Academic Journal
Mechanisms of antibody-mediated enhancement of immune responses.
| Τίτλος: | Mechanisms of antibody-mediated enhancement of immune responses. |
|---|---|
| Συγγραφείς: | Cipolla M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., MacLean AJ; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Hernandez B; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Silva Santos GS; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Stamatatos L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Hartweger H; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Merkenschlager J; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.; Laboratory of Lymphocyte Collaboration and Competition, Harvard Medical School, Boston, MA, USA., Bournazos S; Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY, USA., Ravetch JV; Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY, USA., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, The Rockefeller University , New York, NY, USA. |
| Πηγή: | The Journal of experimental medicine [J Exp Med] 2026 Sep 07; Vol. 223 (9). Date of Electronic Publication: 2026 Aug 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Rockefeller University Press |
| Ιατρικοί όροι (MeSH): | Immunologic Memory*/immunology , Antibodies*/immunology, Receptors, IgG/immunology ; Germinal Center/immunology ; Plasma Cells/immunology ; B-Lymphocytes/immunology ; Receptors, Complement 3d/immunology ; Animals ; Humans ; Mice ; Antibody Affinity |
| Περίληψη: | Immune memory responses are rapid and qualitatively distinct from primary responses. They typically develop in the presence of antigen-experienced memory T and B cells and preexisting antibodies. Although the contribution of T and B cells to recall responses is well defined, the contribution of antibody "memory" and the mechanisms by which preexisting antibodies modulate the development of germinal center (GC) and plasma cell responses is not precisely understood. Here, we report on mechanisms that mediate antibody enhancement of GC and plasmablast (PB) compartments, and the parallel process by which antibodies change the affinity threshold for B cell recruitment into immune responses. The data indicate that antibody-mediated enhancement of GC and PB responses is Fc gamma receptor (FcγR) dependent and largely complement receptor 1 and 2 (CR1/2) independent. In contrast, the reduction in the affinity threshold for GC entry is independent of both FcγRs and CR1/2. (© 2026 Cipolla et al.) |
| Grant Information: | 5R37 AI037526 United States NH NIH HHS; 1UM1AI144462-01 United States NH NIH HHS; Stavros Niarchos Foundation; Bulgari; CRI14522 United States CRI Cancer Research Institute; United States HHMI Howard Hughes Medical Institute |
| Substance Nomenclature: | 0 (Receptors, IgG) 0 (Antibodies) 0 (Receptors, Complement 3d) |
| Entry Date(s): | Date Created: 20260807 Date Completed: 20260807 Latest Revision: 20260807 |
| Update Code: | 20260807 |
| DOI: | 10.1084/jem.20260305 |
| PMID: | 42565807 |
| Βάση Δεδομένων: | MEDLINE |
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