Academic Journal
TRP channel activation and cholinergic signaling in insect thermoregulation: evidence from the American cockroach.
| Τίτλος: | TRP channel activation and cholinergic signaling in insect thermoregulation: evidence from the American cockroach. |
|---|---|
| Συγγραφείς: | Maliszewska J; Department of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, Toruń, 87-100, Poland. ojustyna@umk.pl., Jankowska M; Department of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, Toruń, 87-100, Poland., Artkop M; Department of Pathophysiology, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University in Toruń, Bydgoszcz, 85-094, Poland., Rogalska J; Department of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, Toruń, 87-100, Poland. |
| Πηγή: | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology [J Comp Physiol B] 2026 Oct; Vol. 196 (5), pp. 621-631. Date of Electronic Publication: 2026 Jul 27. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8413200 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-136X (Electronic) Linking ISSN: 01741578 NLM ISO Abbreviation: J Comp Physiol B Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin ; New York : Springer-Verlag, [c1984- |
| Ιατρικοί όροι (MeSH): | Periplaneta*/physiology , Periplaneta*/drug effects , Body Temperature Regulation*/physiology , Body Temperature Regulation*/drug effects , Transient Receptor Potential Channels*/metabolism , Receptors, Nicotinic*/metabolism, Capsaicin/pharmacology ; Capsaicin/analogs & derivatives ; Neurons/drug effects ; Neurons/physiology ; TRPV Cation Channels/antagonists & inhibitors ; TRPV Cation Channels/metabolism ; Animals ; Signal Transduction ; Male |
| Περίληψη: | Transient receptor potential (TRP) channels mediate insect thermosensation, yet the downstream neurotransmitter pathways linking TRP activation to behavioral output remain unclear. We investigated the role of nicotinic acetylcholine receptors (nAChRs) in thermoregulatory and neural responses induced by TRP ligands in the American cockroach, Periplaneta americana. Extracellular recordings from the ventral nerve cord showed that capsaicin reduced spontaneous neuronal firing, whereas the selective α7-containing nAChR antagonist MG 624 increased baseline activity. Notably, nicotinic receptor blockade prevented the capsaicin-induced suppression of neuronal activity, suggesting an interaction between cholinergic signaling and capsaicin-induced neuronal modulation. Behaviorally, capsaicin shifted thermal preference toward cooler temperatures, consistent with TRP-mediated heat avoidance. This response, as well as the effect of the TRPV1 antagonist capsazepine, was markedly attenuated by MG 624 pretreatment. Grooming assays revealed differential modulation of antennal and leg grooming, suggesting distinct neural mechanisms and partial interaction between cholinergic and monoaminergic pathways. Despite pronounced neural and behavioral effects, neither TRP ligands nor nicotinic receptor blockade significantly altered whole-animal metabolic rate, as assessed by CO₂ production. Together, these findings indicate that cholinergic signaling contributes to behavioral responses induced by TRP ligands and interacts with capsaicin-induced neuronal modulation in P. americana. The results provide new insight into the neurochemical integration of thermosensory signaling and highlight cholinergic pathways as important contributors to insect thermoregulatory responses. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
| References: | Front Neural Circuits. 2018 Jul 03;12:45. (PMID: 30018539) J Neurosci. 2010 Sep 15;30(37):12219-29. (PMID: 20844118) J Insect Physiol. 2024 Jan;152:104597. (PMID: 38072185) PLoS Biol. 2006 Mar;4(3):e63. (PMID: 16494528) J Therm Biol. 2009 Apr 1;34(3):109-119. (PMID: 20161211) Philos Trans R Soc Lond B Biol Sci. 2019 Nov 11;374(1785):20190369. (PMID: 31544603) J Neurosci. 2010 Aug 4;30(31):10465-71. (PMID: 20685989) Br J Pharmacol. 1998 Jul;124(6):1197-206. (PMID: 9720791) Molecules. 2018 Dec 18;23(12):. (PMID: 30567399) J Neurobiol. 1988 Sep;19(6):489-97. (PMID: 3171574) Curr Biol. 2022 Mar 28;32(6):1362-1375.e8. (PMID: 35176227) Zh Evol Biokhim Fiziol. 2015 Mar-Apr;51(2):139-41. (PMID: 26027390) Neurosci Lett. 1996 Dec 13;220(2):142-6. (PMID: 8981493) Science. 2022 Mar 4;375(6584):eabk2432. (PMID: 35239393) Sci Rep. 2017 Sep 11;7(1):11091. (PMID: 28894186) Neurosci Res. 1994 Mar;19(2):235-40. (PMID: 8008252) Pest Manag Sci. 2021 Aug;77(8):3663-3672. (PMID: 33821538) Curr Biol. 2020 Aug 17;30(16):3167-3182.e4. (PMID: 32619476) Front Physiol. 2013 Feb 05;4:13. (PMID: 23386834) Curr Biol. 2020 Jun 22;30(12):2275-2288.e5. (PMID: 32442464) Curr Biol. 2016 Dec 5;26(23):3116-3128. (PMID: 27818173) Pestic Biochem Physiol. 2025 Sep;213:106532. (PMID: 40744562) Toxicology. 2016 Aug 10;368-369:162-171. (PMID: 27640743) Cell. 2003 Apr 18;113(2):261-73. (PMID: 12705873) J Exp Biol. 2025 Aug 1;228(15):. (PMID: 40611598) J Insect Physiol. 2016 Oct - Nov;93-94:56-63. (PMID: 27568395) Curr Biol. 2021 May 24;31(10):2075-2087.e6. (PMID: 33740429) Br J Pharmacol. 2004 Dec;143(8):1023-32. (PMID: 15492017) Insects. 2019 Nov 22;10(12):. (PMID: 31771114) Sci Rep. 2020 Jun 19;10(1):9963. (PMID: 32561812) Sci Rep. 2015 Jul 30;5:12690. (PMID: 26223769) Temperature (Austin). 2015 Jun 02;2(2):277-96. (PMID: 27227029) J Neurosci. 2008 Oct 1;28(40):9929-38. (PMID: 18829951) Trends Pharmacol Sci. 2007 Jan;28(1):14-22. (PMID: 17156860) J Comp Neurol. 1996 Mar 25;367(1):147-63. (PMID: 8867288) Toxicon. 2025 Mar;256:108264. (PMID: 39889891) Sci Rep. 2023 Sep 14;13(1):15202. (PMID: 37709909) PLoS One. 2012;7(3):e30837. (PMID: 22470415) Pflugers Arch. 2007 Aug;454(5):777-91. (PMID: 17219191) Commun Integr Biol. 2009;2(2):170-3. (PMID: 19513273) Cell. 2011 Feb 18;144(4):614-24. (PMID: 21335241) Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14668-73. (PMID: 18787131) J Comp Neurol. 1995 Oct 9;361(1):165-76. (PMID: 8550877) |
| Contributed Indexing: | Keywords: American cockroach; Capsaicin; MG-624; TRP receptors |
| Substance Nomenclature: | S07O44R1ZM (Capsaicin) 0 (Transient Receptor Potential Channels) 0 (Receptors, Nicotinic) 0 (TRPV Cation Channels) |
| Entry Date(s): | Date Created: 20260727 Date Completed: 20261012 Latest Revision: 20261015 |
| Update Code: | 20261015 |
| PubMed Central ID: | PMC13658535 |
| DOI: | 10.1007/s00360-026-01699-4 |
| PMID: | 42507117 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!