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Taurine mitigates intestinal injury and spatial memory deficits induced by high-fat diet and abdominal irradiation.

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Τίτλος: Taurine mitigates intestinal injury and spatial memory deficits induced by high-fat diet and abdominal irradiation.
Συγγραφείς: Ding X; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China., Du J; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China., Wang Z; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China., Lu L; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China. Electronic address: lulu@irm-cams.ac.cn., Fan S; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China. Electronic address: fansaijun@irm-cams.ac.cn.
Πηγή: Life sciences [Life Sci] 2026 Oct 15; Vol. 403, pp. 124604. Date of Electronic Publication: 2026 Jul 29.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
Imprint Name(s): Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
Ιατρικοί όροι (MeSH): Taurine*/pharmacology , Diet, High-Fat*/adverse effects , Spatial Memory*/drug effects , Spatial Memory*/radiation effects , Memory Disorders*/etiology , Memory Disorders*/drug therapy , Intestines*/drug effects , Intestines*/radiation effects, Gastrointestinal Microbiome/drug effects ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/pathology ; Mucin-2/metabolism ; Animals ; Male ; Female ; Mice ; Mice, Inbred C57BL ; Intestinal Barrier Function ; Akkermansia
Περίληψη: Combined metabolic dysfunction and ionizing radiation produce multifactorial systemic harm, challenging organismal homeostasis and cognitive function. Here, we define a new role for dietary taurine (Tau) protection against combined high-fat diet (HFD) and whole-abdominal irradiation (WAI) stress. In a two-sex murine model, we show that Tau intervention blocks metabolic organ damage and severe structural enteropathy. Histological analyses indicate that Tau preserves the intestinal mucosal barrier, which is accompanied by the restoration of Mucin 2 (MUC2) expression. Furthermore, 16S rRNA sequencing showed that Tau reshapes gut dysbiosis, increasing the relative abundance of the mucin-degrading bacterium Akkermansia muciniphila, which may potentially contribute to mucosal homeostasis. Coincident with the stabilization of this mucin-microbiome interface, we observed that Tau attenuates systemic endotoxemia and reduces inflammatory extracellular vesicle transmission of the gut-brain axis. Consequently, this reduced peripheral inflammation preserves hippocampal dentate gyrus (DG) architecture and ameliorates spatial memory deficit. Importantly, while this microbiome-gut-brain protection is similar in both sexes, systemic immune responses are strikingly sexually dimorphic, mandating a sex-stratified therapeutic approach. Together, these studies reveal a potential microbiome-associated link in Tau-induced systemic resilience, providing a translatable nutritional strategy against combined radiotoxic and metabolic disorders.
(Copyright © 2026 Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Akkermansia muciniphila; Mucosal barrier; Radiotoxicity; Sexual dimorphism; Taurine
Substance Nomenclature: 1EQV5MLY3D (Taurine)
0 (Mucin-2)
SCR Organism: Akkermansia muciniphila
Entry Date(s): Date Created: 20260729 Date Completed: 20260826 Latest Revision: 20260826
Update Code: 20260827
DOI: 10.1016/j.lfs.2026.124604
PMID: 42526595
Βάση Δεδομένων: MEDLINE
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  Data: Taurine mitigates intestinal injury and spatial memory deficits induced by high-fat diet and abdominal irradiation.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Ding+X%22&quot;&gt;Ding X&lt;/searchLink&gt;; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Du+J%22&quot;&gt;Du J&lt;/searchLink&gt;; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+Z%22&quot;&gt;Wang Z&lt;/searchLink&gt;; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Lu+L%22&quot;&gt;Lu L&lt;/searchLink&gt;; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China. Electronic address: lulu@irm-cams.ac.cn.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Fan+S%22&quot;&gt;Fan S&lt;/searchLink&gt;; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin, 300192, China. Electronic address: fansaijun@irm-cams.ac.cn.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Combined metabolic dysfunction and ionizing radiation produce multifactorial systemic harm, challenging organismal homeostasis and cognitive function. Here, we define a new role for dietary taurine (Tau) protection against combined high-fat diet (HFD) and whole-abdominal irradiation (WAI) stress. In a two-sex murine model, we show that Tau intervention blocks metabolic organ damage and severe structural enteropathy. Histological analyses indicate that Tau preserves the intestinal mucosal barrier, which is accompanied by the restoration of Mucin 2 (MUC2) expression. Furthermore, 16S rRNA sequencing showed that Tau reshapes gut dysbiosis, increasing the relative abundance of the mucin-degrading bacterium Akkermansia muciniphila, which may potentially contribute to mucosal homeostasis. Coincident with the stabilization of this mucin-microbiome interface, we observed that Tau attenuates systemic endotoxemia and reduces inflammatory extracellular vesicle transmission of the gut-brain axis. Consequently, this reduced peripheral inflammation preserves hippocampal dentate gyrus (DG) architecture and ameliorates spatial memory deficit. Importantly, while this microbiome-gut-brain protection is similar in both sexes, systemic immune responses are strikingly sexually dimorphic, mandating a sex-stratified therapeutic approach. Together, these studies reveal a potential microbiome-associated link in Tau-induced systemic resilience, providing a translatable nutritional strategy against combined radiotoxic and metabolic disorders.&lt;br /&gt; (Copyright &#169; 2026 Elsevier Inc. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;Akkermansia muciniphila; Mucosal barrier; Radiotoxicity; Sexual dimorphism; Taurine
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  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260729 &lt;i&gt;Date Completed: &lt;/i&gt;20260826 &lt;i&gt;Latest Revision: &lt;/i&gt;20260826
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PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42526595
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        Value: 10.1016/j.lfs.2026.124604
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      – Code: eng
        Text: English
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        StartPage: 124604
    Subjects:
      – SubjectFull: Gastrointestinal Microbiome drug effects
        Type: general
      – SubjectFull: Intestinal Mucosa drug effects
        Type: general
      – SubjectFull: Intestinal Mucosa pathology
        Type: general
      – SubjectFull: Mucin-2 metabolism
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        Type: general
      – SubjectFull: Intestinal Barrier Function
        Type: general
      – SubjectFull: Akkermansia
        Type: general
      – SubjectFull: Taurine pharmacology
        Type: general
      – SubjectFull: Diet, High-Fat adverse effects
        Type: general
      – SubjectFull: Spatial Memory drug effects
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      – SubjectFull: Spatial Memory radiation effects
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      – SubjectFull: Intestines radiation effects
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      – TitleFull: Taurine mitigates intestinal injury and spatial memory deficits induced by high-fat diet and abdominal irradiation.
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              Text: 2026 Oct 15
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