietary intake, food matrix composition, and processing conditions that influence the formation of bioactive metabolites. In this context, dietary ACNs represent promising candidates for functional food development owing to their precise bidirectional modulation of the MAPK pathways. Future studies should prioritize mechanism-driven randomized controlled trials using physiologically relevant concentrations of microbiota-derived metabolites. (Copyright © 2026. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Anthocyanins; Chronic Diseases; Clinical Trials; ERK1/2 Activation; Inflammaging; JNK/p38 Inhibition; MAPK Signaling Pathway |
| Substance Nomenclature: | 0 (Anthocyanins) |
| Entry Date(s): | Date Created: 20260822 Date Completed: 20260822 Latest Revision: 20260822 |
| Update Code: | 20260823 |
| DOI: | 10.1016/j.foodres.2026.119932 |
| PMID: | 42632688 |
| Βάση Δεδομένων: | MEDLINE |
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