Academic Journal
Advances in non-invasive brain stimulation for borderline personality disorder: clinical targets and future directions - an updated narrative review.
| Τίτλος: | Advances in non-invasive brain stimulation for borderline personality disorder: clinical targets and future directions - an updated narrative review. |
|---|---|
| Συγγραφείς: | Lisoni J; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy., Nibbio G; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Ardesi M; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Alberti R; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Gervasi E; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Magni S; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Bezzi F; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Cicolari CAC; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Baglioni A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Bertoni L; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy., Deste G; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Department of Mental Health and Addiction Services, ASST Vallecamonica, Esine, Italy., Barlati S; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Vita A; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. |
| Πηγή: | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2026 Oct; Vol. 27 (8), pp. 556-571. Date of Electronic Publication: 2026 Aug 22. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare Original Publication: Glasgow : WFSBP, 2000- |
| Ιατρικοί όροι (MeSH): | Borderline Personality Disorder*/therapy , Borderline Personality Disorder*/physiopathology , Transcranial Direct Current Stimulation*/methods , Transcranial Magnetic Stimulation*/methods , Dorsolateral Prefrontal Cortex*/physiopathology, Humans ; Psychotherapy ; Prefrontal Cortex |
| Περίληψη: | Introduction: Borderline Personality Disorder (BPD) remains a major therapeutic challenge, given incomplete response to first-line psychotherapies and limited treatment accessibility. Non-Invasive Brain Stimulation (NIBS), particularly repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), has emerged as promising interventions. Methods: This narrative review provides an updated overview of recent evidence on NIBS in BPD, focusing on: new tDCS studies, NIBS to improve interpersonal dysfunction and social cognition, the combination between NIBS and psychotherapies, and the role of comorbid BPD as a moderating factor on NIBS outcomes. Results: Preliminary evidence supports a symptom-oriented application of NIBS in BPD: right dorsolateral prefrontal cortex (DLPFC) stimulation appears mainly associated with improvements in impulsivity, whereas left DLPFC stimulation improves emotion regulation and cold cognitive functioning. Emerging studies targeting the right ventrolateral prefrontal cortex suggest beneficial effects on rejection-related emotional responses and interpersonal sensitivity. Studies combining NIBS with psychotherapy show acceptable feasibility profiles, although additive effects remain uncertain. Available evidence also suggests that comorbid BPD may not substantially impair antidepressant response to NIBS. Conclusions: NIBS represents a promising adjunctive intervention for BPD. However, larger sham-controlled trials, biomarker-informed studies, replication studies, and long-term follow-up assessments are needed before definitive clinical recommendations can be established. |
| Contributed Indexing: | Keywords: Borderline personality disorder; Transcranial direct current stimulation; depressive symptoms; emotion dysregulation; impulsivity; transcranial magnetic stimulation |
| Entry Date(s): | Date Created: 20260822 Date Completed: 20260927 Latest Revision: 20260927 |
| Update Code: | 20260928 |
| DOI: | 10.1080/15622975.2026.2720930 |
| PMID: | 42632061 |
| Βάση Δεδομένων: | MEDLINE |
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