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Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response.

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Τίτλος: Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response.
Συγγραφείς: Blanco-Fernandez J; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Lisci M; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Foged MM; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Chapuis C; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Pflästerer T; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland., Kleele T; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland., Jourdain AA; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Πηγή: Science advances [Sci Adv] 2026 Aug 21; Vol. 12 (34), pp. eaed6318. Date of Electronic Publication: 2026 Aug 19.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Imprint Name(s): Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
Ιατρικοί όροι (MeSH): Interleukin-13*/metabolism , Mitochondria*/metabolism , Mitochondria*/genetics , Interleukin-4*/metabolism , Macrophages*/metabolism , Macrophages*/cytology , Integrated Stress Response* , Cellular Reprogramming*, STAT6 Transcription Factor/metabolism ; DNA, Mitochondrial/genetics ; Proteomics/methods ; Interferon-gamma/pharmacology ; Lipopolysaccharides/pharmacology ; Animals ; Mice ; Membrane Potential, Mitochondrial ; Metabolic Reprogramming
Περίληψη: Mitochondria drive cellular reprogramming by integrating metabolism and signaling. In macrophages, mitochondria are central to immunometabolic responses to external cues, but the extent to which they are remodeled and participate in macrophage reprogramming remains unclear. Here, we integrate transcriptomics with whole-cell and purified mitochondrial proteomics to profile lipopolysaccharide (LPS)/interferon-γ (IFN-γ)- and interleukin-4 (IL-4)/IL-13-stimulated macrophages. We reveal a notable disconnect between mitochondrial transcript and protein levels following either stimulus and a signal transducer and activator of transcription 6 (STAT6)-dependent increase in mitochondrial DNA (mtDNA) expression and intramitochondrial translation in IL-4/IL-13 macrophages. We demonstrate that pharmacological inhibition of mitochondrial translation or individual respiratory chain complexes variably impairs reprogramming, whereas ATP synthase inhibition uniquely triggers a heme-regulated inhibitor (HRI)-dependent integrated stress response (ISR) through mitochondrial hyperpolarization, thereby preventing IL-4/IL-13 reprogramming. Mechanistically, we show that restoring mitochondrial membrane potential or inhibiting the ISR rescues IL-4/IL-13-mediated reprogramming. Together, we identify mtDNA expression, intramitochondrial translation, and mitochondrial membrane potential as critical, drug-sensitive determinants of the IL-4/IL-13 response.
References: Bioinformatics. 2015 Jan 15;31(2):166-9. (PMID: 25260700)
Nat Commun. 2020 Feb 4;11(1):698. (PMID: 32019928)
Immunity. 2021 Jan 12;54(1):68-83.e6. (PMID: 33238133)
J Biol Chem. 2021 Dec;297(6):101341. (PMID: 34695418)
Nat Commun. 2019 Jan 18;10(1):338. (PMID: 30659183)
Sci Adv. 2021 Dec 10;7(50):eabl5182. (PMID: 34878835)
Sci Adv. 2025 Jan 24;11(4):eadu4369. (PMID: 39841842)
Bioinformatics. 2012 Aug 15;28(16):2184-5. (PMID: 22743226)
Diabetes. 2014 Jan;63(1):152-61. (PMID: 23990363)
J Biol Chem. 2014 Mar 21;289(12):8019-28. (PMID: 24505138)
Curr Genet. 2008 Jul;54(1):13-22. (PMID: 18481068)
Immunity. 2015 Mar 17;42(3):419-30. (PMID: 25786174)
Sci Rep. 2020 Oct 6;10(1):16554. (PMID: 33024179)
Nature. 2013 Apr 11;496(7444):238-42. (PMID: 23535595)
J Biol Chem. 2010 Dec 17;285(51):39976-85. (PMID: 20923771)
Nucleic Acids Res. 2021 Jan 8;49(D1):D1541-D1547. (PMID: 33174596)
PLoS One. 2015 Dec 23;10(12):e0145342. (PMID: 26699615)
J Antimicrob Chemother. 2022 Apr 27;77(5):1218-1227. (PMID: 35211738)
Science. 2021 Oct 15;374(6565):eabe9977. (PMID: 34648346)
Cell Metab. 2021 Dec 7;33(12):2464-2483.e18. (PMID: 34800366)
Cell Metab. 2013 Mar 5;17(3):386-98. (PMID: 23473033)
Nat Rev Rheumatol. 2022 Jul;18(7):384-397. (PMID: 35672464)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
BMC Biol. 2014 May 27;12:34. (PMID: 24884669)
Cell Metab. 2013 Mar 5;17(3):399-410. (PMID: 23473034)
Innovation (Camb). 2024 Oct 21;5(6):100722. (PMID: 39529960)
Nat Struct Mol Biol. 2018 Mar;25(3):217-224. (PMID: 29459785)
EMBO Rep. 2016 Oct;17(10):1374-1395. (PMID: 27629041)
Nat Methods. 2014 Mar;11(3):319-24. (PMID: 24487582)
Immunity. 2018 Dec 18;49(6):1021-1033.e6. (PMID: 30566880)
Cell Metab. 2021 Dec 7;33(12):2398-2414.e9. (PMID: 34715039)
Elife. 2013 May 28;2:e00498. (PMID: 23741617)
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2097-2102. (PMID: 30674674)
Nature. 2011 Apr 28;472(7344):476-80. (PMID: 21525932)
Nat Biotechnol. 2008 Dec;26(12):1367-72. (PMID: 19029910)
Nucleic Acids Res. 2018 May 18;46(9):4425-4439. (PMID: 29506156)
Immunity. 2016 Oct 18;45(4):817-830. (PMID: 27760338)
Science. 2011 Jun 10;332(6035):1284-8. (PMID: 21566158)
Elife. 2020 May 28;9:. (PMID: 32463360)
Nat Immunol. 2023 May;24(5):731. (PMID: 37024535)
Cell Chem Biol. 2025 Apr 17;32(4):620-630.e6. (PMID: 40250406)
Cell. 2024 May 23;187(11):2601-2627. (PMID: 38788685)
Cell Metab. 2006 Jul;4(1):13-24. (PMID: 16814729)
Nat Commun. 2025 May 1;16(1):4080. (PMID: 40312422)
J Exp Med. 1997 May 5;185(9):1661-70. (PMID: 9151903)
J Proteome Res. 2011 Apr 1;10(4):1794-805. (PMID: 21254760)
Cell. 2016 Jul 28;166(3):624-636. (PMID: 27374331)
Nat Immunol. 2016 Jan;17(1):34-40. (PMID: 26681460)
Mol Cell Proteomics. 2018 Dec;17(12):2534-2545. (PMID: 30385480)
Nat Methods. 2020 Dec;17(12):1229-1236. (PMID: 33257825)
J Immunol. 2010 Jul 1;185(1):605-14. (PMID: 20498354)
Sci Rep. 2016 Sep 16;6:32886. (PMID: 27633668)
Mol Syst Biol. 2016 Oct 20;12(10):883. (PMID: 27951527)
Int J Biol Sci. 2025 Apr 21;21(7):2935-2953. (PMID: 40384854)
FASEB J. 2015 Aug;29(8):3582-92. (PMID: 25977255)
Cell Metab. 2018 Sep 4;28(3):490-503.e7. (PMID: 30043752)
BMC Bioinformatics. 2011 Aug 04;12:323. (PMID: 21816040)
Immunity. 2025 Oct 14;58(10):2489-2504.e8. (PMID: 41005293)
J Biol Chem. 2024 Apr;300(4):107151. (PMID: 38462161)
Nat Metab. 2019 Jul;1(7):731-742. (PMID: 32259027)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2414187121. (PMID: 39503847)
Methods. 2013 Sep 1;63(1):41-9. (PMID: 23816787)
EMBO Rep. 2021 Apr 7;22(4):e51635. (PMID: 33586863)
J Exp Med. 2013 Oct 21;210(11):2477-91. (PMID: 24101381)
Mol Biol Cell. 2006 Nov;17(11):4632-44. (PMID: 16928960)
Nat Commun. 2023 Nov 17;14(1):7471. (PMID: 37978290)
Immunity. 2014 Feb 20;40(2):274-88. (PMID: 24530056)
Nature. 2020 Mar;579(7799):427-432. (PMID: 32132707)
Immunity. 2012 Mar 23;36(3):401-14. (PMID: 22342844)
J Vis Exp. 2023 Jun 2;(196):. (PMID: 37335104)
Nat Immunol. 2017 Sep;18(9):985-994. (PMID: 28714978)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Curr Opin Immunol. 2025 Aug;95:102566. (PMID: 40424975)
Bioinformatics. 2015 Nov 15;31(22):3718-20. (PMID: 26209431)
Nucleic Acids Res. 2025 Jan 6;53(D1):D543-D553. (PMID: 39494541)
Science. 2017 Jun 9;356(6342):1072-1076. (PMID: 28495875)
PLoS One. 2018 Mar 14;13(3):e0194126. (PMID: 29538444)
Anal Chem. 2015 Apr 21;87(8):4110-6. (PMID: 25837572)
Mol Cell Proteomics. 2014 Sep;13(9):2513-26. (PMID: 24942700)
Nat Commun. 2018 Oct 22;9(1):4383. (PMID: 30348985)
Nat Immunol. 2016 Sep;17(9):1037-1045. (PMID: 27348412)
Cell Rep. 2016 Oct 11;17(3):684-696. (PMID: 27732846)
Nat Commun. 2022 Nov 30;13(1):7389. (PMID: 36450731)
J Am Chem Soc. 2011 Oct 19;133(41):16386-9. (PMID: 21919507)
J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):465-468, 468.e1. (PMID: 25017538)
Nature. 2023 Mar;615(7952):490-498. (PMID: 36890227)
Nature. 2010 Mar 4;464(7285):104-7. (PMID: 20203610)
Cell. 2016 Oct 6;167(2):457-470.e13. (PMID: 27667687)
Nature. 2020 Mar;579(7799):433-437. (PMID: 32132706)
Sci Rep. 2021 Jun 18;11(1):12841. (PMID: 34145306)
J Clin Invest. 2011 Jul;121(7):2736-49. (PMID: 21670502)
Sci Adv. 2025 Jan 24;11(4):eadq7307. (PMID: 39841829)
Cell Metab. 2018 Sep 4;28(3):463-475.e4. (PMID: 30184486)
Substance Nomenclature: 0 (Interleukin-13)
207137-56-2 (Interleukin-4)
0 (STAT6 Transcription Factor)
0 (DNA, Mitochondrial)
82115-62-6 (Interferon-gamma)
0 (Lipopolysaccharides)
Entry Date(s): Date Created: 20260819 Date Completed: 20260819 Latest Revision: 20260822
Update Code: 20260822
PubMed Central ID: PMC13488931
DOI: 10.1126/sciadv.aed6318
PMID: 42616903
Βάση Δεδομένων: MEDLINE
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  Data: Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response.
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  Data: <searchLink fieldCode="AU" term="%22Blanco-Fernandez+J%22">Blanco-Fernandez J</searchLink>; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lisci+M%22">Lisci M</searchLink>; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Foged+MM%22">Foged MM</searchLink>; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chapuis+C%22">Chapuis C</searchLink>; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pflästerer+T%22">Pflästerer T</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kleele+T%22">Kleele T</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jourdain+AA%22">Jourdain AA</searchLink>; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Aug 21; Vol. 12 (34), pp. eaed6318. <i>Date of Electronic Publication: </i>2026 Aug 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101653440 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2375-2548 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223752548%22">23752548 </searchLink><i>NLM ISO Abbreviation: </i>Sci Adv <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: Washington, DC : American Association for the Advancement of Science, [2015]-
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  Data: <searchLink fieldCode="MM" term="%22Interleukin-13%22">Interleukin-13*</searchLink>/<searchLink fieldCode="MM" term="%22Interleukin-13+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Mitochondria%22">Mitochondria*</searchLink>/<searchLink fieldCode="MM" term="%22Mitochondria+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Mitochondria%22">Mitochondria*</searchLink>/<searchLink fieldCode="MM" term="%22Mitochondria+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Interleukin-4%22">Interleukin-4*</searchLink>/<searchLink fieldCode="MM" term="%22Interleukin-4+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Macrophages%22">Macrophages*</searchLink>/<searchLink fieldCode="MM" term="%22Macrophages+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Macrophages%22">Macrophages*</searchLink>/<searchLink fieldCode="MM" term="%22Macrophages+cytology%22">cytology</searchLink> <br /><searchLink fieldCode="MM" term="%22Integrated+Stress+Response%22">Integrated Stress Response*</searchLink> <br /><searchLink fieldCode="MM" term="%22Cellular+Reprogramming%22">Cellular Reprogramming*</searchLink><br /><searchLink fieldCode="MH" term="%22STAT6+Transcription+Factor%22">STAT6 Transcription Factor</searchLink>/<searchLink fieldCode="MH" term="%22STAT6+Transcription+Factor+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22DNA%2C+Mitochondrial%22">DNA, Mitochondrial</searchLink>/<searchLink fieldCode="MH" term="%22DNA%2C+Mitochondrial+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Proteomics%22">Proteomics</searchLink>/<searchLink fieldCode="MH" term="%22Proteomics+methods%22">methods</searchLink> ; <searchLink fieldCode="MH" term="%22Interferon-gamma%22">Interferon-gamma</searchLink>/<searchLink fieldCode="MH" term="%22Interferon-gamma+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Lipopolysaccharides%22">Lipopolysaccharides</searchLink>/<searchLink fieldCode="MH" term="%22Lipopolysaccharides+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Membrane+Potential%2C+Mitochondrial%22">Membrane Potential, Mitochondrial</searchLink> ; <searchLink fieldCode="MH" term="%22Metabolic+Reprogramming%22">Metabolic Reprogramming</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Mitochondria drive cellular reprogramming by integrating metabolism and signaling. In macrophages, mitochondria are central to immunometabolic responses to external cues, but the extent to which they are remodeled and participate in macrophage reprogramming remains unclear. Here, we integrate transcriptomics with whole-cell and purified mitochondrial proteomics to profile lipopolysaccharide (LPS)/interferon-γ (IFN-γ)- and interleukin-4 (IL-4)/IL-13-stimulated macrophages. We reveal a notable disconnect between mitochondrial transcript and protein levels following either stimulus and a signal transducer and activator of transcription 6 (STAT6)-dependent increase in mitochondrial DNA (mtDNA) expression and intramitochondrial translation in IL-4/IL-13 macrophages. We demonstrate that pharmacological inhibition of mitochondrial translation or individual respiratory chain complexes variably impairs reprogramming, whereas ATP synthase inhibition uniquely triggers a heme-regulated inhibitor (HRI)-dependent integrated stress response (ISR) through mitochondrial hyperpolarization, thereby preventing IL-4/IL-13 reprogramming. Mechanistically, we show that restoring mitochondrial membrane potential or inhibiting the ISR rescues IL-4/IL-13-mediated reprogramming. Together, we identify mtDNA expression, intramitochondrial translation, and mitochondrial membrane potential as critical, drug-sensitive determinants of the IL-4/IL-13 response.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Bioinformatics. 2015 Jan 15;31(2):166-9. (PMID: <searchLink fieldCode="PM" term="%2225260700%22">25260700)</searchLink><br />Nat Commun. 2020 Feb 4;11(1):698. (PMID: <searchLink fieldCode="PM" term="%2232019928%22">32019928)</searchLink><br />Immunity. 2021 Jan 12;54(1):68-83.e6. (PMID: <searchLink fieldCode="PM" term="%2233238133%22">33238133)</searchLink><br />J Biol Chem. 2021 Dec;297(6):101341. (PMID: <searchLink fieldCode="PM" term="%2234695418%22">34695418)</searchLink><br />Nat Commun. 2019 Jan 18;10(1):338. (PMID: <searchLink fieldCode="PM" term="%2230659183%22">30659183)</searchLink><br />Sci Adv. 2021 Dec 10;7(50):eabl5182. (PMID: <searchLink fieldCode="PM" term="%2234878835%22">34878835)</searchLink><br />Sci Adv. 2025 Jan 24;11(4):eadu4369. (PMID: <searchLink fieldCode="PM" term="%2239841842%22">39841842)</searchLink><br />Bioinformatics. 2012 Aug 15;28(16):2184-5. (PMID: <searchLink fieldCode="PM" term="%2222743226%22">22743226)</searchLink><br />Diabetes. 2014 Jan;63(1):152-61. (PMID: <searchLink fieldCode="PM" term="%2223990363%22">23990363)</searchLink><br />J Biol Chem. 2014 Mar 21;289(12):8019-28. (PMID: <searchLink fieldCode="PM" term="%2224505138%22">24505138)</searchLink><br />Curr Genet. 2008 Jul;54(1):13-22. (PMID: <searchLink fieldCode="PM" term="%2218481068%22">18481068)</searchLink><br />Immunity. 2015 Mar 17;42(3):419-30. (PMID: <searchLink fieldCode="PM" term="%2225786174%22">25786174)</searchLink><br />Sci Rep. 2020 Oct 6;10(1):16554. (PMID: <searchLink fieldCode="PM" term="%2233024179%22">33024179)</searchLink><br />Nature. 2013 Apr 11;496(7444):238-42. (PMID: <searchLink fieldCode="PM" term="%2223535595%22">23535595)</searchLink><br />J Biol Chem. 2010 Dec 17;285(51):39976-85. (PMID: <searchLink fieldCode="PM" term="%2220923771%22">20923771)</searchLink><br />Nucleic Acids Res. 2021 Jan 8;49(D1):D1541-D1547. (PMID: <searchLink fieldCode="PM" term="%2233174596%22">33174596)</searchLink><br />PLoS One. 2015 Dec 23;10(12):e0145342. (PMID: <searchLink fieldCode="PM" term="%2226699615%22">26699615)</searchLink><br />J Antimicrob Chemother. 2022 Apr 27;77(5):1218-1227. (PMID: <searchLink fieldCode="PM" term="%2235211738%22">35211738)</searchLink><br />Science. 2021 Oct 15;374(6565):eabe9977. (PMID: <searchLink fieldCode="PM" term="%2234648346%22">34648346)</searchLink><br />Cell Metab. 2021 Dec 7;33(12):2464-2483.e18. (PMID: <searchLink fieldCode="PM" term="%2234800366%22">34800366)</searchLink><br />Cell Metab. 2013 Mar 5;17(3):386-98. (PMID: <searchLink fieldCode="PM" term="%2223473033%22">23473033)</searchLink><br />Nat Rev Rheumatol. 2022 Jul;18(7):384-397. (PMID: <searchLink fieldCode="PM" term="%2235672464%22">35672464)</searchLink><br />Genome Biol. 2014;15(12):550. (PMID: <searchLink fieldCode="PM" term="%2225516281%22">25516281)</searchLink><br />BMC Biol. 2014 May 27;12:34. (PMID: <searchLink fieldCode="PM" term="%2224884669%22">24884669)</searchLink><br />Cell Metab. 2013 Mar 5;17(3):399-410. (PMID: <searchLink fieldCode="PM" term="%2223473034%22">23473034)</searchLink><br />Innovation (Camb). 2024 Oct 21;5(6):100722. (PMID: <searchLink fieldCode="PM" term="%2239529960%22">39529960)</searchLink><br />Nat Struct Mol Biol. 2018 Mar;25(3):217-224. (PMID: <searchLink fieldCode="PM" term="%2229459785%22">29459785)</searchLink><br />EMBO Rep. 2016 Oct;17(10):1374-1395. (PMID: <searchLink fieldCode="PM" term="%2227629041%22">27629041)</searchLink><br />Nat Methods. 2014 Mar;11(3):319-24. (PMID: <searchLink fieldCode="PM" term="%2224487582%22">24487582)</searchLink><br />Immunity. 2018 Dec 18;49(6):1021-1033.e6. (PMID: <searchLink fieldCode="PM" term="%2230566880%22">30566880)</searchLink><br />Cell Metab. 2021 Dec 7;33(12):2398-2414.e9. (PMID: <searchLink fieldCode="PM" term="%2234715039%22">34715039)</searchLink><br />Elife. 2013 May 28;2:e00498. (PMID: <searchLink fieldCode="PM" term="%2223741617%22">23741617)</searchLink><br />Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2097-2102. (PMID: <searchLink fieldCode="PM" term="%2230674674%22">30674674)</searchLink><br />Nature. 2011 Apr 28;472(7344):476-80. (PMID: <searchLink fieldCode="PM" term="%2221525932%22">21525932)</searchLink><br />Nat Biotechnol. 2008 Dec;26(12):1367-72. (PMID: <searchLink fieldCode="PM" term="%2219029910%22">19029910)</searchLink><br />Nucleic Acids Res. 2018 May 18;46(9):4425-4439. (PMID: <searchLink fieldCode="PM" term="%2229506156%22">29506156)</searchLink><br />Immunity. 2016 Oct 18;45(4):817-830. (PMID: <searchLink fieldCode="PM" term="%2227760338%22">27760338)</searchLink><br />Science. 2011 Jun 10;332(6035):1284-8. (PMID: <searchLink fieldCode="PM" term="%2221566158%22">21566158)</searchLink><br />Elife. 2020 May 28;9:. (PMID: <searchLink fieldCode="PM" term="%2232463360%22">32463360)</searchLink><br />Nat Immunol. 2023 May;24(5):731. (PMID: <searchLink fieldCode="PM" term="%2237024535%22">37024535)</searchLink><br />Cell Chem Biol. 2025 Apr 17;32(4):620-630.e6. (PMID: <searchLink fieldCode="PM" term="%2240250406%22">40250406)</searchLink><br />Cell. 2024 May 23;187(11):2601-2627. (PMID: <searchLink fieldCode="PM" term="%2238788685%22">38788685)</searchLink><br />Cell Metab. 2006 Jul;4(1):13-24. (PMID: <searchLink fieldCode="PM" term="%2216814729%22">16814729)</searchLink><br />Nat Commun. 2025 May 1;16(1):4080. (PMID: <searchLink fieldCode="PM" term="%2240312422%22">40312422)</searchLink><br />J Exp Med. 1997 May 5;185(9):1661-70. (PMID: <searchLink fieldCode="PM" term="%229151903%22">9151903)</searchLink><br />J Proteome Res. 2011 Apr 1;10(4):1794-805. (PMID: <searchLink fieldCode="PM" term="%2221254760%22">21254760)</searchLink><br />Cell. 2016 Jul 28;166(3):624-636. (PMID: <searchLink fieldCode="PM" term="%2227374331%22">27374331)</searchLink><br />Nat Immunol. 2016 Jan;17(1):34-40. (PMID: <searchLink fieldCode="PM" term="%2226681460%22">26681460)</searchLink><br />Mol Cell Proteomics. 2018 Dec;17(12):2534-2545. (PMID: <searchLink fieldCode="PM" term="%2230385480%22">30385480)</searchLink><br />Nat Methods. 2020 Dec;17(12):1229-1236. (PMID: <searchLink fieldCode="PM" term="%2233257825%22">33257825)</searchLink><br />J Immunol. 2010 Jul 1;185(1):605-14. (PMID: <searchLink fieldCode="PM" term="%2220498354%22">20498354)</searchLink><br />Sci Rep. 2016 Sep 16;6:32886. (PMID: <searchLink fieldCode="PM" term="%2227633668%22">27633668)</searchLink><br />Mol Syst Biol. 2016 Oct 20;12(10):883. (PMID: <searchLink fieldCode="PM" term="%2227951527%22">27951527)</searchLink><br />Int J Biol Sci. 2025 Apr 21;21(7):2935-2953. (PMID: <searchLink fieldCode="PM" term="%2240384854%22">40384854)</searchLink><br />FASEB J. 2015 Aug;29(8):3582-92. (PMID: <searchLink fieldCode="PM" term="%2225977255%22">25977255)</searchLink><br />Cell Metab. 2018 Sep 4;28(3):490-503.e7. (PMID: <searchLink fieldCode="PM" term="%2230043752%22">30043752)</searchLink><br />BMC Bioinformatics. 2011 Aug 04;12:323. (PMID: <searchLink fieldCode="PM" term="%2221816040%22">21816040)</searchLink><br />Immunity. 2025 Oct 14;58(10):2489-2504.e8. (PMID: <searchLink fieldCode="PM" term="%2241005293%22">41005293)</searchLink><br />J Biol Chem. 2024 Apr;300(4):107151. (PMID: <searchLink fieldCode="PM" term="%2238462161%22">38462161)</searchLink><br />Nat Metab. 2019 Jul;1(7):731-742. (PMID: <searchLink fieldCode="PM" term="%2232259027%22">32259027)</searchLink><br />Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: <searchLink fieldCode="PM" term="%2216199517%22">16199517)</searchLink><br />Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2414187121. (PMID: <searchLink fieldCode="PM" term="%2239503847%22">39503847)</searchLink><br />Methods. 2013 Sep 1;63(1):41-9. (PMID: <searchLink fieldCode="PM" term="%2223816787%22">23816787)</searchLink><br />EMBO Rep. 2021 Apr 7;22(4):e51635. (PMID: <searchLink fieldCode="PM" term="%2233586863%22">33586863)</searchLink><br />J Exp Med. 2013 Oct 21;210(11):2477-91. (PMID: <searchLink fieldCode="PM" term="%2224101381%22">24101381)</searchLink><br />Mol Biol Cell. 2006 Nov;17(11):4632-44. (PMID: <searchLink fieldCode="PM" term="%2216928960%22">16928960)</searchLink><br />Nat Commun. 2023 Nov 17;14(1):7471. (PMID: <searchLink fieldCode="PM" term="%2237978290%22">37978290)</searchLink><br />Immunity. 2014 Feb 20;40(2):274-88. (PMID: <searchLink fieldCode="PM" term="%2224530056%22">24530056)</searchLink><br />Nature. 2020 Mar;579(7799):427-432. (PMID: <searchLink fieldCode="PM" term="%2232132707%22">32132707)</searchLink><br />Immunity. 2012 Mar 23;36(3):401-14. (PMID: <searchLink fieldCode="PM" term="%2222342844%22">22342844)</searchLink><br />J Vis Exp. 2023 Jun 2;(196):. (PMID: <searchLink fieldCode="PM" term="%2237335104%22">37335104)</searchLink><br />Nat Immunol. 2017 Sep;18(9):985-994. (PMID: <searchLink fieldCode="PM" term="%2228714978%22">28714978)</searchLink><br />Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: <searchLink fieldCode="PM" term="%2223104886%22">23104886)</searchLink><br />Curr Opin Immunol. 2025 Aug;95:102566. (PMID: <searchLink fieldCode="PM" term="%2240424975%22">40424975)</searchLink><br />Bioinformatics. 2015 Nov 15;31(22):3718-20. (PMID: <searchLink fieldCode="PM" term="%2226209431%22">26209431)</searchLink><br />Nucleic Acids Res. 2025 Jan 6;53(D1):D543-D553. (PMID: <searchLink fieldCode="PM" term="%2239494541%22">39494541)</searchLink><br />Science. 2017 Jun 9;356(6342):1072-1076. (PMID: <searchLink fieldCode="PM" term="%2228495875%22">28495875)</searchLink><br />PLoS One. 2018 Mar 14;13(3):e0194126. (PMID: <searchLink fieldCode="PM" term="%2229538444%22">29538444)</searchLink><br />Anal Chem. 2015 Apr 21;87(8):4110-6. (PMID: <searchLink fieldCode="PM" term="%2225837572%22">25837572)</searchLink><br />Mol Cell Proteomics. 2014 Sep;13(9):2513-26. (PMID: <searchLink fieldCode="PM" term="%2224942700%22">24942700)</searchLink><br />Nat Commun. 2018 Oct 22;9(1):4383. (PMID: <searchLink fieldCode="PM" term="%2230348985%22">30348985)</searchLink><br />Nat Immunol. 2016 Sep;17(9):1037-1045. (PMID: <searchLink fieldCode="PM" term="%2227348412%22">27348412)</searchLink><br />Cell Rep. 2016 Oct 11;17(3):684-696. (PMID: <searchLink fieldCode="PM" term="%2227732846%22">27732846)</searchLink><br />Nat Commun. 2022 Nov 30;13(1):7389. (PMID: <searchLink fieldCode="PM" term="%2236450731%22">36450731)</searchLink><br />J Am Chem Soc. 2011 Oct 19;133(41):16386-9. (PMID: <searchLink fieldCode="PM" term="%2221919507%22">21919507)</searchLink><br />J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):465-468, 468.e1. (PMID: <searchLink fieldCode="PM" term="%2225017538%22">25017538)</searchLink><br />Nature. 2023 Mar;615(7952):490-498. (PMID: <searchLink fieldCode="PM" term="%2236890227%22">36890227)</searchLink><br />Nature. 2010 Mar 4;464(7285):104-7. (PMID: <searchLink fieldCode="PM" term="%2220203610%22">20203610)</searchLink><br />Cell. 2016 Oct 6;167(2):457-470.e13. (PMID: <searchLink fieldCode="PM" term="%2227667687%22">27667687)</searchLink><br />Nature. 2020 Mar;579(7799):433-437. (PMID: <searchLink fieldCode="PM" term="%2232132706%22">32132706)</searchLink><br />Sci Rep. 2021 Jun 18;11(1):12841. (PMID: <searchLink fieldCode="PM" term="%2234145306%22">34145306)</searchLink><br />J Clin Invest. 2011 Jul;121(7):2736-49. (PMID: <searchLink fieldCode="PM" term="%2221670502%22">21670502)</searchLink><br />Sci Adv. 2025 Jan 24;11(4):eadq7307. (PMID: <searchLink fieldCode="PM" term="%2239841829%22">39841829)</searchLink><br />Cell Metab. 2018 Sep 4;28(3):463-475.e4. (PMID: <searchLink fieldCode="PM" term="%2230184486%22">30184486)</searchLink>
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