Academic Journal
Προβολή σε EDS

Acute sleep deprivation rank-dependently enhances offensive aggression via the PVN in male mice.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Acute sleep deprivation rank-dependently enhances offensive aggression via the PVN in male mice.
Συγγραφείς: Lu Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Li Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Chen S; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Li Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Yu T; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Yin X; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Yan S; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Liu Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China., Liu Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Yang R; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Zhao Y; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China., Zhao Y; Nursing School, Hebei Medical University, Shijiazhuang 050031, China., Yin X; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. Electronic address: yinxixi2002@163.com., Song H; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Core Facilities and Centers, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China. Electronic address: songhan@hebmu.edu.cn., Shi H; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Nursing School, Hebei Medical University, Shijiazhuang 050031, China. Electronic address: shihs@hebmu.edu.cn.
Πηγή: Behavioural brain research [Behav Brain Res] 2026 Oct 18; Vol. 515, pp. 116410. Date of Electronic Publication: 2026 Aug 14.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE
Imprint Name(s): Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
Ιατρικοί όροι (MeSH): Sleep Deprivation*/physiopathology , Sleep Deprivation*/metabolism , Aggression*/physiology , Paraventricular Hypothalamic Nucleus*/metabolism , Behavior, Animal*/physiology , Dominance-Subordination* , Social Dominance* , Hierarchy, Social*, Proto-Oncogene Proteins c-fos/metabolism ; Prefrontal Cortex/metabolism ; Neurons/metabolism ; Animals ; Male ; Mice, Inbred ICR ; Mice
Περίληψη: Sleep loss is a well-recognized trigger of aggression and emotional dysregulation, yet it remains unclear whether its effect on aggressive behavior interacts with social hierarchy. Here, we investigated how acute sleep deprivation (ASD) modulates offensive and defensive aggression in dominant versus subordinate male mice and explored the underlying neural mechanisms. Adult ICR mice were subjected to 12-hour overnight ASD, followed by the resident-intruder test (RIT) for offensive aggression, the defensive aggression test (DAT), and the social dominance test (SDT). ASD selectively increased the total attack time in the RIT without affecting defensive aggression or altering social rank. When stratified by social rank, ASD significantly enhanced offensive aggression in dominant, but not subordinate, mice. c-Fos immunofluorescence revealed that ASD reduced neuronal activation in the medial prefrontal cortex (mPFC) while increasing it in the paraventricular nucleus (PVN). In dominant mice, ASD further increased c-Fos expression in the ventrolateral ventromedial hypothalamus (VMHvl) and PVN, with PVN activation positively correlating with attack duration. Chemogenetic inhibition of PVN neurons using hM4Di completely reversed the ASD-induced enhancement of offensive aggression. These findings demonstrate that ASD rapidly and selectively potentiates offensive aggression in dominant individuals via PVN-dependent mechanisms, revealing a critical interaction between sleep loss and social hierarchy. This study provides new insights into the neurobiological basis of sleep-related violence and suggests that targeting the PVN or sleep regulation may offer novel intervention strategies for aggression control.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
Contributed Indexing: Keywords: Acute sleep deprivation; Chemogenetic inhibition; Offensive aggression; Paraventricular nucleus; Social hierarchy
Substance Nomenclature: 0 (Proto-Oncogene Proteins c-fos)
Entry Date(s): Date Created: 20260814 Date Completed: 20260904 Latest Revision: 20260904
Update Code: 20260905
DOI: 10.1016/j.bbr.2026.116410
PMID: 42600896
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.bbr.2026.116410?
    Name: ScienceDirect (all content) (s7799221)
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=18727549&ISBN=&volume=515&issue=&date=20261018&spage=116410&pages=116410&title=Behavioural brain research&atitle=Acute%20sleep%20deprivation%20rank-dependently%20enhances%20offensive%20aggression%20via%20the%20PVN%20in%20male%20mice.&aulast=Lu%20Y&id=DOI:10.1016/j.bbr.2026.116410
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 42600896
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Acute sleep deprivation rank-dependently enhances offensive aggression via the PVN in male mice.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Yu+T%22">Yu T</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Yan+S%22">Yan S</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Nursing School, Hebei Medical University, Shijiazhuang 050031, China.<br /><searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. Electronic address: yinxixi2002@163.com.<br /><searchLink fieldCode="AU" term="%22Song+H%22">Song H</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Core Facilities and Centers, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China. Electronic address: songhan@hebmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Hebei Key Laboratory of Early Life Health Promotion (SZX202419), Hebei Medical University, Shijiazhuang 050031, China; Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Nursing School, Hebei Medical University, Shijiazhuang 050031, China. Electronic address: shihs@hebmu.edu.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228004872%22">Behavioural brain research</searchLink> [Behav Brain Res] 2026 Oct 18; Vol. 515, pp. 116410. <i>Date of Electronic Publication: </i>2026 Aug 14.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2FNorth-Holland+Biomedical+Press%22">Elsevier/North-Holland Biomedical Press </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8004872 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7549 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201664328%22">01664328 </searchLink><i>NLM ISO Abbreviation: </i>Behav Brain Res <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Amsterdam, Elsevier/North-Holland Biomedical Press.
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Sleep+Deprivation%22">Sleep Deprivation*</searchLink>/<searchLink fieldCode="MM" term="%22Sleep+Deprivation+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Sleep+Deprivation%22">Sleep Deprivation*</searchLink>/<searchLink fieldCode="MM" term="%22Sleep+Deprivation+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Aggression%22">Aggression*</searchLink>/<searchLink fieldCode="MM" term="%22Aggression+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Paraventricular+Hypothalamic+Nucleus%22">Paraventricular Hypothalamic Nucleus*</searchLink>/<searchLink fieldCode="MM" term="%22Paraventricular+Hypothalamic+Nucleus+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Behavior%2C+Animal%22">Behavior, Animal*</searchLink>/<searchLink fieldCode="MM" term="%22Behavior%2C+Animal+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dominance-Subordination%22">Dominance-Subordination*</searchLink> <br /><searchLink fieldCode="MM" term="%22Social+Dominance%22">Social Dominance*</searchLink> <br /><searchLink fieldCode="MM" term="%22Hierarchy%2C+Social%22">Hierarchy, Social*</searchLink><br /><searchLink fieldCode="MH" term="%22Proto-Oncogene+Proteins+c-fos%22">Proto-Oncogene Proteins c-fos</searchLink>/<searchLink fieldCode="MH" term="%22Proto-Oncogene+Proteins+c-fos+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Prefrontal+Cortex%22">Prefrontal Cortex</searchLink>/<searchLink fieldCode="MH" term="%22Prefrontal+Cortex+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Neurons%22">Neurons</searchLink>/<searchLink fieldCode="MH" term="%22Neurons+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%2C+Inbred+ICR%22">Mice, Inbred ICR</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Sleep loss is a well-recognized trigger of aggression and emotional dysregulation, yet it remains unclear whether its effect on aggressive behavior interacts with social hierarchy. Here, we investigated how acute sleep deprivation (ASD) modulates offensive and defensive aggression in dominant versus subordinate male mice and explored the underlying neural mechanisms. Adult ICR mice were subjected to 12-hour overnight ASD, followed by the resident-intruder test (RIT) for offensive aggression, the defensive aggression test (DAT), and the social dominance test (SDT). ASD selectively increased the total attack time in the RIT without affecting defensive aggression or altering social rank. When stratified by social rank, ASD significantly enhanced offensive aggression in dominant, but not subordinate, mice. c-Fos immunofluorescence revealed that ASD reduced neuronal activation in the medial prefrontal cortex (mPFC) while increasing it in the paraventricular nucleus (PVN). In dominant mice, ASD further increased c-Fos expression in the ventrolateral ventromedial hypothalamus (VMHvl) and PVN, with PVN activation positively correlating with attack duration. Chemogenetic inhibition of PVN neurons using hM4Di completely reversed the ASD-induced enhancement of offensive aggression. These findings demonstrate that ASD rapidly and selectively potentiates offensive aggression in dominant individuals via PVN-dependent mechanisms, revealing a critical interaction between sleep loss and social hierarchy. This study provides new insights into the neurobiological basis of sleep-related violence and suggests that targeting the PVN or sleep regulation may offer novel intervention strategies for aggression control.<br /> (Copyright © 2026 Elsevier B.V. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Acute sleep deprivation; Chemogenetic inhibition; Offensive aggression; Paraventricular nucleus; Social hierarchy
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Proto-Oncogene Proteins c-fos)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260814 <i>Date Completed: </i>20260904 <i>Latest Revision: </i>20260904
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260905
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.bbr.2026.116410
– Name: AN
  Label: PMID
  Group: ID
  Data: 42600896
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42600896
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.bbr.2026.116410
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 116410
    Subjects:
      – SubjectFull: Proto-Oncogene Proteins c-fos metabolism
        Type: general
      – SubjectFull: Prefrontal Cortex metabolism
        Type: general
      – SubjectFull: Neurons metabolism
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Mice, Inbred ICR
        Type: general
      – SubjectFull: Mice
        Type: general
      – SubjectFull: Sleep Deprivation physiopathology
        Type: general
      – SubjectFull: Sleep Deprivation metabolism
        Type: general
      – SubjectFull: Aggression physiology
        Type: general
      – SubjectFull: Paraventricular Hypothalamic Nucleus metabolism
        Type: general
      – SubjectFull: Behavior, Animal physiology
        Type: general
      – SubjectFull: Dominance-Subordination
        Type: general
      – SubjectFull: Social Dominance
        Type: general
      – SubjectFull: Hierarchy, Social
        Type: general
    Titles:
      – TitleFull: Acute sleep deprivation rank-dependently enhances offensive aggression via the PVN in male mice.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lu Y
      – PersonEntity:
          Name:
            NameFull: Li Y
      – PersonEntity:
          Name:
            NameFull: Chen S
      – PersonEntity:
          Name:
            NameFull: Li Y
      – PersonEntity:
          Name:
            NameFull: Yu T
      – PersonEntity:
          Name:
            NameFull: Yin X
      – PersonEntity:
          Name:
            NameFull: Yan S
      – PersonEntity:
          Name:
            NameFull: Liu Y
      – PersonEntity:
          Name:
            NameFull: Liu Y
      – PersonEntity:
          Name:
            NameFull: Yang R
      – PersonEntity:
          Name:
            NameFull: Zhao Y
      – PersonEntity:
          Name:
            NameFull: Zhao Y
      – PersonEntity:
          Name:
            NameFull: Yin X
      – PersonEntity:
          Name:
            NameFull: Song H
      – PersonEntity:
          Name:
            NameFull: Shi H
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 18
              M: 10
              Text: 2026 Oct 18
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1872-7549
          Numbering:
            – Type: volume
              Value: 515
          Titles:
            – TitleFull: Behavioural brain research
              Type: main
ResultId 1