Academic Journal
Curcumin attenuates acrylamide-induced cerebellar neurofilament accumulation, BDNF decline and motor dysfunction.
| Τίτλος: | Curcumin attenuates acrylamide-induced cerebellar neurofilament accumulation, BDNF decline and motor dysfunction. |
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| Συγγραφείς: | Duan L; Department of Health Toxicology, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong-Road, Wuhan 430030, PR China., Dang Z; The First Clinical College of Wuhan University, 238 Jiefang-Road, Wuchang District, Wuhan 430060, PR China., Li Z; The First Clinical College of Wuhan University, 238 Jiefang-Road, Wuchang District, Wuhan 430060, PR China., Zhang Y; Department of Health Toxicology, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong-Road, Wuhan 430030, PR China., Yan D; Department of Pathology, Renmin Hospital of Wuhan University, 238 Jiefang-Road, Wuchang District, Wuhan 430060, PR China. Electronic address: dandanyan@whu.edu.cn., Yan H; Department of Health Toxicology, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong-Road, Wuhan 430030, PR China. Electronic address: yanhong@mails.tjmu.edu.cn. |
| Πηγή: | Neurotoxicology [Neurotoxicology] 2026 Sep; Vol. 116, pp. 103548. Date of Electronic Publication: 2026 Aug 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2001- : Amsterdam : Elsevier Science Original Publication: Park Forest South, Ill., Pathotox Publishers. |
| Ιατρικοί όροι (MeSH): | Brain-Derived Neurotrophic Factor*/metabolism , Curcumin*/pharmacology , Acrylamide*/toxicity , Cerebellum*/drug effects , Cerebellum*/metabolism , Cerebellum*/pathology , Neuroprotective Agents*/pharmacology , Neurofilament Proteins*/metabolism , Intermediate Filaments*/drug effects , Intermediate Filaments*/metabolism , Motor Activity*/drug effects, Oxidative Stress/drug effects ; Cyclic AMP Response Element-Binding Protein/metabolism ; Animals ; Male ; Rats ; Rats, Sprague-Dawley |
| Περίληψη: | Acrylamide (ACR), a well-established neurotoxicant in humans, is commonly encountered in daily life. Previous studies have implicated cerebellar injury in ACR-induced neurotoxicity. Curcumin, a polyphenolic compound with potent neuroprotective properties, has shown protective effects in maintaining cerebellar function by suppressing oxidative stress. This study aimed to determine whether curcumin could alleviate ACR-induced motor dysfunction and cerebellar injury in rats. Administration of ACR at a dose of 10 mg/kg/day for 7 weeks induced mild gait abnormality, impaired motor coordination and balance, and significant cerebellar neuronal loss. These alterations were accompanied by oxidative stress, neurofilament accumulation and microtubule dynamic instability. ACR increased cerebellar malondialdehyde (MDA) level, reduced glutathione (GSH) level and activities of total superoxide dismutase (T-SOD) and catalase (CAT). At the molecular level, ACR exposure increased the expression of neurofilament light chain (NF-L) and reduced the levels of phosphorylated cAMP response element-binding protein (P-CREB) and brain-derived neurotrophic factor (BDNF). ACR increased tau phosphorylation and decreased acetylated α-tubulin. Curcumin intervention partially alleviated ACR-induced motor dysfunction and cerebellar cytoskeletal injury, attenuated oxidative stress, reduced NF-L accumulation, increased ERK1/2 and Akt phosphorylation, and elevated P-CREB and BDNF levels. However, curcumin had limited effects on cerebellar tau phosphorylation and microtubule instability. These results provide novel insights into the protective effects of curcumin against ACR-induced cerebellar toxicity and highlight its therapeutic potential as a protective intervention against ACR-induced neurotoxicity. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dandan Yan, Hong Yan reports financial support was provided by National Natural Science Foundation of China. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Acrylamide; CREB/BDNF; Cerebellum; Curcumin; Neurofilaments |
| Substance Nomenclature: | 0 (Brain-Derived Neurotrophic Factor) IT942ZTH98 (Curcumin) 20R035KLCI (Acrylamide) 0 (Neuroprotective Agents) 0 (Bdnf protein, rat) 0 (Neurofilament Proteins) 0 (Cyclic AMP Response Element-Binding Protein) |
| Entry Date(s): | Date Created: 20260817 Date Completed: 20260909 Latest Revision: 20260909 |
| Update Code: | 20260910 |
| DOI: | 10.1016/j.neuro.2026.103548 |
| PMID: | 42607891 |
| Βάση Δεδομένων: | MEDLINE |
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