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Advances in Research on Dioscorea nipponica Makino: Chemical Constituents, Biological Activities and Developmental Prospects.

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Τίτλος: Advances in Research on Dioscorea nipponica Makino: Chemical Constituents, Biological Activities and Developmental Prospects.
Συγγραφείς: Yuan L; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China., Sun YE; Shandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China., Liang YP; Shandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China., Yao DH; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China., Guo YP; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China., Song X; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China., He ZD; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China., Zhao B; Shandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China.
Πηγή: Molecules (Basel, Switzerland) [Molecules] 2026 Jul 14; Vol. 31 (14). Date of Electronic Publication: 2026 Jul 14.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI, c1995-
Ιατρικοί όροι (MeSH): Dioscorea*/chemistry , Phytochemicals*/chemistry , Phytochemicals*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/pharmacology, Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Humans ; Animals
Περίληψη: Ethnopharmacological Relevance: Dioscorea nipponica Makino is a traditional medicinal plant widely used in East Asia for the treatment of rheumatic disorders, inflammatory diseases, and cardiovascular conditions. Its rhizome has long been applied in clinical practice for relieving pain, promoting blood circulation, and reducing swelling.
Aim of the Study: This narrative review aims to provide a comprehensive and critical overview of the phytochemical constituents, pharmacological activities, and underlying mechanisms of D. nipponica and to identify current research gaps and future perspectives.
Materials and Methods: The literature was searched in PubMed, Web of Science, ScienceDirect, CNKI and Wanfang Data from database inception to December 2025. The combined retrieval keywords were set as: (Dioscorea nipponica Makino OR Chuanshanlong) AND (chemical constituents OR steroidal saponins OR flavonoids OR phenols) AND (biological activity OR anti-inflammatory OR cardioprotective OR hepatotoxicity OR clinical application). Both English and Chinese publications were retrieved, and studies written in other languages were excluded.
Results: Phytochemical studies have identified diverse secondary metabolites, particularly steroidal saponins, along with diarylheptanoids and phenanthrenes. These compounds exhibit multiple pharmacological activities, including anti-inflammatory, anti-tumor, immunomodulatory, and cardioprotective effects. Mechanistic studies indicate that these activities are mediated through the modulation of key signaling pathways such as NF-κB, PI3K/Akt, AMPK, and the NLRP3 inflammasome. However, current research remains fragmented, with limited integration of chemical composition, molecular targets, and therapeutic outcomes.
Conclusions: D. nipponica represents a promising source of bioactive natural products, with steroidal saponins as the major contributors to its pharmacological effects. Future studies should focus on multi-component interactions, pharmacokinetics, quality control, and clinical validation to support its rational development and sustainable utilization.
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J Ethnopharmacol. 2014 Sep 11;155(2):1164-70. (PMID: 24973689)
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Grant Information: 2025ZD1801402 China University of Science and Technology; YDZX2023090 Centrally Government Guided Local Science and Technology Development Fund Project; DEEJ-YB-2023-12-112 Dong'e Ejiao Fund Project; 2024KCXTD012 Innovation Team Project of Guangdong Provincial Department of Education; JCYJ20241202124709013 Basic Research Fund in Shenzhen Natural Science Foundation
Contributed Indexing: Keywords: Dioscorea nipponica; anti-inflammatory activity; steroidal saponins; traditional medicine
Substance Nomenclature: 0 (Phytochemicals)
0 (Plant Extracts)
0 (Anti-Inflammatory Agents)
Entry Date(s): Date Created: 20260728 Date Completed: 20260729 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13415829
DOI: 10.3390/molecules31142460
PMID: 42513142
Βάση Δεδομένων: MEDLINE
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  Data: Advances in Research on Dioscorea nipponica Makino: Chemical Constituents, Biological Activities and Developmental Prospects.
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  Data: <searchLink fieldCode="AU" term="%22Yuan+L%22">Yuan L</searchLink>; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.<br /><searchLink fieldCode="AU" term="%22Sun+YE%22">Sun YE</searchLink>; Shandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China.<br /><searchLink fieldCode="AU" term="%22Liang+YP%22">Liang YP</searchLink>; Shandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China.<br /><searchLink fieldCode="AU" term="%22Yao+DH%22">Yao DH</searchLink>; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.<br /><searchLink fieldCode="AU" term="%22Guo+YP%22">Guo YP</searchLink>; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.<br /><searchLink fieldCode="AU" term="%22Song+X%22">Song X</searchLink>; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.<br /><searchLink fieldCode="AU" term="%22He+ZD%22">He ZD</searchLink>; College of Pharmacy, Shenzhen Technology University, No. 3002, Lantian Road, Pingshan District, Shenzhen 518118, China.<br /><searchLink fieldCode="AU" term="%22Zhao+B%22">Zhao B</searchLink>; Shandong Key Laboratory of Gelatine Medicines Research and Development, Dong'e Ejiao Co., Ltd., No. 78, Ejiao Street, Liaocheng 252201, China.
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  Data: <searchLink fieldCode="JN" term="%22100964009%22">Molecules (Basel, Switzerland)</searchLink> [Molecules] 2026 Jul 14; Vol. 31 (14). <i>Date of Electronic Publication: </i>2026 Jul 14.
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– Name: Abstract
  Label: Abstract
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  Data: Ethnopharmacological Relevance: Dioscorea nipponica Makino is a traditional medicinal plant widely used in East Asia for the treatment of rheumatic disorders, inflammatory diseases, and cardiovascular conditions. Its rhizome has long been applied in clinical practice for relieving pain, promoting blood circulation, and reducing swelling.<br />Aim of the Study: This narrative review aims to provide a comprehensive and critical overview of the phytochemical constituents, pharmacological activities, and underlying mechanisms of D. nipponica and to identify current research gaps and future perspectives.<br />Materials and Methods: The literature was searched in PubMed, Web of Science, ScienceDirect, CNKI and Wanfang Data from database inception to December 2025. The combined retrieval keywords were set as: (Dioscorea nipponica Makino OR Chuanshanlong) AND (chemical constituents OR steroidal saponins OR flavonoids OR phenols) AND (biological activity OR anti-inflammatory OR cardioprotective OR hepatotoxicity OR clinical application). Both English and Chinese publications were retrieved, and studies written in other languages were excluded.<br />Results: Phytochemical studies have identified diverse secondary metabolites, particularly steroidal saponins, along with diarylheptanoids and phenanthrenes. These compounds exhibit multiple pharmacological activities, including anti-inflammatory, anti-tumor, immunomodulatory, and cardioprotective effects. Mechanistic studies indicate that these activities are mediated through the modulation of key signaling pathways such as NF-κB, PI3K/Akt, AMPK, and the NLRP3 inflammasome. However, current research remains fragmented, with limited integration of chemical composition, molecular targets, and therapeutic outcomes.<br />Conclusions: D. nipponica represents a promising source of bioactive natural products, with steroidal saponins as the major contributors to its pharmacological effects. Future studies should focus on multi-component interactions, pharmacokinetics, quality control, and clinical validation to support its rational development and sustainable utilization.
– Name: Ref
  Label: References
  Group: RefInfo
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– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: 2025ZD1801402 China University of Science and Technology; YDZX2023090 Centrally Government Guided Local Science and Technology Development Fund Project; DEEJ-YB-2023-12-112 Dong'e Ejiao Fund Project; 2024KCXTD012 Innovation Team Project of Guangdong Provincial Department of Education; JCYJ20241202124709013 Basic Research Fund in Shenzhen Natural Science Foundation
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  Data: <i>Keywords: </i>Dioscorea nipponica; anti-inflammatory activity; steroidal saponins; traditional medicine
– Name: NumberCAS
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  Data: 0 (Phytochemicals)<br />0 (Plant Extracts)<br />0 (Anti-Inflammatory Agents)
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  Data: <i>Date Created: </i>20260728 <i>Date Completed: </i>20260729 <i>Latest Revision: </i>20260813
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  Data: 10.3390/molecules31142460
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  Data: 42513142
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42513142
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        Text: English
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      – SubjectFull: Anti-Inflammatory Agents chemistry
        Type: general
      – SubjectFull: Anti-Inflammatory Agents pharmacology
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      – SubjectFull: Humans
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      – SubjectFull: Animals
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      – SubjectFull: Dioscorea chemistry
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      – SubjectFull: Plant Extracts pharmacology
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      – TitleFull: Advances in Research on Dioscorea nipponica Makino: Chemical Constituents, Biological Activities and Developmental Prospects.
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              Text: 2026 Jul 14
              Type: published
              Y: 2026
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              Value: 1420-3049
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