Academic Journal
Gut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience.
| Τίτλος: | Gut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience. |
|---|---|
| Συγγραφείς: | Kryczyk-Poprawa A; Department of Inorganic Chemistry and Pharmaceutical Analytics, Faculty of Pharmacy, Jagiellonian University Medical College, 31-008 Krakow, Poland., Rząsa-Duran E; Branch in Krakow-Hospital Pharmacy, Maria Sklodowska-Curie National Research Institute of Oncology, Garncarska 11 Str., 31-115 Krakow, Poland., Varga JT; Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary., Lehoczki A; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Zábó V; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Fazekas-Pongor V; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Major D; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Csípő T; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Szappanos Á; Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary., Lipécz Á; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Fekete M; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary. |
| Πηγή: | Nutrients [Nutrients] 2026 Jul 31; Vol. 18 (15). Date of Electronic Publication: 2026 Jul 31. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI Publishing |
| Ιατρικοί όροι (MeSH): | Polyphenols*/pharmacology , Polyphenols*/administration & dosage , Dietary Fiber*/administration & dosage , Dietary Fiber*/pharmacology , Gastrointestinal Microbiome*/physiology , Gastrointestinal Microbiome*/drug effects , Healthy Aging*/physiology , Geroscience*, Humans ; Aging ; Animals |
| Περίληψη: | Age-related alterations in the gut microbiota contribute to chronic low-grade inflammation, immune dysregulation, metabolic dysfunction, frailty, sarcopenia, and cognitive decline. Dietary polyphenols and fermentable fiber modulate microbial composition and metabolism, promoting the production of bioactive metabolites, including short-chain fatty acids, secondary bile acids, indole derivatives, and urolithins, which regulate intestinal barrier integrity, immune homeostasis, mitochondrial function, and gut-organ communication. This narrative review critically synthesizes evidence from experimental studies, observational cohorts, randomized controlled trials, systematic reviews, and meta-analyses to examine microbiota-mediated mechanisms linking these dietary components to healthy aging within the geroscience framework. Although mechanistic evidence is compelling, translation into clinically meaningful aging outcomes remains limited because most intervention studies are small and heterogeneous and primarily rely on surrogate biomarkers. Current evidence supports polyphenol- and fiber-rich dietary patterns as biologically plausible strategies for promoting healthy aging through modulation of the gut microbiota; however, establishing causal relationships will require standardized microbiome methodologies, validated microbiome-derived biomarkers, integrated multi-omics approaches, and adequately powered longitudinal studies and randomized controlled trials. |
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| Grant Information: | TKP2021-NKTA-47 Ministry of Innovation and Technology; RRF-2.3.1-21-2022-00003 Ministry of Innovation and Technology; No. 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1 European University for Well-Being (EUniWell) program; the Cooperative Translational Research Program (KTKP) the Faculty of Medicine, Semmelweis University |
| Contributed Indexing: | Keywords: dietary fiber; geroscience; gut microbiota; gut–brain axis; gut–muscle axis; healthy aging; immunosenescence; inflammaging; longevity; polyphenols; short-chain fatty acids |
| Substance Nomenclature: | 0 (Polyphenols) 0 (Dietary Fiber) |
| Entry Date(s): | Date Created: 20260813 Date Completed: 20260813 Latest Revision: 20260815 |
| Update Code: | 20260815 |
| PubMed Central ID: | PMC13468338 |
| DOI: | 10.3390/nu18152478 |
| PMID: | 42588100 |
| Βάση Δεδομένων: | MEDLINE |
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