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Photosensitive response mouse model: A potential tool for studying mechanisms of photosensitive epilepsy and initial screening of anti-epileptic drugs.

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Τίτλος: Photosensitive response mouse model: A potential tool for studying mechanisms of photosensitive epilepsy and initial screening of anti-epileptic drugs.
Συγγραφείς: Li M; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Long X; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Wang X; Institute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Zhao D; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Jia Z; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Li Q; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Wang H; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Chen Z; Institute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Chen D; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Jia Y; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Chai J; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Liu M; Jiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Huang Z; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Hua R; Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China., Fang X; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Zou WQ; Institute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Xiong Y; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Yang Y; Nanchang City Key Laboratory of Biological Psychiatry, Health Commission of Jiangxi Province Key Laboratory of Psychiatry, Jiangxi Provincial Clinical Research Center on Mental Disorders, Jiangxi Mental Hospital (Affiliated Mental Hospital), Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Hong D; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Huang P; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Πηγή: The Journal of physiology [J Physiol] 2026 Sep; Vol. 604 (17), pp. 7413-7438. Date of Electronic Publication: 2026 Aug 18.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE
Imprint Name(s): Publication: Oxford : Blackwell : Cambridge Univ. Press
Original Publication: London, Cambridge Univ. Press.
Ιατρικοί όροι (MeSH): Anticonvulsants*/pharmacology , Anticonvulsants*/therapeutic use , Epilepsy, Reflex*/drug therapy , Epilepsy, Reflex*/physiopathology , Primary Visual Cortex*/drug effects , Primary Visual Cortex*/physiopathology , Primary Visual Cortex*/physiology , Disease Models, Animal*, Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiopathology ; Prefrontal Cortex/physiology ; Pentylenetetrazole/pharmacology ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Photic Stimulation ; Local Field Potential Measurement
Περίληψη: Numerous studies have investigated the mechanisms underlying photosensitive epilepsy, yet they remain poorly understood. Progress in this field has been substantially hampered by the scarcity of valid animal models and the difficulty in establishing them. Here we presented flashing lights at varying frequencies to head-fixed mice while recording local field potentials (LFPs) in the primary visual cortex (V1). We identified approximately 5 Hz as the resonant frequency for eliciting photosensitive responses. By modulating the luminance within the behavioural chamber we found that the response amplitude diminished with reduced stimulus contrast. Dual-region LFP recordings revealed that the photosensitive response propagated to the medial prefrontal cortex (mPFC), with the response in V1 being both stronger and earlier than those in the mPFC. Acute treatment with pentylenetetrazole (PTZ) enhanced the photosensitive response in V1, whereas chronic PTZ treatment did not. Furthermore we demonstrated that several anti-epileptic drugs effectively attenuated the photosensitive response in both V1 and mPFC. Collectively our findings establish a murine photosensitivity model as a promising platform for the investigation of the mechanisms underlying photosensitive epilepsy and for the initial screening of potential antiepileptic therapeutics. KEY POINTS: The resonant frequency of the photosensitive response in mice is approximately 5 Hz. Photosensitive response decreases as the stimulus contrast reduces, and its response to red light is weaker than that to white light. The photosensitive response can propagate to the medial prefrontal cortex (mPFC) region but does not induce clinical epileptic seizures. Some anti-epileptic drugs can alleviate the photosensitive response.
(© 2026 The Author(s). The Journal of Physiology © 2026 The Physiological Society.)
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Ital J Neurol Sci. 1995 Feb-Mar;16(1-2):119-25. (PMID: 7642345)
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Grant Information: 82201674 National Natural Science Foundation of China; 82271439 National Natural Science Foundation of China; 82271557 National Natural Science Foundation of China; 82260268 National Natural Science Foundation of China; 20224BAB216044 Natural Science of Foundation of Jiangxi Province; 20232BAB206069 Natural Science of Foundation of Jiangxi Province; Key Laboratory Project of Neurological Diseases in Jiangxi; 202410472007 China National University Student Innovation & Entrepreneurship Development Program of Xinxiang Medical University; 242102310372 Key Scientific and Technological Projects of Henan
Contributed Indexing: Keywords: flashing lights; photosensitive epilepsy; screening antiepileptic drugs
Substance Nomenclature: 0 (Anticonvulsants)
WM5Z385K7T (Pentylenetetrazole)
Entry Date(s): Date Created: 20260818 Date Completed: 20260901 Latest Revision: 20260903
Update Code: 20260903
PubMed Central ID: PMC13532922
DOI: 10.1113/JP290618
PMID: 42610328
Βάση Δεδομένων: MEDLINE
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  Data: Photosensitive response mouse model: A potential tool for studying mechanisms of photosensitive epilepsy and initial screening of anti-epileptic drugs.
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  Data: <searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Long+X%22">Long X</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Institute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Zhao+D%22">Zhao D</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Jia+Z%22">Jia Z</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Institute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Jia+Y%22">Jia Y</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Chai+J%22">Chai J</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Jiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Hua+R%22">Hua R</searchLink>; Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Fang+X%22">Fang X</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Zou+WQ%22">Zou WQ</searchLink>; Institute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Nanchang City Key Laboratory of Biological Psychiatry, Health Commission of Jiangxi Province Key Laboratory of Psychiatry, Jiangxi Provincial Clinical Research Center on Mental Disorders, Jiangxi Mental Hospital (Affiliated Mental Hospital), Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Hong+D%22">Hong D</searchLink>; 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– Name: Abstract
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  Data: Numerous studies have investigated the mechanisms underlying photosensitive epilepsy, yet they remain poorly understood. Progress in this field has been substantially hampered by the scarcity of valid animal models and the difficulty in establishing them. Here we presented flashing lights at varying frequencies to head-fixed mice while recording local field potentials (LFPs) in the primary visual cortex (V1). We identified approximately 5 Hz as the resonant frequency for eliciting photosensitive responses. By modulating the luminance within the behavioural chamber we found that the response amplitude diminished with reduced stimulus contrast. Dual-region LFP recordings revealed that the photosensitive response propagated to the medial prefrontal cortex (mPFC), with the response in V1 being both stronger and earlier than those in the mPFC. Acute treatment with pentylenetetrazole (PTZ) enhanced the photosensitive response in V1, whereas chronic PTZ treatment did not. Furthermore we demonstrated that several anti-epileptic drugs effectively attenuated the photosensitive response in both V1 and mPFC. Collectively our findings establish a murine photosensitivity model as a promising platform for the investigation of the mechanisms underlying photosensitive epilepsy and for the initial screening of potential antiepileptic therapeutics. KEY POINTS: The resonant frequency of the photosensitive response in mice is approximately 5 Hz. Photosensitive response decreases as the stimulus contrast reduces, and its response to red light is weaker than that to white light. The photosensitive response can propagate to the medial prefrontal cortex (mPFC) region but does not induce clinical epileptic seizures. Some anti-epileptic drugs can alleviate the photosensitive response.<br /> (© 2026 The Author(s). The Journal of Physiology © 2026 The Physiological Society.)
– Name: Ref
  Label: References
  Group: RefInfo
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– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: 82201674 National Natural Science Foundation of China; 82271439 National Natural Science Foundation of China; 82271557 National Natural Science Foundation of China; 82260268 National Natural Science Foundation of China; 20224BAB216044 Natural Science of Foundation of Jiangxi Province; 20232BAB206069 Natural Science of Foundation of Jiangxi Province; Key Laboratory Project of Neurological Diseases in Jiangxi; 202410472007 China National University Student Innovation & Entrepreneurship Development Program of Xinxiang Medical University; 242102310372 Key Scientific and Technological Projects of Henan
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  Data: <i>Keywords: </i>flashing lights; photosensitive epilepsy; screening antiepileptic drugs
– Name: NumberCAS
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  Data: 0 (Anticonvulsants)<br />WM5Z385K7T (Pentylenetetrazole)
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  Data: <i>Date Created: </i>20260818 <i>Date Completed: </i>20260901 <i>Latest Revision: </i>20260903
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  Data: 10.1113/JP290618
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        Value: 10.1113/JP290618
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      – Code: eng
        Text: English
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        StartPage: 7413
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      – SubjectFull: Prefrontal Cortex drug effects
        Type: general
      – SubjectFull: Prefrontal Cortex physiopathology
        Type: general
      – SubjectFull: Prefrontal Cortex physiology
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      – SubjectFull: Pentylenetetrazole pharmacology
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      – SubjectFull: Animals
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      – SubjectFull: Male
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      – SubjectFull: Mice
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      – SubjectFull: Mice, Inbred C57BL
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      – SubjectFull: Photic Stimulation
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      – SubjectFull: Local Field Potential Measurement
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      – SubjectFull: Anticonvulsants pharmacology
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      – SubjectFull: Anticonvulsants therapeutic use
        Type: general
      – SubjectFull: Epilepsy, Reflex drug therapy
        Type: general
      – SubjectFull: Epilepsy, Reflex physiopathology
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      – SubjectFull: Primary Visual Cortex drug effects
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      – SubjectFull: Disease Models, Animal
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      – TitleFull: Photosensitive response mouse model: A potential tool for studying mechanisms of photosensitive epilepsy and initial screening of anti-epileptic drugs.
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              Text: 2026 Sep
              Type: published
              Y: 2026
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            – TitleFull: The Journal of physiology
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