Academic Journal
Circulating levels of TL1A and its decoy receptor DcR3 in systemic sclerosis.
| Τίτλος: | Circulating levels of TL1A and its decoy receptor DcR3 in systemic sclerosis. |
|---|---|
| Συγγραφείς: | Poulia V; First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Medical School General Hospital of Athens, ″LAIKO″ 17 Agiou Thoma str., 115 27, Athens, Greece., Vlachogiannis NI; First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Medical School General Hospital of Athens, ″LAIKO″ 17 Agiou Thoma str., 115 27, Athens, Greece., Avdi AP; First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Medical School General Hospital of Athens, ″LAIKO″ 17 Agiou Thoma str., 115 27, Athens, Greece., Bournia VK; First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Medical School General Hospital of Athens, ″LAIKO″ 17 Agiou Thoma str., 115 27, Athens, Greece., Bamias G; GI Unit, 3rd Department of Internal Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Athens, Greece., Tektonidou MG; First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Medical School General Hospital of Athens, ″LAIKO″ 17 Agiou Thoma str., 115 27, Athens, Greece., Sfikakis PP; First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Medical School General Hospital of Athens, ″LAIKO″ 17 Agiou Thoma str., 115 27, Athens, Greece., Panopoulos S; First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Medical School General Hospital of Athens, ″LAIKO″ 17 Agiou Thoma str., 115 27, Athens, Greece. sty.panopoulos@gmail.com. |
| Πηγή: | Clinical rheumatology [Clin Rheumatol] 2026 Oct; Vol. 45 (10), pp. 6181-6187. Date of Electronic Publication: 2026 Aug 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2008->: Heidelberg : Springer Original Publication: Brussels : Acta Medica Belgica, [1982- |
| Ιατρικοί όροι (MeSH): | Tumor Necrosis Factor Ligand Superfamily Member 15*/blood , Receptors, Tumor Necrosis Factor, Member 6b*/blood , Scleroderma, Systemic*/blood , Scleroderma, Systemic*/complications , Lung Diseases, Interstitial*/blood, Biomarkers/blood ; Humans ; Female ; Male ; Middle Aged ; Adult ; Aged ; ROC Curve ; Case-Control Studies ; Severity of Illness Index |
| Περίληψη: | Introduction/objective: Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is a profibrotic and proinflammatory cytokine. Experimental evidence implicates TL1A-mediated interactions in interstitial lung disease (ILD); such interactions are disrupted by decoy receptor 3 (DcR3) binding to TL1A. We examined the potential clinical value of circulating TL1A and DcR3 levels in systemic sclerosis (SSc). Methods: Consecutive unselected patients with SSc (n = 41) of varying disease duration, severity, and treatment modalities; individuals with primary Raynaud's phenomenon (pRP) (n = 52); and apparently healthy individuals (n = 49) were studied. Serum TL1A and DcR3 levels were measured by ELISA. Results: TL1A levels were increased in SSc patients compared to healthy individuals whereas DcR3 levels were increased in SSc compared to both pRP and healthy individuals (all p < 0.001). Clinical features, pulmonary function tests, and treatment modalities were analyzed at baseline and annually for two consecutive years. Using receiver operating characteristic (ROC) analysis and the MINIMISE endpoint for mortality and morbidity we found that baseline serum levels of DcR3, but not TL1A, were predictive of SSc progression over 2 years (AUC = 0.684, p = 0.04). While no associations between TL1A levels and disease characteristics were noted, patients with DcR3 levels above the ROC-defined cut-off had significantly higher erythrocyte sedimentation rate, higher prevalence of ILD confirmed by high resolution chest computed tomography, and lower diffusion capacity for carbon monoxide. Conclusions: Increased circulating DcR3 levels are associated with SSc-ILD in unselected patients and may serve as a biomarker of disease progression. Further studies are needed to explore the clinical value in selected SSc patient subgroups. Keypoints • TL1A and DcR3 are elevated in the serum of patients with systemic sclerosis. • DcR3 levels are associated with SSc-ILD and higher systemic inflammation. • Circulating DcR3 levels may serve as a prognostic biomarker in SSc. (© 2026. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).) |
| Competing Interests: | Declarations. Disclosures: None. |
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| Grant Information: | 0794 Special Account for Research Grants (SARG), National and Kapodistrian University of Athens |
| Contributed Indexing: | Keywords: Biomarkers; Disease progression; Risk stratification; Systematic sclerosis |
| Substance Nomenclature: | 0 (Tumor Necrosis Factor Ligand Superfamily Member 15) 0 (Receptors, Tumor Necrosis Factor, Member 6b) 0 (TNFSF15 protein, human) 0 (TNFRSF6B protein, human) 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20260820 Date Completed: 20260916 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s10067-026-08344-z |
| PMID: | 42622765 |
| Βάση Δεδομένων: | MEDLINE |
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