Academic Journal
The role of hypoglycemic phytochemicals in improving male reproductive dysfunction: a systematic review of preclinical evidence.
| Τίτλος: | The role of hypoglycemic phytochemicals in improving male reproductive dysfunction: a systematic review of preclinical evidence. |
|---|---|
| Συγγραφείς: | Ayebazibwe G; Department of Pharmacology, School of Medicine, Kabale University, Kampala, Uganda., Ninsiima HI; Departmental of Human Physiology, School of Medicine, Kabale University, Kampala, Uganda., Mandera I; Departmental of Nursing Science, School of Medicine, Kabale University, Kampala, Uganda., Kyokunda LT; Department of Pathology, School of Medicine, Kabale University, Kampala, Uganda., Okello D; Department of Biological Sciences, Faculty of Science, Kabale University, Kampala, Uganda., Matovu D; Department of Pharmacology, School of Medicine, Kabale University, Kampala, Uganda. |
| Πηγή: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2026 Jul 13; Vol. 17, pp. 1814324. Date of Electronic Publication: 2026 Jul 13 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Systematic Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation] |
| Ιατρικοί όροι (MeSH): | Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/pharmacology , Infertility, Male*/drug therapy , Infertility, Male*/etiology, Oxidative Stress/drug effects ; Spermatogenesis/drug effects ; Spermatozoa/drug effects ; Male ; Humans ; Animals |
| Περίληψη: | Diabetes mellitus (DM), which affects over 500 million individuals (7%) globally, is associated with male reproductive dysfunction in more than 15% of affected individuals. The preclinical mechanisms by which hypoglycemic phytochemical compounds alleviate reproductive dysfunction in this population are scattered. A detailed systematic review of the preclinical evidence, with a focus on mechanisms of action and application potential, is currently necessary. The objectives were to analyze preclinical evidence on the therapeutic potential and mechanistic pathways through which hypoglycemic phytochemicals improve male reproductive function in diabetes mellitus. Methodology: The protocol was registered in PROSPERO prior to screening, and PRISMA guidelines 2020 were followed. Papers included in the search were published from October 2010 to October 2025 and were identified using the PubMed, Connecting Repositories, and Google Scholar databases. Results: Only 35 studies published between 2012 and 2025 that investigated improvements in male reproductive dysfunction in preclinical settings were reviewed. Discussion: The hypoglycemic phytochemicals improved diabetes-induced reproductive dysfunction through their effects on oxidative stress, sperm parameters, spermatogenesis, testicular morphology, testosterone, follicle-stimulating hormone, and luteinizing hormone. There were variations in the outcomes measured and methodologies. The majority of hypoglycemic phytochemicals reduced reactive oxygen species, which may be inadequate in humans, where there is also a psychological impact on erection. Conclusion: The review showed that hypoglycemic phytochemicals have the potential to improve male reproductive dysfunction in preclinical models of diabetes mellitus. The synthesis highlights the beneficial effects on glycemic control, sperm quality, hormonal regulation, oxidative stress, and testicular histology via integrated metabolic and reproductive mechanisms. Standardized phytochemicals should be used to study efficacy and safety before clinical trials. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251230781, identifier CRD420251230781. (Copyright © 2026 Ayebazibwe, Ninsiima, Mandera, Kyokunda, Okello and Matovu.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: hypoglycemic phytochemicals; male infertility; preclinical models; sperm parameters; testosterone; type 2 diabetes |
| Substance Nomenclature: | 0 (Phytochemicals) 0 (Hypoglycemic Agents) |
| Entry Date(s): | Date Created: 20260728 Date Completed: 20260729 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13402205 |
| DOI: | 10.3389/fendo.2026.1814324 |
| PMID: | 42516752 |
| Βάση Δεδομένων: | MEDLINE |
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