Academic Journal
Acute sleep deprivation rank-dependently enhances offensive aggression via the PVN in male mice.
| Τίτλος: | Acute sleep deprivation rank-dependently enhances offensive aggression via the PVN in male mice. |
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| Συγγραφείς: | Lu Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Li Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Chen S; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Li Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Yu T; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Yin X; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Yan S; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Liu Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China., Liu Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Yang R; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Zhao Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Zhao Y; Nursing School, Hebei Medical University, Shijiazhuang 050031, China., Yin X; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. Electronic address: yinxixi2002@163.com., Song H; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Core Facilities and Centers, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China. Electronic address: songhan@hebmu.edu.cn., Shi H; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Nursing School, Hebei Medical University, Shijiazhuang 050031, China. Electronic address: shihs@hebmu.edu.cn. |
| Πηγή: | Behavioural brain research [Behav Brain Res] 2026 Oct 18; Vol. 515, pp. 116410. Date of Electronic Publication: 2026 Aug 14. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Sleep Deprivation*/physiopathology , Sleep Deprivation*/metabolism , Aggression*/physiology , Paraventricular Hypothalamic Nucleus*/metabolism , Behavior, Animal*/physiology , Dominance-Subordination* , Social Dominance* , Hierarchy, Social*, Proto-Oncogene Proteins c-fos/metabolism ; Prefrontal Cortex/metabolism ; Neurons/metabolism ; Animals ; Male ; Mice, Inbred ICR ; Mice |
| Περίληψη: | Sleep loss is a well-recognized trigger of aggression and emotional dysregulation, yet it remains unclear whether its effect on aggressive behavior interacts with social hierarchy. Here, we investigated how acute sleep deprivation (ASD) modulates offensive and defensive aggression in dominant versus subordinate male mice and explored the underlying neural mechanisms. Adult ICR mice were subjected to 12-hour overnight ASD, followed by the resident-intruder test (RIT) for offensive aggression, the defensive aggression test (DAT), and the social dominance test (SDT). ASD selectively increased the total attack time in the RIT without affecting defensive aggression or altering social rank. When stratified by social rank, ASD significantly enhanced offensive aggression in dominant, but not subordinate, mice. c-Fos immunofluorescence revealed that ASD reduced neuronal activation in the medial prefrontal cortex (mPFC) while increasing it in the paraventricular nucleus (PVN). In dominant mice, ASD further increased c-Fos expression in the ventrolateral ventromedial hypothalamus (VMHvl) and PVN, with PVN activation positively correlating with attack duration. Chemogenetic inhibition of PVN neurons using hM4Di completely reversed the ASD-induced enhancement of offensive aggression. These findings demonstrate that ASD rapidly and selectively potentiates offensive aggression in dominant individuals via PVN-dependent mechanisms, revealing a critical interaction between sleep loss and social hierarchy. This study provides new insights into the neurobiological basis of sleep-related violence and suggests that targeting the PVN or sleep regulation may offer novel intervention strategies for aggression control. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper |
| Contributed Indexing: | Keywords: Acute sleep deprivation; Chemogenetic inhibition; Offensive aggression; Paraventricular nucleus; Social hierarchy |
| Substance Nomenclature: | 0 (Proto-Oncogene Proteins c-fos) |
| Entry Date(s): | Date Created: 20260814 Date Completed: 20260904 Latest Revision: 20260904 |
| Update Code: | 20260905 |
| DOI: | 10.1016/j.bbr.2026.116410 |
| PMID: | 42600896 |
| Βάση Δεδομένων: | MEDLINE |
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