Academic Journal
Approaching a connectome of the human foveal retina.
| Τίτλος: | Approaching a connectome of the human foveal retina. |
|---|---|
| Συγγραφείς: | Kim YJ; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA 98195., Packer O; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA 98195., Macrina T; Zetta AI, Sherrill, NY 13461., Pollreisz A; Department of Ophthalmology, Medical University of Vienna, Vienna 1090, Austria., Curcio CA; Department of Ophthalmology and Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294., Lee K; Zetta AI, Sherrill, NY 13461., Kemnitz N; Zetta AI, Sherrill, NY 13461., Ih D; Zetta AI, Sherrill, NY 13461., Nguyen T; Zetta AI, Sherrill, NY 13461., Lu R; Zetta AI, Sherrill, NY 13461., Popovych S; Zetta AI, Sherrill, NY 13461., Halageri A; Zetta AI, Sherrill, NY 13461., Bae JA; Zetta AI, Sherrill, NY 13461., Strout J; Zetta AI, Sherrill, NY 13461., Gerhard S; Aware LLC, Effretikon 8307, Switzerland., Smith RG; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104., Martin PR; Faculty of Medicine and Health, Save Sight Institute and Discipline of Ophthalmology, The University of Sydney, Sydney, NSW 2000, Australia., Grünert U; Faculty of Medicine and Health, Save Sight Institute and Discipline of Ophthalmology, The University of Sydney, Sydney, NSW 2000, Australia., Dacey DM; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA 98195.; Washington National Primate Research Center, Seattle, WA 98195. |
| Πηγή: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Aug 18; Vol. 123 (33), pp. e2603286123. Date of Electronic Publication: 2026 Aug 11. |
| Τύπος έκδοσης: | Journal Article; Research Support, N.I.H., Extramural |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : National Academy of Sciences |
| Ιατρικοί όροι (MeSH): | Connectome*/methods , Fovea Centralis*/physiology , Fovea Centralis*/cytology, Retinal Ganglion Cells/physiology ; Retinal Ganglion Cells/cytology ; Synapses/physiology ; Retina/physiology ; Humans ; Animals |
| Περίληψη: | The foveal retina is a unique primate specialization and a promising target for the first connectome of a human central nervous system structure. In the fovea, neural cells and circuits are miniaturized and compressed to sample the visual image at high spatial resolution, initiating form, color, and motion perception. Here, we report a working-draft human foveal connectome. We used deep learning to segment all cells and their synaptic connections in a piece of human fovea. We classified ~3,000 cells into 51 neuronal types and three glial types based on morphology and connectivity. Some cell types and synaptic motifs-including the midget and small bistratified ganglion cell circuits-are conserved between human and nonhuman primates. However, most other cell types and related synaptic connectivity remain unexplored. We find that in comparison to peripheral retina, the human foveal retina shows reduced cell type diversity with markedly unequal densities and distinct patterns of synaptic connectivity. For example, foveal H1 horizontal cells are present at high density relative to H2 cells and receive unexpected synaptic input from S cones, predicting fovea-specific chromatic properties of downstream receptive fields. Retinal ganglion cells could be divided into only 13 types-a contrast to the ~20 types in peripheral retina and the 40+ types recognized in mouse retina-but consistent with recent transcriptomic studies of human fovea. These findings support the hypothesis that the human fovea has traded a repertoire of feature detectors for high-precision, saccade-supported active vision centered around a small number of high-density visual pathways. |
| Competing Interests: | Competing interests statement:T.M., K.L., N.K., D.I., T.N., R.L., S.P., A.H., J.A.B., and J.S. declare financial interests in Zetta AI. S.G. is owner of Aware LLC and developed the NeuroMaps.app. The remaining authors declare no competing interests. |
| Σχόλια: | Update of: bioRxiv. 2026 Jan 28:2025.04.05.647403. doi: 10.1101/2025.04.05.647403.. (PMID: 40799563) Update of: Res Sq. 2025 Aug 20:rs.3.rs-7312705. doi: 10.21203/rs.3.rs-7312705/v1.. (PMID: 40894061) |
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| Grant Information: | P51 OD010425 United States OD NIH HHS; RF1-MH129260 HHS | NIH (NIH); R01 EY028282 United States EY NEI NIH HHS; P30 EY001730 United States EY NEI NIH HHS; EY-028282 HHS | NIH (NIH); RF1 MH129260 United States MH NIMH NIH HHS |
| Contributed Indexing: | Keywords: color vision; connectomics; foveal retina; human vision; neural circuitry |
| Entry Date(s): | Date Created: 20260811 Date Completed: 20260811 Latest Revision: 20260825 |
| Update Code: | 20260825 |
| PubMed Central ID: | PMC13486570 |
| DOI: | 10.1073/pnas.2603286123 |
| PMID: | 42579483 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1091-6490 |
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| DOI: | 10.1073/pnas.2603286123 |