Academic Journal
Superiority of Adjuvant Hyperfractionated Radiotherapy Over Chemotherapy Following Radical Cystectomy.
| Title: | Superiority of Adjuvant Hyperfractionated Radiotherapy Over Chemotherapy Following Radical Cystectomy. |
|---|---|
| Authors: | Salah Ibrahim A; Radiotherapy Department at South Egypt Cancer Institute, Assiut University, Egypt., Gamal DA; Clinical Oncology Department at Assiut University Hospital, Assiut University, Egypt., Hadia A; Medical Oncology Department at South Egypt Cancer Institute, Assiut university, Egypt., Hasaballah A; Radiotherapy Department at South Egypt Cancer Institute, Assiut University, Egypt. |
| Source: | Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2026 Jul 01; Vol. 27 (7), pp. 2571-2580. Date of Electronic Publication: 2026 Jul 01. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III |
| Language: | English |
| Journal Info: | Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention |
| MeSH Terms: | Urinary Bladder Neoplasms*/therapy , Urinary Bladder Neoplasms*/pathology , Cystectomy*/mortality , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Cisplatin/administration & dosage ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/administration & dosage ; Humans ; Female ; Male ; Gemcitabine ; Chemotherapy, Adjuvant ; Follow-Up Studies ; Survival Rate ; Dose Fractionation, Radiation ; Aged ; Middle Aged ; Prognosis ; Radiotherapy, Adjuvant |
| Abstract: | Background: Bladder cancer (LABC) after radical cystectomy (RC) is common, even with chemotherapy, and is associated with high morbidity and mortality. Therefore, this work aimed to investigate the effect and efficacy of adjuvant sandwich chemotherapy plus radiotherapy versus adjuvant chemotherapy alone for LABC after RC. Methodology: This phase III trial was conducted in 125 patients with bladder cancer who underwent RC and were randomized to one of the following two adjuvant treatments. The chemotherapy plus RT arm received 2 cycles of gemcitabine and cisplatin before and after RT, with a 1-week break between chemotherapy and RT. The second arm, receiving chemotherapy alone, had 4 cycles of gemcitabine and cisplatin. Results: LRF was significantly reduced in the combined group (P < 0.001); however, DM was comparable between groups (p = 0.3). Furthermore, 64.9% of patients in the combined group were still alive, compared with only 5.9% in the chemotherapy group. Moreover, the mean time to local failure was not significantly different between the two groups (24.0 ± 0.1 vs. 26.5 ± 9.8, p = 0.08, respectively, for the combined group compared with the chemotherapy arm), but the mean time to DM was significantly prolonged in the combined group compared with the chemotherapy group (51.2 ± 14.9 vs. 29.7 ± 12.1, p < 0.001, respectively). Conclusion: Adjuvant chemotherapy plus RT was associated with significant improvements in LRFS and improvements in OS compared with chemotherapy alone in LABC. |
| Contributed Indexing: | Keywords: Chemotherapy; Radical cystectomy; bladder cancer; radiotherapy |
| Substance Nomenclature: | Q20Q21Q62J (Cisplatin) 0W860991D6 (Deoxycytidine) 0 (Gemcitabine) |
| Entry Date(s): | Date Created: 20260729 Date Completed: 20260729 Latest Revision: 20260729 |
| Update Code: | 20260730 |
| DOI: | 10.31557/APJCP.2026.27.7.2571 |
| PMID: | 42522819 |
| Database: | MEDLINE |
| ISSN: | 2476-762X |
|---|---|
| DOI: | 10.31557/APJCP.2026.27.7.2571 |