Academic Journal
Taurine mitigates intestinal injury and spatial memory deficits induced by high-fat diet and abdominal irradiation.
| Τίτλος: | Taurine mitigates intestinal injury and spatial memory deficits induced by high-fat diet and abdominal irradiation. |
|---|---|
| Συγγραφείς: | Ding X; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China., Du J; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China., Wang Z; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China., Lu L; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China. Electronic address: lulu@irm-cams.ac.cn., Fan S; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China. Electronic address: fansaijun@irm-cams.ac.cn. |
| Πηγή: | Life sciences [Life Sci] 2026 Oct 15; Vol. 403, pp. 124604. Date of Electronic Publication: 2026 Jul 29. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Taurine*/pharmacology , Diet, High-Fat*/adverse effects , Spatial Memory*/drug effects , Spatial Memory*/radiation effects , Memory Disorders*/etiology , Memory Disorders*/drug therapy , Intestines*/drug effects , Intestines*/radiation effects, Gastrointestinal Microbiome/drug effects ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/pathology ; Mucin-2/metabolism ; Animals ; Male ; Female ; Mice ; Mice, Inbred C57BL ; Intestinal Barrier Function ; Akkermansia |
| Περίληψη: | Combined metabolic dysfunction and ionizing radiation produce multifactorial systemic harm, challenging organismal homeostasis and cognitive function. Here, we define a new role for dietary taurine (Tau) protection against combined high-fat diet (HFD) and whole-abdominal irradiation (WAI) stress. In a two-sex murine model, we show that Tau intervention blocks metabolic organ damage and severe structural enteropathy. Histological analyses indicate that Tau preserves the intestinal mucosal barrier, which is accompanied by the restoration of Mucin 2 (MUC2) expression. Furthermore, 16S rRNA sequencing showed that Tau reshapes gut dysbiosis, increasing the relative abundance of the mucin-degrading bacterium Akkermansia muciniphila, which may potentially contribute to mucosal homeostasis. Coincident with the stabilization of this mucin-microbiome interface, we observed that Tau attenuates systemic endotoxemia and reduces inflammatory extracellular vesicle transmission of the gut-brain axis. Consequently, this reduced peripheral inflammation preserves hippocampal dentate gyrus (DG) architecture and ameliorates spatial memory deficit. Importantly, while this microbiome-gut-brain protection is similar in both sexes, systemic immune responses are strikingly sexually dimorphic, mandating a sex-stratified therapeutic approach. Together, these studies reveal a potential microbiome-associated link in Tau-induced systemic resilience, providing a translatable nutritional strategy against combined radiotoxic and metabolic disorders. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Akkermansia muciniphila; Mucosal barrier; Radiotoxicity; Sexual dimorphism; Taurine |
| Substance Nomenclature: | 1EQV5MLY3D (Taurine) 0 (Mucin-2) |
| SCR Organism: | Akkermansia muciniphila |
| Entry Date(s): | Date Created: 20260729 Date Completed: 20260826 Latest Revision: 20260826 |
| Update Code: | 20260827 |
| DOI: | 10.1016/j.lfs.2026.124604 |
| PMID: | 42526595 |
| Βάση Δεδομένων: | MEDLINE |
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