Academic Journal
Recent Advances in Fluorescent Sensors for On-Site Forensic Analysis.
| Τίτλος: | Recent Advances in Fluorescent Sensors for On-Site Forensic Analysis. |
|---|---|
| Συγγραφείς: | Wang Q; Yunnan Police College, Kunming, China.; Key Laboratory of Smart Drug Control, Ministry of Education, Kunming, China.; Key Laboratory of Drug Analysis and Anti-Drug Technology, Ministry of Public Security, Kunming, China.; Key Laboratory of Smart Drug Control of Yunnan Province, Kunming, China., Liu X; Yunnan Police College, Kunming, China.; Key Laboratory of Smart Drug Control, Ministry of Education, Kunming, China.; Key Laboratory of Drug Analysis and Anti-Drug Technology, Ministry of Public Security, Kunming, China.; Key Laboratory of Smart Drug Control of Yunnan Province, Kunming, China., Yang L; Yunnan Police College, Kunming, China.; Key Laboratory of Smart Drug Control, Ministry of Education, Kunming, China.; Key Laboratory of Drug Analysis and Anti-Drug Technology, Ministry of Public Security, Kunming, China.; Key Laboratory of Smart Drug Control of Yunnan Province, Kunming, China., Yin Q; Yunnan Police College, Kunming, China.; Key Laboratory of Smart Drug Control, Ministry of Education, Kunming, China.; Key Laboratory of Drug Analysis and Anti-Drug Technology, Ministry of Public Security, Kunming, China.; Key Laboratory of Smart Drug Control of Yunnan Province, Kunming, China. |
| Πηγή: | Luminescence : the journal of biological and chemical luminescence [Luminescence] 2026 Aug; Vol. 41 (8), pp. e70598. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley & Sons Country of Publication: England NLM ID: 100889025 Publication Model: Print Cited Medium: Internet ISSN: 1522-7243 (Electronic) Linking ISSN: 15227235 NLM ISO Abbreviation: Luminescence Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Chichester, Sussex, UK : Wiley & Sons, c1999- |
| Ιατρικοί όροι (MeSH): | Fluorescent Dyes*/chemistry , Illicit Drugs*/analysis , Forensic Sciences*, Explosive Agents/analysis ; Humans ; Fluorescence |
| Περίληψη: | Fluorescent sensors have become essential tools for achieving on-site detection in forensic science owing to their inherently high sensitivity and specificity. In recent years, with the continuous advancement of science and technology, the application of fluorescent sensing technology in the forensic field has been significantly enhanced. It has demonstrated particularly promising prospects in the detection of illicit drugs and toxicological substances, the analysis of gunshot and explosive residues, as well as the detection of latent fingerprints. However, substantial challenges remain in several key areas, including structural sensor design, signal amplification technologies, simultaneous multitarget detection, and the further miniaturization and intelligentization of fluorescent devices. This paper systematically reviews the latest research progress of fluorescent sensors in forensic science reported in recent years. Furthermore, it explores the development trends of fluorescent sensing technology for on-site forensic detection. The aim of this review is to provide a comprehensive reference for the future development of fluorescent sensors characterized by high targeting capability, low background interference, exceptional portability, and advanced intelligence. (© 2026 John Wiley & Sons Ltd.) |
| References: | A. E. Cozens, S. D. Johnson, and T. C. Lee, “A Systematic Review of Sensors to Combat Crime and Routes to Further Sensor Development,” Frontiers in Chemistry 13 (2025): 1568867. L. S. De Azevedo, A. S. Castro, D. V. Buchaim, et al., “Chemical Analysis of Gunshot Residues (GSR): Historical Evolution, Forensic Relevance, Technological Advances, and Contemporary Challenges,” AIMS Bioengineering 12, no. 4 (2025): 593–612. L. McNeill, D. Megson, P. E. Linton, et al., “Lab‐on‐a‐Chip Approaches for the Detection of Controlled Drugs, Including New Psychoactive Substances: A Systematic Review,” Forensic Chemistry 26 (2021): 100370. Q. Abuhassan, A. Aldulaimi, O. S. Waleed, et al., “Nanomaterial‐Based Sensors for Methamphetamine Detection: Advances, Challenges, and Forensic Applications,” Sensor Review (2026): 1–19, https://doi.org/10.1108/SR‐11‐2025‐0925. S. O. Fakayode, C. Lisse, W. Medawala, et al., “Fluorescent Chemical Sensors: Applications in Analytical, Environmental, Forensic, Pharmaceutical, Biological, and Biomedical Sample Measurement, and Clinical Diagnosis,” Applied Spectroscopy Reviews 59, no. 1 (2024): 1–89. S. Rasheed, M. Ikram, D. Ahmad, M. N. Abbas, and M. Shafique, “Advancements in Colorimetric and Fluorescent‐Based Sensing Approaches for Point‐of‐Care Testing in Forensic Sample Analysis,” Microchemical Journal 206 (2024): 111438. R. Huang, T. Liu, H. Peng, et al., “Molecular Design and Architectonics Towards Film‐Based Fluorescent Sensing,” Chemical Society Reviews 53, no. 13 (2024): 6960–6991. Q. Li, W. Zhang, X. Liu, and H. Zhang, “Preparation of Complex Biological Sample‐Compatible “Turn‐On”‐Type Ratiometric Fluorescent Molecularly Imprinted Polymer Microspheres via One‐Pot Surface‐Initiated ATRP,” Mikrochimica Acta 189, no. 12 (2022): 464. Z. He, X. Zheng, R. Liu, et al., “Recent Advances in HPV Detection: From Traditional Methods to Nanotechnology and the Application of Quantum Dots,” International Journal of Nanomedicine 20 (2025): 6333–6356. S. Chen, S. Zhou, J. Fu, et al., “A Near Infrared Fluorescence Imprinted Sensor Based on Zinc Oxide Nanorods for Rapid Determination of Ketoprofen,” Analytical Methods 13, no. 25 (2021): 2836–2846. X. Liu, L. Tian, R. Ren, T. Wang, and Y. Wang, “Constructing Hollow ZIF‐8/CDs@MIPs Fluorescent Sensor From Osmanthus Leaves to Specifically Recognize Bovine Hemoglobin,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 287 (2023): 122121. Z. Xu, H. Zhou, L. Li, et al., “Immunoassay System Based on the Technology of Time‐Resolved Fluorescence Resonance Energy Transfer,” Sensors (Basel) 24, no. 5 (2024): 1430. A. Bilgic and A. Cimen, “Two Novel BODIPY‐Functional Magnetite Fluorescent Nano‐Sensors for Detecting of Cr(VI) Ions in Aqueous Solutions,” Journal of Fluorescence 30, no. 4 (2020): 867–881. J. Krämer, R. Kang, L. M. Grimm, L. de Cola, P. Picchetti, and F. Biedermann, “Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids,” Chemical Reviews 122, no. 3 (2022): 3459–3636. J. Wang, L. K. Gil‐Herrera, O. Akbulut, and A. G. Dumanli, “Investigating the Fluorescence in C‐Dots Immobilised on Alginate Hydrogels—A Study on Diffusion Kinetics and Adsorption Mechanisms,” RSC Advances 15, no. 21 (2025): 16281–16291. X. Zhu, Y. Li, P. Cao, et al., “Recent Advances of Graphene Quantum Dots in Chemiresistive Gas Sensors,” Nanomaterials (Basel) 13, no. 21 (2023): 2880. M. S. Dar and N. K. Sahu, “Graphene Quantum Dot‐Crafted Nanocomposites: Shaping the Future Landscape of Biomedical Advances,” Discover Nano 19, no. 1 (2024): 79. Y. Luo, C. Cui, X. Zhang, et al., “Carbon Dots‐Based Fluorescence Assay for the Facile and Reliable Detection of Ag+ in Natural Water and Serum Samples,” Molecules 28, no. 4 (2023): 1566. J. Yan, S. Liu, D. Sun, et al., “Molecularly Imprinted Ratiometric Fluorescent Sensors for Analysis of Pharmaceuticals and Biomarkers,” Sensors (Basel) 24, no. 21 (2024): 7068. D. Svechkarev, M. R. Sadykov, K. W. Bayles, and A. M. Mohs, “Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis,” ACS Sensors 3, no. 3 (2018): 700–708. W. Liu, Y. Ren, X. Song, X. Li, and J. Wang, “High‐Sensitively Fluorescent Switch‐Type Sensing for Ag+ and Halide Anions of 2D Cd‐Based Network Constructed With Logic Gates,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 315 (2024): 124260. S. Takada, N. Kondo, M. Hagimori, and T. Temma, “Development of a Switching‐Type Fluorescence Sensor for the Detection of Boronic Acid‐Containing Agents,” Analytical Sciences 38, no. 10 (2022): 1289–1296. Z. Wang, Y. Tong, B. Liu, C. Dong, J. Yan, and W. Niu, “A Novel Label‐Free Carbon Dots‐Based Fluorescent Aptamer Sensor for the Detection of Fentanyl,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 340 (2025): 126338. M. P. Chantada‐Vázquez, J. Sánchez‐González, E. Peña‐Vázquez, et al., “Synthesis and Characterization of Novel Molecularly Imprinted Polymer‐Coated Mn‐Doped ZnS Quantum Dots for Specific Fluorescent Recognition of Cocaine,” Biosensors & Bioelectronics 75 (2016): 213–221. D. Peng and Z. Zhao, “Highly Efficient Ferric Ion Sensing and High Resolution Latent Fingerprint Imaging Based on Fluorescent Silicon Quantum Dots,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 299 (2023): 122827. N. K. B. Lotey, R. Lemos, F. D'Silva, et al., “Highly Fluorescent Bio‐Synthesized Carbon Quantum Dots for Latent Fingerprint Detection,” Journal of Fluorescence 35, no. 1 (2025): 1–12. L. Yang, Z. Fu, J. Xie, and Z. Ding, “Portable Sensing of Hydrogen Peroxide Using MOF‐Based Nanozymes,” Food Research International 197 (2024): 115272. H. Q. Yuan, Y. Yuan, S. Y. Liu, et al., “Simultaneous and Instrument‐Free Detection of Quinine and Crystal Violet Based on a Dual‐Emissive Eu3+‐Functionalized Metal‐Organic Framework,” Journal of Hazardous Materials 489 (2025): 137458. M. Masteri‐Farahani, S. Mashhadi‐Ramezani, and N. Mosleh, “Molecularly Imprinted Polymer Containing Fluorescent Graphene Quantum Dots as a New Fluorescent Nanosensor for Detection of Methamphetamine,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 229 (2020): 118021. R. Hu, Y. Yan, L. Jiang, C. Huang, and X. Shen, “Determination of Total Cathinones With a Single Molecularly Imprinted Fluorescent Sensor Assisted by Electromembrane Microextraction,” Mikrochimica Acta 189, no. 9 (2022): 324. Y. Yan, L. Jiang, S. Zhang, X. Shen, and C. Huang, “Specific “Light‐Up” Sensor Made Easy: An Aggregation Induced Emission Monomer for Molecular Imprinting,” Biosensors & Bioelectronics 205 (2022): 114113. J. Miao, J. Yu, X. Zhao, et al., “Molecular Imprinting‐Based Triple‐Emission Ratiometric Fluorescence Sensor With Aggregation‐Induced Emission Effect for Visual Detection of Doxycycline,” Journal of Hazardous Materials 470 (2024): 134218. J. Dong, C. Zhao, J. Ning, Y. Liu, and X. Dou, “Noncovalent Interaction‐Based Probe Design for PET‐Facilitated Fluorescence Sensing of Synthetic Cannabinoids,” ACS Omega 10, no. 14 (2025): 14306–14315. E. G. Shcherbakova, B. Zhang, S. Gozem, et al., “Supramolecular Sensors for Opiates and Their Metabolites,” Journal of the American Chemical Society 139, no. 42 (2017): 14954–14960. Y. Wang, Z. Wang, Y. Tong, et al., “Aptamer‐Based Fluorescent Sensor for Highly Sensitive Detection of Methamphetamine,” Luminescence 39, no. 2 (2024): e4687. C. Ma, Y. Zhang, and Y. Zhang, “Aptamer‐Controlled Gold Nanozyme Sensor for Fluorescent and Colorimetric Dual‐Channel Detection of Methamphetamine,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 323 (2024): 124883. S. Chen, W. Zhou, and M. Lai, “Synthetic Cathinones: Epidemiology, Toxicity, Potential for Abuse, and Current Public Health Perspective,” Brain Sciences 14, no. 4 (2024): 334. Y. Lin, Y. Li, H. Chang, et al., “Rapid Testing of Δ9‐Tetrahydrocannabinol and Its Metabolite On‐Site Using a Label‐Free Ratiometric Fluorescence Assay on a Smartphone,” Analytical Chemistry 95, no. 18 (2023): 7363–7371. Z. Fan, X. Cai, X. Xu, et al., “Development of a Rapid Time‐Resolved Fluorescence Immunoassay for Cannabidiol Quantification in Cannabis sativa L,” Industrial Crops and Products 226 (2025): 120626. J. Canoura, T. Nguyen, C. Byrd, R. Hill, Y. Liu, and Y. Xiao, “Generation of High‐Affinity Aptamers for Indazole Synthetic Cannabinoids,” Analytical Chemistry 96, no. 28 (2024): 11488–11497. Y. Wang, J. Dong, Y. Liu, L. Liang, Y. du, and X. Dou, “Zinc(II)‐Enhanced Excimer Probe for Recognition of MDMB‐CA Synthetic Cannabinoids,” Angewandte Chemie, International Edition 64, no. 17 (2025): e202423576. Z. Wu, H. Zhou, Q. Han, X. Lin, D. Han, and X. Li, “A Cost‐Effective Fluorescence Biosensor for Cocaine Based on a “Mix‐and‐Detect” Strategy,” Analyst 145, no. 13 (2020): 4664–4670. J. Guo, S. Tian, K. Liu, and J. Guo, “IoT‐Enabled Fluorescence Sensor for Quantitative KET Detection and Anti‐Drug Situational Awareness,” IEEE Transactions on Nanobioscience 20, no. 1 (2021): 2–8. A. E. Barber, H. Hodges, S. E. G. Porter, E. Richardson, K. Rowland, and A. Soles, “Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue,” Journal of Visualized Experiments 147 (2019): e59471. D. Dey, A. Dhaka, H. K. Pratihari, S. A. Hussain, and A. Datta Roy, “Sensing of Gunshot Residue Components From Real Sample Using Fluorescence Resonance Energy Transfer,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 319 (2024): 124512. M. Bener, F. Burak Şen, and R. Apak, “Protamine Gold Nanoclusters‐Based Fluorescence Turn‐On Sensor for Rapid Determination of Trinitrotoluene (TNT),” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 279 (2022): 121462. F. B. Şen, M. Bener, and R. Apak, “A Simple Determination of Trinitrotoluene (TNT) Based on Fluorescence Quenching of Rhodamine 110 With FRET Mechanism,” Journal of Fluorescence 31, no. 4 (2021): 989–997. F. B. Şen, N. Beğiç, M. Bener, and R. Apak, “Fluorescence Turn‐Off Sensing of TNT by Polyethylenimine Capped Carbon Quantum Dots,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 271 (2022): 120884. R. Batool, N. Riaz, H. M. Junaid, et al., “Fluorene‐Based Fluorometric and Colorimetric Conjugated Polymers for Sensitive Detection of 2,4,6‐Trinitrophenol Explosive in Aqueous Medium,” ACS Omega 7, no. 1 (2021): 1057–1070. S. M. Anju, R. K. Anjana, N. S. Vijila, et al., “Tb‐Doped BSA‐Gold Nanoclusters as a Bimodal Probe for the Selective Detection of TNT,” Analytical and Bioanalytical Chemistry 412, no. 17 (2020): 4165–4172. Y. H. Chen, S. Y. Kuo, W. K. Tsai, et al., “Dual Colorimetric and Fluorescent Imaging of Latent Fingerprints on Both Porous and Nonporous Surfaces With Near‐Infrared Fluorescent Semiconducting Polymer Dots,” Analytical Chemistry 88, no. 23 (2016): 11616–11623. X. Cui, T. Lei, J. Zhang, et al., “Smartphone‐Assisted Miniature Device Based on Nitrogen and Sulfur Co‐Doped Carbon Dots for Point‐of‐Care Testing of Tetracycline,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 283 (2022): 121727. L. Guo, Y. Zhang, L. Du, et al., “Development of an Accurate Hand‐Held Sensing Platform for Nitrite Detection Based on Nitrogen‐Doped Carbon Dots,” Talanta 278 (2024): 126527. X. Ma, W. Sun, F. Gao, et al., “Smartphone‐Assisted Film Fluorescent Sensor for Quantitative and Visual Detection of Fluoride Ions,” Chemistry, an Asian Journal 20 (2025): e202500533. L. Guo, L. Du, Y. Zhang, et al., “Development of an Accurate Synchronous Transport Signal Hand‐Held Sensing Platform for Fluorescence‐Based Berberine On‐Site Detection,” Analytica Chimica Acta 1331 (2024): 343304. H. Ruan, Y. Yu, J. Xie, L. Zhou, and Y. Li, “Fluorescent Sulfur Quantum Dot Reinforced PVA Hydrogel With Integrated Self‐Powered Sensing and Triboelectric Energy Harvesting for Wireless Motion Monitoring,” ACS Applied Nano Materials 8 (2025): 1234–1245. W. Xu, M. Althumayri, A. Y. Tarman, and H. Ceylan Koydemir, “An Integrated Wearable Fluorescence Sensor for E. coli Detection in Catheter Bags,” Biosensors & Bioelectronics 260 (2025): 117539. Y. Qin, Q. Guo, W. Han, et al., “Photonic Olfactory Sensors Enabling Efficient Recognition of Volatile Industrial Fragrances,” Advanced Optical Materials 13 (2025): 2401205. M. H. Hu, J. Zhou, W. H. Luo, et al., “Development of a Smart Fluorescent Sensor That Specifically Recognizes the c‐MYC G‐Quadruplex,” Analytical Chemistry 91, no. 3 (2019): 2480–2487. J. Yan, Q. Fu, S. Zhang, et al., “A Sensitive Ratiometric Fluorescent Sensor Based on Carbon Dots and CdTe Quantum Dots for Visual Detection of Biogenic Amines in Food Samples,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 282 (2022): 121706. J. Palma‐Roldán, V. Román‐Pizarro, M. Á. García‐Granados, J. M. Fernández‐Romero, and Á. Écija‐Arenas, “Application of Magneto‐Luminescent Gold Nanoclusters With Microfluidic Systems to the Determination Analysis of Tetracyclines,” Mikrochimica Acta 192, no. 8 (2025): 545. X. Li, C. Hao, J. Wei, et al., “A Sensitive Sensor for Silver Ion Detection Based on FRET and Microfluidic Chip Using a Dual‐Color Fluorescence Strategy,” ACS Applied Nano Materials 8 (2025): 2345–2356. Y. Wu, X. Xu, Y. Zhu, et al., “Research Progress on Multiplexed Pathogen Detection Using Optical Biosensors,” Biosensors 15, no. 6 (2025): 378. S. Liu, J. Zhao, J. Wu, et al., “A Microfluidic Paper‐Based Fluorescent Sensor Integrated With a Smartphone Platform for Rapid On‐Site Detection of Omethoate Pesticide,” Food Chemistry 463 (2025): 141205. G. Han, J. Cai, L. Yang, X. Li, and X. Wang, “Fluorescent Paper Based on CQDs/Rhodamine B: A Ratio and Sensitive Detection Platform for On‐Site Fe3+ Sensing,” Molecules 29, no. 7 (2024): 1658. |
| Grant Information: | ZHJDNB202304 Open Fund Project of Key Laboratory of Smart Drug Control; 202523001034ZR-005 Yunnan Police College's scientific research project "230 Scientific Research"; 202523001034ZR-009 Yunnan Police College's scientific research project "230 Scientific Research" |
| Contributed Indexing: | Keywords: fluorescent sensors; forensic science; gunshot residue; illicit drugs and toxicological substances; on‐site detection |
| Substance Nomenclature: | 0 (Fluorescent Dyes) 0 (Illicit Drugs) 0 (Explosive Agents) |
| Entry Date(s): | Date Created: 20260812 Date Completed: 20260812 Latest Revision: 20260816 |
| Update Code: | 20260817 |
| PubMed Central ID: | PMC13463209 |
| DOI: | 10.1002/bio.70598 |
| PMID: | 42583700 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!