Academic Journal
A Substance Abuse, Violence and Unhealthy Alcohol Use Syndemic Predicts Depression: A Longitudinal Study of Black Women Living With HIV in Four US Cities.
| Τίτλος: | A Substance Abuse, Violence and Unhealthy Alcohol Use Syndemic Predicts Depression: A Longitudinal Study of Black Women Living With HIV in Four US Cities. |
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| Συγγραφείς: | Dyer T; School of Public Health, Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, USA., Turpin R; College of Public Health, Department of Global and Community Health, George Mason University, Fairfax, Virginia, USA., Boyd D; College of Social Work, The Ohio State University, Columbus, Ohio, USA., Mittal M; School of Public Health, Department of Family Science, University of Maryland, College Park, Maryland, USA., Najib C; School of Public Health, Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, USA., Owusu C; School of Public Health, Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, USA., Watson L; Centers For Disease Control and Prevention, National HIV Surveillance Branch, Atlanta, Georgia, USA., Kempf MC; Schools of Nursing, Public Health, and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Konkle-Parker D; Schools of Nursing, Medicine and Population Health, University of Mississippi Medical Center, Oxford, Mississippi, USA., Tien P; Department of Medicine, Department of Veteran Affairs Medical Center, University of California, San Francisco and Medical Service, San Francisco, California, USA., Wingood G; Department of Sociomedical Sciences, Columbia University Mailman School of Public Health, New York City, New York, USA., Neilands T; Division of Prevention Science, Department of Medicine, University of California, San Francisco, California, USA., Johnson M; Division of Prevention Science, Department of Medicine, University of California, San Francisco, California, USA., Weiser S; Division of HIV, ID and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA., Arnold E; Division of Prevention Science, Department of Medicine, University of California, San Francisco, California, USA., Turan J; School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA., Turan B; School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA., Topper E; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Norcini-Pala A; Department of Community Health Sciences, School of Public Health, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA. |
| Πηγή: | Brain and behavior [Brain Behav] 2026 Aug; Vol. 16 (8), pp. e71609. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hoboken, NJ : John Wiley & Sons |
| Ιατρικοί όροι (MeSH): | Depression*/epidemiology , Substance-Related Disorders*/epidemiology , Substance-Related Disorders*/psychology , Black or African American*/statistics & numerical data , HIV Infections*/epidemiology , HIV Infections*/psychology , Alcoholism*/epidemiology , Intimate Partner Violence*/statistics & numerical data , Intimate Partner Violence*/psychology , Violence*/statistics & numerical data, United States/epidemiology ; Humans ; Female ; Longitudinal Studies ; Adult ; Syndemic ; Middle Aged |
| Περίληψη: | Objective: Black women living with HIV (BWLH) have a heightened susceptibility to depression due to factors such as intimate partner violence (IPV), alcohol use, and substance abuse. This study examined the relationship between Substance Abuse, Violence, and Heavy Alcohol use (SAVA) among BWLH to determine whether this relationship creates distinct syndemic classes and whether class membership was associated with depressive symptoms. Methods: Data for this study were drawn from the WAVE sub-study, which included women enrolled in the WIHS (n = 363) collected between April 2016 and April 2017 in four US cities. Latent class analysis was used to identify subgroups based on cannabis use, alcohol use, substance use, and violence. Regression analyses explored the association between baseline syndemic class membership and depressive symptoms at 6, 12, and 18 months. Results: Three latent classes were identified: "syndemic," "non-syndemic low substance use," and "non-syndemic moderate cannabis use." Women in the syndemic class, characterized by higher levels of substance use and violence, had significantly higher depressive symptoms compared to those in the non-syndemic classes. Longitudinal regression revealed that membership in the syndemic class was associated with a 54% increased risk of depressive symptoms at 6 months, 34% at 12 months, and 51% at 18 months. Bidirectional analyses indicated that baseline violence was associated with increased risk for substance use, and vice versa. Conclusions: Findings highlight the high prevalence of SAVA syndemic factors and their association with depressive symptoms among BWLH and the need for integrated and culturally competent care that addresses both mental health and syndemic factors to improve outcomes for this vulnerable population. (© 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.) |
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| Grant Information: | U48DP006382 Centers for Disease Control and Prevention, Prevention Research Centers; R25MH067127 National Institute on Mental Health; R15MH129191 National Institute on Mental Health; CO-US-412-6417 Gilead Sciences; 1L60MD019864 Health Disparities Loan Repayment Program; K01MD016346 United States MD NIMHD NIH HHS; K01MH125724 United States MH NIMH NIH HHS; R01MH131177 United States MH NIMH NIH HHS; R01HL165686 United States HL NHLBI NIH HHS |
| Entry Date(s): | Date Created: 20260731 Date Completed: 20260731 Latest Revision: 20260802 |
| Update Code: | 20260802 |
| PubMed Central ID: | PMC13425611 |
| DOI: | 10.1002/brb3.71609 |
| PMID: | 42533671 |
| Βάση Δεδομένων: | MEDLINE |
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