Academic Journal
Protective effects of Rhus coriaria L. fruit extract against experimental calcium oxalate nephrolithiasis via modulation of oxidative stress and renal injury.
| Τίτλος: | Protective effects of Rhus coriaria L. fruit extract against experimental calcium oxalate nephrolithiasis via modulation of oxidative stress and renal injury. |
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| Συγγραφείς: | Koç MK; Department of Urology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey., Kalyenci B; Department of Urology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey. bedreddin84@windowslive.com.; Adıyaman University Central Campus Faculty of Medicine Dean's, Office Altınşehir, Center District, Adıyaman, Turkey. bedreddin84@windowslive.com., Yılmaz E; Department of Pharmacognosy, Faculty of Pharmacy, Adıyaman University, Adıyaman, Türkiye, Turkey., Gök HN; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Türkiye, Turkey., Öztürk EE; Department of Biochemistry, Faculty of Veterinary Medicine, Harran University, Şanlıurfa, Türkiye, Turkey., Özercan MR; Department of Pathology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey. |
| Πηγή: | Urolithiasis [Urolithiasis] 2026 Aug 04; Vol. 54 (1). Date of Electronic Publication: 2026 Aug 04. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Germany NLM ID: 101602699 Publication Model: Electronic Cited Medium: Internet ISSN: 2194-7236 (Electronic) Linking ISSN: 21947228 NLM ISO Abbreviation: Urolithiasis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin : Springer, [2013]- |
| Ιατρικοί όροι (MeSH): | Oxidative Stress*/drug effects , Plant Extracts*/pharmacology , Plant Extracts*/therapeutic use , Nephrolithiasis*/chemically induced , Nephrolithiasis*/prevention & control , Nephrolithiasis*/drug therapy , Nephrolithiasis*/urine , Nephrolithiasis*/pathology , Rhus*/chemistry, Fruit/chemistry ; Ethylene Glycol/toxicity ; Osteopontin/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Kidney/pathology ; Kidney/drug effects ; Animals ; Rats ; Male ; Calcium Oxalate ; Disease Models, Animal ; Cell Adhesion Molecules |
| Περίληψη: | Calcium oxalate nephrolithiasis is strongly associated with oxidative stress, renal tubular injury, and inflammation. Natural products rich in polyphenols may serve as promising complementary preventive strategies. This study investigated the antiurolithiatic and renoprotective effects of Rhus coriaria fruit extract in an ethylene glycol-induced rat model of nephrolithiasis. Forty-two male rats were randomized into seven groups (n = 6): control, ethylene glycol (EG), EG + potassium citrate, R. coriaria 250 mg/kg/day, R. coriaria 500 mg/kg/day, EG + R. coriaria 250 mg/kg/day, and EG + R. coriaria 500 mg/kg/day. Nephrolithiasis was induced with 1% ethylene glycol for 28 days. Serum biochemistry, urinary lithogenic parameters, oxidative stress markers including total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA), histopathology, and immunohistochemical expression of kidney injury molecule-1 (KIM-1) and osteopontin (OPN) were evaluated. Phytochemical characterization of the extract was performed by high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD). Gallic acid was identified as the predominant phenolic constituent, together with smaller amounts of protocatechuic acid and ellagic acid. Ethylene glycol significantly increased urinary lithogenic parameters, oxidative stress indices, crystal deposition, tubular injury, and OPN expression. Treatment with R. coriaria significantly reduced urinary oxalate and calcium levels, improved TAS, SOD, and CAT levels, lowered TOS and MDA concentrations, and markedly attenuated crystal deposition, inflammation, and tubular dilatation. OPN expression was substantially decreased in treated groups, whereas KIM-1 showed a decreasing trend. Protective effects were more pronounced at the 500 mg/kg/day dose. R. coriaria fruit extract exerted significant antiurolithiatic and renoprotective effects in experimental calcium oxalate nephrolithiasis. These findings suggest that R. coriaria may represent a potential adjunctive strategy for calcium oxalate stone disease. (© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Ethical Approval: All procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals and complied with ARRIVE guidelines. The experimental protocol was approved by the Adıyaman University Animal Experiments Local Ethics Committee (meeting date: October 24, 2024; session no: 6; decision no: 01; protocol no: 2024/043). |
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| Grant Information: | Project No: TIPFTUP/2025-0001 Adıyaman University Scientific Research Projects Coordination Unit |
| Contributed Indexing: | Keywords: Rhus coriaria; Calcium oxalate; Kidney stone; Nephrolithiasis; Oxidative stress; Phytotherapy |
| Substance Nomenclature: | 0 (Plant Extracts) FC72KVT52F (Ethylene Glycol) 2612HC57YE (Calcium Oxalate) 106441-73-0 (Osteopontin) 0 (Antioxidants) 0 (Havcr1 protein, rat) 0 (Cell Adhesion Molecules) |
| SCR Disease Name: | Nephrolithiasis, Calcium Oxalate |
| Entry Date(s): | Date Created: 20260804 Date Completed: 20260804 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s00240-026-02032-y |
| PMID: | 42550246 |
| Βάση Δεδομένων: | MEDLINE |
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