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Divergent co-transmission by a predictive motor circuit modulates auditory processing.

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Τίτλος: Divergent co-transmission by a predictive motor circuit modulates auditory processing.
Συγγραφείς: Bennett MM; Department of Biology, West Virginia University, Morgantown, WV, USA. Electronic address: marryn.bennett@mso.umt.edu., Cheong HSJ; Zuckerman Institute, Columbia University, New York, NY, USA., Boone KN; Department of Biology, West Virginia University, Morgantown, WV, USA., Salman F; Department of Biology, West Virginia University, Morgantown, WV, USA., Ralston JD; Department of Biology, West Virginia University, Morgantown, WV, USA., Luthman JM; Department of Biology, West Virginia University, Morgantown, WV, USA., Daly KC; Department of Biology, West Virginia University, Morgantown, WV, USA; Department of Neuroscience, West Virginia University, Morgantown, WV, USA., Card GM; Zuckerman Institute, Columbia University, New York, NY, USA., Dacks AM; Department of Biology, West Virginia University, Morgantown, WV, USA; Department of Biology, Case Western Reserve University, Cleveland, OH, USA. Electronic address: amd358@case.edu.
Πηγή: Current biology : CB [Curr Biol] 2026 Aug 17; Vol. 36 (16), pp. 4006-4023.e9. Date of Electronic Publication: 2026 Jul 27.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE
Imprint Name(s): Publication: Cambridge, MA : Cell Press
Original Publication: London, UK : Current Biology Ltd., c1991-
Ιατρικοί όροι (MeSH): Auditory Perception*/physiology , Drosophila melanogaster*/physiology , Drosophila*/physiology, Histamine/metabolism ; Neurons/physiology ; Sexual Behavior, Animal/physiology ; Drosophila Proteins/metabolism ; Animals ; Courtship ; Male ; Female
Περίληψη: During behavior, predictive motor circuits modify sensory processing in anticipation of self-induced (reafferent) stimulation. However, specialized networks processing different facets of sensory information can be impacted by reafference generated by the same behavior. Here, we describe a predictive motor circuit in Drosophila that implements co-transmission to differentially modify auditory neurons that process sound in separate behavioral contexts. The metathoracic ascending histamine neurons (MtAHNs) become active prior to flight and co-transmit Dh44 and histamine, each of which suppresses auditory neurons integrated into distinct networks that support escape and courtship, respectively. Disrupting the release of either transmitter reduces courtship success, and co-transmission of Dh44 is present in Drosophila species that have an auditory component to their courtship displays but not in species whose courtship behavior lacks song production. Our results indicate that divergent co-transmission by predictive motor circuits may represent an efficient means of differentially modulating sensory subnetworks impacted by common reafferent feedback.
(Copyright © 2026 Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of interests The authors declare no competing interests.
Contributed Indexing: Keywords: Dh44; Drosophila; auditory processing; co-transmission; corollary discharge; flight; histamine
Substance Nomenclature: 820484N8I3 (Histamine)
0 (Drosophila Proteins)
Entry Date(s): Date Created: 20260727 Date Completed: 20260817 Latest Revision: 20261010
Update Code: 20261010
DOI: 10.1016/j.cub.2026.06.080
PMID: 42508399
Βάση Δεδομένων: MEDLINE
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  Data: During behavior, predictive motor circuits modify sensory processing in anticipation of self-induced (reafferent) stimulation. However, specialized networks processing different facets of sensory information can be impacted by reafference generated by the same behavior. Here, we describe a predictive motor circuit in Drosophila that implements co-transmission to differentially modify auditory neurons that process sound in separate behavioral contexts. The metathoracic ascending histamine neurons (MtAHNs) become active prior to flight and co-transmit Dh44 and histamine, each of which suppresses auditory neurons integrated into distinct networks that support escape and courtship, respectively. Disrupting the release of either transmitter reduces courtship success, and co-transmission of Dh44 is present in Drosophila species that have an auditory component to their courtship displays but not in species whose courtship behavior lacks song production. Our results indicate that divergent co-transmission by predictive motor circuits may represent an efficient means of differentially modulating sensory subnetworks impacted by common reafferent feedback.<br /> (Copyright © 2026 Elsevier Inc. All rights reserved.)
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  Data: Declaration of interests The authors declare no competing interests.
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