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Distinct Neural Modes Carry Information About Attempted Grasp Timing and Force in the Sensorimotor Cortex.

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Τίτλος: Distinct Neural Modes Carry Information About Attempted Grasp Timing and Force in the Sensorimotor Cortex.
Συγγραφείς: Blumenthal GH; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213., Dekleva BM; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213., Gontier C; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213., Gonzalez IC; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219., Gonzalez-Martinez JA; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213., Yu BM; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.; Departments of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.; Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213., Batista AP; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213., Sobinov AR; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637., Miller LE; Department of Neuroscience, Northwestern University, Chicago, Illinois 60208., Gaunt RA; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213., Boninger ML; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213., Chase SM; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.; Departments of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213., Collinger JL; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219 collinger@pitt.edu.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Departments of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.
Πηγή: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2026 Sep 09; Vol. 46 (36). Date of Electronic Publication: 2026 Sep 09.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
Imprint Name(s): Publication: Washington, DC : Society for Neuroscience
Original Publication: [Baltimore, Md.] : The Society, c1981-
Ιατρικοί όροι (MeSH): Hand Strength*/physiology , Sensorimotor Cortex*/physiology , Psychomotor Performance*/physiology, Somatosensory Cortex/physiology ; Quadriplegia/physiopathology ; Quadriplegia/etiology ; Humans ; Male ; Adult
Περίληψη: Humans perform a variety of complex hand movements to manipulate objects, requiring precise control of changing forces. Understanding the role of sensorimotor cortex and the cortical dynamics underlying these actions is crucial for developing interventions that restore dexterous hand function after injury or disease. In this study, two male individuals with tetraplegia resulting from cervical spinal cord injury attempted a series of isometric grasps. Neural activity was recorded from the motor and somatosensory cortices using intracortical microelectrode arrays while participants attempted to exert a static or ramping force up and down. Despite their inability to execute movement and limited afferent input, the spiking activity in motor and somatosensory cortex was modulated with the task. Within the neural response, we identified independent neural modes-distinct patterns of population-level neural activity that were informative about both the timing and magnitude of the attempted force. Moreover, distinct neural modes were observed during static and dynamic grasping conditions, suggesting independent control schemes for maintaining and changing forces. These modes were related to phases of the task, including the onset, offset, holding periods, as well as increasing and decreasing attempted forces. These results will inform the design of intracortical brain-computer interface (iBCI) systems that can leverage the patterns of grasp and force control evident in sensorimotor cortex during attempted movement to restore dexterous hand function.
(Copyright © 2026 Blumenthal et al.)
Σχόλια: Update of: bioRxiv. 2026 Feb 02:2026.02.01.702680. doi: 10.64898/2026.02.01.702680.. (PMID: 41676631)
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Grant Information: T32 NS086749 United States NS NINDS NIH HHS; U01 NS123125 United States NS NINDS NIH HHS; UH3 NS107714 United States NS NINDS NIH HHS
Contributed Indexing: Keywords: force; grasp; human; motor control; motor cortex; somatosensory cortex
Entry Date(s): Date Created: 20260728 Date Completed: 20260909 Latest Revision: 20260912
Update Code: 20260912
PubMed Central ID: PMC13560907
DOI: 10.1523/JNEUROSCI.0205-26.2026
PMID: 42521627
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
Header DbId: cmedm
DbLabel: MEDLINE
An: 42521627
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
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  Data: Distinct Neural Modes Carry Information About Attempted Grasp Timing and Force in the Sensorimotor Cortex.
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  Data: <searchLink fieldCode="AU" term="%22Blumenthal+GH%22">Blumenthal GH</searchLink>; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Dekleva+BM%22">Dekleva BM</searchLink>; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Gontier+C%22">Gontier C</searchLink>; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Gonzalez+IC%22">Gonzalez IC</searchLink>; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Martinez+JA%22">Gonzalez-Martinez JA</searchLink>; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Yu+BM%22">Yu BM</searchLink>; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.; Departments of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.; Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Batista+AP%22">Batista AP</searchLink>; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Sobinov+AR%22">Sobinov AR</searchLink>; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637.<br /><searchLink fieldCode="AU" term="%22Miller+LE%22">Miller LE</searchLink>; Department of Neuroscience, Northwestern University, Chicago, Illinois 60208.<br /><searchLink fieldCode="AU" term="%22Gaunt+RA%22">Gaunt RA</searchLink>; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Boninger+ML%22">Boninger ML</searchLink>; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Chase+SM%22">Chase SM</searchLink>; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.; Departments of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.<br /><searchLink fieldCode="AU" term="%22Collinger+JL%22">Collinger JL</searchLink>; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219 collinger@pitt.edu.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.; Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213.; Departments of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.
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  Data: Humans perform a variety of complex hand movements to manipulate objects, requiring precise control of changing forces. Understanding the role of sensorimotor cortex and the cortical dynamics underlying these actions is crucial for developing interventions that restore dexterous hand function after injury or disease. In this study, two male individuals with tetraplegia resulting from cervical spinal cord injury attempted a series of isometric grasps. Neural activity was recorded from the motor and somatosensory cortices using intracortical microelectrode arrays while participants attempted to exert a static or ramping force up and down. Despite their inability to execute movement and limited afferent input, the spiking activity in motor and somatosensory cortex was modulated with the task. Within the neural response, we identified independent neural modes-distinct patterns of population-level neural activity that were informative about both the timing and magnitude of the attempted force. Moreover, distinct neural modes were observed during static and dynamic grasping conditions, suggesting independent control schemes for maintaining and changing forces. These modes were related to phases of the task, including the onset, offset, holding periods, as well as increasing and decreasing attempted forces. These results will inform the design of intracortical brain-computer interface (iBCI) systems that can leverage the patterns of grasp and force control evident in sensorimotor cortex during attempted movement to restore dexterous hand function.<br /> (Copyright © 2026 Blumenthal et al.)
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  Data: Update of: bioRxiv. 2026 Feb 02:2026.02.01.702680. doi: 10.64898/2026.02.01.702680.. (PMID: <searchLink fieldCode="PM" term="%2241676631%22">41676631)</searchLink>
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