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Protective effects of Rhus coriaria L. fruit extract against experimental calcium oxalate nephrolithiasis via modulation of oxidative stress and renal injury.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Protective effects of Rhus coriaria L. fruit extract against experimental calcium oxalate nephrolithiasis via modulation of oxidative stress and renal injury.
Συγγραφείς: Koç MK; Department of Urology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey., Kalyenci B; Department of Urology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey. bedreddin84@windowslive.com.; Adıyaman University Central Campus Faculty of Medicine Dean's, Office Altınşehir, Center District, Adıyaman, Turkey. bedreddin84@windowslive.com., Yılmaz E; Department of Pharmacognosy, Faculty of Pharmacy, Adıyaman University, Adıyaman, Türkiye, Turkey., Gök HN; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Türkiye, Turkey., Öztürk EE; Department of Biochemistry, Faculty of Veterinary Medicine, Harran University, Şanlıurfa, Türkiye, Turkey., Özercan MR; Department of Pathology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey.
Πηγή: Urolithiasis [Urolithiasis] 2026 Aug 04; Vol. 54 (1). Date of Electronic Publication: 2026 Aug 04.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Germany NLM ID: 101602699 Publication Model: Electronic Cited Medium: Internet ISSN: 2194-7236 (Electronic) Linking ISSN: 21947228 NLM ISO Abbreviation: Urolithiasis Subsets: MEDLINE
Imprint Name(s): Original Publication: Berlin : Springer, [2013]-
Ιατρικοί όροι (MeSH): Oxidative Stress*/drug effects , Plant Extracts*/pharmacology , Plant Extracts*/therapeutic use , Nephrolithiasis*/chemically induced , Nephrolithiasis*/prevention & control , Nephrolithiasis*/drug therapy , Nephrolithiasis*/urine , Nephrolithiasis*/pathology , Rhus*/chemistry, Fruit/chemistry ; Ethylene Glycol/toxicity ; Osteopontin/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Kidney/pathology ; Kidney/drug effects ; Animals ; Rats ; Male ; Calcium Oxalate ; Disease Models, Animal ; Cell Adhesion Molecules
Περίληψη: Calcium oxalate nephrolithiasis is strongly associated with oxidative stress, renal tubular injury, and inflammation. Natural products rich in polyphenols may serve as promising complementary preventive strategies. This study investigated the antiurolithiatic and renoprotective effects of Rhus coriaria fruit extract in an ethylene glycol-induced rat model of nephrolithiasis. Forty-two male rats were randomized into seven groups (n = 6): control, ethylene glycol (EG), EG + potassium citrate, R. coriaria 250 mg/kg/day, R. coriaria 500 mg/kg/day, EG + R. coriaria 250 mg/kg/day, and EG + R. coriaria 500 mg/kg/day. Nephrolithiasis was induced with 1% ethylene glycol for 28 days. Serum biochemistry, urinary lithogenic parameters, oxidative stress markers including total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA), histopathology, and immunohistochemical expression of kidney injury molecule-1 (KIM-1) and osteopontin (OPN) were evaluated. Phytochemical characterization of the extract was performed by high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD). Gallic acid was identified as the predominant phenolic constituent, together with smaller amounts of protocatechuic acid and ellagic acid. Ethylene glycol significantly increased urinary lithogenic parameters, oxidative stress indices, crystal deposition, tubular injury, and OPN expression. Treatment with R. coriaria significantly reduced urinary oxalate and calcium levels, improved TAS, SOD, and CAT levels, lowered TOS and MDA concentrations, and markedly attenuated crystal deposition, inflammation, and tubular dilatation. OPN expression was substantially decreased in treated groups, whereas KIM-1 showed a decreasing trend. Protective effects were more pronounced at the 500 mg/kg/day dose. R. coriaria fruit extract exerted significant antiurolithiatic and renoprotective effects in experimental calcium oxalate nephrolithiasis. These findings suggest that R. coriaria may represent a potential adjunctive strategy for calcium oxalate stone disease.
(© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethical Approval: All procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals and complied with ARRIVE guidelines. The experimental protocol was approved by the Adıyaman University Animal Experiments Local Ethics Committee (meeting date: October 24, 2024; session no: 6; decision no: 01; protocol no: 2024/043).
References: Urolithiasis. 2025 Apr 17;53(1):74. (PMID: 40244440)
Res Rep Urol. 2025 Nov 20;17:449-459. (PMID: 41292547)
Transl Androl Urol. 2014 Sep 1;3(3):256-276. (PMID: 25383321)
Indian J Urol. 2025 Jul-Sep;41(3):210-215. (PMID: 40756241)
Nat Rev Urol. 2023 Oct;20(10):615-637. (PMID: 37161031)
Nat Rev Nephrol. 2021 Jun;17(6):417-433. (PMID: 33514941)
Transl Androl Urol. 2025 Aug 30;14(8):2428-2438. (PMID: 40949433)
Urolithiasis. 2023 Mar 7;51(1):45. (PMID: 36881140)
Nutrients. 2023 Aug 28;15(17):. (PMID: 37686790)
Minerva Urol Nephrol. 2025 Aug;77(4):472-478. (PMID: 40891477)
Front Immunol. 2025 May 21;16:1540075. (PMID: 40469275)
Sci Rep. 2025 Nov 7;15(1):39098. (PMID: 41203807)
Food Sci Nutr. 2025 Nov 20;13(11):e71238. (PMID: 41280747)
Clin Chem. 1988 Mar;34(3):497-500. (PMID: 3349599)
Urolithiasis. 2025 Mar 21;53(1):54. (PMID: 40116953)
Clin Biochem. 2004 Apr;37(4):277-85. (PMID: 15003729)
Eur J Med Res. 2025 Dec 10;30(1):1224. (PMID: 41372793)
Indian J Pharmacol. 2025 Jul 1;57(4):212-218. (PMID: 40686352)
Anal Biochem. 1966 Dec;17(3):369-76. (PMID: 5965976)
J Food Biochem. 2019 Nov;43(11):e13030. (PMID: 31482601)
Anal Biochem. 1979 Jun;95(2):351-8. (PMID: 36810)
Pharm Biol. 2016 Oct;54(10):2092-102. (PMID: 26957014)
Urolithiasis. 2025 Jul 9;53(1):137. (PMID: 40632241)
Clin Biochem. 2005 Dec;38(12):1103-11. (PMID: 16214125)
Clin Kidney J. 2025 Aug 04;18(9):sfaf244. (PMID: 40978115)
J Urol. 2013 Sep;190(3):1102-9. (PMID: 23499748)
J Ethnopharmacol. 2025 Jan 30;337(Pt 1):118839. (PMID: 39299358)
Urolithiasis. 2023 Mar 3;51(1):43. (PMID: 36867274)
Front Physiol. 2020 Oct 20;11:566506. (PMID: 33192563)
Int Urol Nephrol. 2024 Dec;56(12):3687-3718. (PMID: 39042342)
J Clin Med. 2025 Sep 04;14(17):. (PMID: 40944007)
Front Pharmacol. 2022 Nov 09;13:1036423. (PMID: 36452224)
Microsc Res Tech. 2024 Jul;87(7):1494-1506. (PMID: 38415887)
Naunyn Schmiedebergs Arch Pharmacol. 2025 Dec;398(12):17793-17801. (PMID: 40560393)
Nat Rev Dis Primers. 2016 Feb 25;2:16008. (PMID: 27188687)
J Ethnopharmacol. 2025 Jan 30;337(Pt 2):118905. (PMID: 39374879)
PLoS One. 2025 Dec 5;20(12):e0336892. (PMID: 41348736)
Methods Enzymol. 1984;105:121-6. (PMID: 6727660)
Braz J Biol. 2022 Apr 27;84:e259100. (PMID: 35588519)
Phytomedicine. 2022 Nov;106:154429. (PMID: 36099652)
J Clin Med. 2025 Apr 22;14(9):. (PMID: 40363917)
Drug Chem Toxicol. 2021 Jan;44(1):75-83. (PMID: 33319629)
Grant Information: Project No: TIPFTUP/2025-0001 Adıyaman University Scientific Research Projects Coordination Unit
Contributed Indexing: Keywords: Rhus coriaria; Calcium oxalate; Kidney stone; Nephrolithiasis; Oxidative stress; Phytotherapy
Substance Nomenclature: 0 (Plant Extracts)
FC72KVT52F (Ethylene Glycol)
2612HC57YE (Calcium Oxalate)
106441-73-0 (Osteopontin)
0 (Antioxidants)
0 (Havcr1 protein, rat)
0 (Cell Adhesion Molecules)
SCR Disease Name: Nephrolithiasis, Calcium Oxalate
Entry Date(s): Date Created: 20260804 Date Completed: 20260804 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1007/s00240-026-02032-y
PMID: 42550246
Βάση Δεδομένων: MEDLINE
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  Data: Protective effects of Rhus coriaria L. fruit extract against experimental calcium oxalate nephrolithiasis via modulation of oxidative stress and renal injury.
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  Data: <searchLink fieldCode="AU" term="%22Koç+MK%22">Koç MK</searchLink>; Department of Urology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Kalyenci+B%22">Kalyenci B</searchLink>; Department of Urology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey. bedreddin84@windowslive.com.; Adıyaman University Central Campus Faculty of Medicine Dean's, Office Altınşehir, Center District, Adıyaman, Turkey. bedreddin84@windowslive.com.<br /><searchLink fieldCode="AU" term="%22Yılmaz+E%22">Yılmaz E</searchLink>; Department of Pharmacognosy, Faculty of Pharmacy, Adıyaman University, Adıyaman, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Gök+HN%22">Gök HN</searchLink>; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Öztürk+EE%22">Öztürk EE</searchLink>; Department of Biochemistry, Faculty of Veterinary Medicine, Harran University, Şanlıurfa, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Özercan+MR%22">Özercan MR</searchLink>; Department of Pathology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye, Turkey.
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  Data: <searchLink fieldCode="JN" term="%22101602699%22">Urolithiasis</searchLink> [Urolithiasis] 2026 Aug 04; Vol. 54 (1). <i>Date of Electronic Publication: </i>2026 Aug 04.
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  Data: <searchLink fieldCode="MM" term="%22Oxidative+Stress%22">Oxidative Stress*</searchLink>/<searchLink fieldCode="MM" term="%22Oxidative+Stress+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Plant+Extracts%22">Plant Extracts*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Extracts+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Plant+Extracts%22">Plant Extracts*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Extracts+therapeutic+use%22">therapeutic use</searchLink> <br /><searchLink fieldCode="MM" term="%22Nephrolithiasis%22">Nephrolithiasis*</searchLink>/<searchLink fieldCode="MM" term="%22Nephrolithiasis+chemically+induced%22">chemically induced</searchLink> <br /><searchLink fieldCode="MM" term="%22Nephrolithiasis%22">Nephrolithiasis*</searchLink>/<searchLink fieldCode="MM" term="%22Nephrolithiasis+prevention+%26+control%22">prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Nephrolithiasis%22">Nephrolithiasis*</searchLink>/<searchLink fieldCode="MM" term="%22Nephrolithiasis+drug+therapy%22">drug therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Nephrolithiasis%22">Nephrolithiasis*</searchLink>/<searchLink fieldCode="MM" term="%22Nephrolithiasis+urine%22">urine</searchLink> <br /><searchLink fieldCode="MM" term="%22Nephrolithiasis%22">Nephrolithiasis*</searchLink>/<searchLink fieldCode="MM" term="%22Nephrolithiasis+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Rhus%22">Rhus*</searchLink>/<searchLink fieldCode="MM" term="%22Rhus+chemistry%22">chemistry</searchLink><br /><searchLink fieldCode="MH" term="%22Fruit%22">Fruit</searchLink>/<searchLink fieldCode="MH" term="%22Fruit+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Ethylene+Glycol%22">Ethylene Glycol</searchLink>/<searchLink fieldCode="MH" term="%22Ethylene+Glycol+toxicity%22">toxicity</searchLink> ; <searchLink fieldCode="MH" term="%22Osteopontin%22">Osteopontin</searchLink>/<searchLink fieldCode="MH" term="%22Osteopontin+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Antioxidants%22">Antioxidants</searchLink>/<searchLink fieldCode="MH" term="%22Antioxidants+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Antioxidants%22">Antioxidants</searchLink>/<searchLink fieldCode="MH" term="%22Antioxidants+therapeutic+use%22">therapeutic use</searchLink> ; <searchLink fieldCode="MH" term="%22Kidney%22">Kidney</searchLink>/<searchLink fieldCode="MH" term="%22Kidney+pathology%22">pathology</searchLink> ; <searchLink fieldCode="MH" term="%22Kidney%22">Kidney</searchLink>/<searchLink fieldCode="MH" term="%22Kidney+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%22">Rats</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Calcium+Oxalate%22">Calcium Oxalate</searchLink> ; <searchLink fieldCode="MH" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal</searchLink> ; <searchLink fieldCode="MH" term="%22Cell+Adhesion+Molecules%22">Cell Adhesion Molecules</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Calcium oxalate nephrolithiasis is strongly associated with oxidative stress, renal tubular injury, and inflammation. Natural products rich in polyphenols may serve as promising complementary preventive strategies. This study investigated the antiurolithiatic and renoprotective effects of Rhus coriaria fruit extract in an ethylene glycol-induced rat model of nephrolithiasis. Forty-two male rats were randomized into seven groups (n = 6): control, ethylene glycol (EG), EG + potassium citrate, R. coriaria 250 mg/kg/day, R. coriaria 500 mg/kg/day, EG + R. coriaria 250 mg/kg/day, and EG + R. coriaria 500 mg/kg/day. Nephrolithiasis was induced with 1% ethylene glycol for 28 days. Serum biochemistry, urinary lithogenic parameters, oxidative stress markers including total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA), histopathology, and immunohistochemical expression of kidney injury molecule-1 (KIM-1) and osteopontin (OPN) were evaluated. Phytochemical characterization of the extract was performed by high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD). Gallic acid was identified as the predominant phenolic constituent, together with smaller amounts of protocatechuic acid and ellagic acid. Ethylene glycol significantly increased urinary lithogenic parameters, oxidative stress indices, crystal deposition, tubular injury, and OPN expression. Treatment with R. coriaria significantly reduced urinary oxalate and calcium levels, improved TAS, SOD, and CAT levels, lowered TOS and MDA concentrations, and markedly attenuated crystal deposition, inflammation, and tubular dilatation. OPN expression was substantially decreased in treated groups, whereas KIM-1 showed a decreasing trend. Protective effects were more pronounced at the 500 mg/kg/day dose. R. coriaria fruit extract exerted significant antiurolithiatic and renoprotective effects in experimental calcium oxalate nephrolithiasis. These findings suggest that R. coriaria may represent a potential adjunctive strategy for calcium oxalate stone disease.<br /> (© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Competing interests: The authors declare no competing interests. Ethical Approval: All procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals and complied with ARRIVE guidelines. The experimental protocol was approved by the Adıyaman University Animal Experiments Local Ethics Committee (meeting date: October 24, 2024; session no: 6; decision no: 01; protocol no: 2024/043).
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Urolithiasis. 2025 Apr 17;53(1):74. (PMID: <searchLink fieldCode="PM" term="%2240244440%22">40244440)</searchLink><br />Res Rep Urol. 2025 Nov 20;17:449-459. (PMID: <searchLink fieldCode="PM" term="%2241292547%22">41292547)</searchLink><br />Transl Androl Urol. 2014 Sep 1;3(3):256-276. (PMID: <searchLink fieldCode="PM" term="%2225383321%22">25383321)</searchLink><br />Indian J Urol. 2025 Jul-Sep;41(3):210-215. (PMID: <searchLink fieldCode="PM" term="%2240756241%22">40756241)</searchLink><br />Nat Rev Urol. 2023 Oct;20(10):615-637. (PMID: <searchLink fieldCode="PM" term="%2237161031%22">37161031)</searchLink><br />Nat Rev Nephrol. 2021 Jun;17(6):417-433. (PMID: <searchLink fieldCode="PM" term="%2233514941%22">33514941)</searchLink><br />Transl Androl Urol. 2025 Aug 30;14(8):2428-2438. (PMID: <searchLink fieldCode="PM" term="%2240949433%22">40949433)</searchLink><br />Urolithiasis. 2023 Mar 7;51(1):45. (PMID: <searchLink fieldCode="PM" term="%2236881140%22">36881140)</searchLink><br />Nutrients. 2023 Aug 28;15(17):. (PMID: <searchLink fieldCode="PM" term="%2237686790%22">37686790)</searchLink><br />Minerva Urol Nephrol. 2025 Aug;77(4):472-478. (PMID: <searchLink fieldCode="PM" term="%2240891477%22">40891477)</searchLink><br />Front Immunol. 2025 May 21;16:1540075. (PMID: <searchLink fieldCode="PM" term="%2240469275%22">40469275)</searchLink><br />Sci Rep. 2025 Nov 7;15(1):39098. (PMID: <searchLink fieldCode="PM" term="%2241203807%22">41203807)</searchLink><br />Food Sci Nutr. 2025 Nov 20;13(11):e71238. (PMID: <searchLink fieldCode="PM" term="%2241280747%22">41280747)</searchLink><br />Clin Chem. 1988 Mar;34(3):497-500. (PMID: <searchLink fieldCode="PM" term="%223349599%22">3349599)</searchLink><br />Urolithiasis. 2025 Mar 21;53(1):54. (PMID: <searchLink fieldCode="PM" term="%2240116953%22">40116953)</searchLink><br />Clin Biochem. 2004 Apr;37(4):277-85. (PMID: <searchLink fieldCode="PM" term="%2215003729%22">15003729)</searchLink><br />Eur J Med Res. 2025 Dec 10;30(1):1224. (PMID: <searchLink fieldCode="PM" term="%2241372793%22">41372793)</searchLink><br />Indian J Pharmacol. 2025 Jul 1;57(4):212-218. (PMID: <searchLink fieldCode="PM" term="%2240686352%22">40686352)</searchLink><br />Anal Biochem. 1966 Dec;17(3):369-76. (PMID: <searchLink fieldCode="PM" term="%225965976%22">5965976)</searchLink><br />J Food Biochem. 2019 Nov;43(11):e13030. (PMID: <searchLink fieldCode="PM" term="%2231482601%22">31482601)</searchLink><br />Anal Biochem. 1979 Jun;95(2):351-8. (PMID: <searchLink fieldCode="PM" term="%2236810%22">36810)</searchLink><br />Pharm Biol. 2016 Oct;54(10):2092-102. (PMID: <searchLink fieldCode="PM" term="%2226957014%22">26957014)</searchLink><br />Urolithiasis. 2025 Jul 9;53(1):137. (PMID: <searchLink fieldCode="PM" term="%2240632241%22">40632241)</searchLink><br />Clin Biochem. 2005 Dec;38(12):1103-11. (PMID: <searchLink fieldCode="PM" term="%2216214125%22">16214125)</searchLink><br />Clin Kidney J. 2025 Aug 04;18(9):sfaf244. (PMID: <searchLink fieldCode="PM" term="%2240978115%22">40978115)</searchLink><br />J Urol. 2013 Sep;190(3):1102-9. (PMID: <searchLink fieldCode="PM" term="%2223499748%22">23499748)</searchLink><br />J Ethnopharmacol. 2025 Jan 30;337(Pt 1):118839. (PMID: <searchLink fieldCode="PM" term="%2239299358%22">39299358)</searchLink><br />Urolithiasis. 2023 Mar 3;51(1):43. (PMID: <searchLink fieldCode="PM" term="%2236867274%22">36867274)</searchLink><br />Front Physiol. 2020 Oct 20;11:566506. (PMID: <searchLink fieldCode="PM" term="%2233192563%22">33192563)</searchLink><br />Int Urol Nephrol. 2024 Dec;56(12):3687-3718. (PMID: <searchLink fieldCode="PM" term="%2239042342%22">39042342)</searchLink><br />J Clin Med. 2025 Sep 04;14(17):. (PMID: <searchLink fieldCode="PM" term="%2240944007%22">40944007)</searchLink><br />Front Pharmacol. 2022 Nov 09;13:1036423. (PMID: <searchLink fieldCode="PM" term="%2236452224%22">36452224)</searchLink><br />Microsc Res Tech. 2024 Jul;87(7):1494-1506. (PMID: <searchLink fieldCode="PM" term="%2238415887%22">38415887)</searchLink><br />Naunyn Schmiedebergs Arch Pharmacol. 2025 Dec;398(12):17793-17801. (PMID: <searchLink fieldCode="PM" term="%2240560393%22">40560393)</searchLink><br />Nat Rev Dis Primers. 2016 Feb 25;2:16008. (PMID: <searchLink fieldCode="PM" term="%2227188687%22">27188687)</searchLink><br />J Ethnopharmacol. 2025 Jan 30;337(Pt 2):118905. (PMID: <searchLink fieldCode="PM" term="%2239374879%22">39374879)</searchLink><br />PLoS One. 2025 Dec 5;20(12):e0336892. (PMID: <searchLink fieldCode="PM" term="%2241348736%22">41348736)</searchLink><br />Methods Enzymol. 1984;105:121-6. (PMID: <searchLink fieldCode="PM" term="%226727660%22">6727660)</searchLink><br />Braz J Biol. 2022 Apr 27;84:e259100. (PMID: <searchLink fieldCode="PM" term="%2235588519%22">35588519)</searchLink><br />Phytomedicine. 2022 Nov;106:154429. (PMID: <searchLink fieldCode="PM" term="%2236099652%22">36099652)</searchLink><br />J Clin Med. 2025 Apr 22;14(9):. (PMID: <searchLink fieldCode="PM" term="%2240363917%22">40363917)</searchLink><br />Drug Chem Toxicol. 2021 Jan;44(1):75-83. (PMID: <searchLink fieldCode="PM" term="%2233319629%22">33319629)</searchLink>
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  Data: <i>Keywords: </i>Rhus coriaria; Calcium oxalate; Kidney stone; Nephrolithiasis; Oxidative stress; Phytotherapy
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  Data: Nephrolithiasis, Calcium Oxalate
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  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260804 <i>Date Completed: </i>20260804 <i>Latest Revision: </i>20261008
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20261008
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1007/s00240-026-02032-y
– Name: AN
  Label: PMID
  Group: ID
  Data: 42550246
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42550246
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00240-026-02032-y
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Fruit chemistry
        Type: general
      – SubjectFull: Ethylene Glycol toxicity
        Type: general
      – SubjectFull: Osteopontin metabolism
        Type: general
      – SubjectFull: Antioxidants pharmacology
        Type: general
      – SubjectFull: Antioxidants therapeutic use
        Type: general
      – SubjectFull: Kidney pathology
        Type: general
      – SubjectFull: Kidney drug effects
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Calcium Oxalate
        Type: general
      – SubjectFull: Disease Models, Animal
        Type: general
      – SubjectFull: Cell Adhesion Molecules
        Type: general
      – SubjectFull: Oxidative Stress drug effects
        Type: general
      – SubjectFull: Plant Extracts pharmacology
        Type: general
      – SubjectFull: Plant Extracts therapeutic use
        Type: general
      – SubjectFull: Nephrolithiasis chemically induced
        Type: general
      – SubjectFull: Nephrolithiasis prevention & control
        Type: general
      – SubjectFull: Nephrolithiasis drug therapy
        Type: general
      – SubjectFull: Nephrolithiasis urine
        Type: general
      – SubjectFull: Nephrolithiasis pathology
        Type: general
      – SubjectFull: Rhus chemistry
        Type: general
    Titles:
      – TitleFull: Protective effects of Rhus coriaria L. fruit extract against experimental calcium oxalate nephrolithiasis via modulation of oxidative stress and renal injury.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Koç MK
      – PersonEntity:
          Name:
            NameFull: Kalyenci B
      – PersonEntity:
          Name:
            NameFull: Yılmaz E
      – PersonEntity:
          Name:
            NameFull: Gök HN
      – PersonEntity:
          Name:
            NameFull: Öztürk EE
      – PersonEntity:
          Name:
            NameFull: Özercan MR
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 04
              M: 08
              Text: 2026 Aug 04
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2194-7236
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Urolithiasis
              Type: main
ResultId 1