Academic Journal
A preliminary investigation of antimicrobial, antibiofilm, and antiproliferative properties of a seed-derived endophytic fungus (Eremothecium coryli) from Basella alba L.: a crude extract-based screening study.
| Τίτλος: | A preliminary investigation of antimicrobial, antibiofilm, and antiproliferative properties of a seed-derived endophytic fungus (Eremothecium coryli) from Basella alba L.: a crude extract-based screening study. |
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| Συγγραφείς: | Saha M; Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, 563103, Karnataka, India., Pamidimukkala K; Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, 563103, Karnataka, India. kiranmayee@sduaher.ac.in. |
| Πηγή: | Antonie van Leeuwenhoek [Antonie Van Leeuwenhoek] 2026 Aug 01; Vol. 119 (9). Date of Electronic Publication: 2026 Aug 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Netherlands NLM ID: 0372625 Publication Model: Electronic Cited Medium: Internet ISSN: 1572-9699 (Electronic) Linking ISSN: 00036072 NLM ISO Abbreviation: Antonie Van Leeuwenhoek Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2004- : Berlin : Springer Original Publication: Wageningen, Netherland [etc.] Veenman [etc.] |
| Ιατρικοί όροι (MeSH): | Biofilms*/drug effects , Cell Proliferation*/drug effects , Endophytes*/chemistry , Endophytes*/isolation & purification , Ascomycota*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Anti-Infective Agents*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Antineoplastic Agents*/pharmacology , Complex Mixtures*/pharmacology , Complex Mixtures*/chemistry, Seeds/microbiology ; Bacteria/drug effects ; Humans ; Cell Line, Tumor ; Microbial Sensitivity Tests |
| Περίληψη: | This study presents a preliminary investigation into the antimicrobial, antibiofilm, and antiproliferative potential of Eremothecium coryli, an endophytic fungus isolated from the seeds of Basella alba L. The biological activities were evaluated using a crude extract-based screening study, employing the lyophilized cell-free supernatant (LCFS) of the fungal culture. Antibacterial and antibiofilm activities were assessed against selected multidrug-resistant bacterial pathogens, while antiproliferative activity was evaluated against breast cancer cell lines and a normal breast epithelial cell line. The LCFS demonstrated measurable antibacterial activity and significant biofilm-inhibition in a concentration-dependent manner. In cytotoxicity assays, selective growth inhibition of breast cancer cell lines was observed when compared with normal cells. Chemical profiling using Liquid Chromatography-Mass Spectrometry and Gas Chromatography-Mass Spectrometry enabled putative metabolite identification, revealing the presence of compounds previously reported to exhibit antimicrobial and anticancer activities. However, these identifications are tentative and based on spectral library matching. Overall, this preliminary investigation highlights the biological potential of E. coryli-derived metabolites. Further purification and validation are necessary to confirm compound identities, elucidate mechanisms of action, and assess in vivo relevance. (© 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
| Competing Interests: | Declarations. Competing interests: The authors have no relevant financial or non-financial interests to disclose. Ethics declaration: Not applicable. |
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| Contributed Indexing: | Keywords: Biofilm; Breast cancer cell lines; Initial cell attachment; Mass spectrometry; Multidrug-resistant bacteria |
| Substance Nomenclature: | 0 (Anti-Infective Agents) 0 (Anti-Bacterial Agents) 0 (Antineoplastic Agents) 0 (Complex Mixtures) |
| Entry Date(s): | Date Created: 20260801 Date Completed: 20260801 Latest Revision: 20260905 |
| Update Code: | 20260905 |
| DOI: | 10.1007/s10482-026-02368-w |
| PMID: | 42541521 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1572-9699 |
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| DOI: | 10.1007/s10482-026-02368-w |