Academic Journal
Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases.
| Τίτλος: | Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases. |
|---|---|
| Συγγραφείς: | Ran S; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Zhou S; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Ma H; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Zhang F; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Yang Y; Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China., Abulajiang M; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Yang X; Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China., Li S; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Zhang Q; Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.; Department of Pharmacy, Sichuan Provincial People's Hospital East Sichuan Hospital & Dazhou First People's Hospital, Dazhou, 635000, China. |
| Πηγή: | International journal of biological sciences [Int J Biol Sci] 2026 Jul 20; Vol. 22 (12), pp. 6767-6789. Date of Electronic Publication: 2026 Jul 20 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Lake Haven, N.S.W., Australia : Ivyspring International, c2004- |
| Ιατρικοί όροι (MeSH): | Aging*/physiology , Cellular Senescence*/physiology , Cellular Senescence*/drug effects , Senotherapeutics*/therapeutic use, Humans ; Animals ; Epigenesis, Genetic ; Apoptosis |
| Περίληψη: | With the acceleration of global population aging, the pathological accumulation of senescent cells (SnCs) has been confirmed as the core biological mechanism driving multiple aging-related diseases. This article aims to systematically review the formation mechanism of SnCs and their pathological roles in various tissue lesions, and to specifically evaluate the progress of three cutting-edge intervention strategies (Senolytics, Immuno-senolytics and Senomorphics). Senolytics selectively induces programmed apoptosis in SnCs by antagonizing senescent cell anti-apoptotic pathways. Immuno-senolytics include vaccines, engineered cell therapy and specific antibodies, which utilize the immune surveillance mechanism to achieve efficient elimination of SnCs. Senomorphics precisely reshape the SASP profile by targeting signaling axis or interfering with epigenetic modifications. Although the strategies have demonstrated remarkable potential for reversing pathology, their clinical translation still faces challenges such as the heterogeneity of SnCs, the lack of specific markers, and potential off-target toxicity. Future research should focus on multidisciplinary collaboration, aiming to optimize spatiotemporal targeted delivery systems and combination drug regimens to build a safer and more precise anti-senescence treatment system. (© The author(s).) |
| Competing Interests: | Competing Interests: The authors have declared that no competing interest exists. |
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| Contributed Indexing: | Keywords: cellular senescence; epigenetic regulation; immuno-senolytics; senolytics; senomorphics |
| Substance Nomenclature: | 0 (Senotherapeutics) |
| Entry Date(s): | Date Created: 20260729 Date Completed: 20260729 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13412423 |
| DOI: | 10.7150/ijbs.138243 |
| PMID: | 42524598 |
| Βάση Δεδομένων: | MEDLINE |
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