Academic Journal
Gut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience.
| Title: | Gut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience. |
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| Authors: | Kryczyk-Poprawa A; Department of Inorganic Chemistry and Pharmaceutical Analytics, Faculty of Pharmacy, Jagiellonian University Medical College, 31-008 Krakow, Poland., Rząsa-Duran E; Branch in Krakow-Hospital Pharmacy, Maria Sklodowska-Curie National Research Institute of Oncology, Garncarska 11 Str., 31-115 Krakow, Poland., Varga JT; Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary., Lehoczki A; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Zábó V; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Fazekas-Pongor V; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Major D; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Csípő T; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Szappanos Á; Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary., Lipécz Á; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary., Fekete M; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary. |
| Source: | Nutrients [Nutrients] 2026 Jul 31; Vol. 18 (15). Date of Electronic Publication: 2026 Jul 31. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI Publishing |
| MeSH Terms: | Polyphenols*/pharmacology , Polyphenols*/administration & dosage , Dietary Fiber*/administration & dosage , Dietary Fiber*/pharmacology , Gastrointestinal Microbiome*/physiology , Gastrointestinal Microbiome*/drug effects , Healthy Aging*/physiology , Geroscience*, Humans ; Aging ; Animals |
| Abstract: | Age-related alterations in the gut microbiota contribute to chronic low-grade inflammation, immune dysregulation, metabolic dysfunction, frailty, sarcopenia, and cognitive decline. Dietary polyphenols and fermentable fiber modulate microbial composition and metabolism, promoting the production of bioactive metabolites, including short-chain fatty acids, secondary bile acids, indole derivatives, and urolithins, which regulate intestinal barrier integrity, immune homeostasis, mitochondrial function, and gut-organ communication. This narrative review critically synthesizes evidence from experimental studies, observational cohorts, randomized controlled trials, systematic reviews, and meta-analyses to examine microbiota-mediated mechanisms linking these dietary components to healthy aging within the geroscience framework. Although mechanistic evidence is compelling, translation into clinically meaningful aging outcomes remains limited because most intervention studies are small and heterogeneous and primarily rely on surrogate biomarkers. Current evidence supports polyphenol- and fiber-rich dietary patterns as biologically plausible strategies for promoting healthy aging through modulation of the gut microbiota; however, establishing causal relationships will require standardized microbiome methodologies, validated microbiome-derived biomarkers, integrated multi-omics approaches, and adequately powered longitudinal studies and randomized controlled trials. |
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| Grant Information: | TKP2021-NKTA-47 Ministry of Innovation and Technology; RRF-2.3.1-21-2022-00003 Ministry of Innovation and Technology; No. 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1 European University for Well-Being (EUniWell) program; the Cooperative Translational Research Program (KTKP) the Faculty of Medicine, Semmelweis University |
| Contributed Indexing: | Keywords: dietary fiber; geroscience; gut microbiota; gut–brain axis; gut–muscle axis; healthy aging; immunosenescence; inflammaging; longevity; polyphenols; short-chain fatty acids |
| Substance Nomenclature: | 0 (Polyphenols) 0 (Dietary Fiber) |
| Entry Date(s): | Date Created: 20260813 Date Completed: 20260813 Latest Revision: 20260815 |
| Update Code: | 20260815 |
| PubMed Central ID: | PMC13468338 |
| DOI: | 10.3390/nu18152478 |
| PMID: | 42588100 |
| Database: | MEDLINE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=20726643&ISBN=&volume=18&issue=15&date=20260731&spage=&pages=&title=Nutrients&atitle=Gut%20Microbiota-Targeted%20Nutrition%20for%20Healthy%20Aging%3A%20Mechanistic%20Roles%20of%20Polyphenols%20and%20Dietary%20Fiber%20in%20Geroscience.&aulast=Kryczyk-Poprawa%20A&id=DOI:10.3390/nu18152478 Name: Full Text Finder (for New FTF UI) (ns324271) Category: fullText Text: Full Text Finder MouseOverText: Full Text Finder |
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| Header | DbId: cmedm DbLabel: MEDLINE An: 42588100 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Gut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kryczyk-Poprawa+A%22">Kryczyk-Poprawa A</searchLink>; Department of Inorganic Chemistry and Pharmaceutical Analytics, Faculty of Pharmacy, Jagiellonian University Medical College, 31-008 Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Rząsa-Duran+E%22">Rząsa-Duran E</searchLink>; Branch in Krakow-Hospital Pharmacy, Maria Sklodowska-Curie National Research Institute of Oncology, Garncarska 11 Str., 31-115 Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Varga+JT%22">Varga JT</searchLink>; Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Lehoczki+A%22">Lehoczki A</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Zábó+V%22">Zábó V</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Fazekas-Pongor+V%22">Fazekas-Pongor V</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Major+D%22">Major D</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Csípő+T%22">Csípő T</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Szappanos+Á%22">Szappanos Á</searchLink>; Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Lipécz+Á%22">Lipécz Á</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Fekete+M%22">Fekete M</searchLink>; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.; Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101521595%22">Nutrients</searchLink> [Nutrients] 2026 Jul 31; Vol. 18 (15). <i>Date of Electronic Publication: </i>2026 Jul 31. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Review – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+Publishing%22">MDPI Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101521595 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2072-6643 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220726643%22">20726643 </searchLink><i>NLM ISO Abbreviation: </i>Nutrients <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Original Publication</i>: Basel, Switzerland : MDPI Publishing – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Polyphenols%22">Polyphenols*</searchLink>/<searchLink fieldCode="MM" term="%22Polyphenols+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Polyphenols%22">Polyphenols*</searchLink>/<searchLink fieldCode="MM" term="%22Polyphenols+administration+%26+dosage%22">administration & dosage</searchLink> <br /><searchLink fieldCode="MM" term="%22Dietary+Fiber%22">Dietary Fiber*</searchLink>/<searchLink fieldCode="MM" term="%22Dietary+Fiber+administration+%26+dosage%22">administration & dosage</searchLink> <br /><searchLink fieldCode="MM" term="%22Dietary+Fiber%22">Dietary Fiber*</searchLink>/<searchLink fieldCode="MM" term="%22Dietary+Fiber+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Gastrointestinal+Microbiome%22">Gastrointestinal Microbiome*</searchLink>/<searchLink fieldCode="MM" term="%22Gastrointestinal+Microbiome+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Gastrointestinal+Microbiome%22">Gastrointestinal Microbiome*</searchLink>/<searchLink fieldCode="MM" term="%22Gastrointestinal+Microbiome+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Healthy+Aging%22">Healthy Aging*</searchLink>/<searchLink fieldCode="MM" term="%22Healthy+Aging+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Geroscience%22">Geroscience*</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Aging%22">Aging</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Age-related alterations in the gut microbiota contribute to chronic low-grade inflammation, immune dysregulation, metabolic dysfunction, frailty, sarcopenia, and cognitive decline. Dietary polyphenols and fermentable fiber modulate microbial composition and metabolism, promoting the production of bioactive metabolites, including short-chain fatty acids, secondary bile acids, indole derivatives, and urolithins, which regulate intestinal barrier integrity, immune homeostasis, mitochondrial function, and gut-organ communication. This narrative review critically synthesizes evidence from experimental studies, observational cohorts, randomized controlled trials, systematic reviews, and meta-analyses to examine microbiota-mediated mechanisms linking these dietary components to healthy aging within the geroscience framework. Although mechanistic evidence is compelling, translation into clinically meaningful aging outcomes remains limited because most intervention studies are small and heterogeneous and primarily rely on surrogate biomarkers. Current evidence supports polyphenol- and fiber-rich dietary patterns as biologically plausible strategies for promoting healthy aging through modulation of the gut microbiota; however, establishing causal relationships will require standardized microbiome methodologies, validated microbiome-derived biomarkers, integrated multi-omics approaches, and adequately powered longitudinal studies and randomized controlled trials. – Name: Ref Label: References Group: RefInfo Data: Cells. 2022 Jan 21;11(3):. (PMID: <searchLink fieldCode="PM" term="%2235159168%22">35159168)</searchLink><br />Nutrients. 2024 May 29;16(11):. (PMID: <searchLink fieldCode="PM" term="%2238892628%22">38892628)</searchLink><br />Int J Mol Sci. 2025 Sep 09;26(18):. (PMID: <searchLink fieldCode="PM" term="%2241009354%22">41009354)</searchLink><br />Int J Tryptophan Res. 2020 Jun 11;13:1178646920928984. (PMID: <searchLink fieldCode="PM" term="%2232577079%22">32577079)</searchLink><br />Nutrients. 2025 Sep 12;17(18):. 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(PMID: <searchLink fieldCode="PM" term="%2236981235%22">36981235)</searchLink> – Name: GrantInfo Label: Grant Information Group: Grant Data: TKP2021-NKTA-47 Ministry of Innovation and Technology; RRF-2.3.1-21-2022-00003 Ministry of Innovation and Technology; No. 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1 European University for Well-Being (EUniWell) program; the Cooperative Translational Research Program (KTKP) the Faculty of Medicine, Semmelweis University – Name: SubjectMinor Label: Contributed Indexing Group: Data: <i>Keywords: </i>dietary fiber; geroscience; gut microbiota; gut–brain axis; gut–muscle axis; healthy aging; immunosenescence; inflammaging; longevity; polyphenols; short-chain fatty acids – Name: NumberCAS Label: Substance Nomenclature Group: ID Data: 0 (Polyphenols)<br />0 (Dietary Fiber) – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20260813 <i>Date Completed: </i>20260813 <i>Latest Revision: </i>20260815 – Name: DateUpdate Label: Update Code Group: Date Data: 20260815 – Name: PubmedCentralID Label: PubMed Central ID Group: ID Data: PMC13468338 – Name: DOI Label: DOI Group: ID Data: 10.3390/nu18152478 – Name: AN Label: PMID Group: ID Data: 42588100 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nu18152478 Languages: – Code: eng Text: English Subjects: – SubjectFull: Humans Type: general – SubjectFull: Aging Type: general – SubjectFull: Animals Type: general – SubjectFull: Polyphenols pharmacology Type: general – SubjectFull: Polyphenols administration & dosage Type: general – SubjectFull: Dietary Fiber administration & dosage Type: general – SubjectFull: Dietary Fiber pharmacology Type: general – SubjectFull: Gastrointestinal Microbiome physiology Type: general – SubjectFull: Gastrointestinal Microbiome drug effects Type: general – SubjectFull: Healthy Aging physiology Type: general – SubjectFull: Geroscience Type: general Titles: – TitleFull: Gut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kryczyk-Poprawa A – PersonEntity: Name: NameFull: Rząsa-Duran E – PersonEntity: Name: NameFull: Varga JT – PersonEntity: Name: NameFull: Lehoczki A – PersonEntity: Name: NameFull: Zábó V – PersonEntity: Name: NameFull: Fazekas-Pongor V – PersonEntity: Name: NameFull: Major D – PersonEntity: Name: NameFull: Csípő T – PersonEntity: Name: NameFull: Szappanos Á – PersonEntity: Name: NameFull: Lipécz Á – PersonEntity: Name: NameFull: Fekete M IsPartOfRelationships: – BibEntity: Dates: – D: 31 M: 07 Text: 2026 Jul 31 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2072-6643 Numbering: – Type: volume Value: 18 – Type: issue Value: 15 Titles: – TitleFull: Nutrients Type: main |
| ResultId | 1 |