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Towards zebrafish models of personality disorders.

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Τίτλος: Towards zebrafish models of personality disorders.
Συγγραφείς: Cai H; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Suo Q; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Li Q; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Li Z; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Wang Y; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Fu Z; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Wang Y; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Jiang X; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Stewart AM; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, USA., Perfilova VV; Volgograd State Medical University, Volgograd, Russia., Sawitri NLN; Indonesia International Institute for Life-Sciences, Jakarta, Indonesia., Sin LK; Taylor's University, Kuala Lumpur, Malaysia., Chew JJ; Taylor's University, Kuala Lumpur, Malaysia., Yang L; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., Cui J; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China., de Abreu MS; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, USA; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil. Electronic address: abreu_murilo@hotmail.com., Kalueff AV; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, USA; St. Petersburg State University, St Petersburg, Russia; COBRAIN Center, M. Heratsi Yerevan State Medical University, Yerevan, Armenia. Electronic address: avkalueff@gmail.com.
Πηγή: Behavioural brain research [Behav Brain Res] 2026 Oct 18; Vol. 515, pp. 116406. Date of Electronic Publication: 2026 Aug 05.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE
Imprint Name(s): Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
Ιατρικοί όροι (MeSH): Personality Disorders*/physiopathology , Behavior, Animal*/physiology , Zebrafish* , Disease Models, Animal*, Animals ; Humans
Περίληψη: Personality disorders (PDs) are increasingly recognized and highly prevalent, yet remarkably poorly understood, diagnosed and treated mental conditions. Common PDs include antisocial, avoidant, borderline, dependent, histrionic, narcissistic, obsessive-compulsive personality, and paranoid disorders. Experimental (animal) models are a valuable tool to study various brain illnesses, including PDs. However, characterized by complex and frequently overlapping aberrant behaviors, PDs pose major challenges for their preclinical modeling. Here, we discuss the potential utility of zebrafish (Danio rerio) as complementary translational models relevant to studying PDs. Paralleling clinical symptoms and traits of PDs to specific behavioral phenotypes, biomarkers and paradigms in these fish, we critically evaluate the existing challenges and limitations of such models, and provide a conceptual framework for further research in this field. Despite clear conceptual and practical challenges, we argue that zebrafish models not only provide a powerful platform for elucidating neurobiological mechanisms of a wide range of key PD traits (e.g., impulsivity, aggression, emotional dysregulation), but may markedly accelerate both translational modeling of these disorders and therapeutic discovery.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest. A.V.K. is the Chair of the International Zebrafish Neuroscience Research Consortium that initiated this collaborative study.
Contributed Indexing: Keywords: Biological psychiatry; Experimental models; Personality disorders; Translational research; Zebrafish
Entry Date(s): Date Created: 20260805 Date Completed: 20260904 Latest Revision: 20260904
Update Code: 20260905
DOI: 10.1016/j.bbr.2026.116406
PMID: 42556646
Βάση Δεδομένων: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Cai+H%22">Cai H</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Suo+Q%22">Suo Q</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Fu+Z%22">Fu Z</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Stewart+AM%22">Stewart AM</searchLink>; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, USA.<br /><searchLink fieldCode="AU" term="%22Perfilova+VV%22">Perfilova VV</searchLink>; Volgograd State Medical University, Volgograd, Russia.<br /><searchLink fieldCode="AU" term="%22Sawitri+NLN%22">Sawitri NLN</searchLink>; Indonesia International Institute for Life-Sciences, Jakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Sin+LK%22">Sin LK</searchLink>; Taylor's University, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Chew+JJ%22">Chew JJ</searchLink>; Taylor's University, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Cui+J%22">Cui J</searchLink>; Department of Biosciences and Bioinformatics, School of Science, Xi'an-Jiaotong-Liverpool University (XJTLU), China; Suzhou Municipal Key Laboratory on Neurobiology and Cell Signaling, XJTLU, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22de+Abreu+MS%22">de Abreu MS</searchLink>; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, USA; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil. Electronic address: abreu_murilo@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Kalueff+AV%22">Kalueff AV</searchLink>; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, USA; St. Petersburg State University, St Petersburg, Russia; COBRAIN Center, M. Heratsi Yerevan State Medical University, Yerevan, Armenia. Electronic address: avkalueff@gmail.com.
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  Data: Personality disorders (PDs) are increasingly recognized and highly prevalent, yet remarkably poorly understood, diagnosed and treated mental conditions. Common PDs include antisocial, avoidant, borderline, dependent, histrionic, narcissistic, obsessive-compulsive personality, and paranoid disorders. Experimental (animal) models are a valuable tool to study various brain illnesses, including PDs. However, characterized by complex and frequently overlapping aberrant behaviors, PDs pose major challenges for their preclinical modeling. Here, we discuss the potential utility of zebrafish (Danio rerio) as complementary translational models relevant to studying PDs. Paralleling clinical symptoms and traits of PDs to specific behavioral phenotypes, biomarkers and paradigms in these fish, we critically evaluate the existing challenges and limitations of such models, and provide a conceptual framework for further research in this field. Despite clear conceptual and practical challenges, we argue that zebrafish models not only provide a powerful platform for elucidating neurobiological mechanisms of a wide range of key PD traits (e.g., impulsivity, aggression, emotional dysregulation), but may markedly accelerate both translational modeling of these disorders and therapeutic discovery.<br /> (Copyright © 2026 Elsevier B.V. All rights reserved.)
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  Data: Declaration of Competing Interest The authors declare no conflicts of interest. A.V.K. is the Chair of the International Zebrafish Neuroscience Research Consortium that initiated this collaborative study.
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