Academic Journal
Pathogenic bacterial profile and antimicrobial susceptibility patterns in odontogenic facial cellulitis among Egyptian patients: A cross-sectional study.
| Τίτλος: | Pathogenic bacterial profile and antimicrobial susceptibility patterns in odontogenic facial cellulitis among Egyptian patients: A cross-sectional study. |
|---|---|
| Συγγραφείς: | Maaty FANA; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt., Moshy SE; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt., Gramoun A; Consultant at Azante Medical Reporting and Analytics, Munich, Germany., Abdelmoteleb M; Botany Department, Faculty of Science, Mansoura University, Mansoura, Egypt., Emara A; Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt., Bashir MH; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt., Abbass MMS; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt. marwa.magdy@dentistry.cu.edu.eg.; Oral Biology Division, Basic Sciences Department, Faculty of Dentistry, GUC University, Cairo, Egypt. marwa.magdy@dentistry.cu.edu.eg. |
| Πηγή: | Scientific reports [Sci Rep] 2026 Aug 06; Vol. 16 (1). Date of Electronic Publication: 2026 Aug 06. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Cellulitis*/microbiology , Cellulitis*/drug therapy , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Face*/microbiology , Bacteria*/drug effects , Bacteria*/isolation & purification , Bacteria*/genetics , Bacteria*/classification, Egypt/epidemiology ; RNA, Ribosomal, 16S/genetics ; Humans ; Male ; Microbial Sensitivity Tests ; Cross-Sectional Studies ; Female ; Adult ; Young Adult ; Adolescent ; Middle Aged |
| Περίληψη: | Odontogenic facial cellulitis is the most common facial space infection worldwide, originating from untreated dental caries and progressing to life-threatening complications. This stems from the polymicrobial nature of the disease, along with the widespread and over-the-counter misuse of antibiotics in Egypt. This study aims to identify the pathogenic bacterial species involved in odontogenic facial cellulitis in an Egyptian patient sample. Forty-four samples were collected from patients presenting with odontogenic facial cellulitis. Bacterial profiles were investigated using selective media, Gram staining/colony identification, biochemical tests, and Clinical and Laboratory Standards Institute standardized antibiotic susceptibility testing. Resistant strains (≥ 3 agents) were identified using 16 S rRNA sequencing and deposited in the NCBI GenBank. Odontogenic cellulitis originated primarily from lower posterior teeth, specifically the lower first molar, and spread commonly in the submandibular and submental spaces. Regarding bacterial profile, the Gram-positive cocci were the predominant ones. Complete resistance to metronidazole was reported, while previous antibiotic administration showed no statistically significant association with susceptibility to amoxicillin and clindamycin. Among multidrug-resistant isolates, 16 S rRNA sequencing identified predominantly Bacillus, Enterococcus, and Staphylococcus species. Two isolates showed < 90% identity to known species, suggesting possible novel taxa and informing empirical therapy through phenotypic resistance profiles. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki ethical standards. Accordingly, Ethical approval was obtained from the Ethics and Research Committee of the Faculty of Dentistry, Cairo University (approval number 25322). |
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| Contributed Indexing: | Keywords: 16S rRNA sequencing; Antibiotic resistance; Egypt; Odontogenic facial cellulitis; Polymicrobial infection |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) 0 (RNA, Ribosomal, 16S) |
| Entry Date(s): | Date Created: 20260806 Date Completed: 20260807 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13448242 |
| DOI: | 10.1038/s41598-026-64016-7 |
| PMID: | 42562861 |
| Βάση Δεδομένων: | MEDLINE |
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