Academic Journal
Sensory-secretory neuroimmune circuits of the ocular surface.
| Τίτλος: | Sensory-secretory neuroimmune circuits of the ocular surface. |
|---|---|
| Συγγραφείς: | Li Z; Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, 450000, China. Electronic address: tzhijieli@jnu.edu.cn., Li J; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
| Πηγή: | Experimental eye research [Exp Eye Res] 2026 Oct; Vol. 271, pp. 111183. Date of Electronic Publication: 2026 Jul 27. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0007 (Electronic) Linking ISSN: 00144835 NLM ISO Abbreviation: Exp Eye Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Academic Press Original Publication: London. |
| Ιατρικοί όροι (MeSH): | Dry Eye Syndromes*/immunology , Dry Eye Syndromes*/physiopathology , Tears*/metabolism , Neuroimmunomodulation*/physiology , Conjunctiva*/innervation , Conjunctiva*/immunology , Cornea*/innervation, Immunity, Mucosal/physiology ; Humans ; Animals ; Lacrimal Apparatus |
| Περίληψη: | The ocular surface is a sensory-rich mucosal barrier in which trigeminal input, autonomic output, tear composition, epithelial stress, glandular secretion, goblet-cell function and local immunity are closely coupled. This review uses the sensory-secretory mucosal immune unit as a tissue-level map across four measurable output domains: secretory function, neural state, immune activity and barrier integrity. The term is not proposed as a new anatomical compartment or as a renamed lacrimal functional unit or eye-associated lymphoid tissue. Direct ocular evidence is distinguished from ocular-adjacent observations and cross-barrier analogies, particularly for cytokine-neuron, microbiome-neuron and mucosal-drainage pathways. Dry eye disease, allergic conjunctivitis and neurotrophic keratopathy are compared as overlapping but distinct patterns of circuit failure, with dry eye disease framed as sensory-autonomic dysfunction, allergic conjunctivitis as type 2 neuroimmune amplification and neurotrophic keratopathy as sensory denervation with impaired epithelial repair. The review also considers lacrimal drainage, nasal mucosal continuity and regional eye-draining lymph nodes as conditional antigen-handling routes. Emphasis is placed on paired secretory, neural, immune and barrier readouts that may help define the dominant failing process and guide intervention studies. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Allergic conjunctivitis; Autonomic nervous system; Dry eye disease; Mucosal immunity; Neuroimmunology; Neurotrophic keratopathy; Ocular surface; Trigeminal nerve |
| Entry Date(s): | Date Created: 20260727 Date Completed: 20260831 Latest Revision: 20260831 |
| Update Code: | 20260901 |
| DOI: | 10.1016/j.exer.2026.111183 |
| PMID: | 42508745 |
| Βάση Δεδομένων: | MEDLINE |
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