Academic Journal
Core Size and PEG Coating Govern the Dual Magnetic Particle Imaging and Hyperthermia Performance of Iron Oxide Nanoparticles.
| Τίτλος: | Core Size and PEG Coating Govern the Dual Magnetic Particle Imaging and Hyperthermia Performance of Iron Oxide Nanoparticles. |
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| Συγγραφείς: | Mostufa S; Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas79409, United States., Wang H; Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas79409, United States., Rezaei B; Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas79409, United States., Shahriar M; Department of Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, Texas79409, United States., Xu C; Department of Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, Texas79409, United States., He R; Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas79409, United States., Wu K; Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas79409, United States. |
| Πηγή: | ACS applied bio materials [ACS Appl Bio Mater] 2026 Aug 17; Vol. 9 (16), pp. 7671-7681. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : ACS Publications, [2018]- |
| Ιατρικοί όροι (MeSH): | Polyethylene Glycols*/chemistry , Polyethylene Glycols*/pharmacology , Coated Materials, Biocompatible*/chemistry , Coated Materials, Biocompatible*/pharmacology , Coated Materials, Biocompatible*/chemical synthesis , Magnetic Iron Oxide Nanoparticles*/chemistry , Magnetite Nanoparticles*/chemistry , Magnetic Particle Imaging* , Hyperthermia, Induced*, Cell Survival/drug effects ; Particle Size ; Materials Testing ; Humans ; Surface Properties |
| Περίληψη: | Magnetic particle imaging (MPI) and magnetic hyperthermia therapy (MHT) both rely strongly on the dynamic magnetic response of magnetic nanoparticles (MNPs), yet the particle design requirements for achieving strong imaging contrast and efficient heating are not always aligned. Here, we systematically investigate the effects of core size and PEG surface coating on the dual MPI-MHT performance of iron oxide MNPs. Six formulations with core sizes of 10, 20, and 30 nm, either uncoated Fe3O4 or PEG-coated Fe3O4 (Fe3O4@PEG), were systematically evaluated. MPI performance was assessed using magnetic particle spectroscopy (MPS) under an excitation field of 10 mT at 7.7 and 11.4 kHz. Harmonic analysis revealed that 20 nm Fe3O4@PEG nanoparticles generated the strongest MPI response, characterized by enhanced higher-order harmonic magnitudes and slower harmonic decay. MHT performance was then evaluated under various alternating magnetic field (AMF) conditions: 30 mT at 101.5 kHz, 15 mT at 434.4 kHz, 25 mT at 252.5 kHz, and 10 mT at 951.8 kHz. Results demonstrate that 20 nm Fe3O4@PEG nanoparticles also showed superior heating efficiency, especially under low-field, high-frequency excitation. These findings suggest that a 20 nm core size, combined with a PEG coating, provides an optimal balance between rapid magnetic response, colloidal stability, and energy dissipation. Furthermore, colloidal stability over seven days and cell viability assays confirm that the MNPs are colloidally stable and that 20 and 30 nm MNPs are biocompatible under the tested conditions for up to 48 h. This study provides a rational design framework for developing dual-functional iron oxide nanoparticles for image-guided magnetic hyperthermia and other integrated diagnostic-therapeutic biomedical applications. (© 2026 American Chemical Society.) |
| Grant Information: | R16GM158539 United States GM NIGMS NIH HHS; R03EB036435 United States EB NIBIB NIH HHS |
| Contributed Indexing: | Keywords: biocompatibility; magnetic hyperthermia therapy; magnetic nanoparticle; magnetic particle imaging; magnetic particle spectroscopy |
| Substance Nomenclature: | 3WJQ0SDW1A (Polyethylene Glycols) 0 (Coated Materials, Biocompatible) 0 (Magnetite Nanoparticles) |
| Entry Date(s): | Date Created: 20260817 Date Completed: 20260817 Latest Revision: 20260817 |
| Update Code: | 20260817 |
| DOI: | 10.1021/acsabm.6c01122 |
| PMID: | 42606052 |
| Βάση Δεδομένων: | MEDLINE |
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