Academic Journal
A novel integrative and conjugative element in Streptococcus pyogenes carries a cfr-like gene associated with linezolid resistance in other species.
| Τίτλος: | A novel integrative and conjugative element in Streptococcus pyogenes carries a cfr-like gene associated with linezolid resistance in other species. |
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| Συγγραφείς: | Amusin DB; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Simons LM; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Garcia DS; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Hauser AR; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Office E; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Jaggi P; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA., Williams DB; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Kociolek LK; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Pediatric Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Patel AB; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Pediatric Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Shulman ST; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Pediatric Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Guzman-Cottrill JA; Department of Pediatrics, Division of Infectious Diseases, Oregon Health & Science University Doernbecher Children's Hospital, Portland, Oregon, USA., Tanz RR; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Advanced General Pediatrics & Primary Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Ozer EA; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. |
| Πηγή: | MSphere [mSphere] 2026 Sep 29; Vol. 11 (9), pp. e0027726. Date of Electronic Publication: 2026 Aug 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101674533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-5042 (Electronic) Linking ISSN: 23795042 NLM ISO Abbreviation: mSphere Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : American Society for Microbiology, [2015]- |
| Ιατρικοί όροι (MeSH): | Streptococcus pyogenes*/genetics , Streptococcus pyogenes*/drug effects , Streptococcus pyogenes*/isolation & purification , Linezolid*/pharmacology , Anti-Bacterial Agents*/pharmacology , Drug Resistance, Multiple, Bacterial*/genetics , Bacterial Proteins*/genetics , Interspersed Repetitive Sequences*, Streptococcal Infections/microbiology ; Pharyngitis/microbiology ; Clindamycin/pharmacology ; Humans ; Microbial Sensitivity Tests ; Whole Genome Sequencing ; Conjugation, Genetic |
| Περίληψη: | Treatment of severe invasive Streptococcus pyogenes infections has historically relied on β-lactam antibiotics with adjunctive clindamycin. Rising rates of lincosamide resistance have led to adoption of linezolid as an alternative adjunctive therapy. This report describes a clinical S. pyogenes isolate carrying a multi-drug resistance gene, cfr(C), known to confer the phenicol, lincosamide, oxazolidinone, pleuromutilin, and streptogramin A (PhLOPS Importance: Treatment of severe invasive Streptococcus pyogenes infection has traditionally relied on the adjunctive use of clindamycin with β-lactam antibiotic therapy. However, rising rates of clindamycin non-susceptibility have led clinicians to adopt linezolid as an alternative therapy. We identified S. pyogenes isolated from a child with pharyngitis that carried the cfr(C) gene. This gene causes resistance to multiple antibiotics, including clindamycin and linezolid, in other bacterial species. At the time of this study, we found no other instances of the cfr(C) gene carried by S. pyogenes in either published reports or the public genome sequence database. While this isolate remained sensitive to linezolid, the expanded host range of cfr(C) found in a novel potentially mobile genomic element may herald the eventual emergence of broader antibiotic resistance in S. pyogenes. |
| Competing Interests: | The authors declare no conflict of interest. |
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| Grant Information: | T32GM144295 United States NH NIH HHS; BAA 75D301-19C-06841 United States JG JG CDC HHS; BAA 75D301-22-R-72097 United States JG JG CDC HHS; S10 OD032243 United States NH NIH HHS |
| Contributed Indexing: | Keywords: Group A streptococcus; Streptococcus pyogenes; cfr; linezolid; oxazolidinones |
| Substance Nomenclature: | ISQ9I6J12J (Linezolid) 0 (Anti-Bacterial Agents) 3U02EL437C (Clindamycin) 0 (Bacterial Proteins) |
| Entry Date(s): | Date Created: 20260821 Date Completed: 20260929 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| PubMed Central ID: | PMC13621865 |
| DOI: | 10.1128/msphere.00277-26 |
| PMID: | 42627159 |
| Βάση Δεδομένων: | MEDLINE |
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