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Single-cell transcriptomic analysis of ferroptosis-associated cell populations in the progression of diabetic retinopathy.

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Τίτλος: Single-cell transcriptomic analysis of ferroptosis-associated cell populations in the progression of diabetic retinopathy.
Συγγραφείς: Duan BF; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China., Shao YN; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China., Mao ZQ; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China., Li XN; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China., Fan HM; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China., Cai Y; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China., Zheng HW; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China., Peng SJ; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China., You ZP; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China. yzp7477@163.com.
Πηγή: International ophthalmology [Int Ophthalmol] 2026 Aug 07; Vol. 46 (1). Date of Electronic Publication: 2026 Aug 07.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE
Imprint Name(s): Publication: Dordrecht : Kluwer
Original Publication: The Hague, Junk.
Ιατρικοί όροι (MeSH): Diabetic Retinopathy*/genetics , Diabetic Retinopathy*/metabolism , Diabetic Retinopathy*/pathology , Ferroptosis*/genetics , Gene Expression Profiling*/methods , Transcriptome* , Gene Expression Regulation*, Ependymoglial Cells/metabolism ; Ependymoglial Cells/pathology ; Animals ; Rats ; Disease Progression ; Single-Cell Gene Expression Analysis ; Single-Cell Analysis ; Diabetes Mellitus, Experimental ; Disease Models, Animal ; Rats, Sprague-Dawley ; Male
Περίληψη: Background: Diabetic retinopathy (DR), a common microvascular complication of diabetes mellitus, has been associated with ferroptosis-related pathological mechanisms. Evidence indicates that ferroptosis may contribute to retinal injury and disease progression. The present analysis aimed to characterize ferroptosis-associated cell subsets and their roles in the progression of DR.
Method: Single-cell RNA sequencing data derived from diabetic rat models of DR were obtained from the Gene Expression Omnibus database. A total of 464 ferroptosis-related genes were used to calculate ferroptosis scores. Data processing and analysis were performed using the Seurat R package, with differentially expressed genes identified via the FindAllMarkers function. Functional enrichment analyses were conducted using the clusterProfiler package. Protein-protein interaction networks were constructed using the STRING database, and intercellular communication was predicted using CellChat. Key findings were validated through reverse transcription quantitative polymerase chain reaction (RT-qPCR).
Results: Cell clustering identified nine principal retinal cell types. Compared with normal control groups, the DR group demonstrated altered proportions of Müller cells, vascular endothelial cells, microglia, and cone photoreceptor cells. Ferroptosis-score-related differences were most evident in Müller cells and rod cells. In the revised WT-baseline sensitivity analysis, the high-ratio ferroptosis-score cell distribution remained significantly altered in Rod and Müller cells after multiple-testing correction.
Conclusion: This study identified key ferroptosis-associated retinal cell populations, with an emphasis on the functional roles of ferroptosis-associated Müller cell subsets in the context of DR. These findings provide further insight into the cellular mechanisms underlying DR and highlight potential molecular targets for therapeutic intervention.
(© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
Competing Interests: Declarations. Ethics approval statement: This study received approval from the ethics committees of both the Affiliated Eye Hospital of Nanchang University (No. YLP20250123). Conflict of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References: Diabetes Metab Res Rev. 2003 Nov-Dec;19(6):442-55. (PMID: 14648803)
Prog Retin Eye Res. 2018 Mar;63:20-68. (PMID: 29126927)
Eye (Lond). 2010 Oct;24(10):1576-84. (PMID: 20508651)
Clin Diabetes. 2022 Spring;40(2):222-232. (PMID: 35669299)
Int J Mol Sci. 2018 Jan 01;19(1):. (PMID: 29301251)
Front Immunol. 2022 Nov 01;13:1039241. (PMID: 36389728)
Diabetes Res Clin Pract. 2017 Jun;128:40-50. (PMID: 28437734)
Exp Cell Res. 2024 Jun 1;439(1):114087. (PMID: 38735619)
Diabetol Metab Syndr. 2024 Feb 26;16(1):49. (PMID: 38409074)
J Inorg Biochem. 2021 Oct;223:111553. (PMID: 34340059)
Cells. 2022 Dec 31;12(1):. (PMID: 36611964)
Cell Physiol Biochem. 2018;48(2):705-717. (PMID: 30025404)
Bioengineered. 2022 Apr;13(4):10540-10551. (PMID: 35441580)
Matrix Biol. 2015 Sep;47:44-53. (PMID: 25960419)
Am J Pathol. 2024 Jun;194(6):1078-1089. (PMID: 38417697)
Cell Death Discov. 2022 Oct 25;8(1):426. (PMID: 36284090)
Neuron. 2012 Oct 18;76(2):266-80. (PMID: 23083731)
FEBS J. 2023 Feb;290(4):878-891. (PMID: 34923749)
Front Cell Dev Biol. 2021 Sep 27;9:732820. (PMID: 34646826)
Prog Retin Eye Res. 2016 Mar;51:156-86. (PMID: 26297071)
Antioxidants (Basel). 2023 Jun 10;12(6):. (PMID: 37371981)
Neural Regen Res. 2023 May;18(5):976-982. (PMID: 36254977)
Circulation. 2006 Aug 8;114(6):597-605. (PMID: 16894049)
Acta Diabetol. 2025 Jun;62(6):831-844. (PMID: 39508857)
Front Endocrinol (Lausanne). 2023 Sep 13;14:1234824. (PMID: 37772084)
Biomed Res Int. 2015;2015:854593. (PMID: 25866817)
J Biomed Sci. 2017 Jul 27;24(1):50. (PMID: 28750629)
OMICS. 2012 May;16(5):284-7. (PMID: 22455463)
Front Med (Lausanne). 2023 May 24;10:1195678. (PMID: 37293297)
Nat Protoc. 2025 Jan;20(1):180-219. (PMID: 39289562)
Ophthalmology. 2021 Aug;128(8):1169-1179. (PMID: 33359888)
Annu Rev Vis Sci. 2022 Sep 15;8:135-169. (PMID: 35385673)
Front Immunol. 2024 Jan 11;14:1288137. (PMID: 38274828)
Exp Eye Res. 2018 Nov;176:1-9. (PMID: 29944850)
Exp Diabetes Res. 2010;2010:. (PMID: 20827392)
Glia. 2002 Sep;39(3):292-303. (PMID: 12203395)
Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4457-64. (PMID: 14507893)
Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H238-46. (PMID: 19395553)
Prog Retin Eye Res. 2016 Mar;51:1-40. (PMID: 26113209)
Adv Sci (Weinh). 2025 Jun;12(22):e2416997. (PMID: 40279631)
Cleve Clin J Med. 2024 Aug 1;91(8):503-510. (PMID: 39089852)
Bioengineered. 2022 Apr;13(4):8240-8254. (PMID: 35302431)
Acta Histochem. 2017 Mar;119(2):142-149. (PMID: 28110937)
Ocul Immunol Inflamm. 2019;27(5):836-843. (PMID: 29608341)
Ir Med J. 2011 Feb;104(2):37. (PMID: 21465870)
Nucleic Acids Res. 2023 Jan 6;51(D1):D870-D876. (PMID: 36300619)
Annu Rev Neurosci. 2015 Jul 8;38:221-46. (PMID: 25897874)
Cell Metab. 2013 Mar 5;17(3):329-41. (PMID: 23473030)
Curr Pharm Des. 2018;24(40):4726-4741. (PMID: 30644339)
Grant Information: 82260212 the National Natural Science Foundation of China
Contributed Indexing: Keywords: Cell communication; Diabetic retinopathy; Differentially expressed genes; Ferroptosis; Single-cell analysis
Entry Date(s): Date Created: 20260807 Date Completed: 20260808 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1007/s10792-026-04197-2
PMID: 42568025
Βάση Δεδομένων: MEDLINE
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  Data: Single-cell transcriptomic analysis of ferroptosis-associated cell populations in the progression of diabetic retinopathy.
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  Data: <searchLink fieldCode="AU" term="%22Duan+BF%22">Duan BF</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Shao+YN%22">Shao YN</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Mao+ZQ%22">Mao ZQ</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Li+XN%22">Li XN</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Fan+HM%22">Fan HM</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Zheng+HW%22">Zheng HW</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Peng+SJ%22">Peng SJ</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22You+ZP%22">You ZP</searchLink>; The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, 463 Bayi Road, Nanchang, 330006, Jiangxi, China. yzp7477@163.com.
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  Data: <searchLink fieldCode="MM" term="%22Diabetic+Retinopathy%22">Diabetic Retinopathy*</searchLink>/<searchLink fieldCode="MM" term="%22Diabetic+Retinopathy+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Diabetic+Retinopathy%22">Diabetic Retinopathy*</searchLink>/<searchLink fieldCode="MM" term="%22Diabetic+Retinopathy+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Diabetic+Retinopathy%22">Diabetic Retinopathy*</searchLink>/<searchLink fieldCode="MM" term="%22Diabetic+Retinopathy+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Ferroptosis%22">Ferroptosis*</searchLink>/<searchLink fieldCode="MM" term="%22Ferroptosis+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Gene+Expression+Profiling%22">Gene Expression Profiling*</searchLink>/<searchLink fieldCode="MM" term="%22Gene+Expression+Profiling+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Transcriptome%22">Transcriptome*</searchLink> <br /><searchLink fieldCode="MM" term="%22Gene+Expression+Regulation%22">Gene Expression Regulation*</searchLink><br /><searchLink fieldCode="MH" term="%22Ependymoglial+Cells%22">Ependymoglial Cells</searchLink>/<searchLink fieldCode="MH" term="%22Ependymoglial+Cells+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Ependymoglial+Cells%22">Ependymoglial Cells</searchLink>/<searchLink fieldCode="MH" term="%22Ependymoglial+Cells+pathology%22">pathology</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%22">Rats</searchLink> ; <searchLink fieldCode="MH" term="%22Disease+Progression%22">Disease Progression</searchLink> ; <searchLink fieldCode="MH" term="%22Single-Cell+Gene+Expression+Analysis%22">Single-Cell Gene Expression Analysis</searchLink> ; <searchLink fieldCode="MH" term="%22Single-Cell+Analysis%22">Single-Cell Analysis</searchLink> ; <searchLink fieldCode="MH" term="%22Diabetes+Mellitus%2C+Experimental%22">Diabetes Mellitus, Experimental</searchLink> ; <searchLink fieldCode="MH" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%2C+Sprague-Dawley%22">Rats, Sprague-Dawley</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Diabetic retinopathy (DR), a common microvascular complication of diabetes mellitus, has been associated with ferroptosis-related pathological mechanisms. Evidence indicates that ferroptosis may contribute to retinal injury and disease progression. The present analysis aimed to characterize ferroptosis-associated cell subsets and their roles in the progression of DR.<br />Method: Single-cell RNA sequencing data derived from diabetic rat models of DR were obtained from the Gene Expression Omnibus database. A total of 464 ferroptosis-related genes were used to calculate ferroptosis scores. Data processing and analysis were performed using the Seurat R package, with differentially expressed genes identified via the FindAllMarkers function. Functional enrichment analyses were conducted using the clusterProfiler package. Protein-protein interaction networks were constructed using the STRING database, and intercellular communication was predicted using CellChat. Key findings were validated through reverse transcription quantitative polymerase chain reaction (RT-qPCR).<br />Results: Cell clustering identified nine principal retinal cell types. Compared with normal control groups, the DR group demonstrated altered proportions of Müller cells, vascular endothelial cells, microglia, and cone photoreceptor cells. Ferroptosis-score-related differences were most evident in Müller cells and rod cells. In the revised WT-baseline sensitivity analysis, the high-ratio ferroptosis-score cell distribution remained significantly altered in Rod and Müller cells after multiple-testing correction.<br />Conclusion: This study identified key ferroptosis-associated retinal cell populations, with an emphasis on the functional roles of ferroptosis-associated Müller cell subsets in the context of DR. These findings provide further insight into the cellular mechanisms underlying DR and highlight potential molecular targets for therapeutic intervention.<br /> (© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Ethics approval statement: This study received approval from the ethics committees of both the Affiliated Eye Hospital of Nanchang University (No. YLP20250123). Conflict of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Diabetes Metab Res Rev. 2003 Nov-Dec;19(6):442-55. (PMID: <searchLink fieldCode="PM" term="%2214648803%22">14648803)</searchLink><br />Prog Retin Eye Res. 2018 Mar;63:20-68. (PMID: <searchLink fieldCode="PM" term="%2229126927%22">29126927)</searchLink><br />Eye (Lond). 2010 Oct;24(10):1576-84. (PMID: <searchLink fieldCode="PM" term="%2220508651%22">20508651)</searchLink><br />Clin Diabetes. 2022 Spring;40(2):222-232. (PMID: <searchLink fieldCode="PM" term="%2235669299%22">35669299)</searchLink><br />Int J Mol Sci. 2018 Jan 01;19(1):. (PMID: <searchLink fieldCode="PM" term="%2229301251%22">29301251)</searchLink><br />Front Immunol. 2022 Nov 01;13:1039241. (PMID: <searchLink fieldCode="PM" term="%2236389728%22">36389728)</searchLink><br />Diabetes Res Clin Pract. 2017 Jun;128:40-50. (PMID: <searchLink fieldCode="PM" term="%2228437734%22">28437734)</searchLink><br />Exp Cell Res. 2024 Jun 1;439(1):114087. (PMID: <searchLink fieldCode="PM" term="%2238735619%22">38735619)</searchLink><br />Diabetol Metab Syndr. 2024 Feb 26;16(1):49. (PMID: <searchLink fieldCode="PM" term="%2238409074%22">38409074)</searchLink><br />J Inorg Biochem. 2021 Oct;223:111553. (PMID: <searchLink fieldCode="PM" term="%2234340059%22">34340059)</searchLink><br />Cells. 2022 Dec 31;12(1):. (PMID: <searchLink fieldCode="PM" term="%2236611964%22">36611964)</searchLink><br />Cell Physiol Biochem. 2018;48(2):705-717. (PMID: <searchLink fieldCode="PM" term="%2230025404%22">30025404)</searchLink><br />Bioengineered. 2022 Apr;13(4):10540-10551. (PMID: <searchLink fieldCode="PM" term="%2235441580%22">35441580)</searchLink><br />Matrix Biol. 2015 Sep;47:44-53. (PMID: <searchLink fieldCode="PM" term="%2225960419%22">25960419)</searchLink><br />Am J Pathol. 2024 Jun;194(6):1078-1089. (PMID: <searchLink fieldCode="PM" term="%2238417697%22">38417697)</searchLink><br />Cell Death Discov. 2022 Oct 25;8(1):426. (PMID: <searchLink fieldCode="PM" term="%2236284090%22">36284090)</searchLink><br />Neuron. 2012 Oct 18;76(2):266-80. (PMID: <searchLink fieldCode="PM" term="%2223083731%22">23083731)</searchLink><br />FEBS J. 2023 Feb;290(4):878-891. (PMID: <searchLink fieldCode="PM" term="%2234923749%22">34923749)</searchLink><br />Front Cell Dev Biol. 2021 Sep 27;9:732820. (PMID: <searchLink fieldCode="PM" term="%2234646826%22">34646826)</searchLink><br />Prog Retin Eye Res. 2016 Mar;51:156-86. (PMID: <searchLink fieldCode="PM" term="%2226297071%22">26297071)</searchLink><br />Antioxidants (Basel). 2023 Jun 10;12(6):. (PMID: <searchLink fieldCode="PM" term="%2237371981%22">37371981)</searchLink><br />Neural Regen Res. 2023 May;18(5):976-982. (PMID: <searchLink fieldCode="PM" term="%2236254977%22">36254977)</searchLink><br />Circulation. 2006 Aug 8;114(6):597-605. (PMID: <searchLink fieldCode="PM" term="%2216894049%22">16894049)</searchLink><br />Acta Diabetol. 2025 Jun;62(6):831-844. (PMID: <searchLink fieldCode="PM" term="%2239508857%22">39508857)</searchLink><br />Front Endocrinol (Lausanne). 2023 Sep 13;14:1234824. (PMID: <searchLink fieldCode="PM" term="%2237772084%22">37772084)</searchLink><br />Biomed Res Int. 2015;2015:854593. (PMID: <searchLink fieldCode="PM" term="%2225866817%22">25866817)</searchLink><br />J Biomed Sci. 2017 Jul 27;24(1):50. (PMID: <searchLink fieldCode="PM" term="%2228750629%22">28750629)</searchLink><br />OMICS. 2012 May;16(5):284-7. (PMID: <searchLink fieldCode="PM" term="%2222455463%22">22455463)</searchLink><br />Front Med (Lausanne). 2023 May 24;10:1195678. (PMID: <searchLink fieldCode="PM" term="%2237293297%22">37293297)</searchLink><br />Nat Protoc. 2025 Jan;20(1):180-219. (PMID: <searchLink fieldCode="PM" term="%2239289562%22">39289562)</searchLink><br />Ophthalmology. 2021 Aug;128(8):1169-1179. (PMID: <searchLink fieldCode="PM" term="%2233359888%22">33359888)</searchLink><br />Annu Rev Vis Sci. 2022 Sep 15;8:135-169. (PMID: <searchLink fieldCode="PM" term="%2235385673%22">35385673)</searchLink><br />Front Immunol. 2024 Jan 11;14:1288137. (PMID: <searchLink fieldCode="PM" term="%2238274828%22">38274828)</searchLink><br />Exp Eye Res. 2018 Nov;176:1-9. (PMID: <searchLink fieldCode="PM" term="%2229944850%22">29944850)</searchLink><br />Exp Diabetes Res. 2010;2010:. (PMID: <searchLink fieldCode="PM" term="%2220827392%22">20827392)</searchLink><br />Glia. 2002 Sep;39(3):292-303. (PMID: <searchLink fieldCode="PM" term="%2212203395%22">12203395)</searchLink><br />Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4457-64. (PMID: <searchLink fieldCode="PM" term="%2214507893%22">14507893)</searchLink><br />Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H238-46. (PMID: <searchLink fieldCode="PM" term="%2219395553%22">19395553)</searchLink><br />Prog Retin Eye Res. 2016 Mar;51:1-40. (PMID: <searchLink fieldCode="PM" term="%2226113209%22">26113209)</searchLink><br />Adv Sci (Weinh). 2025 Jun;12(22):e2416997. (PMID: <searchLink fieldCode="PM" term="%2240279631%22">40279631)</searchLink><br />Cleve Clin J Med. 2024 Aug 1;91(8):503-510. (PMID: <searchLink fieldCode="PM" term="%2239089852%22">39089852)</searchLink><br />Bioengineered. 2022 Apr;13(4):8240-8254. (PMID: <searchLink fieldCode="PM" term="%2235302431%22">35302431)</searchLink><br />Acta Histochem. 2017 Mar;119(2):142-149. (PMID: <searchLink fieldCode="PM" term="%2228110937%22">28110937)</searchLink><br />Ocul Immunol Inflamm. 2019;27(5):836-843. (PMID: <searchLink fieldCode="PM" term="%2229608341%22">29608341)</searchLink><br />Ir Med J. 2011 Feb;104(2):37. (PMID: <searchLink fieldCode="PM" term="%2221465870%22">21465870)</searchLink><br />Nucleic Acids Res. 2023 Jan 6;51(D1):D870-D876. (PMID: <searchLink fieldCode="PM" term="%2236300619%22">36300619)</searchLink><br />Annu Rev Neurosci. 2015 Jul 8;38:221-46. (PMID: <searchLink fieldCode="PM" term="%2225897874%22">25897874)</searchLink><br />Cell Metab. 2013 Mar 5;17(3):329-41. (PMID: <searchLink fieldCode="PM" term="%2223473030%22">23473030)</searchLink><br />Curr Pharm Des. 2018;24(40):4726-4741. (PMID: <searchLink fieldCode="PM" term="%2230644339%22">30644339)</searchLink>
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  Data: 82260212 the National Natural Science Foundation of China
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  Data: <i>Keywords: </i>Cell communication; Diabetic retinopathy; Differentially expressed genes; Ferroptosis; Single-cell analysis
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        Text: English
    Subjects:
      – SubjectFull: Ependymoglial Cells metabolism
        Type: general
      – SubjectFull: Ependymoglial Cells pathology
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Disease Progression
        Type: general
      – SubjectFull: Single-Cell Gene Expression Analysis
        Type: general
      – SubjectFull: Single-Cell Analysis
        Type: general
      – SubjectFull: Diabetes Mellitus, Experimental
        Type: general
      – SubjectFull: Disease Models, Animal
        Type: general
      – SubjectFull: Rats, Sprague-Dawley
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Diabetic Retinopathy genetics
        Type: general
      – SubjectFull: Diabetic Retinopathy metabolism
        Type: general
      – SubjectFull: Diabetic Retinopathy pathology
        Type: general
      – SubjectFull: Ferroptosis genetics
        Type: general
      – SubjectFull: Gene Expression Profiling methods
        Type: general
      – SubjectFull: Transcriptome
        Type: general
      – SubjectFull: Gene Expression Regulation
        Type: general
    Titles:
      – TitleFull: Single-cell transcriptomic analysis of ferroptosis-associated cell populations in the progression of diabetic retinopathy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Duan BF
      – PersonEntity:
          Name:
            NameFull: Shao YN
      – PersonEntity:
          Name:
            NameFull: Mao ZQ
      – PersonEntity:
          Name:
            NameFull: Li XN
      – PersonEntity:
          Name:
            NameFull: Fan HM
      – PersonEntity:
          Name:
            NameFull: Cai Y
      – PersonEntity:
          Name:
            NameFull: Zheng HW
      – PersonEntity:
          Name:
            NameFull: Peng SJ
      – PersonEntity:
          Name:
            NameFull: You ZP
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 07
              M: 08
              Text: 2026 Aug 07
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1573-2630
          Numbering:
            – Type: volume
              Value: 46
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: International ophthalmology
              Type: main
ResultId 1