Academic Journal
Integrative genomic and transcriptomic analysis of hypertension in a Taiwanese population.
| Τίτλος: | Integrative genomic and transcriptomic analysis of hypertension in a Taiwanese population. |
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| Συγγραφείς: | Chang SN; Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital Yun-Ling Branch, Dou-Liu City., Lee GW; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei., Chen JJ; Taichung Municipal Geriatric and Rehabilitation General Hospital, Taichung., Wang CH; Division of Cardiovascular Surgery, Department of Surgery, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Cardiovascular Center, National Taiwan University Hospital., Chiu FC; Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital Yun-Ling Branch, Dou-Liu City., Huang PS; Division of Cardiology, Department of Internal Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei.; Graduate Institute of Clinical Medicine, College of Medicine., Chuang EY; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei.; Bioinformatics and Biostatistics Core, Centers of Genomic and Precision Medicine.; Research and Development Center for Medical Devices, National Taiwan University., Tsai CT; Graduate Institute of Clinical Medicine, College of Medicine.; Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Cardiovascular Center, National Taiwan University Hospital.; Department of Geriatrics and Gerontology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan. |
| Πηγή: | Journal of hypertension [J Hypertens] 2026 Oct 01; Vol. 44 (10), pp. 1812-1821. Date of Electronic Publication: 2026 Jul 27. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wolters Kluwer Health, Inc Country of Publication: Netherlands NLM ID: 8306882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5598 (Electronic) Linking ISSN: 02636352 NLM ISO Abbreviation: J Hypertens Subsets: MEDLINE |
| Imprint Name(s): | Publication: [Alphen aan den Rijn, the Netherlands] : Wolters Kluwer Health, Inc. Original Publication: London ; New York : Gower Academic Pub., [1983- |
| Ιατρικοί όροι (MeSH): | Hypertension*/genetics , Gene Expression Profiling* , Transcriptome*, East Asian People/genetics ; Female ; Humans ; Male ; Middle Aged ; Genetic Predisposition to Disease ; Genetic Risk Score ; Genome-Wide Association Study ; Genomics ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Taiwan |
| Περίληψη: | Objectives: Hypertension is highly prevalent in Asian populations and represents a major cardiovascular risk factor. However, most genome-wide association studies (GWASs) and transcriptome-wide association studies (TWASs) have focused primarily on Caucasian cohorts. This study aimed to identify genetic loci and gene expression signatures associated with hypertension in an Asian population. Methods: We analyzed 10 739 hypertensive patients and 49 668 controls from the Taiwan Biobank, testing 4 512 191 genome-wide single nucleotide polymorphisms (SNPs). Integrated GWAS, TWAS, and expression quantitative trait locus (eQTL) analyses were conducted to characterize genetic risk. Additionally, a polygenic risk score (PRS) was constructed using a split-sample design to evaluate genetic risk stratification. Results: We identified 14 loci significantly associated with hypertension, including a novel locus at 5p13.1. eQTL analysis linked this locus to DAB2 expression in whole blood. TWAS detected 55 hypertension-associated genes, with 20 (36%) overlapping GWAS loci. Several novel genes outside GWAS loci, including FBXL15, KCNIP2, and CRIP3, were highly significant and implicated in vascular biology and hypertension mechanisms. PRS analysis effectively differentiated hypertension risk, with individuals in the top 10% showing a > 3.5-fold increased risk compared to the bottom 10%. Conclusions: Our findings provide new insights into the genetic and transcriptomic landscape of hypertension in Asians. The identification of novel loci and genes advances understanding of disease biology and may guide precision medicine approaches for risk prediction and therapeutic development. (Copyright © 2026 The Author(s). Published by Wolters Kluwer Health, LLC.) |
| References: | Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, et al. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nat Genet 2024; 56:778–791. Cabrera CP, Ng FL, Nicholls HL, Gupta A, Barnes MR, Munroe PB, et al. Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Hum Mol Genet 2019; 28:R151–r161. Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet 2017; 49:403–415. Lu X, Wang L, Lin X, Huang J, Charles Gu C, He M, et al. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. Hum Mol Genet 2014; 24:865–874. Lin YJ, Li JP, Lai YC, Liu TY, Chiou JS, Lu HF, et al. Blood pressure genetics in Han Taiwanese with cross-trait analysis in east Asians: insights into comorbidities, all-cause mortality, and cardiovascular mortality. Hypertension 2025; 82:2227–2240. Suvila K, McCabe EL, Lima JAC, Aittokallio J, Yano Y, Cheng S, et al. Self-reported age of hypertension onset and hypertension-mediated organ damage in middle-aged individuals. Am J Hypertens 2020; 33:644–651. Wellman JL, Holmes B, Hill SY. Accuracy of self-reported hypertension:effect of age, gender, and history of alcohol dependence. J Clin Hypertens (Greenwich) 2020; 22:842–849. Wei C-Y, Yang J-H, Yeh E-C, Tsai M-F, Kao H-J, Lo C-Z, et al. Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese. npj Genomic Med 2021; 6:10. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81:559–575. Grace C, Farrall M, Watkins H, Goel A. Manhattan++: displaying genome-wide association summary statistics with multiple annotation layers. BMC Bioinformatics 2019; 20:610. Loh P-R, Tucker G, Bulik-Sullivan BK, Vilhjalmsson BJ, Finucane HK, Salem RM, et al. Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat Genet 2015; 47:284–290. Pruim RJ, Welch RP, Sanna S, Teslovich TM, Chines PS, Gliedt TP, et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 2010; 26:2336–2337. Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, et al. Trans-ethnic association study of blood pressure determinants in over 750 000 individuals. Nat Genet 2019; 51:51–62. Watanabe K, Taskesen E, Van Bochoven A, Posthuma D. Functional mapping and annotation of genetic associations with FUMA. Nat Commun 2017; 8:1826. Barbeira AN, Dickinson SP, Bonazzola R, Zheng J, Wheeler HE, Torres JM, et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat Commun 2018; 9:1825. Choi SW, O’Reilly PF. PRSice-2: polygenic risk score software for biobank-scale data. Gigascience 2019; 8:giz082. Packer M, Lam CS, Lund LH, Maurer MS, Borlaug BA. Characterization of the inflammatory-metabolic phenotype of heart failure with a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution and potential treatment of the disease. Eur J Heart Fail 2020; 22:1551–1567. Grubb S, Calloe K, Thomsen M. Impact of KChIP2 on cardiac electrophysiology and the progression of heart failure. Front Physiol 2012; 3:118. Dutta RK. Genetic and molecular alterations in aldosterone producing adenomas. 2020; Department of Clinical and Experimental Medicine, Division of Cell Biology: Linköping University Electronic Press,. Maj C, Salvi E, Citterio L, Borisov O, Simonini M, Glorioso V, et al. Dissecting the polygenic basis of primary hypertension: identification of key pathway-specific components. Front Cardiovasc Med 2022; 9:814502. Albert FW, Kruglyak L. The role of regulatory variation in complex traits and disease. Nat Rev Genet 2015; 16:197–212. Roselli C, Rienstra M, Ellinor PT. Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond. Circ Res 2020; 127:21–33. Wang Y, Wang Y, Adi D, He X, Liu F, Abudesimu A, et al. Dab2 gene variant is associated with increased coronary artery disease risk in Chinese Han population. Medicine (Baltimore) 2020; 99:e20924. Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 2010; 466:714–719. Otsuka T, Takada H, Nishiyama Y, Kodani E, Saiki Y, Kato K, et al. Dyslipidemia and the risk of developing hypertension in a working-age male population. J Am Heart Assoc 2016; 5:e003053. Adamson SE, Polanowska-Grabowska R, Marqueen K, Griffiths R, Angdisen J, Breevoort SR, et al. Deficiency of Dab2 (disabled homolog 2) in myeloid cells exacerbates inflammation in liver and atherosclerotic plaques in LDLR (low-density lipoprotein receptor)-null mice – brief report. Arterioscler Thromb Vasc Biol 2018; 38:1020–1029. Tao W, Moore R, Meng Y, Yeasky TM, Smith ER, Xu X-X. Disabled-2 determines commitment of a preadipocyte population in juvenile mice. Sci Rep 2016; 6:35947. Liu C, Li H, Qi Q, Lu L, Gan W, Loos RJ, et al. Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans. J Hypertens 2011; 29:70–75. Hotta K, Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, Matsuo T, et al. Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women. J Hum Genet 2012; 57:46–51. Li C, Kim YK, Dorajoo R, Li H, Lee I-T, Cheng C-Y, et al. Genome-wide association study meta-analysis of long-term average blood pressure in East Asians. Circ Cardiovasc Genet 2017; 10:e001527. Rodriguez M, Chen J, Jain PP, Babicheva A, Xiong M, Li J, et al. Upregulation of calcium homeostasis modulators in contractile-to-proliferative phenotypical transition of pulmonary arterial smooth muscle cells. Front Physiol 2021; 12:714785. Verhaaren BF, Debette S, Bis JC, Smith JA, Ikram MK, Adams HH, et al. Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circ Cardiovasc Genet 2015; 8:398–409. Schlauch KA, Read RW, Lombardi VC, Elhanan G, Metcalf WJ, Slonim AD, et al. A comprehensive genome-wide and phenome-wide examination of BMI and obesity in a Northern Nevadan Cohort. G3 2020; 10:645–664. Qi H, Xie YY, Yang XJ, Xia J, Liu K, Zhang FX, et al. Susceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure. BMC Genomics 2024; 25:612. Cui Y, He S, Xing C, Lu K, Wang J, Xing G, et al. SCFFBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. EMBO J 2011; 30:2675–2689. Tu L, Desroches-Castan A, Mallet C, Guyon L, Cumont A, Phan C, et al. Selective BMP-9 inhibition partially protects against experimental pulmonary hypertension. Circ Res 2019; 124:846–855. Huang H, Wang W, Yang G, Zhang Y, Li X, Liu H, et al. Circulating bone morphogenetic protein-9 levels are associated with hypertension and insulin resistance in humans. J Am Soc Hypertens 2018; 12:372–380. Lee MY, Park C, Berent RM, Park PJ, Fuchs R, Syn H, et al. Smooth muscle cell genome browser: enabling the identification of novel serum response factor target genes. PLoS One 2015; 10:e0133751. Smirnov SV, Aaronson PI. Ca(2+)-activated and voltage-gated K+ currents in smooth muscle cells isolated from human mesenteric arteries. J Physiol 1992; 457:431–454. van der Laan SW, Fall T, Soumaré A, Teumer A, Sedaghat S, Baumert J, et al. Cystatin C and cardiovascular disease: a Mendelian randomization study. J Am Coll Cardiol 2016; 68:934–945. Byonanebye DM, Polizzotto MN, Neesgaard B, Sarcletti M, Matulionyte R, Braun DL, et al. Incidence of hypertension in people with HIV who are treated with integrase inhibitors versus other antiretroviral regimens in the RESPOND cohort consortium. HIV Med 2022; 23:895–910. Manor O, Segal E. Robust prediction of expression differences among human individuals using only genotype information. PLoS Genet 2013; 9:e1003396. |
| Contributed Indexing: | Keywords: biobank; expression quantitative trait loci; genome-wide association study; hypertension; transcriptome-wide association study Taiwan |
| Entry Date(s): | Date Created: 20260728 Date Completed: 20260826 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| PubMed Central ID: | PMC13566396 |
| DOI: | 10.1097/HJH.0000000000004395 |
| PMID: | 42517328 |
| Βάση Δεδομένων: | MEDLINE |
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