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Advances in non-invasive brain stimulation for borderline personality disorder: clinical targets and future directions - an updated narrative review.

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Τίτλος: Advances in non-invasive brain stimulation for borderline personality disorder: clinical targets and future directions - an updated narrative review.
Συγγραφείς: Lisoni J; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy., Nibbio G; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Ardesi M; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Alberti R; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Gervasi E; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Magni S; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Bezzi F; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Cicolari CAC; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Baglioni A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Bertoni L; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy., Deste G; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Department of Mental Health and Addiction Services, ASST Vallecamonica, Esine, Italy., Barlati S; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Vita A; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Πηγή: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2026 Oct; Vol. 27 (8), pp. 556-571. Date of Electronic Publication: 2026 Aug 22.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE
Imprint Name(s): Publication: London : Informa Healthcare
Original Publication: Glasgow : WFSBP, 2000-
Ιατρικοί όροι (MeSH): Borderline Personality Disorder*/therapy , Borderline Personality Disorder*/physiopathology , Transcranial Direct Current Stimulation*/methods , Transcranial Magnetic Stimulation*/methods , Dorsolateral Prefrontal Cortex*/physiopathology, Humans ; Psychotherapy ; Prefrontal Cortex
Περίληψη: Introduction: Borderline Personality Disorder (BPD) remains a major therapeutic challenge, given incomplete response to first-line psychotherapies and limited treatment accessibility. Non-Invasive Brain Stimulation (NIBS), particularly repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), has emerged as promising interventions.
Methods: This narrative review provides an updated overview of recent evidence on NIBS in BPD, focusing on: new tDCS studies, NIBS to improve interpersonal dysfunction and social cognition, the combination between NIBS and psychotherapies, and the role of comorbid BPD as a moderating factor on NIBS outcomes.
Results: Preliminary evidence supports a symptom-oriented application of NIBS in BPD: right dorsolateral prefrontal cortex (DLPFC) stimulation appears mainly associated with improvements in impulsivity, whereas left DLPFC stimulation improves emotion regulation and cold cognitive functioning. Emerging studies targeting the right ventrolateral prefrontal cortex suggest beneficial effects on rejection-related emotional responses and interpersonal sensitivity. Studies combining NIBS with psychotherapy show acceptable feasibility profiles, although additive effects remain uncertain. Available evidence also suggests that comorbid BPD may not substantially impair antidepressant response to NIBS.
Conclusions: NIBS represents a promising adjunctive intervention for BPD. However, larger sham-controlled trials, biomarker-informed studies, replication studies, and long-term follow-up assessments are needed before definitive clinical recommendations can be established.
Contributed Indexing: Keywords: Borderline personality disorder; Transcranial direct current stimulation; depressive symptoms; emotion dysregulation; impulsivity; transcranial magnetic stimulation
Entry Date(s): Date Created: 20260822 Date Completed: 20260927 Latest Revision: 20260927
Update Code: 20260928
DOI: 10.1080/15622975.2026.2720930
PMID: 42632061
Βάση Δεδομένων: MEDLINE
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  Availability: 0
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DbLabel: MEDLINE
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Advances in non-invasive brain stimulation for borderline personality disorder: clinical targets and future directions - an updated narrative review.
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  Data: <searchLink fieldCode="AU" term="%22Lisoni+J%22">Lisoni J</searchLink>; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Nibbio+G%22">Nibbio G</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Ardesi+M%22">Ardesi M</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Alberti+R%22">Alberti R</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Gervasi+E%22">Gervasi E</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Magni+S%22">Magni S</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bezzi+F%22">Bezzi F</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Cicolari+CAC%22">Cicolari CAC</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Baglioni+A%22">Baglioni A</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bertoni+L%22">Bertoni L</searchLink>; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Deste+G%22">Deste G</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Department of Mental Health and Addiction Services, ASST Vallecamonica, Esine, Italy.<br /><searchLink fieldCode="AU" term="%22Barlati+S%22">Barlati S</searchLink>; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Vita+A%22">Vita A</searchLink>; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101120023%22">The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry</searchLink> [World J Biol Psychiatry] 2026 Oct; Vol. 27 (8), pp. 556-571. <i>Date of Electronic Publication: </i>2026 Aug 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Informa+Healthcare%22">Informa Healthcare </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101120023 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1814-1412 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215622975%22">15622975 </searchLink><i>NLM ISO Abbreviation: </i>World J Biol Psychiatry <i>Subsets: </i>MEDLINE
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  Data: <i>Publication</i>: London : Informa Healthcare<br /><i>Original Publication</i>: Glasgow : WFSBP, 2000-
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  Data: <searchLink fieldCode="MM" term="%22Borderline+Personality+Disorder%22">Borderline Personality Disorder*</searchLink>/<searchLink fieldCode="MM" term="%22Borderline+Personality+Disorder+therapy%22">therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Borderline+Personality+Disorder%22">Borderline Personality Disorder*</searchLink>/<searchLink fieldCode="MM" term="%22Borderline+Personality+Disorder+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Transcranial+Direct+Current+Stimulation%22">Transcranial Direct Current Stimulation*</searchLink>/<searchLink fieldCode="MM" term="%22Transcranial+Direct+Current+Stimulation+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Transcranial+Magnetic+Stimulation%22">Transcranial Magnetic Stimulation*</searchLink>/<searchLink fieldCode="MM" term="%22Transcranial+Magnetic+Stimulation+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Dorsolateral+Prefrontal+Cortex%22">Dorsolateral Prefrontal Cortex*</searchLink>/<searchLink fieldCode="MM" term="%22Dorsolateral+Prefrontal+Cortex+physiopathology%22">physiopathology</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Psychotherapy%22">Psychotherapy</searchLink> ; <searchLink fieldCode="MH" term="%22Prefrontal+Cortex%22">Prefrontal Cortex</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Introduction: Borderline Personality Disorder (BPD) remains a major therapeutic challenge, given incomplete response to first-line psychotherapies and limited treatment accessibility. Non-Invasive Brain Stimulation (NIBS), particularly repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), has emerged as promising interventions.<br />Methods: This narrative review provides an updated overview of recent evidence on NIBS in BPD, focusing on: new tDCS studies, NIBS to improve interpersonal dysfunction and social cognition, the combination between NIBS and psychotherapies, and the role of comorbid BPD as a moderating factor on NIBS outcomes.<br />Results: Preliminary evidence supports a symptom-oriented application of NIBS in BPD: right dorsolateral prefrontal cortex (DLPFC) stimulation appears mainly associated with improvements in impulsivity, whereas left DLPFC stimulation improves emotion regulation and cold cognitive functioning. Emerging studies targeting the right ventrolateral prefrontal cortex suggest beneficial effects on rejection-related emotional responses and interpersonal sensitivity. Studies combining NIBS with psychotherapy show acceptable feasibility profiles, although additive effects remain uncertain. Available evidence also suggests that comorbid BPD may not substantially impair antidepressant response to NIBS.<br />Conclusions: NIBS represents a promising adjunctive intervention for BPD. However, larger sham-controlled trials, biomarker-informed studies, replication studies, and long-term follow-up assessments are needed before definitive clinical recommendations can be established.
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  Data: <i>Keywords: </i>Borderline personality disorder; Transcranial direct current stimulation; depressive symptoms; emotion dysregulation; impulsivity; transcranial magnetic stimulation
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  Data: <i>Date Created: </i>20260822 <i>Date Completed: </i>20260927 <i>Latest Revision: </i>20260927
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PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42632061
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