Academic Journal
Phytochemical Profiling, Biological Evaluation, and Molecular Insights Into the Urease Inhibitory Potential of Fraxinus angustifolia Crude Extract and Fractions.
| Τίτλος: | Phytochemical Profiling, Biological Evaluation, and Molecular Insights Into the Urease Inhibitory Potential of Fraxinus angustifolia Crude Extract and Fractions. |
|---|---|
| Συγγραφείς: | Belkhir S; Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, 06000, Algeria., Rahmani-Berboucha M; Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, 06000, Algeria., Zemam SS; Laboratory of Enterobacteria and Other Related Bacteria, Pasteur Institute of Algeria, Algiers, 16000, Algeria., Debbache-Benaida N; Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, 06000, Algeria., Ceylan FD; Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Istanbul, 34469, Turkey., Adrar N; Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Istanbul, 34469, Turkey., Atia A; Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, 06000, Algeria., Saidene N; Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, 06000, Algeria., Benamrouche N; Laboratory of Enterobacteria and Other Related Bacteria, Pasteur Institute of Algeria, Algiers, 16000, Algeria.; Faculty of Medicine, University of Health Sciences, Algiers, 16000, Algeria., Atmani-Kilani D; Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, 06000, Algeria., Capanoglu E; Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Istanbul, 34469, Turkey. |
| Πηγή: | Chemistry & biodiversity [Chem Biodivers] 2026 Aug; Vol. 23 (8), pp. e71583. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| Ιατρικοί όροι (MeSH): | Urease*/antagonists & inhibitors , Urease*/metabolism , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/isolation & purification , Fraxinus*/chemistry , Fraxinus*/metabolism , Phytochemicals*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/isolation & purification , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/isolation & purification, Helicobacter pylori/drug effects ; Plant Leaves/chemistry ; Plant Leaves/metabolism ; Molecular Docking Simulation ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship |
| Περίληψη: | Fraxinus angustifolia Vahl. has long been used in traditional medicine for the management of inflammatory and gastrointestinal disorders. This study investigated the anti-urease, anti-Helicobacter pylori, and anti-inflammatory activities of the ethanolic leaf extract and its phenolic fractions, with a focus on the mechanisms underlying these effects. The extracts exhibited inhibition of urease activity and bacterial growth, with the aqueous fraction of chloroform (AC) showing the most pronounced effect (urease IC (© 2026 Wiley‐VHCA AG.) |
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| Contributed Indexing: | Keywords: Fraxinus angustifolia; H. pylori; HPLC‐DAD; anti‐urease activity; polyphenols |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) 0 (Plant Extracts) 0 (Enzyme Inhibitors) 0 (Phytochemicals) 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20260814 Date Completed: 20260814 Latest Revision: 20260816 |
| Update Code: | 20260816 |
| PubMed Central ID: | PMC13475581 |
| DOI: | 10.1002/cbdv.71583 |
| PMID: | 42599635 |
| Βάση Δεδομένων: | MEDLINE |
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