Academic Journal
View in EDS

Enhancing tobacco quality through microbial-enzymatic processing: mechanisms, applications, and future perspectives.

Bibliographic Details
Title: Enhancing tobacco quality through microbial-enzymatic processing: mechanisms, applications, and future perspectives.
Authors: Xu L; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China., Zhang P; National Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou, China., Zhang H; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China., Liu PP; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China., Jin Z; China Tobacco Jilin Industrial Co., Ltd., Changchun, China., Gong JS; School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China., Lu ZM; National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, School of Biotechnology, Jiangnan University, Wuxi, China., Zheng QX; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China., Xu GY; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China., Zhai N; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China., Zhou HN; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China., Li YE; China Tobacco Jilin Industrial Co., Ltd., Changchun, China., Jin LF; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Source: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2026 Jul 16; Vol. 14, pp. 1895350. Date of Electronic Publication: 2026 Jul 16 (Print Publication: 2026).
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101632513 Publication Model: eCollection Cited Medium: Print ISSN: 2296-4185 (Print) Linking ISSN: 22964185 NLM ISO Abbreviation: Front Bioeng Biotechnol Subsets: PubMed not MEDLINE
Imprint Name(s): Original Publication: Lausanne : Frontiers Media S.A., [2013]-
Abstract: Aging represents a critical stage in tobacco processing that balances the internal chemical composition of tobacco leaves, reduces undesirable odors and irritation, and enhances smoking quality. Microbial fermentation and enzymatic catalysis are pivotal to this process, as they not only accelerate the fermentation period but also regulate the internal chemical constituents of the leaves, thereby improving aging efficiency. Consequently, the screening of suitable enzymes and functional strains is of paramount importance. This review summarizes recent advances in the application of enzymes and microorganisms for tobacco quality improvement, aiming to elucidate the mechanisms of enzymatic catalysis degrades macromolecules and generates aroma compounds, while also revealing the metabolic regulatory functions of microbial communities. This review aims to provide researchers with a comprehensive understanding of the latest developments in this field, while offering insights into the mining and engineering of core enzyme systems and functional strains.
(Copyright © 2026 Xu, Zhang, Zhang, Liu, Jin, Gong, Lu, Zheng, Xu, Zhai, Zhou, Li and Jin.)
Competing Interests: Authors ZJ and Y-EL were employed by China Tobacco Jilin Industrial Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References: Curr Microbiol. 2018 Oct;75(10):1306-1315. (PMID: 29869679)
Arch Microbiol. 2021 Nov;203(9):5723-5733. (PMID: 34480626)
Front Bioeng Biotechnol. 2022 Dec 16;10:1069796. (PMID: 36588960)
Chem Res Toxicol. 2021 Apr 19;34(4):1034-1045. (PMID: 33667338)
Front Microbiol. 2024 Nov 25;15:1468492. (PMID: 39654681)
Front Bioeng Biotechnol. 2024 Mar 13;12:1383083. (PMID: 38544979)
Bioresour Bioprocess. 2023 May 2;10(1):32. (PMID: 38647749)
Microbiologyopen. 2020 Mar;9(3):e984. (PMID: 31893578)
AMB Express. 2023 Aug 21;13(1):87. (PMID: 37603100)
Chemosphere. 2023 Sep;335:139050. (PMID: 37247679)
Front Bioeng Biotechnol. 2022 Dec 21;10:1093755. (PMID: 36619396)
Int J Biol Macromol. 2016 Oct;91:188-97. (PMID: 27211300)
Front Bioeng Biotechnol. 2023 Aug 25;11:1201957. (PMID: 37691904)
Front Microbiol. 2025 Jul 16;16:1623279. (PMID: 40740331)
Food Chem Toxicol. 2006 Nov;44(11):1789-98. (PMID: 16904804)
BMC Biotechnol. 2016 Nov 21;16(1):81. (PMID: 27871279)
Front Plant Sci. 2022 Nov 29;13:1074029. (PMID: 36523627)
Molecules. 2020 Apr 09;25(7):. (PMID: 32283792)
Front Bioeng Biotechnol. 2024 Mar 19;12:1332113. (PMID: 38567082)
Protein Expr Purif. 2024 Dec;224:106564. (PMID: 39111349)
Arch Biochem Biophys. 2022 Mar 30;718:109122. (PMID: 35063417)
Front Microbiol. 2024 Sep 17;15:1451582. (PMID: 39355430)
Biochem Biophys Rep. 2023 Aug 19;35:101532. (PMID: 37637940)
World J Microbiol Biotechnol. 2012 May;28(5):2077-86. (PMID: 22806029)
J Microbiol Biotechnol. 2024 Aug 28;34(8):1727-1737. (PMID: 39049482)
Crit Rev Biotechnol. 2021 Jun;41(4):513-534. (PMID: 33541157)
Appl Biochem Biotechnol. 2025 Jan;197(1):613-630. (PMID: 39207681)
Front Microbiol. 2024 Jul 05;15:1416734. (PMID: 39035444)
Biotechnol Biofuels Bioprod. 2024 Dec 18;17(1):144. (PMID: 39695820)
Sci Rep. 2022 Nov 10;12(1):19182. (PMID: 36357535)
J Sep Sci. 2008 Mar;31(4):721-6. (PMID: 18307165)
BMC Microbiol. 2020 Nov 19;20(1):356. (PMID: 33213368)
Environ Res. 2020 Apr;183:109258. (PMID: 32311908)
BMC Microbiol. 2022 Aug 15;22(1):197. (PMID: 35965316)
Bioresour Technol. 2026 Apr;445:134028. (PMID: 41554444)
Bioresour Bioprocess. 2025 May 21;12(1):43. (PMID: 40397057)
Microbiologyopen. 2020 Feb;9(2):e965. (PMID: 31808296)
Science. 1937 Oct 29;86(2235):404. (PMID: 17832645)
Front Bioeng Biotechnol. 2023 Jan 13;11:1108766. (PMID: 36714011)
Front Bioeng Biotechnol. 2024 Mar 07;12:1340160. (PMID: 38515623)
Appl Microbiol Biotechnol. 2017 May;101(10):4279-4287. (PMID: 28184985)
Front Microbiol. 2024 Nov 14;15:1481158. (PMID: 39611089)
Front Bioeng Biotechnol. 2024 Dec 06;12:1493766. (PMID: 39713101)
BMC Plant Biol. 2019 Dec 16;19(1):555. (PMID: 31842767)
Carbohydr Polym. 2021 Jun 1;261:117865. (PMID: 33766353)
Bioresour Technol. 2010 Sep;101(18):6935-41. (PMID: 20434329)
Open Life Sci. 2025 Oct 18;20(1):20251185. (PMID: 41142940)
Food Chem Toxicol. 2007 Jun;45(6):1039-50. (PMID: 17303297)
Crit Rev Toxicol. 2012 Mar;42(3):244-78. (PMID: 22263649)
Front Bioeng Biotechnol. 2025 Aug 12;13:1636506. (PMID: 40873436)
Appl Environ Microbiol. 2007 Feb;73(3):825-37. (PMID: 17142368)
Plant Cell Physiol. 2021 Nov 17;62(9):1460-1477. (PMID: 34184745)
Regul Toxicol Pharmacol. 2014 Oct;70(1):138-48. (PMID: 24973503)
Front Microbiol. 2020 Jul 21;11:1539. (PMID: 32793132)
Front Microbiol. 2021 Jul 14;12:683365. (PMID: 34335509)
Chem Mater. 2022 Dec 13;34(23):10623-10630. (PMID: 37323159)
Sci Rep. 2025 Feb 12;15(1):5304. (PMID: 39939685)
Appl Microbiol Biotechnol. 2023 Jul;107(13):4217-4232. (PMID: 37209161)
Food Chem Toxicol. 2004;42 Suppl:S53-83. (PMID: 15072838)
Nicotine Tob Res. 2019 Jun 21;21(7):991-995. (PMID: 29401309)
Front Microbiol. 2025 Jan 23;16:1538773. (PMID: 39916861)
Food Chem Toxicol. 2005 Apr;43(4):559-68. (PMID: 15721203)
N Engl J Med. 2016 Oct 6;375(14):1372-1381. (PMID: 27705269)
Sci Rep. 2023 Aug 10;13(1):12992. (PMID: 37563246)
Front Microbiol. 2025 Dec 03;16:1717865. (PMID: 41415817)
J Agric Food Chem. 2017 Oct 11;65(40):8957-8965. (PMID: 28880081)
Front Microbiol. 2023 Feb 24;14:1138877. (PMID: 36910204)
J Agric Food Chem. 2012 Jun 27;60(25):6454-61. (PMID: 22676549)
Appl Biochem Biotechnol. 2024 Jan;196(1):506-521. (PMID: 37148443)
Front Microbiol. 2025 Jul 09;16:1603337. (PMID: 40703232)
Contributed Indexing: Keywords: aging process; enzymatic treatment; fermentation; microbial community; tobacco processing
Entry Date(s): Date Created: 20260731 Date Completed: 20260731 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13422442
DOI: 10.3389/fbioe.2026.1895350
PMID: 42534884
Database: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=22964185&ISBN=&volume=14&issue=&date=20260716&spage=1895350&pages=1895350&title=Frontiers in bioengineering and biotechnology&atitle=Enhancing%20tobacco%20quality%20through%20microbial-enzymatic%20processing%3A%20mechanisms%2C%20applications%2C%20and%20future%20perspectives.&aulast=Xu%20L&id=DOI:10.3389/fbioe.2026.1895350
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 42534884
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Enhancing tobacco quality through microbial-enzymatic processing: mechanisms, applications, and future perspectives.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; National Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+PP%22">Liu PP</searchLink>; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Jin+Z%22">Jin Z</searchLink>; China Tobacco Jilin Industrial Co., Ltd., Changchun, China.<br /><searchLink fieldCode="AU" term="%22Gong+JS%22">Gong JS</searchLink>; School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Lu+ZM%22">Lu ZM</searchLink>; National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, School of Biotechnology, Jiangnan University, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Zheng+QX%22">Zheng QX</searchLink>; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+GY%22">Xu GY</searchLink>; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhai+N%22">Zhai N</searchLink>; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+HN%22">Zhou HN</searchLink>; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+YE%22">Li YE</searchLink>; China Tobacco Jilin Industrial Co., Ltd., Changchun, China.<br /><searchLink fieldCode="AU" term="%22Jin+LF%22">Jin LF</searchLink>; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101632513%22">Frontiers in bioengineering and biotechnology</searchLink> [Front Bioeng Biotechnol] 2026 Jul 16; Vol. 14, pp. 1895350. <i>Date of Electronic Publication: </i>2026 Jul 16 (<i>Print Publication: </i>2026).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Review
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media+S%2EA%22">Frontiers Media S.A </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101632513 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2296-4185 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222964185%22">22964185 </searchLink><i>NLM ISO Abbreviation: </i>Front Bioeng Biotechnol <i>Subsets: </i>PubMed not MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Lausanne : Frontiers Media S.A., [2013]-
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aging represents a critical stage in tobacco processing that balances the internal chemical composition of tobacco leaves, reduces undesirable odors and irritation, and enhances smoking quality. Microbial fermentation and enzymatic catalysis are pivotal to this process, as they not only accelerate the fermentation period but also regulate the internal chemical constituents of the leaves, thereby improving aging efficiency. Consequently, the screening of suitable enzymes and functional strains is of paramount importance. This review summarizes recent advances in the application of enzymes and microorganisms for tobacco quality improvement, aiming to elucidate the mechanisms of enzymatic catalysis degrades macromolecules and generates aroma compounds, while also revealing the metabolic regulatory functions of microbial communities. This review aims to provide researchers with a comprehensive understanding of the latest developments in this field, while offering insights into the mining and engineering of core enzyme systems and functional strains.<br /> (Copyright © 2026 Xu, Zhang, Zhang, Liu, Jin, Gong, Lu, Zheng, Xu, Zhai, Zhou, Li and Jin.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Authors ZJ and Y-EL were employed by China Tobacco Jilin Industrial Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Curr Microbiol. 2018 Oct;75(10):1306-1315. (PMID: <searchLink fieldCode="PM" term="%2229869679%22">29869679)</searchLink><br />Arch Microbiol. 2021 Nov;203(9):5723-5733. (PMID: <searchLink fieldCode="PM" term="%2234480626%22">34480626)</searchLink><br />Front Bioeng Biotechnol. 2022 Dec 16;10:1069796. (PMID: <searchLink fieldCode="PM" term="%2236588960%22">36588960)</searchLink><br />Chem Res Toxicol. 2021 Apr 19;34(4):1034-1045. (PMID: <searchLink fieldCode="PM" term="%2233667338%22">33667338)</searchLink><br />Front Microbiol. 2024 Nov 25;15:1468492. (PMID: <searchLink fieldCode="PM" term="%2239654681%22">39654681)</searchLink><br />Front Bioeng Biotechnol. 2024 Mar 13;12:1383083. (PMID: <searchLink fieldCode="PM" term="%2238544979%22">38544979)</searchLink><br />Bioresour Bioprocess. 2023 May 2;10(1):32. (PMID: <searchLink fieldCode="PM" term="%2238647749%22">38647749)</searchLink><br />Microbiologyopen. 2020 Mar;9(3):e984. (PMID: <searchLink fieldCode="PM" term="%2231893578%22">31893578)</searchLink><br />AMB Express. 2023 Aug 21;13(1):87. (PMID: <searchLink fieldCode="PM" term="%2237603100%22">37603100)</searchLink><br />Chemosphere. 2023 Sep;335:139050. (PMID: <searchLink fieldCode="PM" term="%2237247679%22">37247679)</searchLink><br />Front Bioeng Biotechnol. 2022 Dec 21;10:1093755. (PMID: <searchLink fieldCode="PM" term="%2236619396%22">36619396)</searchLink><br />Int J Biol Macromol. 2016 Oct;91:188-97. (PMID: <searchLink fieldCode="PM" term="%2227211300%22">27211300)</searchLink><br />Front Bioeng Biotechnol. 2023 Aug 25;11:1201957. (PMID: <searchLink fieldCode="PM" term="%2237691904%22">37691904)</searchLink><br />Front Microbiol. 2025 Jul 16;16:1623279. (PMID: <searchLink fieldCode="PM" term="%2240740331%22">40740331)</searchLink><br />Food Chem Toxicol. 2006 Nov;44(11):1789-98. (PMID: <searchLink fieldCode="PM" term="%2216904804%22">16904804)</searchLink><br />BMC Biotechnol. 2016 Nov 21;16(1):81. (PMID: <searchLink fieldCode="PM" term="%2227871279%22">27871279)</searchLink><br />Front Plant Sci. 2022 Nov 29;13:1074029. (PMID: <searchLink fieldCode="PM" term="%2236523627%22">36523627)</searchLink><br />Molecules. 2020 Apr 09;25(7):. (PMID: <searchLink fieldCode="PM" term="%2232283792%22">32283792)</searchLink><br />Front Bioeng Biotechnol. 2024 Mar 19;12:1332113. (PMID: <searchLink fieldCode="PM" term="%2238567082%22">38567082)</searchLink><br />Protein Expr Purif. 2024 Dec;224:106564. (PMID: <searchLink fieldCode="PM" term="%2239111349%22">39111349)</searchLink><br />Arch Biochem Biophys. 2022 Mar 30;718:109122. (PMID: <searchLink fieldCode="PM" term="%2235063417%22">35063417)</searchLink><br />Front Microbiol. 2024 Sep 17;15:1451582. (PMID: <searchLink fieldCode="PM" term="%2239355430%22">39355430)</searchLink><br />Biochem Biophys Rep. 2023 Aug 19;35:101532. (PMID: <searchLink fieldCode="PM" term="%2237637940%22">37637940)</searchLink><br />World J Microbiol Biotechnol. 2012 May;28(5):2077-86. (PMID: <searchLink fieldCode="PM" term="%2222806029%22">22806029)</searchLink><br />J Microbiol Biotechnol. 2024 Aug 28;34(8):1727-1737. (PMID: <searchLink fieldCode="PM" term="%2239049482%22">39049482)</searchLink><br />Crit Rev Biotechnol. 2021 Jun;41(4):513-534. (PMID: <searchLink fieldCode="PM" term="%2233541157%22">33541157)</searchLink><br />Appl Biochem Biotechnol. 2025 Jan;197(1):613-630. (PMID: <searchLink fieldCode="PM" term="%2239207681%22">39207681)</searchLink><br />Front Microbiol. 2024 Jul 05;15:1416734. (PMID: <searchLink fieldCode="PM" term="%2239035444%22">39035444)</searchLink><br />Biotechnol Biofuels Bioprod. 2024 Dec 18;17(1):144. (PMID: <searchLink fieldCode="PM" term="%2239695820%22">39695820)</searchLink><br />Sci Rep. 2022 Nov 10;12(1):19182. (PMID: <searchLink fieldCode="PM" term="%2236357535%22">36357535)</searchLink><br />J Sep Sci. 2008 Mar;31(4):721-6. (PMID: <searchLink fieldCode="PM" term="%2218307165%22">18307165)</searchLink><br />BMC Microbiol. 2020 Nov 19;20(1):356. (PMID: <searchLink fieldCode="PM" term="%2233213368%22">33213368)</searchLink><br />Environ Res. 2020 Apr;183:109258. (PMID: <searchLink fieldCode="PM" term="%2232311908%22">32311908)</searchLink><br />BMC Microbiol. 2022 Aug 15;22(1):197. (PMID: <searchLink fieldCode="PM" term="%2235965316%22">35965316)</searchLink><br />Bioresour Technol. 2026 Apr;445:134028. (PMID: <searchLink fieldCode="PM" term="%2241554444%22">41554444)</searchLink><br />Bioresour Bioprocess. 2025 May 21;12(1):43. (PMID: <searchLink fieldCode="PM" term="%2240397057%22">40397057)</searchLink><br />Microbiologyopen. 2020 Feb;9(2):e965. (PMID: <searchLink fieldCode="PM" term="%2231808296%22">31808296)</searchLink><br />Science. 1937 Oct 29;86(2235):404. (PMID: <searchLink fieldCode="PM" term="%2217832645%22">17832645)</searchLink><br />Front Bioeng Biotechnol. 2023 Jan 13;11:1108766. (PMID: <searchLink fieldCode="PM" term="%2236714011%22">36714011)</searchLink><br />Front Bioeng Biotechnol. 2024 Mar 07;12:1340160. (PMID: <searchLink fieldCode="PM" term="%2238515623%22">38515623)</searchLink><br />Appl Microbiol Biotechnol. 2017 May;101(10):4279-4287. (PMID: <searchLink fieldCode="PM" term="%2228184985%22">28184985)</searchLink><br />Front Microbiol. 2024 Nov 14;15:1481158. (PMID: <searchLink fieldCode="PM" term="%2239611089%22">39611089)</searchLink><br />Front Bioeng Biotechnol. 2024 Dec 06;12:1493766. (PMID: <searchLink fieldCode="PM" term="%2239713101%22">39713101)</searchLink><br />BMC Plant Biol. 2019 Dec 16;19(1):555. (PMID: <searchLink fieldCode="PM" term="%2231842767%22">31842767)</searchLink><br />Carbohydr Polym. 2021 Jun 1;261:117865. (PMID: <searchLink fieldCode="PM" term="%2233766353%22">33766353)</searchLink><br />Bioresour Technol. 2010 Sep;101(18):6935-41. (PMID: <searchLink fieldCode="PM" term="%2220434329%22">20434329)</searchLink><br />Open Life Sci. 2025 Oct 18;20(1):20251185. (PMID: <searchLink fieldCode="PM" term="%2241142940%22">41142940)</searchLink><br />Food Chem Toxicol. 2007 Jun;45(6):1039-50. (PMID: <searchLink fieldCode="PM" term="%2217303297%22">17303297)</searchLink><br />Crit Rev Toxicol. 2012 Mar;42(3):244-78. (PMID: <searchLink fieldCode="PM" term="%2222263649%22">22263649)</searchLink><br />Front Bioeng Biotechnol. 2025 Aug 12;13:1636506. (PMID: <searchLink fieldCode="PM" term="%2240873436%22">40873436)</searchLink><br />Appl Environ Microbiol. 2007 Feb;73(3):825-37. (PMID: <searchLink fieldCode="PM" term="%2217142368%22">17142368)</searchLink><br />Plant Cell Physiol. 2021 Nov 17;62(9):1460-1477. (PMID: <searchLink fieldCode="PM" term="%2234184745%22">34184745)</searchLink><br />Regul Toxicol Pharmacol. 2014 Oct;70(1):138-48. (PMID: <searchLink fieldCode="PM" term="%2224973503%22">24973503)</searchLink><br />Front Microbiol. 2020 Jul 21;11:1539. (PMID: <searchLink fieldCode="PM" term="%2232793132%22">32793132)</searchLink><br />Front Microbiol. 2021 Jul 14;12:683365. (PMID: <searchLink fieldCode="PM" term="%2234335509%22">34335509)</searchLink><br />Chem Mater. 2022 Dec 13;34(23):10623-10630. (PMID: <searchLink fieldCode="PM" term="%2237323159%22">37323159)</searchLink><br />Sci Rep. 2025 Feb 12;15(1):5304. (PMID: <searchLink fieldCode="PM" term="%2239939685%22">39939685)</searchLink><br />Appl Microbiol Biotechnol. 2023 Jul;107(13):4217-4232. (PMID: <searchLink fieldCode="PM" term="%2237209161%22">37209161)</searchLink><br />Food Chem Toxicol. 2004;42 Suppl:S53-83. (PMID: <searchLink fieldCode="PM" term="%2215072838%22">15072838)</searchLink><br />Nicotine Tob Res. 2019 Jun 21;21(7):991-995. (PMID: <searchLink fieldCode="PM" term="%2229401309%22">29401309)</searchLink><br />Front Microbiol. 2025 Jan 23;16:1538773. (PMID: <searchLink fieldCode="PM" term="%2239916861%22">39916861)</searchLink><br />Food Chem Toxicol. 2005 Apr;43(4):559-68. (PMID: <searchLink fieldCode="PM" term="%2215721203%22">15721203)</searchLink><br />N Engl J Med. 2016 Oct 6;375(14):1372-1381. (PMID: <searchLink fieldCode="PM" term="%2227705269%22">27705269)</searchLink><br />Sci Rep. 2023 Aug 10;13(1):12992. (PMID: <searchLink fieldCode="PM" term="%2237563246%22">37563246)</searchLink><br />Front Microbiol. 2025 Dec 03;16:1717865. (PMID: <searchLink fieldCode="PM" term="%2241415817%22">41415817)</searchLink><br />J Agric Food Chem. 2017 Oct 11;65(40):8957-8965. (PMID: <searchLink fieldCode="PM" term="%2228880081%22">28880081)</searchLink><br />Front Microbiol. 2023 Feb 24;14:1138877. (PMID: <searchLink fieldCode="PM" term="%2236910204%22">36910204)</searchLink><br />J Agric Food Chem. 2012 Jun 27;60(25):6454-61. (PMID: <searchLink fieldCode="PM" term="%2222676549%22">22676549)</searchLink><br />Appl Biochem Biotechnol. 2024 Jan;196(1):506-521. (PMID: <searchLink fieldCode="PM" term="%2237148443%22">37148443)</searchLink><br />Front Microbiol. 2025 Jul 09;16:1603337. (PMID: <searchLink fieldCode="PM" term="%2240703232%22">40703232)</searchLink>
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>aging process; enzymatic treatment; fermentation; microbial community; tobacco processing
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260731 <i>Date Completed: </i>20260731 <i>Latest Revision: </i>20260813
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260814
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC13422442
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3389/fbioe.2026.1895350
– Name: AN
  Label: PMID
  Group: ID
  Data: 42534884
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42534884
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3389/fbioe.2026.1895350
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1895350
    Titles:
      – TitleFull: Enhancing tobacco quality through microbial-enzymatic processing: mechanisms, applications, and future perspectives.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Xu L
      – PersonEntity:
          Name:
            NameFull: Zhang P
      – PersonEntity:
          Name:
            NameFull: Zhang H
      – PersonEntity:
          Name:
            NameFull: Liu PP
      – PersonEntity:
          Name:
            NameFull: Jin Z
      – PersonEntity:
          Name:
            NameFull: Gong JS
      – PersonEntity:
          Name:
            NameFull: Lu ZM
      – PersonEntity:
          Name:
            NameFull: Zheng QX
      – PersonEntity:
          Name:
            NameFull: Xu GY
      – PersonEntity:
          Name:
            NameFull: Zhai N
      – PersonEntity:
          Name:
            NameFull: Zhou HN
      – PersonEntity:
          Name:
            NameFull: Li YE
      – PersonEntity:
          Name:
            NameFull: Jin LF
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 16
              M: 07
              Text: 2026 Jul 16
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 2296-4185
          Numbering:
            – Type: volume
              Value: 14
          Titles:
            – TitleFull: Frontiers in bioengineering and biotechnology
              Type: main
ResultId 1