Academic Journal
Development of the zebrafish foveal analogue: a quantitative atlas of high-acuity zone growth and retinal regionalisation.
| Τίτλος: | Development of the zebrafish foveal analogue: a quantitative atlas of high-acuity zone growth and retinal regionalisation. |
|---|---|
| Συγγραφείς: | Syed H; The University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK., Patil M; The University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK., Jakins W; The University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK., Yoon HJ; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Allcock N; Electron Microscopy Facility, College of Life Sciences, University of Leicester, Leicester LE1 7HG, UK., Douglas G; Hercules Facility, College of Science and Engineering, University of Leicester, Leicester LE1 7RH, UK., Norton WHJ; Division of Biosciences Education, University of Leicester, University Rd, Leicester LE1 7RH, UK., Thomas MG; The University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.; Division of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.; Department of Ophthalmology, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK. |
| Πηγή: | Biology open [Biol Open] 2026 Sep 15; Vol. 15 (9). Date of Electronic Publication: 2026 Sep 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101578018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-6390 (Electronic) Linking ISSN: 20466390 NLM ISO Abbreviation: Biol Open Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge : Company of Biologists Ltd. |
| Ιατρικοί όροι (MeSH): | Fovea Centralis*/growth & development , Zebrafish* , Retina* , Visual Acuity*, Animals ; X-Ray Microtomography ; Humans |
| Περίληψη: | The vertebrate retina contains specialised regions for high-acuity vision, exemplified by the human fovea and its zebrafish analogue, the high-acuity zone (HAZ). Despite the widespread use of zebrafish to model retinal disease, a stage-resolved quantitative reference describing normal eye, photoreceptor layer (PRL) and lens growth has been lacking. Here, we apply contrast-enhanced micro-computed tomography (micro-CT) to construct the first three-dimensional micro-CT normative atlas of wild-type zebrafish eye development across five larval stages [3, 5, 7, 10 and 18 days post-fertilisation (dpf)], mapping circumferential PRL thickness, eye and lens morphology, and compartment growth rates. Regional PRL thickening within the temporo-ventral region of the expected HAZ emerged by 5 dpf and was sustained by a localised redistribution of growth, persisting and extending towards the optic nerve through 18 dpf. The PRL, lens and eye grew through four phases, alternating between disproportionate PRL expansion and coordinated growth, while the eye remodelled from a nasal-dominant to a temporo-ventral-dominant form. This regional specialisation was protracted relative to gross ocular growth and could proceed independently of it, paralleling the extended postnatal maturation of the human fovea. This atlas provides a quantitative baseline for distinguishing disease-induced changes from normal variation, supporting zebrafish models of foveal hypoplasia and related disorders. (© 2026. Published by The Company of Biologists.) |
| Competing Interests: | Competing interests The authors declare no competing or financial interests. |
| References: | Exp Eye Res. 2023 Sep;234:109611. (PMID: 37536437) FASEB J. 2020 Apr;34(4):5552-5562. (PMID: 32103543) Nat Rev Genet. 2007 May;8(5):353-67. (PMID: 17440532) Dev Dyn. 2009 Sep;238(9):2254-65. (PMID: 19504455) Neuron. 2020 Jul 22;107(2):320-337.e6. (PMID: 32473094) Zebrafish. 2004;1(3):257-71. (PMID: 18248236) Cell. 2019 Feb 21;176(5):1222-1237.e22. (PMID: 30712875) Elife. 2021 Sep 16;10:. (PMID: 34528510) Ophthalmology. 2022 Jun;129(6):708-718. (PMID: 35157951) Lancet Glob Health. 2017 Dec;5(12):e1221-e1234. (PMID: 29032195) J Med Genet. 2003 Sep;40(9):641-50. (PMID: 12960208) Proc Natl Acad Sci U S A. 2025 Dec 30;122(52):e2515449122. (PMID: 41452983) Cells. 2020 Oct 06;9(10):. (PMID: 33036185) Transl Vis Sci Technol. 2022 Mar 2;11(3):17. (PMID: 35285860) Proc Biol Sci. 2016 Mar 16;283(1826):20160058. (PMID: 26936243) Dev Dyn. 2021 Nov;250(11):1584-1599. (PMID: 33866663) Ophthalmology. 2011 Aug;118(8):1653-60. (PMID: 21529956) Annu Rev Vis Sci. 2020 Sep 15;6:237-259. (PMID: 32320630) Annu Rev Vis Sci. 2015 Nov 24;1:125-153. (PMID: 28532376) Zebrafish. 2015 Feb;12(1):11-20. (PMID: 25521241) J Neurobiol. 2003 Jan;54(1):148-60. (PMID: 12486702) Proc Biol Sci. 2012 Dec 05;280(1752):20122490. (PMID: 23222448) Eye (Lond). 2017 Jan;31(1):68-86. (PMID: 27612182) Nat Methods. 2012 Jun 28;9(7):676-82. (PMID: 22743772) Exp Eye Res. 2019 Jul;184:234-242. (PMID: 31075224) Prog Neurobiol. 1998 Apr;54(5):549-80. (PMID: 9550191) Curr Biol. 2020 Aug 3;30(15):2927-2942.e7. (PMID: 32531283) N Engl J Med. 2000 Feb 17;342(7):483-92. (PMID: 10675430) J Comp Neurol. 1999 Feb 22;404(4):515-36. (PMID: 9987995) Vis Neurosci. 1999 Sep-Oct;16(5):881-8. (PMID: 10580723) Semin Cell Dev Biol. 2001 Dec;12(6):485-90. (PMID: 11735384) J Comp Neurol. 1995 Sep 4;359(4):537-50. (PMID: 7499546) Prog Retin Eye Res. 2018 Sep;66:49-84. (PMID: 29609042) Sci Rep. 2018 Nov 8;8(1):16531. (PMID: 30410001) Neuron. 2020 Jul 22;107(2):207-209. (PMID: 32702344) J Anat. 2023 Mar;242(3):544-551. (PMID: 36256534) Arch Ophthalmol. 1969 Aug;82(2):151-9. (PMID: 4183671) Curr Biol. 2018 Jul 9;28(13):2018-2032.e5. (PMID: 29937350) Nat Neurosci. 2018 Sep;21(9):1281-1289. (PMID: 30127430) Sci Rep. 2020 Dec 8;10(1):21450. (PMID: 33293601) Br J Ophthalmol. 2022 May;106(5):593-599. (PMID: 33148537) Zebrafish. 2016 Aug;13(4):310-6. (PMID: 27058023) Eye (Lond). 2014 Apr;28(4):367-80. (PMID: 24503724) PLoS One. 2012;7(6):e40132. (PMID: 22761952) Nat Commun. 2014 Sep 03;5:4777. (PMID: 25182715) Prog Mol Biol Transl Sci. 2011;100:287-330. (PMID: 21377629) Vision Res. 1986;26(6):847-55. (PMID: 3750868) Ophthalmology. 1984 Jun;91(6):603-12. (PMID: 6462623) Am J Ophthalmol. 2012 Nov;154(5):767-778.e2. (PMID: 22935600) Vet Ophthalmol. 2013 Jul;16 Suppl 1:15-33. (PMID: 23750503) Tissue Cell. 2012 Aug;44(4):264-79. (PMID: 22608306) Bioessays. 2024 Jan;46(1):e2300054. (PMID: 38037292) Elife. 2019 May 07;8:. (PMID: 31063133) Nat Protoc. 2019 Jul;14(7):2152-2176. (PMID: 31227823) Biol Open. 2018 Oct 31;7(11):. (PMID: 30237290) Elife. 2021 Jun 29;10:. (PMID: 34184634) Development. 2022 Dec 15;149(24):. (PMID: 36520654) Dev Biol. 1996 Dec 15;180(2):646-63. (PMID: 8954734) Prog Retin Eye Res. 2013 Jul;35:63-81. (PMID: 23500068) Methods Cell Biol. 2010;100:153-204. (PMID: 21111217) J Comp Neurol. 1996 Jul 22;371(2):222-34. (PMID: 8835728) Chemosphere. 2023 May;324:138348. (PMID: 36898440) Cells. 2020 Sep 30;9(10):. (PMID: 33007938) Dev Cell. 2017 Jul 10;42(1):68-81.e6. (PMID: 28648799) |
| Grant Information: | SGANYN2210 Fight for Sight UK; 24/01 Ulverscroft Foundation; RM38J0003M20 United Kingdom WT_ Wellcome Trust; BB/S019510/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; United Kingdom WT_ Wellcome Trust; SGL021\1066 United Kingdom AMS_ Academy of Medical Sciences; MR/W007002/1 United Kingdom MRC_ Medical Research Council; RESPHD2501 Fight for Sight UK |
| Contributed Indexing: | Keywords: Fovea; High-acuity zone; Retina; Zebrafish |
| Entry Date(s): | Date Created: 20260807 Date Completed: 20260901 Latest Revision: 20260918 |
| Update Code: | 20260918 |
| PubMed Central ID: | PMC13580590 |
| DOI: | 10.1242/bio.062760 |
| PMID: | 42565224 |
| Βάση Δεδομένων: | MEDLINE |
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