Academic Journal
Gastric Emptying in Response to Neural Gastric Electric Stimulation in an Acute Porcine Model.
| Τίτλος: | Gastric Emptying in Response to Neural Gastric Electric Stimulation in an Acute Porcine Model. |
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| Συγγραφείς: | Sivakumar J; Department of Upper Gastrointestinal Surgery, Peter MacCallum Cancer Centre, Parkville, Australia; Department of Surgery, The University of Melbourne, Parkville, Australia. Electronic address: sivakumar.jonathan@gmail.com., Furness JB; Department of Anatomy and Physiology and Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia., Fallon J; Bionics Institute, Fitzroy, Australia; Medical Bionics Department, The University of Melbourne, Parkville, Australia; Centre for Medical Bionics, Swinburne University of Technology, Hawthorne, Australia., Grayden DB; Department of Biomedical Engineering and Graeme Clark Institute, The University of Melbourne, Parkville, Australia., Papastratos K; Division of Cancer Research, Peter MacCallum Cancer Centre, Parkville, Australia., Cottrell J; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Australia., Zhou J; Bionics Institute, Fitzroy, Australia., Dinning PG; Flinders Medical Centre, College of Medicine and Public Health, Flinders University, Adelaide, Australia., Duong CP; Department of Upper Gastrointestinal Surgery, Peter MacCallum Cancer Centre, Parkville, Australia; Department of Surgery, The University of Melbourne, Parkville, Australia. |
| Πηγή: | Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2026 Oct; Vol. 29 (7), pp. 1182-1190. Date of Electronic Publication: 2026 Jul 16. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 9804159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1403 (Electronic) Linking ISSN: 10947159 NLM ISO Abbreviation: Neuromodulation Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2022- : [New York] : Elsevier Original Publication: Malden, MA : Blackwell Science, c1998- |
| Ιατρικοί όροι (MeSH): | Gastric Emptying*/physiology , Stomach*/physiology , Stomach*/innervation , Electric Stimulation Therapy*/methods, Electric Stimulation/methods ; Gastroparesis/therapy ; Animals ; Swine ; Female ; Vagotomy ; Disease Models, Animal |
| Περίληψη: | Background: Delayed gastric conduit emptying (DGCE) is a common complication following esophagectomy-associated gastric conduit surgery and is often resistant to conventional treatments. Neural gastric electrical stimulation (NGES) is a potential approach to managing DGCE by generating propulsive gastric contractions through timed bursts of high-frequency, multisite stimulation. This study evaluates the efficacy of NGES in increasing gastric emptying in an acute porcine vagally denervated postsurgical conduit. Materials and Methods: Six anaesthetized pigs underwent a staged interventions to assess whether gastric emptying at baseline, after bilateral truncal vagotomy, and after creation of a gastric conduit was accelerated by anterior-plus-posterior (A-plus-P) NGES or anterior-only (A-only) NGES. NGES was delivered through sequential (proximal-to-distal) activation of multiple gastric serosal electrode pairs to induce coordinated peristalsis. Liquid gastric emptying was measured by direct effluent collection, and myoelectrical activity was recorded by the same electrodes. Percentage gastric emptying was compared across conditions using repeated-measures analysis. Results: Vagotomy reduced 15-minute gastric emptying from 30.8 ± 26.0% to 7.9 ± 8.6% (p < 0.01). NGES improved emptying after vagotomy to 48.8 ± 28.3% with A-plus-P electrode stimulation (p = 0.004) and 48.0 ± 27.4% with A-only electrode stimulation (p = 0.003). Gastric tubularization independently increased emptying to 70.0 ± 21.5% (p = 0.006 vs the vagotomized whole stomach), with a peak of 96.3 ± 6.5% when tubularization was combined with A-only NGES. Conclusions: NGES, using gastric surface electrodes, effectively increases gastric emptying after acute vagotomy, with A-only electrode stimulation achieving comparable efficacy to A-plus-P stimulation. These findings position NGES as a promising therapy for DGCE and other refractory gastric motility disorders, supporting progression to chronic animal studies to assess long-term efficacy and safety. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Conflict of Interest The authors reported no conflict of interest. |
| Contributed Indexing: | Keywords: Gastric; gastroparesis; neuromodulation; stimulation; vagotomy |
| Entry Date(s): | Date Created: 20260807 Date Completed: 20261005 Latest Revision: 20261005 |
| Update Code: | 20261006 |
| DOI: | 10.1016/j.neurom.2026.07.005 |
| PMID: | 42563611 |
| Βάση Δεδομένων: | MEDLINE |
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